labmatrix

Translational Research Informatics Software System

Medications

Family History

Questionnaires

Demographics

Visits History

Pathology

Storage Location

Gene Expression

Proteomics

Custody History

Track all clinical & research data in a hierarchical and relational manner that facilitates secure collaborative data entry, and easy ad hoc data retrieval.

Etc… Etc…

Patient Data

Biospecimen Data

The Patient and Biospecimen data hubs in Labmatrix

Patient Data Capture:

•Clinical & demographics info

•Patient’s specimens & derivatives

•Phenotypes & genotypes tracking

•All other customizable study data

Specimen Data Capture:

•Physical measurements & desc.

•Current status & condition

•Storage location & barcodes

•Workflow processing status

•Usage & custody history

Calculate aliquots:

•by volume

•by mass

•by concentration

•by # of slides

Print barcodes:

•existing labels

•new GUID labels

Research BioBank 1B

Pathology Sample A597

(text-only label)

Specimen Barcoding & Aliquoting

- Design flexible specimen storage containers

- Batch assign & update samples to storage locations

- Generate or print freezer maps & barcode labels

Specimen Storage Management (electronic sample inventories)

Freezer Map

Track specimens and

their derivatives’

lineage relationship

Associate image files

and all other types of

flexible, custom-defined

data for specimens

Track Lineage, Images, and Custom-Defined Data

Multiple data record updates

You can update

multiple sample

records:

…via Labmatrix’s

graphic user

interface…

… or through

Excel and/or

other text editors.

(Also through our programmatic API)

Proprietary & Confidential

Define shortcuts to quickly

create all expected sample

records (and their derivatives)

based on your study’s specific

SOPs or workflows

“Specimen Factory”: one-click to generate all samples in your workflow

•Create specimen requests

•Change & monitor approval status

•Check & resolve “pull-list” items

•Update & track shipment status

Manage sample requests, inventory resolution, and shipments

Create any data form - tailored to your research

This is a scalable solution that

communicates with all data sources

Database

ETL Framework

SOAP

tab-delimited text

Data Transformer

Labmatrix Core API

Custom Web Services

DB

SOAP Enterprise

System

RMI API RMI Enterprise

System

WEB UI HTTP

DB

Large Flat Files DB

SQL Scripts

Web Forms, Data Files

XML

Java Objects

.TXT

Federation

Engine

DB DB

Many ways to get data into the system:

Labmatrix

Framework

Now that you have:

•Collected… ()

•Standardized… (Not yet? Use built-in data cleaning tools)

•Normalized… (Not yet? Use built-in formula calculation tools)

…some, or all of your project data, how do you best

make use of them?

14

Exploration Acquisition Analysis Analysis

Typical Scientific Data Workflow

1. Data Acquisition • Excel, Access, homebrews • (Electronic?!) forms, notes • LIMS & instruments output • Labmatrix forms & records • Other enterprise resources • Etc…

2. Data Exploration

3.Data Analysis • SAS, R • Spotfire • Tableau • Statisticians

• Etc…

• Easy, graphical queries • ETL & data cleaning tools • Formulas & calculations • Visualize charts & graphs

Cryptic DB you’ll never

have easy access to

Case Study: Common Problem in Translational Research

The Solution Qiagram: our award-winning “draw-your-question”

interface - SQL or programming training NOT required!

Just drag & drop, and run your query!

Qiagram: a visual data query tool Example 1: “reporting & operational statistics” data query

Qiagram: a visual data query tool Example 2: hypothesis-driven data exploration

Centralize Data: web-accessible system enables multi-site collaboration and

data collection, data/site management, data QA/review/reports, and immediate data

querying results; scalable, web browser client-server architecture

Encourage Standardization: increase & mandate data quality via

standardized (and customizable) data-entry interfaces, standardized vocabularies, and

standardized data models

Enforce User Roles & Permissions: flexible configurations of how

different users/groups/TAs can access specific data sets in collaborative settings

Maintain Security & Compliance: transmit data securely, facilitate

regulatory compliance, and track all data changes via detailed audit logs in this

HIPAA/PHI-compliant system; customizable data backup & recovery plans

Integration & Interoperability: multiple interfaces to communicate with

other data systems in your IT infrastructure; vocabulary & ontology definitions

KEY FRAMEWORK FEATURES