jacc: jan 22, 2019
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JACC: JAN 22, 2019
Dec 18, 2014
THE STUDY:
“HDL PARTICLE SUBFRACTIONS IN HEART FAILURE WITH
PRESERVED OR REDUCED EF .”
JACC: JAN 22, 2019
PRIMARY ENDPOINT: ALL CAUSE MORTALITY
SECONDARY ENDPOINTS: DEATH, MI, CABG, PCI
•
•
JACC: JAN 22, 2019
HDL PARTICLE SIZE AND STRUCTURE EXAMINED
•
• HDL SUBFRACTIONS MODULATE KEY PATHWAYS IN HEART FAILURE AS WELL !
HDL
WHAT IF HDL ( THE GOOD CHOLESTEROL) IS NOT
DOING ANYTHING GOOD, AND HOW CAN WE
TELL?
HDL-C= 60 mg/dl HDL-C=60mg/dl
I’m functional I’m non-functional
CAN HDL CHANGE FROM ANTI-ATHEROGENIC TO
PRO-ATHEROGENIC ???
HDL:
ANTI-ATHEROGENIC OR
PRO-ATHEROGENIC ????
Ansell BJ et al. Curr Opin Lipidol 18;427.2007
Davidson MH. et al. Therapeutic Lipidology . Humana Press 2007
GLOBAL VIEW OF HDL PROTEINS
J Clin Invest 117: 746, 2007
SMOKING AND HDL …………
DON’T FORGET ABOUT HDL !
•THE SECRET OF SUCCESS IS THE
CONSISTENCY TO PURSUE
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