iccai 2017 final program print...

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ICCAI’17PROGRAM

Wednesday July26th,201716:30–18:00 SCAIBusinessMeeting-allICCAIattendeeswelcome!

HotelMichelangelo(seemapp.3)19:30 SCAIBoardandConferenceOrganizersDinner

HotelMichelangelo(seemapp.3)ConferenceSite:Dept.ofElectronics,Information,andBioengineering(DEIB),PolitecnicodiMilano,viaPonzio34/5,Conferenceroom(plenary)andSeminarroom(posters)(seep.3)Thursdayam July27th,20178:00–8:30 Registration(opensalldaysat8:00am–closes3:30pm–2:00pmonSaturday)

8:30–9:15 Welcome

9:15–11:00 DiverseFocusesonComplexAcuteIllnessChair:TimBuchmanandGiuseppeBaselliKeynote: ComputingCardiacControlComplexityandCardioventilatory

CouplinginAcuteIllness(AlbertoPorta)PlenaryandPodiumpresentations:

1. TheTimesofOurLives(TimBuchman)2. Assessment of the status of deep blood vessels by means of video

camera(AlexeiKamshilin)3. TreatmentofstableCOPDpatients in2050:willextracorporealCO2

removalplayarole?(StefanoNava)

11:00–11:30 Coffeebreak

11:30–13:00 ICUmonitoringChair:RandallMoormanandMariaGabriellaSignoriniPlenaryandPodiumpresentations:

1. The state of the art of predictive analytics monitoring (RandallMoorman)

2. A Modified Weibull-Cox Proportional Hazards Model Accuratelypredicts ICU-onset Sepsis in Critically Ill Patients Prior to Clinical(MatthewStanley)

3. Metabolomicsshowssignificantdisruptions tometabolismafterporcineburninjury(ElizabethLusczek)

13:00–14:30 PosterSessions(seelistonthelastpage)&buffet

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Thursdaypm July27th,201714:30–16:30 MathematicalandComputationalModelingApproaches

Chair:JudyDayandRubenZamoraKeynote: ModellingtheComplexityofAcuteIllnessEpidemiology (MarinoGatto)PlenaryandPodiumpresentations:

1. Mechanisticmathematicalmodelingapproaches: an introductionwithapplicationstocompleximmuneprocesses(JudyDay)

2. ApplicationsforData-drivenAnalyses(RubenZamora)3. ModelingtheMetabolicResponsetoAcuteIllness(ElizabethLusczek)4. Estimationofpropertiesoftheheartfrombeattobeatpulsepressure

variationsinatrialfibrillationusingamechanisticmathematicalmodel:input data dependence of posterior uncertainty and modeldegeneration(MaximilianOremek)

16:30–17:00 Coffeebreak

17:00–18:30 ECFP7ShockOmicsInternationalWorkshopChair:RandallMoormanandMariaClaudiaIrigoyenPlenaryandPodiumpresentations:

1. Metabolomic state as early indicator of responsiveness to therapy in theacutephaseofsepticshock(AliceCambiaghi)

2. The role of fluid accumulation in early septic shock: differences in ANS-drivenresponsetotherapy(MartaCarrara)

3. Autodigestion as Mechanism for Multi-Organ Failure in Shock (GeertSchmid-Schonbein)

4. Peptidomiccharacterizationofhemorrhagicshockplasmasamples:effectsoftranexamicacid(ElisaMaffioli)

5. Clustering Shock in the Acute Phase using Graphical Models (FedericoAletti)

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Fridayam July28th,20178:30–10:00 Acutekidneyinjury(AKI)andorganscross-talk:newparadigms

(sponsoredbyFreseniusMedicalCare)Chair:GillesClermont,ManuelaFerrario PlenaryandPodiumpresentations:

1. “Largedatabasesinacutekidneyinjury”or“CriteriaforAKI:amodel-basedperspective”(GillesClermont)

2. Cardiovascular and sympathetic nervous system interaction in acutekidneyinjury”(FedericoPieruzzi)

3. Detrimental mechanisms of organ cross-talk during acute kidney injury(VincenzoCantaluppi)

4. AcutekidneyInjuryandFluidassessmentincriticalcareunits(FrancescoGarzotto)

10:00–10:30 Coffeebreak

10:30–12:15 Coagulopathy&CirculatingBiomarkersChair:MitchellCohenandMarkusHuberLangKeynote: Complex Crosstalking Complement and Coagulation System after

Polytrauma(MarkusHuberLang)PlenaryandPodiumpresentations:

1. Predictingandmodelingcoagulationafter injury.Towardsprecisiontraumacare(MitchellCohen)

2. The complexity of sepsis as seen from circulating biomarkers. TheALBIOStrial”(SergeMasson)

12:15–14:00 PosterSessions(seelistonthelastpage)&buffet

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Fridaypm July28th,201714:00–15:45 SystemsBiology

Chair:YoramVodovotzandSvenZenkerKeynote: AgeingPopulations,ComplexDiseasesandUnmetMedicalNeed:A

ChallengeforInSilicoMedicine(AdrianoHenney)Plenary:

1. Integrating Data-Driven and Mechanistic Computational Models ofInflammationinAcuteIllness(YoramVodovotz)

2. Mechanistic mathematical models and data driven methods fortranslational biomedical applications: mutually exclusive or fruitfullysynergistic(SvenZenker)

3. PanelDiscussion“Insilicomedicine”

15:45–16:15 Coffeebreak

16:15–18:00 LungInjuryChair:AndriyBatchinskyandAndreaAlivertiKeynote: IntegrativeGenomic,Transcriptomic,andProteomicApproachesto

Complex Acute Lung Injury Syndrome Endotypes (Jason D.Christie)

PlenaryandPodiumpresentations:

1. NitricOxide:morethanjustapulmonaryvasodilator(DonNull)2. Ventilator-related mechanical power: real-time calculation and

evaluation with models using different estimates of resistance andelastance(AndreaAliverti)

3. Volutramua versus atelectrauma: insights from imaging, mechanicsandclinicaltrials(LorenzoBall)

20:00 GalaDinneratHotelMichelangelo

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Saturday July29th,20178:45–10:00 Patho-physiologyofhemodynamiccontrolinacuteillness

Chair:MariaClaudiaIrigoyenandFedericoAlettiPlenaryandPodiumpresentations:

1. BaroreflexSensitivityandMortality inSepticDysfunction(MariaClaudiaIrigoyen)

2. Enteral protease inhibition in hemorrhagic shock: effect on autonomic(FedericoAletti)

3. Advanced signal processing for monitoring and assessment in the ICU(RiccardoBarbieri)

4. Adherence to Individualized Fluid and Vasopressor DosingRecommendation is Associated with Mortality Reduction in Sepsis: AMachineLearningApproach(ShamimNemati)

10:00–10:30 Coffeebreak

10:30–12:15 RespiratoryassistanceChair:AndriyBatchinskyandThomasLangerKeynote: FutureProspectiveinExtracorporealOrgansSupport (AlbertoZanella)PlenaryandPodiumpresentations:

1. ECMO transport of ARDS patients: the clinicians perspective (Maj JamesLantry)

2. Aeromedical evacuation at ground and high altitude using the MERKautonomous critical care platform: the researchers perspective (AndriyBatchinsky)

3. Mechanical ventilation during extracorporeal respiratory support: twocooksspoilthebroth?(ThomasLanger)

12:15–13:15 Buffet

13:15–14:30 ClosingceremonyandConcludingRemarks

1. SocietallyandProfessionallyResponsiblePublishing(PhilipLumb)2. TheFutureofSCAI(MitchellCohen)3. ThanksonbehalfoftheLocalOrganizers(GiuseppeBaselli)

14:30–19:00 SocialEvent:VisittoMilanGuidedtourbycoach,leavingformtheconferencesite.

1. Ca’Grandaancienthospital(builtin1456,nowUniversityofMilano)2. BasilofSant’Ambrogio(oldestRomanicchurchinMilano,startedin379)

ReturntoHotelareaattheCentralStation

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ListofPostersOndisplaythroughoutThursdayJuly27thandFridayJuly28th,2017

Contributedabstracts

1. Theselectivesurgicalpost-operativesepsisincidence,inhospitalmortalityand1-yearpostdischargemortality(JackChen)

2. PerformanceofanautomatedSIRSdetectionandquantificationalgorithmforsepsispredictioninanon-selectedcohortofICUpatients(MichaelHagmann)

3. Assessmentofthestatusofdeepbloodvesselsbymeansofvideocamera(AlexeiKamshilin)4. Anauditofcerebralperfusionpressuremonitoringinalevelonetraumaneurointensivecare

unit:targetCPPandtransducerpositioning(ShaydaKarimi)5. Echosonoscopyoftheinternaljugularveinintheestimationofthevolumetricstatus(Viktor

Kolerov)6. Metabolomicsshowssignificantdisruptionstometabolismafterporcineburninjury

(ElizabethLusczek)7. Mechanisticmodelingofhemoglobinglycationandredbloodcellkineticsenables

personalizeddiabetesmonitoring(RoyMalka)8. NationalTraumaCareSystem:StrategiesandApproachestoAchieveZeroPreventableDeaths

(AsadMoten)9. AdherencetoIndividualizedFluidandVasopressorDosingRecommendationisAssociated

withMortalityReductioninSepsis:AMachineLearningApproach(ShamimNemati)10. Estimationofpropertiesoftheheartfrombeattobeatpulsepressurevariationsinatrial

fibrillationusingamechanisticmathematicalmodel:inputdatadependanceofposterioruncertaintyandmodeldegeneration(MaximilianOremek)

11. Restrictiveguidelinesinastrainedhealthsystemdolittletohelpthosewithacutepancreatitis(MRSait)

12. AModifiedWeibull-CoxProportionalHazardsModelAccuratelyPredictsICU-onsetSepsisinCriticallyIllPatientsPriortoClinicalRecognition(MatthewStanley)

13. HeartRateVariabilityDetectsSepsisfromUrinaryTractInfectionduringtheFirstTwoHoursafterICUAdmission(RaviRadhakrishnan)

14. HandMotionAnalysisforskillsassessmentinUltrasoundexaminations(IlariaPacifici)ECFP7ShockOmicsInternationalWorkshop Chair:RandallMoormanandMariaClaudiaIrigoyen

1. Aporcinemodelofseverehemorrhagicshockwithfluidandbloodresuscitationtoevaluateplasmapeptidomicmodifications(GiovanniBabini)

2. Peptidomics:aninnovativeapproachtoStudytheAuto-digestionhypothesisinSepticShockPatients(JuliaBauzai)

3. Differentialgeneexpressioninsepticshockpatientsaccordingtotheearlysupportivetherapyresponse(DanieleBraga)

4. Aninvitromodelforcardiogenicandsepticshockdrugscreeningusingmicrofluidics(ClaudioStorini)