hippo signaling pathway - bio cusa › uploadfile › pathway › hippo... · 2018-06-05 · hippo...

HIPPO SIGNALING PATHWAY

CUSABIO TECHNOLOGY LLCPostal Address: 6161 Savoy Dr. Suite 1018 Houston, TX 77036, USA

Tel : 301-363-4651（Available 9 a.m. to 5 p.m. EST from Monday to Friday）Email: antibody3@cusabio.com Web: www.cusabio.com

Protein

Gene

chemical molecule

Other signal path diagram

phosphorylation+P

dephosphorylation-P

Direct promotion

ubiquitination+u

Direct inhibition

combination

dissociation

complex

BTRC AntibodyCSB-PA897464LA01HU

ID2 AntibodyCSB-PA010967LA01HU

PARD6G AntibodyCSB-PA863155LA01HU

TGFBR1 AntibodyCSB-PA023451LA01HU

SMAD1 AntibodyCSB-PA618998LA01HU

TEAD1 AntibodyCSB-PA023363DSR2HU

CDH1 AntibodyCSB-PA005034MA01HU

MOB1A AntibodyCSB-PA872519HA01HU

Control Ig

G

CCND3Input

120KD→

90KD→

50KD→

25KD→

20KD→

35KD→

250KD→

130KD→

72KD→

95KD→

55KD→

36KD→

Control Ig

G

CDH1Input

Control Ig

G

MOB1AInput

120KD→90KD→

50KD→

35KD→

25KD→

20KD→

MOB1B AntibodyCSB-PA762574HA01HU

120KD→

90KD→

50KD→

35KD→

25KD→

20KD→

Control Ig

G

MOB1BInput

SAV1 AntibodyCSB-PA875672ESR2HU

CCND3 AntibodyCSB-PA004814ESR2HU

CSNK1D AntibodyCSB-PA006067LA01HU-IP

Control Ig

G

CSNK1D

Input

120KD→90KD→

50KD→

35KD→

25KD→

20KD→

120KD→

90KD→

50KD→

35KD→

25KD→

20KD→

Control Ig

G

SAV1Input

CSNK1D AntibodyCSB-PA006067LA01HU

NPHP4 AntibodyCSB-PA015987LA01HU

TGFB1 AntibodyCSB-PA07309A0Rb

YWHAB AntibodyCSB-PA01544A0Rb

SMAD3 AntibodyCSB-PA021788ESR2HU

YWHAQ AntibodyCSB-PA026290ESR1HU

FZD10 AntibodyCSB-PA891782LA01HU

A549Hela

HepG2

120KD→

90KD→

50KD→

25KD→

20KD→

35KD→

MCF-7

PARD6A AntibodyCSB-PA878839LA01HU

120KD→

90KD→

35KD→

50KD→

25KD→

20KD→

HepG2

A549Stomach

Lung

SAV1 AntibodyCSB-PA875672ESR2HU

293TPc3 A549

120KD→90KD→

50KD→

35KD→

25KD→

20KD→

MCF-7NIH/3T3

SMAD2 AntibodyCSB-PA15557A0Rb

120KD→90KD→

50KD→

35KD→

25KD→

20KD→

HelaHepG2

JurkatK562

HeartLiver

Brain

TEAD4 AntibodyCSB-PA618010LA01HU

HelaMCF-7

HepG2

120KD→

90KD→

50KD→

35KD→

25KD→

20KD→

K562

PPP2R2A AntibodyCSB-PA018564LA01HU

120KD→

90KD→

50KD→

35KD→

25KD→

20KD→

BrainLiver

BrainKidney

Par6Par3

aPKC

RASSF6

Lg1Scnb

Dlg

YAP/TAZ

MobLats1/2

SAV1Mst1/2

Mer KIBRAFRMD

F-actin

PP2A

ASPP2Pp1

14-3-3

TGF-β signaling pathway

Wnt signaling pathway

RASSF1A

YAPSmad1Smad4

YAP/TAZSmad2/3

Smad4

YAP/TAZ? YAP/TAZ

TEAD YAP/TAZp73

-P

-P

-P

+P

+P+P

Proapoptotic genesPUMA

?

E-Cad

Crb

Tight junctionTight junction

Adherens junctionAdherens junction

E-CadE-Cad

Crb

E-Cad

Adherens junctionAdherens junction

TCF/LEFYAP

TEAD

14-3-3

YAP/TAZ

Axin2cycD

Sox2Birc2/5

Nkd1myc

SlugId1

Id2

CTGF

Pai-1

Smad7

AREG

ITGB2

FGF1

Birc5

AFP

Gh2

CTGF

Anti-apoptotic genes, Pro-proliferation genes

Pals1PATJAMOT

YAP/TAZ

Ajub