hhc 12cb 09 - aminoaxit

8/3/2019 HHC 12CB 09 - AMINOAXIT

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Gio vin: Bi Xun ng

AMINOAXIT

I/KHI NIM V DANH PHP1. Khi nim:

Aminoaxit l hp cht hu c tp chc, trong phn t cha ng thi nhmCacboxyl (-COOH) v nhm Amino (-NH2).

* CTTQ aminoaxit c 1 nhm amino v 1 nhm cacboxyl: 2. Danh php:a) Thay th:

Axit V.tr (1, 2, 3, ...) nhm (-NH2) + amino + ankanoic.b) Bn h thng:

Axit V.tr ( ,,,,, ..) + nhm (-NH2) + amino + tn axit thng.c) Tn thng: Glixin, alanin, valin, ...II/ CU TO PHN T* Cu to phn t

2 3OO OONH R C H H N R C

(phn t) (ion lng cc)Phn t aminoaxit c nhm COOH th hin tnh axit v nhm NH2 th hin

tnh baz nn thng tng tc vi nhau to ra ion lng cc.Do , iu kin thng chng l cht rn kt tinh, tng i d tan trong nc

v c nhit nng chy cao (phn hy khi nng chy).III/ TNH CHT HA HC1) Tnh lng tnh:

2) Tnh cht ca NH2(baz): A.A + HCl Mui

2 2 2 3OO OONH CH C H HCl H C CH N H Cl

3) Tnh cht ca COOH (axit)

A.A + NaOH mui + H2O2 2 2 2 2NH CH COOH NaOH NH CH COONa H O

este ho:

2 2 2 5 2 2 2 5 2NH CH COOH C H OH NH CH COOC H H O

4) Phn ngtrng ngng (poliamit)* V d:GlixinHNHCH2COOH + HNHCH2COOH NH2CH2CONHCH2COOH + H2O

(Lin kt peptit)axit - aminocaproic

2 2 5 2 5 2( min ) ( )

[ ] [ ]

ot

n

Axit a ocaproic Policaproamit

nNH CH COOH NH CH CO nH O

8/3/2019 HHC 12CB 09 - AMINOAXIT

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Gio vin: Bi Xun ng

IV/ VAI TR V NG DNGAminoaxit thin nhin l cht c s xy dng nn protein trong c th ng vt v

thc vt, ng thi cung cp nng lng cho c th hot ng.Trong s hn 20 aminoaxit thng gp trong protein c mt nhm cc aminoaxit

khng th thay th m c th ngi khng th t tng hp c, phi a t ngoi voqua thc n (nh: Val, Leu, Ile, Met, Thr, Ph, Trp, Lys).

Mt s aminoaxit c dng ph bin trong i sng, nh mui mononatri ca axitglutamic c dng lm m chnh (hay btngt).

Mt s aminoaxit c dng ph bin trong y hc, nh Methionin l thuc b gan,axit glutamic l thuc h tr thn kinh, His cha mt s bnh v d dy.

Mt s aminoaxit c dng lm nguyn liu sn xut t tng hp, nh: [] []

V/ BI TP1. Mt amino axit X, tc dng vi dd NaOH theo t l mol 1:1 v tc dng vi ddHCl

theo t l mol 1:2. Nu cho 10,4 gam X tc dng va vi NaOH thu c 12,6 gammui.

a) Xc nh s nhm chc ca amino axit?b) Xc nh X?c) Nhn bit X vi dd HCl, glixin?

2. Cho C4H11O2N + NaOH A + CH3NH2 + H2O. Vy CTCT ca C4H11O2N l :A. C2H5COOCH2NH2. B. C2H5COONH3CH3.

B. CH3COOCH2CH2NH2. D. C2H5COOCH2CH2NH2.

3. Mt amino axit A c 40,4% C; 7,9% H; 15,7 % N; 36%O v MA = 89. CTPT ca A l :A. C3H5O2N B. C3H7O2N C. C2H5O2N D. C4H9O2N

4. 0,1 mol Aminoaxit A phn ng va vi 100ml dung dch HCl 2M. Mt khc 18g Acng phn ng va vi 200ml dung dch HCl trn. A c khi lng phn t l:

A. 120 B. 90 C. 60 D. 80

5. A l mt Aminoaxit c khi lng phn t l 147. Bit 1mol A tc dng va vi 1mol HCl; 0,5mol tc dng va vi 1mol NaOH.Cng thc phn t ca A l:

A. C5H9NO4. B. C4H7N2O4. C. C5H25NO3. D. C8H5NO2.

6. C 0,01 mol Aminoaxit A phn ng va vi 40ml dung dch NaOH 0,25M. Mtkhc 1,5 gam Aminoaxit A phn ng va vi 80ml dung dch NaOH 0,25M. Khi

lng phn t ca A l :A. 150 B. 75 C. 105 D. 897. Cho 0,01 mol amino axit A tc dng va 80 ml dung dch HCl 0,125 M.C cn

dung dch thu c 1,835 gam mui . Khi lng phn t ca A l :A. 147 B. 97 C. 120 D. 150