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Health and Medical Research: Challenges ARE Opportunities
Cardiovascular Combination Pharmacotherapy
Global Summit, 2014: From concept to reality
Professor Warwick Anderson AM
NHMRC Chief Executive Officer
8 May 2014
Challenges and Opportunities
For government funders, for researchers and institutions: • Post GFC – stable funding • Multidisciplinary, “big science”, data • International collaboration • Focus on outcomes
– health and wealth – community
Ensuring quality – the “reproducibility “ challenge
Health & Medical Research – benefiting Australia
Development Grants Review
Independent, commissioned assessment of the outcomes from NHMRC
Development Grants, available from
http://www.nhmrc.gov.au/_files_nhmrc/file/media/media/rel12/nhmrc_development_grants_r
eview_april_public_121122.pdf
40 completed grants surveyed:
– 85% reached complete or partial proof of concept at completion of the
grant;
– 80% had secured a commercial partner (mostly Australian biotech firms);
– 55% are currently under some form of possible commercial development;
and
– 6 have resulted in product to market or are awaiting regulatory approval
$703,065.00 $715,479.00 $746,075.00 $760,463.00 $774,227.00 $788,958.00 $804,165.00
$-
$100,000.00
$200,000.00
$300,000.00
$400,000.00
$500,000.00
$600,000.00
$700,000.00
$800,000.00
$900,000.00
2009-10 2010-11 2011-12 2012-13 2013-14 2014-15 2015-16
Medical Research Endowment Account forward estimates
NHMRC Grant Funding related to Clinical Trials
$0
$20,000,000
$40,000,000
$60,000,000
$80,000,000
$100,000,000
$120,000,000
$140,000,000
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013
Includes all grants. Source: http://www.nhmrc.gov.au/_files_nhmrc/file/grants/dataset/2013/clinical_trials_2000_2013.xlsx
$0
$20
$40
$60
$80
$100
$120
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013
Millions
NHMRC Grant Funding related to cardiovascular disease and health
Project Grants n = 2,216
Program Grants n = 68
NHMRC’s PRIORITY ACTIONS - Grants
Development Grants n = 43
Centres of Research Excellence
n = 65
Create new knowledge
Accelerate research
translation
Build capability
Partnerships for Better Health Projects
and Centres n = 69 & 2
n = number of active grants as at January 2014
Career Development
Fellowship n = 257
Early Career Fellowship
n = 594
Research Fellowship
n = 427
Practitioner Fellowship
n = 82
Translating Research into
Practice Fellowships
n = 12
Scholarships n = 340
Targeted Calls for Research
Basic Science Clinical Science
Health Services Research Public Health
App Year mean mean mean mean
2001 2.1 2.9 3.1 3.4
2004 2.3 3.2 3.7 4
2007 2.5 3.5 4.6 4.4
2010 2.4 3.6 5 4.7
2013 2.6 3.9 5.4 5.1
Increasing multidisciplinary, team approaches CI #’s, project grants
• More CIs on PHR and HSR applications, progressive increases in all areas, more
marked in HSR and PHR
International collaborations
Global Alliance for Chronic
Disease research
European Union
International Cancer Genome
Consortium
A*STAR Singapore
Juvenile Diabetes Research
Foundation
California Institute for
Regenerative Medicine
National Institute for Health
Research (UK)
Human Frontier Science Program
National Natural Science Foundation of
China
Examples of collaborative grants
Global Alliance for Chronic Disease
Improving blood pressure (BP) control using a simplified treatment strategy including a three-in-one BP
lowering pill in Indian patients (CIs: Prof Anushka Patel, Prof Stephen Jan, Prof Anthony Rodgers, Dr Pallab
Maulik, Dr Ruth Webster, Dr Dorairaj Prabhakaran, Prof Simon Thom)
Funding: $1,067,559
A*STAR
Boosting effectiveness of new vaccines for dengue, HFMD and influenza by targeting vaccine antigens to Clec9A
on dendritic cells (CIs: Prof Ken Shortman, Dr Sylvie Alonso, Dr Mireille Lahoud, A/Pr Paul MacAry)
Funding: $382,653 with Singapore funding of SG$445,200.
NHMRC-European Union Health Collaborative Research Grant
The Use of a Multidrug Pill in Reducing Cardiovascular Events (UMPIRE) trial (CI: Prof Anthony Rodgers)
Funding: $309,625 with EU funding of AUD$4.7M.
The NHMRC Research Translation Faculty • More than 2500 NHMRC researchers, addressing NHMRC’s Major
Health Issues • Steering group • Developing a “Case for Action”
NHMRC 2013-15 Strategic Plan
1. National Health Priority Areas – Arthritis and musculoskeletal conditions, Asthma, Cancer control,
Cardiovascular and stroke, Dementia, Diabetes Mellitus, Injury prevention and control, Mental health (with a focus on depression), Obesity.
2. Improve the health of Aboriginal peoples and Torres Strait Islanders 3. Preparing Australia for the ‘omics’ revolution in health care 4. Primary health care 5. Improving care of patients with multiple and complex chronic diseases 6. Healthy start for a healthy life 7. Claiming benefits for human health not based on evidence 8. New and emerging health threats 9. Health and research in our region
Research Translation Faculty Over 2,800 Faculty members.
Faculty Steering Groups continue to work on developing shortlisted Cases for Action as follows:
Steering Group Shortlisted Case for Action Arthritis and Musculoskeletal Conditions
Re-fracture prevention in patients with minimal trauma fracture/osteoporosis
Asthma Appropriate prescription and use of asthma medication
Cardiovascular Disease and Stroke Appropriateness and performance in the management of CV disorders in Australia
Dementia Primary prevention of dementia using population strategies and big data sources
Diabetes Mellitus Prevention of Diabetes Mellitus Healthy Start for a Healthy Life Healthy Pregnancy Improving Care for Patients with Multiple and Complex Chronic Disease
Achieving safer and better chronic disease care for people with mental illness
Mental Health Embedding e-mental health services into practice
Obesity Prevention of excess gestational and post-partum weight gain
Primary Health Care Improve assessment and management of absolute cardiovascular disease risk
*Cancer, Injury prevention and control, & Claiming benefits for human health not based on
evidence (shortlisting in progress)
http://www.nhmrc.gov.au/
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