gunn’s dots with rtx1 - frcrnet · originally described by robert marcus gunn in 1883, gunn’s...

Gunn’s dots with RTX1Pr Michel Paques

Gunn’s dots

White glistening dots found in normal eyesFirst decribed in 19th centry; few publicationsAttributed to Müller cells without histological demonstration

Originally described by Robert Marcus Gunn in 1883, Gunn’s dots are observed

in the majority of healthy subjects up to 50 years of age

They are commonly attributed to Müller cell’s footplates

Despite their potentiel interest, no specific study yet

Paques et al. 2014

Gunn’s dots imaging by FIAO

Mean diameter 13.5µm ±6 Peak density ~ 200/mm2

While their distribution remain stable, the density of Gunn’s dots slowlydecreases over years

This suggest that they are flat and very close to the ILM

Gunn’s dots are highly anisotropic; their reflectance parallels that of

the ILM

→ This suggests that Gunn’s dots are flat

Franze K et al. PNAS 2007;104:8287-8292

Müller cellfootplate

ILM

Vitreous

From the Jastrow electron microscopy atlaswww.uni-

mainz.de/FB/Medizin/Anatomie/workshop/EM/EMHRetinaE.html

Müller cells footplates are much smaller and much more numerous than Gunn’s dots; However, confluence may increase their apparent size

Ogawa K. Arch Histol Cytol 2002

Qiao et al. BJO 2005

Guinea pig

Rat

Gunn’s dots are still present over the ILM after PVD, raising doubts

that they could be hyalocytes, furthermore, few histological evidence

of a flattened morphology of hyalocytes. However, it is unclear

wether or not all hyalocytes actually detach from the ILM following

PVD

Gunns dots are (probably) not in the retina