group sequential design basics with application … group sequential design basics with application...
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Group Sequential Design Basics with Application Using the
gsDesign R package and its GUI
Keaven M. Anderson
Merck Research Laboratories
February 23, 2011
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Software installation
• R 2.11 – gsDesignExplorer not yet compiled for R 2.12
• gsDesign 2.4-01 from CRAN
• gsDesignExplorer from Biopharmnet– Rename to gsDesignExplorer_1.0-2.zip prior
to installing as an R package from a local zip file
– There is also a version for R 2.9• Rename to gsDesignExplorer_1.0-2.zip, as above
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gsDesignExplorer:Demo for Group Sequential Design with a Time-to-Event
Endpoint
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Summary
• Basic group sequential design theory
• gsDesign R package for deriving group
sequential designs
• gsDesignExplorer GUI interface
• Application to binomial and time-to-event
endpoints
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