gross neuroanatomy measures & introduction to variability references steinmetz h., furst, g.,...

Gross neuroanatomy measures &introduction to variability

References

• Steinmetz H., Furst, G., Freund, H., “Cerebral Cortical Localization: application and validation of the proportional grid system in MR Imaging”, 1989, Journal of Computer Assisted Tomography, 13(1):10-19

• Ono M., Kubik S., Abernathey C.D., Atlas of the cerebral sulci, 1990, Thieme Verlag

Talairach transformation&

variability range of main sulci

Method• Tomographic images are collected on 30 hemispheres of 15 people

(22-63 yo)

• Talairach transformation is performed using 4 AC PC and 5 extreme landmarks

• Sulci are identified manually and projected sagitally

Align extreme pointsShift AC PC vertically and side-to-side

AC

PC AC

PC

Central Sulcus 20 hemispheres

Sylvian Fissure (R) 15 hemispheres

Sylvian Fissure (L) 15 hemispheres

Calossal, Parietooccipital, Marginal sulci, 30 hemispheres

Leftover variability after Talairach transformation

Summary

• Central sulcus (CS) in the postmortem Talairach brain is located 0.5-1.0 cm anterior to the CS in the 30 hemispheres studied here

• 2-3 cm displacement is observed in most of the studied major sulci

Incidence rates of main sulci

Method

• 25 postmortem brains

• Length determined by running a chord inside sulci

• Molded silicon models are developed to study internals of the sulci

Statistics

Statistics