from gene to protein dnaphenotype rna replicationtranscription *transcription translation...
Post on 19-Dec-2015
228 Views
Preview:
TRANSCRIPT
From gene to protein
DNA PhenotypeRNAReplication Transcription
*Transcription
Translation
*Translation
*Gene
The flow of information:1. Storage2. Replication3. Expression
DNA as the Genetic Material
Protein
2. Replication
Review nucleotide structure:
Structural analysis of DNA
DNA Replication and Synthesis
•Complementarity
•”It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism … “
•Mode of DNA Replication
Semiconservative
*Overview: DNA replication
*Complementarity determines which nucleotide will be added
*Chain elongation in a 5’-to-3’ direction
Initiation
*Primase
*Strands must separate•Helicases•SSBPs•DNA gyrase
*Two strands of a double helix are antiparallel
•Continuous DNA synthesis = leading•Discontinuous DNA synthesis = lagging
A large team of enzymes carry out DNA replication:
•Helicases
•SSBPs
•DNA gyrase
Elongation:
•Association of polymerase
•Sliding clamp
•Primase
•DNA synthesis (DNA pol)
•Primer removal and replacement (DNA pol)
•Ligase closes the gaps
The Molecular Basis of Heredity
The Flow of Genetic Information in the Cell
The Genetic Code
top related