equivalent circuit of an axon membrane. hodgkin & huxley’s voltage clamp of the squid giant...
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Equivalent Circuit of an Axon Membrane
Hodgkin & Huxley’s voltage clamp of the squid giant axon
Feedback Amplifier current proportional to
difference (E-input)
Input SignalMeasured
Current
Measured voltage
Hodgkin & Huxley’s voltage clamp of the squid giant axon:Current response to hyper-polarization and de-polarization
early inward Na
late outward K
Hodgkin & Huxley’s voltage clamp of the squid giant axon:Current response to hyper-polarization and de-polarization
late outward K
early Na
Hodgkin & Huxley separation of Na and K currents by variation of bath Na concentration
Separation of Na and K Current-Voltage curves
Separation of Na and K Ionic conductance changes
Rapid changes in gNa
Slow changes in gK
Na and K conductance at various voltage clamp steps
Channel openings and closings during Action Potential
Example of time course of changes in n & n^4 ~ gK and m, h & m^3*h ~ gNa
Voltage dependence of Hodgkin-Huxley model parameters
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