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Epigenetic modifications
Copyright © 2018 Abcam, All rights reserved.
Lpcat1
BBAP/DTX3L
HAT4
ARDT1
me
16
K
3
R1
S5
K
P mecit
o-p
bromo
ac
8
K
ac
12
K
ac
ac
ac
ac
20
K
47
S
91
K
me
MBT
tudor
PWWP bromo
ac
H4
adp
ub
SIRT2spSir2
PRMT1PRMT5PRMT6
CKIIScCK1 PADI4
hKAT1 (HAT1)scKAT1 (Hat1)spKAT1 (Hat1/Hag603)dKAT1 (CG2051)hKAT3A (CBP)hKAT3B (p300)dKAT3 (dCBP/NEJ)hKAT5 (TIP60/PLIP)scKAT5 (Esa1)spKAT5 (Mst1)dKAT5 (dTIP60)hKAT7 (HBO1/MYST2)spKAT7 (Mst2)dKAT7 (CHM)
hKAT3A (CBP)hKAT3B (p300)dKAT3 (dCBP/NEJ)hKAT5 (TIP60/PLIP)scKAT5 (Esa1)spKAT5 (Mst1)dKAT5 (dTIP60)hKAT7 (HBO1/MYST2)spKAT7 (Mst2)dKAT7 (CHM)
hKAT1 (HAT1)scKAT1 (Hat1)spKAT1 (Hat1/Hag603)dKAT1 (CG2051)hKAT5 (TIP60/PLIP)scKAT5 (Esa1)spKAT5 (Mst1)dKAT5 (dTIP60)hKAT7 (HBO1/MYST2)spKAT7 (Mst2)dKAT7 (CHM)
hKAT5 (TIP60/PLIP)scKAT5 (Esa1)spKAT5 (Mst1)dKAT5 (dTIP60)hKAT8 (hMOF/MYST1)scKAT8 (Sas2)spKAT8 (Mst2)dKAT8 (dMOF/CG1894)
hKMT5A (Pr-SET7/8)hKMT5B (SUV4-20H1)hKMT5C (SUV4-20H2)spKMT5 (Set9)dKMT5A (PR-set7)dKMT5B (Su(var)4-20)hKMT3B (NSD1)
RNF20/RNF40UBCH6ScRad6MST1
hKAT3A (CBP)hKAT3B (p300)dKAT3 (dCBP/NEJ)
hKAT3A (CBP)hKAT3B (p300)dKAT3 (dCBP/NEJ)
hKAT3AhKAT5B
ARDT1
5
K
ac 12
K
ac14
K15
K
ac
20
K
ac
30
K120
K
ubP adp
H2B
hKAT3B
NHK-1
ARTD1
1
S
H2A
P
120
T
P119
K
ub29
R
me13
K
adp11
R
me
3
R
me
5
K
ac
cit
PRMT1PRMT6
PRMT1PRMT6
Msk1PKC
PRMT6
PADI4
Bmi/Ring1A
hKAT3A (CBP)hKAT3B (p300)dKAT3 (dCBP/NEJ)hKAT1hKAT5ScKAT5
hKMT6B (EZH1)hKMT6 (EZH2)hKMT3G (NSD)dKMT6 (E/(Z))
PRMT6
spMst1spSir2
hKAT3AhKAT5B
hPRMT4
hPRMT4
PRMT5
PKC beta
PADI4
PADI4
PADI4
PADI4
ARTD1
hKAT3B (p300)hKAT2A (hGCN5)hKAT2B (PCAF)scKAT2 (Gcn5)spKAT2 (Gcn5)dKAT2 (dGCN5/PCAF)
hJAK2
ARTD1
hKMT4 (DOT1L)scKMT4 (Dot1)
ac
P
10
S
14
K
28
S
27
K
26
R
38
P37
K
79
K56
K
45
T
P
41
Y
P
6
T
P
P
bromo
PHD
MBT
tudor
chromo
ZF - CW
PHD
MBT
chromo
BIR
ANKYRIN
PWWP
14-3-3
P14-3-3
H3
P
me
me
chromo
me
chromo
me
cit
cit
ac
adp
adp
iso
30
P
iso
meac
me
ac
36
K
me
me23
K
ac18
R
ac
ac
17
R
me
8
R
me
P
9
K
11
T
P
3
T
P
ac me
4
K
ac me
cit
2
R
me cit
MSK1MSK2
hHDAC1hHDAC2
hPKC-delta
42
R
Rv1988
hKAT3B (P300)scKAT11 (Rtt109)spKAT11 (Rtt109)hKAT2A (GCN5)
DLK/ZIPPRK1
HaspinVrk1
SETMARhKMT2A (MLL1)hKMT2B (MLL2)hKMT2C (MLL3)hKMT2D (MLL4)hKMT2E (MLL5)hKMT2F (hSET1A)hKMT2G (hSET1B)hKMT2H (ASH1)hKMT3C (SMYD2)hKMT3G (NSD3)hKMT7 (SETD7)scKMT2 (Set1)spKMT2 (Set1)dKMT2A (Trx)
hKMT3A (SET2)hKMT3B (NSD1)hKMT3C (SMYD2)NSD2scKMT3 (Set2)spKMT3 (Set2)Zfh Setd3
scFPR4scFPR4
KDM6A (UTX)KDM6B (JMJD3)
PP1
SIRT6
Aurora BPim1MSK1MSK2IKK alpha
hKAT2A (hGCN5)hKAT2B (PCAF)scKAT2 (Gcn5)spKAT2 (Gcn5)dKAT2 (dGCN5/PCAF)hKAT3A (CBP)hKAT3B (p300)dKAT3 (dCBP/NEJ)hKAT6A (MOZ/MYST3)hKAT6B (MORF/MYST4)scKAT6 (Sas3)spKAT6 (Mst2)dKAT6 (CG1894)hKAT10 scKAT10 (Hap2)hKAT12 (TFIIIC90)
hKMT1A (SUV39H1)hKMT1B (SUV39H2)hKMT1C (G9a)hKMT1D (EuHMTase/GLP)hKMT1E (ESET/SETDB1)hKMT1F (CLL8)hKMT8 (RIZ1)spKMT1 (Clr4)dKMT1 (Su(var)3-9)
hKAT2A (hGCN5)hKAT2B (PCAF)scKAT2 (Gcn5)spKAT2 (Gcn5)dKAT2 (dGCN5/PCAF)hKAT12 (TFIIIC90)
hKDM1 (LSD1/BHC110)hKDM3A (JHDM2a)hKDM3B (JHDM2b)hKDM4A (JMJD2A/JHDM3A)hKDM4B (JMJD2B)hKDM4C (JMJD2C/GASC1)hKDM4D (JMJD2D)scKDM4 (Rph1)PHF8
hKAT2A (hGCN5)hKAT2B (PCAF)scKAT2 (Gcn5)spKAT2 (Gcn5)dKAT2 (dGCN5/PCAF)hKAT3A (CBP)hKAT3B (p300)dKAT3 (dCBP/NEJ)hKAT12 (TFIIIC90)
hKDM1 (LSD1/BHC110)spKDM1 (Swm1/Saf110)dKDM1 (Su(var)3-3)hKDM2B (JHDM1b/FBXL10)hKDM5A (JARID1A/RBP2)hKDM5B (JARID1B/PLU1)hKDM5C (JARID1C/SMCX)hKDM5D (JARID1D/SMCY)scKDM5 (Jhd2)spKDM5 (Jmj2)dKDM5 (Lid)
me
WSTF
K5
K119
ub
139
S
P
P
Y142
P
BRCT
ac
H2AXMst1ATMATR
PP4
EYA1/3
hKDM2A (JHDM1a/FBXL11)hKDM2B (JHDM1b/FBXL10)scKDM2 (Jhd1)hKDM4A (JMJD2A/JHDM3A)hKDM4B (JMJD2B)hKDM4C (JMJD2C/GASC1)scKDM4 (Rph1)dKDM2
NH2
O
C
N
N
NH2
O
OH
O
5caC
N
N
NH2
O
OH
5hmC
N
N
NH2
O
5mC
N
N
DNMT
TET
TET
TET
TDG,BER
AM-AR
AM-PD
TDG,BER
Rep
lica
tion Rep
lication
Replication
NH2
O
O
5fC
N
N
Epigenetic modificationsHistone modifications and DNA methylation are epigenetic marks that affect gene expression. This poster highlights the different types of epigenetic modifications and their writers, readers, and erasers.
Epigenetic modifications at AbcamTo help support your research, we have a range of resources, including sample preparation kits, detection assays for epigenetic modifications, recombinant active proteins, inhibitors of epigenetic pathways, and peptide array-tested monoclonal antibodies to histone modifications.
To find out more, check out our epigenetics content library where you can find more posters, guides, protocols, and webinars.
www.abcam.com/epigenetics
Histone modifications
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
Acetylation
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
Deimination
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
O-palmitoylation
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac Deacetylation P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
Phosphorylation
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
Ubiquitination
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
Methylation
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
Dephosphorylation
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
ADPRibosylation
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
Demethylation
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
Isomerization
Histone modifications binding proteins
Chromodomain proteins
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
CHD1 H3K4me2/3
HP1/spSwi6 H3K9me2/3
spChp1 H3K9me2/3
CDY1 H3K9me2/3
PC1/PC2/PC/LHP1 H3K27me3, H3K9me3
MSL3 H3K36me3
hMRG15 H3K36me, H3K4me3
scEaf3 H3K36me, H3K4me3
CBX1,3,5 H3K9me3/2
MPP8 H3K9me3/2
Tip60 H3K9me3/2
CBX2,4,6,7,8 H3K27me3/2, H3K9me3/2
MBT proteins
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac PHF20L1 H3K4me1, H4K20me1
SFMBT H3K9me1/2, H4K20me1/2
L3MBTL1 H4K20me1/2, H1bK26me1/2
L3MBTL1 H3K20me
L3MBTL1/2 H3K9me
MBTD1 H3K20me
PHD proteins
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
scYng1 H3K4me2/3
ING1,2,3,4,5 H3K4me2/3
BPTF/dmNURF301 H3K4me2/3
scSpp1 H3K4me2/3
scSet3 H3K4me2/3
scJhd1 H3K4me3
RAG2 H3K4me3
TAF3 H3K4me3
ICBP90 (Np95) H3K9me2/3
JARID1C H3K9me3
JARID1A H3K4me2/3
KIAA1718 H3K4me2/3
Lid H3K4me2/3
MLL1 H3K4me2/3
PHF2,8 H3K4me2/3
PHO23 H3K4me2/3
Pygo H3K4me2/3
CHD4 H3K9me
ICBP90 H3K9me
SMCX H3K9me
DPF3 H3K14ac
14-3-3 proteins
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
14-3-3 H3S10p, H3S28p
Tudor proteins
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
JMJD2A H3K4me3, H4K20me3
53BP1 H4K20me1/2
spCrb2 H4K20me2
PHF20 H4K20me2
TDRD3 H3R17me2a, H4R3me2a
scSgf29 H3K4me2/3
PHF19 H3K36me3
PHF1 H3K36me3
Bromodomain proteins
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
Polybromo/BAF180 H3ac
scSnf2 H3ac, H4ac
Brd2,3,4,7 H3ac, H4ac
TAF1 H3ac, H4ac
P/CAF H3ac, H4ac, H4K16ac
CBP/p300 H3ac, H4ac
scBdf1 H4ac
hBRG1 H3K14ac
scRsc1,2,4 H3K14ac (Rsc4)
scGcn5 H4ac, H4K16ac
ATAD2 H3K14ac
BRDT H4K5ac, H4K8ac, H3K18ac
CBP/p300 H4K20ac, H3K36ac
GCN5 H4K16ac
PB-2 H3K14ac
TRIM24 H3K23ac
ZF-CW proteinsP
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
ZCWPW1 H3K4me1/2
ANKYRIN proteins
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
G9a/GLP H3K9me2/1
PWWP proteins
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
BRPF1 H3K36me3
DNMT3A H3K36me3
PDP1 H4K20me1
HDGF2 H3K36me3
BRCT proteins
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
MDC1 H2AXS139p (γH2AX)
BIR proteins
P
P
14-3-3
ub
me
me
iso
cit
o-p
adp
PHD
bromo
MBT
tudor
chromo
ZF - CW
BIR
ANKYRIN
PWWP
BRCT
ac
ac
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