detox what.saslove
Post on 25-May-2015
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What is What is
““detoxing” Or detoxing” Or
“cleansing“cleansing””
Is Detox right for you?Is Detox right for you?Detoxification can be beneficial for
those with one or more of the following conditions:
Parasite infestationRecurring headachesBad breathHemorrhoidsIrritabilityFrequent coldsProtruding belly
Seasonal AllergiesFood allergiesChronic constipationFrequent gas & bloatingExcess weightFrequent fatigueImpaired digestionIrritable Bowel Syndrome (IBS)Candida infection
Common Signs & Symptoms Common Signs & Symptoms Linked to Linked to
Chronic Toxicant ExposureChronic Toxicant Exposure
• Marked sensitivity to environmental chemicals, odors, medications, &/or nutritional supplements
• Chronic, debilitating fatigue & lethargy• Depression, anxiety &/or mood swings• Cognitive dysfunction (poor memory and
concentration; learning disorders)
The Liver is the MajorThe Liver is the MajorDetoxifying OrganDetoxifying Organ
The liver utilizes a two-phase system in detoxifying the body of harmful substances:
• 11stst:: Transforms toxins into more water-soluble compounds that are then carried through the blood to the liver for further processing, or to the kidney for elimination.
• 22nd:nd: Completing the detoxification in the liver and sending the toxins back to the kidney for elimination, or into the bile for elimination via the GI tract.
Phase I & Phase IIPhase I & Phase II
• The congested or sluggish liver is characterized by a diminished bile flow, while impaired liver (hepatic) detoxification refers to decreased phase I and/or phase II enzyme activity.
• Phase I detoxification rates that are in excess of phase II activity will also cause toxicity problems due to excessive accumulation of activated intermediates.
Imbalanced DetoxificationImbalanced Detoxification
Phase ICYP P450
Phase IIConjugation
Damage to DNA, RNA, Proteins
Reactive IntermediateNon-Polar Xenobiotic
InertWater-Soluble
Metabolite
Phase 2Phase 2
• Phase 2 enzymes are highly dependent on energy and on adequate dietary protein.
• Phase 2 enzymes can be induced by numerous substances found in fruits, vegetables, spices and herbs.
• Both phase 1 and 2 are highly dependent on adequate nutritional status for their activity
excretoryderivatives
Supportive Nutrients for Detoxification Pathways Supportive Nutrients for Detoxification Pathways
Lipid-soluble molecule
polarwater-soluble( )
Bile
Feces/stools
Serum
Kidneys
Urine
ATPglutathioneglycinetaurineglutamineornithineargininemethyl donorsN-acetylcysteinecysteinemethionine
riboflavin (vit. B2)niacin (vit. B3)pyridoxine (vit. B6)folic acidvitamin B12glutathionebranched-chain amino
acidsflavonoidsphospholipids
Phase II[conjugation
pathways]
Phase I[cytochrome P450
enzymes]
ActivatedIntermediates
Genetic VariationsGenetic Variations
• There are numerous genetic variations in the activity of both phase 1 and phase 2 enzymes.
• This, along with nutritional status and total toxic load may help explain why detoxification abilities for a particular substance may vary as much as 100-fold or more between different individuals.
Causes of Impaired Causes of Impaired Detoxication: SummaryDetoxication: Summary
• Overwhelming toxic load (exogenous + endogenous)
• Impaired excretion (constipation or increased transit time; renal dysfunction)
• Inefficient fuels (macronutrient imbalance)• Deficiency of detoxifying substances
(antioxidants, cofactors, conjugating agents)
• Genetic Variation
Common Signs & Symptoms Common Signs & Symptoms Linked to Linked to
Chronic Toxicant ExposureChronic Toxicant Exposure
• Recurrent headaches• Muscle aching & weakness• Paresthesias and neuropathic pain• Recurrent infections• Infertility
Disorders Linked ToDisorders Linked To Toxicant Exposure Toxicant Exposure
• Chronic Fatigue Syndrome• Fibromyalgia• Multiple Chemical
Sensitivity• Allergies, Asthma • Atherosclerosis• Cancer
[ The Road to Immunity By Stephen Bock]
Potential Benefits of Potential Benefits of the Detoxification Programthe Detoxification Program
• Increased Energy & Vitality• Weight Loss• Breaking Weight Loss Plateaus• Better gut function• Clearer thinking• Improved Skin• Better Sleep• Improved Mood
What are you waiting for?
How to get started on your own Detoxification Program:
Join our Quarterly Group Cleanses and Bring a friend!!
(Individual programs also available)
Contact Lisa Saslove at 805-305-0774 or
lisasasloverd@gmail.com
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