cutera enlighten / picosecond + nanosecond nd:yag tattoo removal

Set Colors Free

Laser Tattoo Removal The Next Wave in Aesthetics

Expected

compounded

growth rate of 19%

through 2017 2

$588Per Treatment

45.2K Procedures

$26.6MM 1

Total Expenditure

1. ASPS 2013 Cosmetic Surgery National Data Bank2. Millennium Research Group, US Markets for Laser, Light, and Energy

Tattoo Demographics The New Face of Tattooees

1. Pew Research Center, MILLENNIALS: A Portrait of Generation Next, Feb 2010

US Tattoo Demographics 1

16% Have Tattoo RegretsDriving Demand for Tattoo Removal

• Top reasons for regrets:

1. Someone’s name is in the tattoo

2. Employment

stigma

3. Change of

heart

76% of people

feel body art

impacts their

employment

chances

Gen X have grown up

Millennials need a job

Tattoo Demographics and PsychologyWorldwide Cultural Homogeneity

• UK Tattoo Demographics 1

29% of people between 16 and 44 have a tattoo

Transcends across all societal classes

• 28% of middle-class

• 19% of AB class

• 27% of working class

• Tattoo Removal 2

32% rise in demand from 2011 to 2012

Employment prospects driving demand

1. http://www.dailymail.co.uk/news/article-2714837/More-quarter-middle-class-people-admit-having-tattoo-letters-scripts-proving-popular.html

2. http://www.stylist.co.uk/beauty/women-and-tattoos

Laser Tattoo RemovalChallenges Impacting Results

Diverse colorsVarying Depth

Formation ChangesSizes Varies

Incomplete ClearanceDespite Multiple Treatments

• Success rates after 10 Tx:

Source: Pier Luca Bencini, et al., “Removal of Tattoos by Q-switched Laser”. Arch Dermatol. 2012; E1-E7.

58% for black tattoos.

51% for black & red tattoos.

12% for other multi-colored tattoos.

enlighten Specifications

• Dual wavelength: 1064 nm and 532 nm

• Selectable pulse

duration: 750 ps and 2 ns

• Highest pulse

energies in class: 600 mJ at 1064 nm

300 mJ at 532 nm

• Small Footprint: 20”x33”x36” 50.8 cm X 83.8 cm X 91.4 cm

• Short warm up time: < 2 minutes

• Power Requirements: 110 VAC

• Novel Architecture: Clean pulse with high reliability

Therapeutic fluence throughout spot size range: 2 – 8 mm

Set Colors Free

What is enlighten™?

+ 2 wavelengths

= The Versatile, High-Powered Choice

Picosecond + Nanosecond

Highest Peak PowerEffective Treatment Outcomes

Highest power in its

class:

• 600 mJ at 1064 nm

• 300 mJ at 532 nm

Dual Pulse Duration Treats All Relevant Ink Sizes

Fountain Pen Ink

Fire Red 8061

Black 8001

Ink Conglomerate

Cutera Picosecond Pulse

Cutera Stretched Pulse

Q-switched Nd:YAG

Q-switched Alexandrite

1064 nm and 532 nm WavelengthsTargets 2 Most Common Colors

96%

23%19%

9%5% 5%

2% 1% 0.3%

0%

20%

40%

60%

80%

100%Ta

ttoo

Color

Fre

quen

cy

Blac

k or

Dark

Blu

e

Red

Gre

en

Yello

w

Whi

te

Lt. B

lue

Blue

Pink

Viol

et

Bla

ck o

r drk

blu

e

Red

Gre

en

Yellow

White

Lt

Blu

e

Blu

e

Pin

k

Vio

let

Nd:YAG1064 nm +++ + + +

532 nm + +++

Pier Luca Bencini, et al., “Removal of Tattoos by Q-switched Laser”. Arch Dermatol. 2012; E1-E7.

1064 nm WavelengthTreats All Skin Types

enlighten is 510k) cleared for the treatment of benign pigmented lesions in all skin typesAP0913 Rev A (05/14)

532 nm WavelengthTargeting Superficial Concerns

Ab

sorp

tio

n (

AU

)

Melanin

Hemoglobin

Wavelength (nm)532 1064755

Alex Nd:YAG

60

70

40

50

20

30

10

KTP

Relative Depth of Penetration(not to scale)

Therapeutic Fluence Customize Your Treatments

Independent control of

fluence and spot-size

enables:

• Precise depth control

• Adjustment of

therapeutic fluence

18

High Energy at Every Spot SizeTargeting Deep Dermal Concerns

8 mm 2 mm

Up to 4x greater

depth of penetration

Relative Depth of Penetration using 1064 nm(not to scale)

19

Designed Around UEasy to Use, Ready When You Are

A New Age in Short Pulse Technology

“With enlighten, the medical

community has a high power,

versatile picosecond device that

allows practitioners to fully

leverage the clinical possibilities of

extremely short pulse duration

treatments.” E. Victor Ross, M.D.

San Diego, California

Tattoo Removal

Clinical Results

Tattoo RemovalBefore and After

• Skin type IV, 2 treatments

• 532 nm, picosecond pulses

Before After 2 treatments

Tattoo RemovalBefore and After

• Skin type III, 3 treatments

• 1064 nm, picosecond pulses,1.3 – 2.5 J/cm 2

Before 3 treatments

Tattoo RemovalBefore and After

• Skin type II, 3 treatments

• 1064 nm, picosecond pulses,1.0 – 2.8 J/cm2

Before 3 treatments

Benign Pigmented Lesions

Clinical Overview

Benign Pigmentation LesionsCommon Disorders• Epidermal pigmentation

Solar lentigines (mottled hyper-pigmentation)

Freckles Post inflammatory hyper-pigmentation

(PIH) Seborrheic Keratoses Café au lait spots Nevus spilus Mole

• Dermal pigmentation Nevus of Ota Nevus of Ito Blue nevus

• Epidermal and dermal pigmentation Becker’s nevus Melasma Acquired dermal melanocytosis (ADM)

• Hori’s nevus• Acquired bilateral nevus of Ota like

maculae (ABNOM) Photos courtesy of Kei Negishi, M.D.

enlightenResults: 532 nm

100% of the subjects showed improvement in a

blinded review

enlightenResults: 1064 nm

73% of the subjects showed improvement in a blinded

review

*Data as submitted to FDA for 510(k) clearance

enlightenAverage Pain Score

Using 532 nm

1.4

Using 1064 nm

2.5

Clinical Results

enlightenBenign Pigmented Lesions

Pulse Width Picosecond Wavelength 532nm Fluence 1J/cm2

Photos Courtesy of Cutera Research Center

Before 3 months post one treatment

enlightenBenign Pigmented Lesions

Before

Pulse Width Picosecond Wavelength 532nm Fluence 0.6J/cm2

3 months post one treatment

Photos Courtesy of Cutera Research Center

enlightenBenign Pigmented Lesions

Pulse WidthPicosecond

PicosecondWavelength

532nm

532nmFluence

0.7J/cm2

0.9J/cm2

Before 3 months post 2 treatments

Photos Courtesy of Cutera Research Center

enlightenBenign Pigmented Lesions

Before

Pulse Width Picosecond Wavelength 1064nm Fluence 4.95 J/cm2

Photos Courtesy of Cutera Research Center

6 weeks post one treatment

enlighten Summary

• enLIGHTen dual wavelengths, dual pulse durations

and high power:

Addresses a diverse range of tattoo colors, ink

compositions and benign pigment concerns

Targets a diverse range of particle sizes from large

tattoo conglomerates to smaller tattoo particle

remnants

Addresses all skin types

• Easy to use

• Fast warm up time

• Ergonomic design