chronic immune activation inflammatory response

Washington D.C., USA, 22-27 July 2012www.aids2012.org

Cytokine storm in Leishmania/HIV-1 co-infected patients can be caused by LPS

and Leishmania infection

Chronic immune activationInflammatory response

ImmunoactivationInflammatory response

LPS

Visceralleishmaniasis

HIV-1/AIDS

Brenchley et al. 2006

Aim: investigate whether LPS from microbial translocation is implicated in the pathogenesis of this co-infection

Immunodeficiency Parasite-specific immunosuppression

600,000 people infected (Brazil) 3,500 anual/cases (Brazil)

Santos-Oliveira et al. 2011

Washington D.C., USA, 22-27 July 2012www.aids2012.org

Under HAART

Which factors contribute to cellular activation and cytokine storm in co-infected patients?

Washington D.C., USA, 22-27 July 2012www.aids2012.org

LPS plays an important role in the immunopathogenesis of visceral leishmaniasis-HIV-1 co-infection, acting as a co-factor to enhance the cellular activation and inflammatory cytokine response.

Conclusions

Acknowledgements

Dr. Carmem Giacoia-Gripp, Eduardo Regis,

Dr. Mariza Morgado and Dr. Alda Da-Cruz – IOC, Fiocruz

Dr. Manoel Oliveira-Neto, Dr. Beatriz Grinzstejn – IPEC, Fiocruz

Dr. Valdir Amato, Dr. Hiro Goto, Dr. José Angelo Lindoso - USP

Dr. Jorge Guerra – FMT

Dr. Priscilla Alexandrino-de-Oliveira – UFMS

Brazilian Ministry of Health - PN/DST-AIDS