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Chapter 1Lecture

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Hole’s Human Anatomyand Physiology

Twelfth Edition

Shier Butler Lewis

Chapter 1Introduction to Human Anatomy & Physiology

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1.1: Introduction

• Questions and observations that have led to knowledge.

• Knowledge about structure and function of the human body.

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1.2: Anatomy & Physiology

• Anatomy – the study of the structure of the human body

• Physiology – the study of the function of the human body

“The complementarity of structure and function.”

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1.3: Levels of Organization

• Subatomic Particles – electrons, protons, and neutrons• Atom – hydrogen atom, lithium atom, etc.

• Molecule – water molecule, glucose molecule, etc.

• Macromolecule – protein molecule, DNA molecule, etc.

• Organelle – mitochondrion, Golgi apparatus, nucleus, etc.

• Cell – muscle cell, nerve cell, etc.

• Tissue – epithelia, connective, muscle and nerve• Organ – skin, femur, heart, kidney, etc. • Organ System – skeletal system, digestive system, etc.

• Organism – the human

Levels of Organization

Subatomic particles

Atom

Molecule

Macromolecule

Organelle

Cell

Tissue

Organ

Organ system

Organism

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Organ Systems

Skeletal system Muscular system

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Integumentary system

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Organ Systems

Nervous system Endocrine system

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Organ Systems

Cardiovascular system Lymphatic system

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Organ Systems

Digestive system Respiratory system Urinary system

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Organ Systems

Male reproductive system Female reproductive system

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1.4: Characteristics of Life (10)

• Movement – change in position; motion

• Responsiveness – reaction to a change

• Growth – increase in body size; no change in shape

• Respiration – obtaining oxygen; removing carbon dioxide; releasing energy from foods

• Reproduction – production of new organisms and new cells

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Characteristics of Life Continued

• Absorption – passage of substances through membranes and into body fluids

• Circulation – movement of substances in body fluids

• Assimilation – changing of absorbed substances into chemically different forms

• Excretion – removal of wastes produced by metabolic reactions

• Digestion – breakdown of food substances into simpler forms

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1.5: Maintenance of Life

• Life depends on five (5) environmental factors:• Water• Food• Oxygen• Heat• Pressure

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Requirements of Organisms

• Water- most abundant substance in body- required for metabolic processes- required for transport of substances- regulates body temperature

• Food- provides necessary nutrients- supplies energy- supplies raw materials

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Requirements of Organisms

• Oxygen (gas)- one-fifth of air- used to release energy from nutrients

• Heat- form of energy - partly controls rate of metabolic reactions

• Pressure - application of force on an object - atmospheric pressure – important for breathing - hydrostatic pressure – keeps blood flowing

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Homeostasis*

* Maintaining of a stable internal environment

• Homeostatic Control Mechanisms – monitors aspects of the internal environment and corrects as needed. Variations are within limits. There are three (3) parts:

• Receptor - provides information about the stimuli

• Control Center - tells what a particular value should be (called the set point)

• Effector - elicits responses that change conditions in the internal environment

Homeostatic Control Mechanisms

Stimulus(Change occursin internalenvironment.) Response

(Change is corrected.)

Receptors Effectors(muscles or glands)

Control center(set point)

(Change is comparedto the set point.)

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Homeostatic Control Mechanisms

ReceptorsThermoreceptorssend signals to thecontrol center.

too high

too low

Normal bodytemperature37°C (98.6°F)

Control centerThe hypothalamusdetects the deviationfrom the set point andsignals effector organs.

Control centerThe hypothalamusdetects the deviationfrom the set point andsignals effector organs. If body temperature

continues to drop,control center signalsmuscles to contractInvoluntarily.

StimulusBody temperaturerises above normal.

EffectorsSkin blood vesselsdilate and sweat glandssecrete.

ResponseBody heat is lost tosurroundings, temperaturedrops toward normal.

ReceptorsThermoreceptorssend signals to thecontrol center.

EffectorsSkin bloodvessels constrictand sweat glandsremain inactive.

StimulusBody temperaturedrops below normal.

EffectorsMuscleactivitygeneratesbody heat.

ResponseBody heat is conserved,temperature rises toward normal.

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• There are two (2) types:

• Negative feedback mechanisms

• Positive feedback mechanisms

Homeostatic Control Mechanisms

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Negative feedback summary:

• Prevents sudden, severe changes in the body

• Corrects the set point

• Causes opposite of bodily disruption to occur, i.e. the ‘negative’

• Most common type of feedback loop

• Examples: body temperature, blood pressure & glucose regulation

Homeostatic Control Mechanisms

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Positive feedback summary:

• Increases (accelerates) the actions of the body

• short-lived

• do not require continuous adjustments

• Examples: blood clotting and child birth

Homeostatic Control Mechanisms

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Animation: Positive and Negative Feedback

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1.6: Organization of the Human Body

Thoracic cavity

Abdominalcavity

Diaphragm

Pelvic cavity

Cranial cavity

Vertebral canal

(a)

Abdominopelviccavity

Abdominalcavity

Pelvic cavity

Right pleuralcavity Mediastinum

Left pleural cavityPericardialcavity

Diaphragm

Vertebral canal

Cranial cavity

Thoraciccavity

(b)

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Thoracic & Abdominal Serous Membranes

Thoracic Membranes• Visceral pleura• Parietal pleura• Visceral pericardium• Parietal pericardium

• Visceral layer – covers an organ• Parietal layer – lines a cavity or body wall

Abdominopelvic Membranes• Parietal peritoneum• Visceral peritoneum• Parietal perineum• Visceral perineum

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1.7: Lifespan Changes

Aging occurs from the microscopic level to the whole-body level.

Can you think of some examples?

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1.8: Anatomical Terminology

Anatomical Position – standing erect, facing forward, upper limbs at the sides, palms facing forward and thumbs out

Integumentary system

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Anatomical Terminology:Orientation and Directional Terms

• Terms of Relative Position (based on anatomical position):• Superior versus Inferior (Cranial vs. Caudal)• Anterior versus Posterior (Ventral vs. Dorsal)• Medial versus Lateral• Ipsi-lateral versus Contra-lateral• Proximal versus Distal• Superficial versus Deep• Internal versus External

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Body Sections or Planes

• Sagittal or Median – divides body into left and right portions• Mid-sagittal – divides body into equal left and right portions

• Transverse or Horizontal – divides body into superior and inferior portions

• Coronal or Frontal – divides body into anterior and posterior portions

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Body Sections

A section along a frontalplane

A section along a transverseplane

A section along themedian plane

Transverse(horizontal)plane

Frontal(coronal)plane

Parasagittalplane

Median(midsagittal)plane

Body Sections

32(a) (b) (c)

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Other Body Sections

(a) (b) (c)

Cross-section

Oblique section

Longitudinal

section

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Abdominal Subdivisions

Righthypochondriacregion

Rightlumbarregion

Rightiliacregion

Epigastricregion

Umbilicalregion

Hypogastricregion

Lefthypochondriacregion

Leftlumbarregion

Leftiliacregion

Right upperquadrant (RUQ)

Left upperquadrant (LUQ)

Right lowerquadrant (RLQ)

Left lowerquadrant (LLQ)

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Body Regions

Otic (ear)

Cervical (neck)

Acromial(point of shoulder)

Mammary (breast)

Brachial(arm)

Antecubital(front of elbow)

Antebrachial(forearm)

Genital(reproductive organs)

Cephalic (head)

Orbital (eye cavity)

Mental (chin)

Sternal

Pectoral(chest)

Inguinal(groin)

Coxal(hip)

Umbilical(navel)

Pedal (foot)

Occipital(back of head)

Acromial(point of shoulder)

Brachial (arm)

Dorsum (back)

Cubital (elbow)

Gluteal (buttocks)

Perineal

Femoral (thigh)

Popliteal (back of knee)

Plantar (sole)(a) (b)

Patellar(front of knee)

Vertebral(spinal column)

Sacral (between hips)

Lumbar(lower back)Abdominal

(abdomen)

Carpal (wrist)

Palmar (palm)

Digital (finger)

Nasal (nose)

Oral (mouth)

Frontal (forehead)

Buccal (cheek)

Tarsal (instep)

Digital (toe)

Axillary (armpit)

Crural (leg)

Sural (calf)

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