cannabis empirical facts for medicals
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Cannabis Empirical Facts for Medicals
byProf. Dr. Musri Musman, M.Sc.
Professor of Natural Products ChemistrySyiah Kuala University, Banda Aceh
Presented at the Annual Scientific Meeting of Perhimpunan Dokter SpesialisKedokteran Jiwa Indonesia (PIT PDSKJI),
7-19 November 2018Indonesia Convention Exhibition, ICE, BSD, Tangerang.
Chemicals of Medical Cannabis 1269 known chemical compounds in/on Cannabis Cannabinoids (144 known in Cannabis) THC, CBD, CBN, CBG, CBC, THCV, etc. THCA, CBDA, CBGA, CBCA, etc. Diverse array of therapeutic effects
Terpenes & Terpenoids (150 known in Cannabis) Limonene, Linolool, Pinene, Myrcene, b-Carophyllene Smell attributes and diverse therapeutic effects
Flavonoids (50 known in Cannabis) Apigenin, Cannflavin-A, Kaempferol, Vitexin, Orientin Very strong anti-oxidants – diverse therapeutic effects
Most Common in Compositions
Cannabinoids THCA, THC, CBDA, CBD, CBGA, CBG, CBN Some on plant ratios of 2:1, >20:1, 3:2 Edibles = array of ratios, common 1:1 THC:CBD
Terpenes & Terpenoids Limonene, Linalool, Pinenes,
β-Myrcene, β-Caryophyllene Diverse effects – modulates cannabinoids Ensemble Effect – they are all important
Whole Plant is Superior Medicine Single chemical entity not very effectiveMarinol® (Dronabinol) – only THC
Two chemicals have better effect than just 1 Sativex® - approximately 1:1 THC:CBD
Cannabis Plant has many compositions!MORE THAN JUST THC and CBD!! Ensemble Effect hugely important
What is the Cannabis CompositionMore than 1+1 = 2 – Synergy FactorWildly different from product to product
Cannabinoids – A Broad TermPhytocannabinoidsCannabis sativa L. ProducedTHCA, CBDA, CBGA, CBCA, etc.
Cannabinoids – A Broad TermProcessed CannabinoidsDecarboxylation has occurredProcessing, Storage, Vaporization
O
OH
HO
OH
HO
OH
HO
O
CBG
THC CBD
CBC
Plant Production of CannabinoidsOH
HO
OH
O
Olivetolic Acid (OVA)
OPP
Geranyl Pyrophosphate (GPP)
Geranyl pryophosphate:olivetolic acid geranyltransferase (GOT)
HO
OH
OH
O
Cannabigerolic Acid (CBGA)
Plant Production of Cannabinoids
Decarboxylation With Heat
THC Oral Metabolism
O
OH
O
OH
11-Hydroxy-THC
HOTHC
O
OH
11-Nor-9-Carboxy-THC
HO O
•Swallowed(not felt)
•Feltpsychoactive
•ExcretedNon-psychoactive
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Izzo, et. al., Trends in Pharmacological Sciences 10, 515-27 (Oct 2009)
Preclinical research identifies a range of possibletherapeutic effects from phytocannabinoids
Cannabinoid Intoxicates? Possible Medicinal Application
THC √ Nausea and Vomiting, Muscular Spasms, PTSD, Pain,Cancer, Inflammation,
CBD x Epilepsy, Psychosis, Anxiety, PTSD, Addiction,Dementia, Cancer, Insomnia
CBDA x Epilepsy, Nausea and Vomiting, CancerCBDV x EpilepsyTHCA x Nausea and Vomiting, EpilepsyTHCV x Diabetes, Obesity, Pain, Inflammation, EpilepsyTHCVA x Under investigationCBG x Glaucoma, Cancer, Inflammation, Anxiety,
Huntingdon’s DiseaseCBGA x Under investigationCBN x Anxiety, Insomnia, Epilepsy, Anti-bacterial effectsCBC x Pain, Inflammation, Cancer
Cannabis for medical treatment:1. alcohol abuse
2. attention-deficit hyperactivity disorder (ADHD or AD/HD)
3. amyotrophic lateral sclerosis
4. collagen-induced arthritis
5. rheumatoid arthritis
6. Asthma
7. Atherosclerosis
8. Autism
9. bipolar disorder
10. childhood mental disorders
11. colorectal cancer
12. Alzheimer
13.skin tumors
14.depression
15.diabetic retinopathy
16.dystonia
17.epilepsy
18.digestive diseases
19.gliomas
20.hepatitis C
21.huntington's disease
22.hypertension
23.urinary incontinence
24. leukemia
25.morning sickness
26.methicillin-resistant Staphylococcus aureus (MRSA)
27.parkinson's disease
28.pruritus
29.posttraumatic stress disorder (PTSD)
30.sickle-cell disease
31.sleep apnea
32. lung cancer and chronic obstructive pulmonary disease
33.breast cancer
34.HIV/AIDS
35.brain cancer
36.opioid dependence
1. Acute Gastritis; Adenomyosis; Alzheimer’s; Amyloidosis; Amyotrophic Lateral Sclerosis (ALS); Anaphylactic or Reaction;Angelman Syndrome; Anorexia; Arthritis; Arthropathy (Gout); Asperger Disorder; Asthma; Attention Deficit Disorder (ADD);Autism.
2. Back Pain; Bell's Palsy; Bipolar Disorder; Bruxism; Bulemia.3. Cachexia; Cancer; Carpal Tunnel Syndrome; Cerebral Aneurysm; CFS; Chronic Pain; Cluster Headaches; CMT Disease;
Colitis; Colitis/Ulcerative Colitis; Colon Diverticulitis; Crohn's disease; CVS; Cystic Fibrosis; Cystitis/Urethritis.4. Darier's Disease; Depression; Diabetes; Diarrhea; Dravet Syndrome; Dupuytren's Contracture; Dyspepsia; Dystonia.5. E. T.; Eczema; Ehlers Danlos; Emphysema; Endometriosis; Epilepsy/Seizure Disorder.6. Felty's syndrome; Fibromyalgia; Friedreich's Ataxia.7. GastroEsophgeal Reflux Disease; Glaucoma; Graves' disease.8. Hemophilia A; Henoch-Schonlein Purpura; Herpes; HIV / AIDS; Hydrocephalus; Hypertension (High Blood Pressure);
Hyperventilation; HYPOGLYCEMIA-MMj Treatment.9. Incontinence; Inflammatory Bowel ; Insomnia; Interstitial Pneumonia; Irritable Bowel Syndrome.10. Limbic Rage Syndrome; Liver Disease; Lupus; Lyme Disease.11. Macular Degeneration; Marfan Syndrome-; mastocytosis; MD; Medical Marijuana as Pain Treatment for Patellofemoral
Pain Syndrome; Medical Marijuana Treatment for Addiction; Melorheostosis; Meniere's Disease; Menopausal Syndrome;Migraines; Motion Sickness; Movement Disorders; MRSA; Multiple Sclerosis (MS); Muscle Spasm; Muscle Spasms; MyofascialPain.
12. Nausea; Nephritis; Neurodegenerative Disorders; Neurofibromatosis; Neuropathy; Nightmares; NPS.13. Osgood-Schlatter; Osteogenesis imperfect.14. Palmar Hyperhydrosis; Pancreatic Cancer; Pancreatitis; Panic Attacks; Panic Disorder; Pectus carinatum (Pigeon
breast/chest); Pemphigus; Peptic Ulcer; Peutz-Jehgers; Polyarteritis Nodosa; Polycythemia vera; Porphyria—AlternativeSymptom Treatments; Post Concussion Syndrome; Post Traumatic Stress Disorder; PPS-Post Polio Syndrome; ProstateCancer; Pruritus.
15. Psoriasis; Pylorospasm reflux.16. Radiation Therapy; Raynaud's phenomenon; Reactive Arthritis; RLS-MMj Treats Symptoms.17. SAD; Schizophrenia(s); Scleroderma; Scoliosis; Selective mutism; Shingles; Sinusitis; Sjogren's Syndrome; Sleep Apnea; Spina
Bifida and Medical Marijuana; Sturge-Weber; Syringomyelia.18. Tenosynovitis; Testicular Cancer; Testicular Torsion; Thoracic Outlet Syndrome; Tic Douloureux; Tietze’s Syndrome; Tinnitus;
Tourette Syndrome and Cannabinoids; TTM.19. Wolff-Parkinson-White Syndrome.
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