cancer hyperthermia part2

Cancer Hyperthermia using MNP’s

Cancer is a class of diseases characterized by out-of-

control cell growth .

Cancer therapy :

Biological therapy

Hormonal therapy

Surgery

Chemotherapy

Radiotherapy

Supportive therapy

Photodynamic-therapy

Hyperthermia

Nanomedicine is the medical application of

nanotechnology

In nanotechnology, a particle is defined as a small

object that behaves as a whole unit in terms of its

transport and properties .

Magnetic nanoparticles are a class of

nanoparticles which can be manipulated using

magnetic field .

Magnetic hyperthermia:Magnetic nanoparticles are used in an experimental

cancer treatment called magnetic hyperthermia in which the fact that nanoparticles heat when they are

placed in an alternative magnetic field is used.

Materials & methods:

1-Raw materials

2- Sample preparation

MNP’s preparation

Characterizationof MNP’s

Transmission Electron

microscopy (TEM)

Dynamic light scattering (DLS)

AtomicForce

Microscopy (AFM)

Cytotoxicity (Tissue Culture)

Cell culture assays are used to assess the

biocompatibility of a material or extract through

the use of isolated cells in vitro.

These techniques are useful in evaluating the

toxicity or irritancy potential of materials and

chemicals.

They provide an excellent way to screen

materials prior to in vivo tests.

Exposed toMF ONLY

With MNP’s&MF

With MNP’sONLY

Control

Cell groups

Cell line

Cell line exposed to MF

0 100 200

0

10

20

30

40

50

60

70

80

90

100

110

%o

f su

rviv

ing

cells

nanoparticles concentration

magnet+nanoparticles

nanoparticles only

magnetic field

Results:

Thanks