cancer and lkb1
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Energy Homeostasisaka. Metabolic Stress
• ATP & AMP• Anabolic pathways– ATP + small molecules => AMP + large
molecule
• Catabolic pathways– AMP + large molecule => ATP + smaller
molecules
How is LKB1 a Tumor Suppressor?
• -LKB1 and AMPK– energy homeostasis (AMP:ATP )
• -prevents cell from dividing if there is an imbalance– Cancerous cells
• If LKB1 is absent the cell divides more often (Peutz Jeghers Syndrome)
Molecular Structure of LKB1• Arg74= reduce catalytic
activity -arginine• RESIDUES MUTATED IN
PJS• Interaction with STRAD– CFT [311-347]= reduced
catalytic activity– c-terminal flanking tail
Asp208
Arg74
Thr230
Glu199
Ser232
Citations• "Adenosine Monophosphate." ChemSpider. N.p., n.d. Web. 06 Dec. 2013.
<http://www.chemspider.com/Chemical-Structure.5858.html>.• "Case Study: Thermodynamics of ATP." Chemwiki. N.p., n.d. Web. 06 Dec. 2013.
<http://chemwiki.ucdavis.edu/Physical_Chemistry/Thermodynamics/Case_Studies/Case_Study:_Thermodynamics_of_ATP>.
• Cell Cycle with Checkpoints. Digital image. N.p., n.d. Web. 5 Dec. 2013. <http://answers.tutorvista.com/145710/what-is-the-cell-cycle.html>.
• Hardie, D. Grahame, and Dario Alessi. "LKB1 and AMPK and the cancer-metabolism link - ten years after." BMC Biology. N.p., n.d. Web. 4 Dec. 2013. <http://www.biomedcentral.com/1741-7007/11/36>.
• Stick Figure. Digital image. Portablestudios. N.p., n.d. Web. <http://portablestudios.com.au/?attachment_id=75#>.
• Serine/threonine Kinase 11. Digital image. Wikipedia. N.p., n.d. Web.• Van Aalten, Daan, and Elton Zeqiraj. "Structure of the LKB1-STRAD-MO25 Complex
Reveals an Allosteric Mechanism of Kinase Activation." ScienceMag. N.p., 5 Nov. 2009. Web. <http://www.sciencemag.org/content/326/5960/1707.full>.
• "What Is Cancer?" What Is Cancer? N.p., n.d. Web. 04 Dec. 2013. <http://www.cancer.org/cancer/cancerbasics/what-is-cancer>.
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