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Building the Biotechnology Sector in Houston
• Introduction• Houston Biotechnology Atmosphere• Why so few companies?• Possible solutions
Building the Biotechnology Sector in Houston
• Introduction• Houston Biotechnology Atmosphere• Why so few companies?• Possible solutions
Building the Biotechnology Sector in Houston
• Introduction• Houston Biotechnology Atmosphere• Why so few companies?• Possible solutions
BioHouston BackgroundNon-profit 501(c)3 founded by Houston-area research institutions to develop the Houston region – defined as College Station, to The Woodlands, to Galveston
Northcut MendelsohnGillis
Regional Research Strength from College Station to Galveston
• Texas Medical Center– Largest medical center in the world; 42+ member
institutions– $2.1 billion spent for additions to facilities from 2002-2004– 800+ acres; 100+ permanent buildings– Ground broken for The University of Texas Research Park
• Texas A&M University-College Station– Ranked 11th by NSF for total research and development
expenditures– 5,200+ acres, including a 324-acre research park– 2.5M+ square feet of research space
• University of Texas Medical Branch-Galveston– Ranked 19th of 121 medical schools in NIH funding– 84 acres; 77 major buildings– 385k+ square feet of research space
Massive but under-recognized research and commercialization assets
Leading Medical Institutions in the U.S.World Class Research Institutions
Baylor College of Medicine
• #1 in Pediatric Research funding-NIH (with TCH)
• #11 in NIH Awards to Med Schools-NIH
• #13 Research Intensive Medical Schools
The University of Texas M. D. Anderson Cancer Center
• #1 in Oncology
• #5 in Gynecology
• #10 in Urology
• #10 in Ear, Nose and Throat
• #10 in Rehabilitation
The University of Texas Medical Branch
• 1 of 2 Infectious Disease and Biodefense National Laboratories
• 1 of 6 Regional Centers of Excellence for Biodefense
• #19 in NIH Awards to Med Schools-NIH
Methodist Hospital
• #10 in Neurology and Neurosurgery
• #17 in Cardiology and Cardiac Surgery
Rice University
• #1 in Nanotechnology Commercialization
The University of Texas Health Science Center School of Public Health
• #1 in Health Education
Texas Children’s Hospital
• #1 in Pediatric Research funding-NIH (with BCM)
• #4 in Pediatrics
Texas Heart Institute
• #9 in Cardiology and Cardiac Surgery
University of Houston
• #2 in Health Law
Source: U.S. News and World Report, 2004, NIH database, Small Times
Other Selected Centers of Excellence
• Gulf Coast Consortium for Bioinformatics
• Gulf Coast Center for Computational Cancer Research
• John S. Dunn, Se. GCC for Chemical Genomics
• John S. Dunn, Sr. GCC For Magnetic Resonance
• Gulf Coast Consortium for Membrane Biology
• Gulf Coast Consortium for Protein Crystallography
• Gulf Coast Consortium for Theoretical and Computational Neuroscience
• Gulf Coast Consortium for Bioinformatics
• Gulf Coast Center for Computational Cancer Research
• John S. Dunn, Se. GCC for Chemical Genomics
• John S. Dunn, Sr. GCC For Magnetic Resonance
• Gulf Coast Consortium for Membrane Biology
• Gulf Coast Consortium for Protein Crystallography
• Gulf Coast Consortium for Theoretical and Computational Neuroscience
Brown Foundation Institute for Molecular Medicine
Brown Foundation Institute for Molecular Medicine
Source: Battelle Memorial Institute and the State Science and Technology Institute study
Research Leadership
• Historical firsts:– First multiple organ
transplant
– First identification of C60
– First draft of the human genome
– One of two National Biocontainment Labs
– First artificial artery– First successfully cloned
companion animal– First total heart
transplant
• National Recognition:– Three Nobel laureates– 16 members of the
National Academy of Sciences
– Two Presidential Advisors– Hundreds of members of
national academies
• Next Generation of Leaders:– #2 in higher education
degrees in bioscience– #3 for university
expenditures in biosciences– 22,000+ biomedical
students in the Texas Medical Center
Houston region highlights
• Total annual academic research investments exceed $1.5 billion
• 140+ life science companies
• Number of companies has doubled since 2003
• Approximately 1/3 are therapeutic, 1/3 are device and 1/3 are tools and service providers
• Recent VC investment activity in region
Best Biotech Fields for Houston to Grow
Oncology
Neuroscience
MetabolicDiseases
Biodefense /InfectiousDisease
CardiovascularMedicine
GenomicsGenetics
Nanotechnology
Texas Emerging Technology Fund
• Initiated in 2005.
• $175 million in funds available
• $52.9 million in total statewide life science grants have been awarded or are currently under final review by State leadership
• 9 Houston region life science companies have received grants for $10.1 million since inception
• Texas Life Science Committee conducts extensive due diligence (business/science/IP) on technologies and companies before forwarding to leadership for final approvals
$3 Billion Cancer Research Initiative Approved in November 2007
• Established Cancer Prevention and Research Institute of Texas
• Peer reviewed distribution of up to $300 mm in grants per year over next decade
• Every $1 invested will require $0.50 in matching spending by recipient organizations
• Public and private educational institutions and medical research facilities will be eligible for grants
• First investment expected in 2009
TanoxA 20-year and $919 Million Journey to
Success
• The Houston region is home to the 2 largest IPO’s in biotech history:– Tanox: Acquired by Genentech for $919
million in 2007– Lexicon Pharmaceuticals: Ten
products in clinical pipeline
Also… – Agennix: Developing drugs for cancer
and diabetic ulcers; in late-stage trials for NSCLC
– Cyberonics: VNSTherapy for epilepsy and depression
– Introgen Therapeutics: In late-stage development of ADVEXIN to treat head and neck cancer
– Repros Therapeutics: Lead drug Proeelex; IND will be submitted to initiate Phase 3 trials for Uterine Fibroid indications
Snapshot of SuccessIntrogen
Texas Life Science Conference
• Largest investment conference in Southwestern U.S.
• 2007 Conference– More than $6 billion in current funds in attendance– 50+ company presentations– Record attendance– Texas Governor Rick Perry addressed meeting
• 2008 Conference will be held November 5-7
Why Houston?
“Nowhere in the country is there such research infrastructure, scientific
leadership, and patient numbers in such close proximity.”
Building the Biotechnology Sector in Houston
• Introduction• Houston Biotechnology Atmosphere• Why so few companies?• Possible solutions
Why so few companies?
• Everybody wants to be “the next San Diego”. • Institutions doing more development. • Easier to export ideas and talent.• Lack of experienced management. • No soft landing for failures.• Insufficient informed Venture Capital.• Unfamiliar value proposition.
Building the Biotechnology Sector in Houston
• Introduction• Houston Biotechnology Atmosphere• Why so few companies?• Possible solutions
Possible solutions
• Support pump priming efforts• Insist on regional cooperation• Strategic recruiting• Monitor the ETF and CPRIT $• Philanthropic investments
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