brain imaging in ad
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© TND 2005
Brain Imaging in ADBrain Imaging in AD
Mony J. de Leon
Professor of Psychiatry
Center for Brain Health
NYU School of Medicine
NY NY 10016
mony.deleon@med.nyu.edu
© TND 2005
General Atrophy in Alzheimer’s Disease
© TND 2005
© TND 2005
© TND 2005
Brain Staging Model for ADBrain Staging Model for AD
NormalNormal
MCIMCI
ADAD
Entorhinal CortexEntorhinal Cortex
HippocampusHippocampus
Temporal NeocortexTemporal Neocortex
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
© TND 2005
ConclusionsConclusions
• In vivo imaging is of use in the early identification of brain changes associated with AD.
• The patterns of imaged brain changes appear to first involve the entorhinal cortex, then the hippocampus, and later the neocortex.
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