bioremir poster a4 v7 - physikalisch-technische …bioremir_poster_a4_v7.pptx author: rabus01...
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JRP-h21 BioReMIRJRP-h21 BioReMIR
Biologically Relevant Metrology of Ionising RadiationWhy the project is needed What the project will change How the project will make this possible
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d • 2.5 million radiotherapy treatments of cancer in EU per year• Combining different radiation types could give better results
• A metrologically sound methodology for determining radiobiological weighting factors will become available
• Developing micro- and nanodosimeters for multi-scale measurement of particle track structure in clinics
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• Combining different radiation types could give better results
• Different biological effectiveness must be taken into account
• Up to 20% variance in prescribed dosage depending on
• Combining different radiation types will become possible where dosage is prescribed in a standardised way
• Treatments at different centres will be comparable (�costs)
• Calibration of nanodosimetry with biological end points
• Developing a prototype treatment planning tool based on multi-scale model for prediction of treatment outcome
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• Up to 20% variance in prescribed dosage depending on methodology for determining biological weighting factors
� Lack of comparability between centres
• Treatments at different centres will be comparable (�costs)
• Novel treatment modalities will become faster available
• Potential of radiotherapy will be fully exploitable
multi-scale model for prediction of treatment outcome
• Establishing uncertainty budget for microdosimetric and nanodosimetric quantities
� Development of full potential of radiotherapy is hampered• Potential of radiotherapy will be fully exploitable
(� cure rates, � quality of life of patients) � Quantitative comparison of treatment plans
WP5: Traceability for biologically relevant metrology of ionising radiation
WP1: Practical easy-to-use detectors for multi-scale characterisation of particle track structure of ionising radiation
WP 1 WP5
characterisation of particle track structure
• Calibration of • Developing portablegas-based
WP 1
WP2WP4
WP5nanodosimetry based on CHOcell line survival
gas-based microdosimeters
WP3WP3• Reference multi-scale
measurement set-up
RADIO-BIOLOGY
NANO-DOSIMETRY
MICRO-DOSIMETRY
1-2 nm1 µm
• Investigate nano-scale technologies for advanced detectors
Exc
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set-upadvanced detectors
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WP2: Extending the multi-scale simulation tool to WP4: Uncertainty budget of track structure quantities WP3: Integrating the multi-scale approach into
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WP2: Extending the multi-scale simulation tool to cell killing and functional changes in cells
Track structure characteristics
WP4: Uncertainty budget of track structure quantities obtained from measurement and simulation
• Uncertainties of micro-/nanodosimetric distributions
WP3: Integrating the multi-scale approach into radiotherapy treatment planning
• Prototype treatment planning tool based on nanodosimetry
∑∞
=
=1
1ν
νν PMChromatin structure− measurement: operating parameters
− simulation: interaction cross section models
• Benchmarking by comparing correlated distributions
• Simulate treatment outcome using radiobiological models
� Evaluated radiotherapy plans for review by clinicians
∑∞
=
=i
i PFν
ν
• Benchmarking by comparing correlated distributions � Evaluated radiotherapy plans for review by clinicians
1.21.3 protons
α-particles
Integration of all cellular damage
Correct repair
Incorrect repair
Apoptosis & Necrosis
0.9
1.0
1.1
Tsi
m/ T
exp
Integration all over the exposed cellsCellular outcome
Tissue outcome
0.1 1 100.75
0.8
0.9
Projectile energy in MeVTissue outcome
Projectile energy in MeV
Knowledge Transfer and Training:
�Stakeholder Committee
Uptake and Exploitation:
� Interaction with companies developing treatment planning tools
Imp
act
�Stakeholder Committee
�Consumer group (healthcare professionals, patients)
�Web page including video on micro-/nanodosimetry suited for general public
� Interaction with companies developing treatment planning tools
�Demonstration of the tools to the clinical community
�Patenting novel detectors and furthering commercialisation
Imp
act
�Web page including video on micro-/nanodosimetry suited for general public
�Conference contributions, papers
�Open source distribution of codes through Geant4 platform
�Patenting novel detectors and furthering commercialisation
�Propose designed reference facility as metrology-based radiobiology end station at accelerators
Imp
act
�Open source distribution of codes through Geant4 platform
� 2 Stakeholder Workshops, 3 training courses
� International School on micro- and nanodosimetry� International School on micro- and nanodosimetry
�Cooperation with standardisation bodies (IAEA, ICRU, ESTRO, EURADOS, ...)
Consortium:
• Multidisciplinary team combining expertise in cutting edge research on metrology
Collaborators:
• Stakeholders from radiotherapy and industry aiding with establishing a pipeline of
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• Multidisciplinary team combining expertise in cutting edge research on metrology of radiation effects at the microscopic scale, radiobiology, and radiotherapy.
• 14 world leading European institutions including 7 NMIs/DIs, 4 research institutes bringing in special skills and 3 clinical partners providing a route to exploitation.
• Stakeholders from radiotherapy and industry aiding with establishing a pipeline of innovation from fundamental metrological research into the clinical environment.
• Clinical and pre-clinical collaborators represent the global elite of cutting edge research for improved radiotherapy.
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bringing in special skills and 3 clinical partners providing a route to exploitation. research for improved radiotherapy.
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