bioitworldexpo - 2011april - the pistoia alliance
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The Pistoia AllianceStrategy, Progress, Momentum
Ramesh Durvasula, PhDDirector, Molecular Sciences & Candidate Optimization
Informatics, Bristol-Myers Squibb
Board Member of Pistoia Alliance
BioITWorld Expo, Boston, April 2011
22
Agenda
Industry Drivers
The Origins of Pistoia
The Mission and Strategy of Pistoia
The Initiatives of Pistoia
33
What is Core to your Business? What is Critical?
Core?
Cri
tical?
Focus
Staff on
Innovation
Externalize
for Cost
Reduction
Externalize
for
Best
Practices
Reduce
Non-Value
Added Work
1990
2011
Pistoia MembershipFebruary2011
55
The Mission of the Pistoia Alliance
Lowering the barriers to innovation
by improving the interoperability of R&D business processes
via pre-competitive collaborations
66
Domains of Action
Biology & Translational
MedicineChemistry
Scientific Collaboration
77
The Focus of Each Domain
Big Data, Analytics, Semantics
Supply Chain, Tech Transfer
Vocabularies, Use Cases,
Best Practices
Biology Chemistry
Scientific Collaboration
The Biology Domain
1. Sequence Services
2. SESL
3. Biology Domain Roadmap
Sequence Services
Biology Domain
1010
Sequence Services – the Rationale
“It takes all the running you
can do, to keep in the same
place!” -- Red Queen
1111
Sequences & Cloud
SESL
Semantic Enrichment of Scientific Literature
Biology Domain
1313
Try this at your desk….
Which diseases are correlated to TCF7L2?
Gene/Protein Literature – Full TextLiterature - Abstracts
Inherited diseases Gene expression
1414
Try it again with Pistoia’s SESL….
Gene naming/synonyms
Gene Function
Literature statistics
Disease co-occurrences
Gene/protein interactions
…all in one report from one
search
HOW? A standard ontology,
data model, query language,
report structure, etc.
1515
The Deliverables of SESL
A Proof-of-Concept to demonstrate feasibility and clarify requirements
A functional specification for query brokering, result filtering, report generation
A potential for a new Business Model
The Roadmap of the Domain
Biology Domain
1717
1818
Breadth of Information Integrated (content)
Co
mp
lexity
of S
erv
ice
-En
ab
lem
en
t
SESL
Sequence
Services
Secure integrated
multi-domain
information services
…
caBIG
SAGE
EATRIS
ELIXIR
Sequences Expression Scientific Literature
Biology Domain Roadmap
Large Scale
Analytics
Multi-
tenant
Security
Hosting &
integration of
private data
1919
A Reality Check: Setting Expectations
2020
Our industry needs a Disruptive Innovation. That Disruption...is Pistoia
IF YOU WANT TO GO FAST, GO ALONE
IF YOU WANT TO GO FAR, GO TOGETHER
Thank you
http://goo.gl/0eytHwww.pistoiaalliance.org
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