bap1 and involvement in mesothelioma, cmml, uveal (eye) melanoma

BAP1 and involvement in Mesothelioma, CMML, Uveal (eye) melanoma

BAP1 is a de-ubiquitinating enzyme (DUB) found in the nucleus

BAP1 has many roles within the cell

Developmental problems in mice

BAP1 mutations are found in many human cancers

• Breast

• Lung

• Skin

• Kidney

• Prostate

• Ovary

• Colorectal

• Pancreatic

Hereditary BAP1 +/- predisposes humans to certain cancers

Mesothelioma

• Leukemia (CMML)

Uveal Melanoma

BAP1 KO Mice Enlarged d spleens

Excess White Blood Cells

Low Platelet d d and Red Blood d Cell Count

Chronic Myelomonocytic Leukemia (CMML)

Inhalation of asbestos fibers canlead to mesothelioma

Surgery Chemotherapy Radiation

Uveal melanomas can be treated with cutting-edge radiosurgery

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