arroz dorado y trigo transgenico
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“Importancia de los transgénicos en la alimentación mundial: caso dely avances en trigo transgénico”
Bioseguridad y Biotecnología ModernaUniv Nal La Molina, Diciembre 2010
Jorge E. Mayer, PhD, MIP (Law)
Manager Germplasm EnhancementGrains Research & Development Corp, Australia
Formerly Golden Rice Golden Rice Project ManagerProject Manager
Equity, a matter
of perspect
ive
Marie Claire, April 2000
Are you eating science’s
mistakes?
Perception is reality!
Source: J Webster
MalawiJanuary 2008
Stein 2006
Clinical and subclinical VADClinical and subclinical VAD
Micronutrient Initiative 2004100 -140 million children suffer from VAD
0
5
10
15
20
25
30
35
40
45
50
Mor
tali
ty (
per
1,00
0 ch
ild in
terv
als)
Sommer et al. Lancet ii:585 (1983)
Normal
Night blindness
Bitot’s spot
Night blindness+ Bitot’s spot
Xerophthalmia severity
Vitamin A status correlated with symptoms and severity of these eye afflictions. In severe cases 900 percent mortality increase!
VAD and children mortality: Their eyes tell storiesVAD and children mortality: Their eyes tell stories
Water
Protein
MineralsLipidsFiber
Carbohydrate
Interventions• Education • Industrial fortification (e.g. butter, oil,
flour)• Supplementation (capsules)Limitations•Distribution (10-thousands of helpers
needed)•Trained medical personnel lacking•Centralised food processing required•Do not reach remote areas•Economically unsustainable
Strategies and their drawbacks
The State of the World’s Children 2008 - UNICEF
010
2030
40
60
80
100
Bangla
desh
Bolivia
Haiti
India
*
Cambo
dia
Nepal
Ethiop
ia
Philipp
ines
Burun
di
S
A
Per
cen
t o
f ch
ildre
n c
ove
red
In average, 38 percent of the children don’t receive vitamin A supplements
Vitamin A supplementation has reached plateau level ($500m)Vitamin A supplementation has reached plateau level ($500m)
• One-off investment.
• Minimal maintenance costs after initial R&D phase.
• Biofortified seeds can be distri-buted worldwide and bred into locally adapted varieties using existing channels.
• Compatible with ongoing fortification, supplementation, and education programs.
• Accessible to everybody.
• It is sustainable.
Cost efficiency of biofortification
Vitamin A status
Po
pu
lati
on
Vitamin requirements
Intake with biofortification
Intake withoutbiofortification Golden Rice
could reduce VAD by more than half
Zimmermann & Qaim 2004 (Philippines); Zimmermann & Ahmed 2006 (Bangladesh); Stein, Sachdev & Qaim 2006 (India); Anderson et al 2004 (SE Asia)
Impact on population’s health statusImpact on population’s health status
Stein 2006
A cost-efficient solutionA cost-efficient solution
Gains for developing countries in Asia up to $15.2 bn p.a. Unskilled labor productivity increase up to $13.8 bn p.a.
Export losses due to EU import ban: under 0.5% !
“... farm productivity gains could be dwarfed by the welfare gains resulting from the potential health-enhancing attributes of
Golden Rice …”
Genetically Modified Rice Adoption : Impact for Welfare and Poverty
Alleviation K Anderson, LA Jackson, CP Nielsen
World Bank Policy Research Working Paper 3380, August 2004
Lies, damn lies, yet no statistics ...
... meanwhile, back in the lab!
Mo
re p
rovi
tam
in A
The principle of provitamin A The principle of provitamin A production is applicable to otherproduction is applicable to othercrops, like potato …crops, like potato …
ControlControl TransgenicTransgenic
Diretto et al 2007
Micronutrients
Provitamin A
Iron
Zinc
Protein
Vitamin E
Micronutrients
Provitamin A
Iron
Zinc
Protein
Vitamin E
RiceRice
SorghumSorghum
CassavaCassava
BananasBananas
Grand Challenges in Global Health
Grand Challenges in Global Health
HarvestPlus CGIAR
HarvestPlus CGIAR
RiceRice
MaizeMaize
WheatWheat
CassavaCassava
BeansBeans
SweetpotatoSweetpotato
International programs, most notably those supported by the Bill & Melinda Gates Foundation, are working towards the biofortification of the most important staple crops of developing countries using conventional and modern methods.
Golden Rice has inspired new approaches to biofortification
Golden Rice has inspired new approaches to biofortification
Engineering Rice for High Beta-Carotene, Vitamin E, Protein, Enhanced Iron and Zinc
(Bioavailability)
Bill & Melinda Gates Foundation
ProVitaMinRice ConsortiumProVitaMinRice Consortium
Peter BeyerCenter for Applied Biosciences University of Freiburg
Bioavailability studies : USA and China. Bioavailability studies : USA and China.
Field testing in India and the Philippines. Field testing in India and the Philippines.
Toxicology, allergenicity, and substantial equivalence.Toxicology, allergenicity, and substantial equivalence.
Introgression into local varieties. Introgression into local varieties.
Regulatory dossiers in India, Bangladesh, the Philippines, Vietnam, Nepal, Africa, etc.
Regulatory dossiers in India, Bangladesh, the Philippines, Vietnam, Nepal, Africa, etc.
Addition of iron, zinc, high-quality protein, vit E. Addition of iron, zinc, high-quality protein, vit E.
Information, seed multiplication, and distribution.Information, seed multiplication, and distribution.
Product development and regulatory approval of nutritionally optimized rice The Philippines and India.
Product development and regulatory approval of nutritionally optimized rice The Philippines and India.
Golden Rice – Long and winding roadsGolden Rice – Long and winding roads
24:1
12:1
2:1
RE
Golden RiceGolden Rice
Bioavailability from different foodstuffsBioavailability from different foodstuffs
eat o
rang
e!
0
50
100
150
200
250
300
350
400
450
500
1 2 4 8 16 32
µg/g ß-carotene for different GR lines
Per
cen
t R
NI (
WH
O/F
AO
)
Assumptions: RNI 400 RE; bioavailability/bioconversion 3:1; retention 80%, baseline 112 RE from other foodstuffs; calculated for 200 g rice in a rural Bangladesh environment (84% rice in the diet)
Contribution to vitamin A status by Golden Rice lines with varying levels of -carotene
Contribution to vitamin A status by Golden Rice lines with varying levels of -carotene
GR2
GR1
Year
Rank 2000 2002 2004 2006
I Swarna IR64 IR64 IR64
II IR64 BPT5204 IR36 Swarna
III BPT5204 Jaya BPT5204 IR36
IV IR36 Swarna Swarna MTU1010
V Jaya IR36Vijetha/
JayaBPT5204
• Popular• Pipeline variety (new traits)• Used in VAD areas
Varietal selection for introgressionVarietal selection for introgression
3-in-1 Approach : Combining Golden Rice, bacterial blight resistance and tungro virus resistance genes into new lines3-in-1 Approach : Combining Golden Rice, bacterial blight
resistance and tungro virus resistance genes into new lines
Phenotypic and molecular selection for GR trait
Screening for bacterial blight resistance
Screening for tungro resistance
Sexual hybridization
Selection for good agronomic traits
PhilRice
Sufficient in Form &
Substance
Applicant
STRP
FPA
Applicant
BPI
Gra
ce p
erio
d
of
60
da
ys f
or
am
en
dm
en
ts
NO
Process &evaluate within5d from receipt
YES
30d for report submission
Risk assessmentevaluation
For PIPs
For public consultation
90d from acceptance
Report within 30d
Submit:• 5 copies of application form• support docs (techn. dossier; copy of PIS & BPI certification thatreg. at. has undergone satisfactoryfield testing in the Philippines.
For importation of reg. art.:• certification for country of import thatreg. art. is of similar event approved locally• notification for country of import in accrodancewith intl agreements on GMOs
BAFPS
BAI
Shall publish PIS in 2 papers+ invite comments within 30d
Report within 30d
For feed
AllReport within 30d
Report within 30d
Release for Propagation Application in the PhilippinesRelease for Propagation
Application in the Philippines
Cost categories Range of costs incurred ($)
• Preparation for regulatory phase 20,000 – 50,000 ()
• Molecular characterization 300,000 – 1,200,000 • Compositional assessment 750,000 – 1,500,000 • Animal performance and safety studies 300,000 – 845,000• Protein production and characterization 162,000 – 1,725,000 ()• Protein safety assessment 195,000 – 855,000 • Non-target organism studies 100,000 – 600,000• Agronomic and phenotypic assessments 130,000 – 460,000• Production of tissues 680,000 – 2,200,000 ?• ELISA dev, validation and expression analysis 415,000 – 610,000 • EPA expenses for PIPs (eg EUPs, tolerances) 150,000 – 715,000 • Environmental fate studies 32,000 – 800,000 • Herbicide residue study 105,000 – 550,000 • EU import (detection methods, fees) 230,000 – 405,000 • Canada costs 40,000 – 195,000 • Stewardship 165,000 – 1,000,000 ?• Toxicology (90-day rat)—when done 250,000 – 300,000• Facility & management overhead costs 560,000 – 4,500,000 • Total 6,180,000 – 15,440,000
Kalaitzadonakes et al. 2007
Compliance costsCompliance costs
(Manalo & Ramon 2007)
US$ 31.4 m incl lab and greenhouse studies in the US.
USS$ 2.6 m for field trials, commercial propagation and post-commercial application
Cost of Bt corn development in the PhilippinesCost of Bt corn development in the Philippines
Orange-fleshed sweetpotato introduction in southern Africa
Orange-fleshed sweetpotato introduction in southern Africa
Familiarity with seed production and distribution systems
Familiarity with breeders
Familiarity with colour
Talking to farmersTalking to farmers
The ProjectThe Project
• Golden Rice Humanitarian Board
• Golden Rice Network• ProVitaMinRice Consortium
– Univ of Freiburg– Michigan State Univ– Baylor College of Med (TX)– IRRI– PhilRice– CLRRI, Vietnam– Chinese Univ of Hong Kong
• Sponsors– B&M Gates Foundation– Syngenta Foundation– Syngenta Crop Protection– USAID– DBT, India
Trigo transgénico
El precio del trigo
Producción, consumo, exportaciones, área sembrada
Tasas de crecimiento del rendimiento
(FAOSTAT; Fischer et al., 2009)
Rendimiento de trigo
(FAOSTAT; Pardey et al., 2007)
t/ha
Rendimiento y fertilizantes
(Fischer et al., 2009)
El precio de los insumos
Disponibilidad de fosfato
Pérdidas por estreses bióticos
(Fischer et al., 2009)
Rendimiento potencial vs real
Déficit del rendimiento
Rendimiento de la producción de trigo en Australia
Molecular markersPhenotyping
Omics
Incremento del rendimiento en maíz GM
Non-GM
GM
Declaración trilateralpara el desarrollo de trigo transgénico
firmada por
» Canadá,
» Estados Unidos y
» Australia
Estrategia común de I&D y comercialización
Ensayos con cereales GM en Australia• En la Univ de Adelaida, líneas de trigo y cebada
con modificaciones genéticas que mejoran la utilización de nutrientes y tolerancia a estreses abióticos (35 genes para mejorar tolerancia a salinidad, sequía, heladas, deficiencia de fósforo, utilización de nitrógeno, asimilación y translocación de zinc).
• En CSIRO, asimilación de carbono bajo sequía y altas temperaturas; almidón modificado y otras modificaciones del grano.
• En Vic DPI, tolerance a estreses ambientales y aumento de fibra dietética.
El futuro
(Fischer et al., 2009)
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