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The Canadian Council on Animal Care:
Animal Use Data
Gilly Griffin
Director of Standards
June 12, 2014, Ottawa, Ontario
www.ccac.ca
Overview
Purpose of the animal use data
Changes for 2013
Required elements
Publication of the 2011 data
Institutions use of the data
CCAC Mandate
The CCAC oversees the ethical use and care of
animals used in science (research, teaching and
testing) on behalf of the Canadian public
Purpose of the Animal Use Data
Public accountability
Changes in numbers and species
Identifies areas of animal welfare concern
CIHR/NSERC Requirement for Metrics
“The Committee suggests that CCAC comes up
with metrics for the data it has collected to date that
is more “usable” and that can create impact.”
Types of Animal Use (2011)
Purpose of Animal Use (2011)
Category of Invasiveness (2011)
33.7%
33.2%
29.2%
3.9%
Sortable File for 2011
Animal Use Data
Publish compiled data
Compare internationally
Analyze data:
trends in types of animals
areas where most pain and distress occur
http://www.ccac.ca/en_/publications/audf
Changes for 2013 data collection
Use of an excel
spreadsheet
Animal Use Data Form
Instructions
document
What happens when we receive the data
Submission
AUDF Received
Approx. 11,000 AUPs from 200
Institutions
Date received noted
Preliminary Review
AUDF Quick Scan
Receipt of AUDF acknowledged
Request for corrections to
incorrect/missing data
AUDF converted to EXCEL if not
already
First Validation
Remove
(zero animals used, embryos,
invertebrates, etc.)
Cats/Dogs (random/purpose
Bred)
CI & PAU
Compare to description and/or
keywords
Species Name
Monkey vs.
Rhesus Macaque
Reuse
Current yr. vs. Previous yr.
Second Validation
Review all issues flagged in first
validation
Flag additional
discrepancies, make final corrections
Institutional Follow-up
Contact Institutions to
deliver/request corrections
Receive corrections to
amend data
STATISTICS
Standard Format
Standard Format – unique protocol number
Unique Protocol Number
Sounds obvious
Permits the CCAC to quickly ask questions about a
particular protocol
Technical Assistance: 1-805-617-7071 or Toll free: 1-866-998-6710 – WEB ID: 119-759-979
Standard Format – category of invasiveness
Categories of Invasiveness
CI A: mostly invertebrates or live isolates
CI B: little or no discomfort or stress
CI C: minor stress or pain of short duration
CI D: moderate to severe distress or discomfort
CI E: severe pain near, at, or above the pain tolerance
threshold of unanesthetized conscious animals
Category of Invasiveness
Unique
Protocol
Number
CI
Protocol Description
Keywords
Species
Number of
Animals
Used
ABC D Rodent models of
cardiac disease used to
identify or validate
common mediators of
hypertensive cardiac
growth. The heart will
be excised to
examine pathology
Major
survival
surgery;
chemical
exposure
Mice 23
Technical Assistance: 1-805-617-7071 or Toll free: 1-866-998-6710 – WEB ID: 119-759-979
Standard Format – purpose of animal use
Purpose of Animal Use
PAU 0: breeding colonies, herd management and
holding protocols
PAU 1: fundamental studies
PAU 2: medical studies, including veterinary medicine
PAU 3: regulatory testing
PAU 4: development of products
PAU 5: educational purposes
Purpose of Animal Use
Always report the primary purpose
Unique
Protocol
Number
PAU
Protocol Description
Keywords
Species
Number
of
Animals
Used
XYZ 1 Anti-diabetic effect of novel
chemical will be studied in
diabetic rats. Fasting blood
glucose and oral glucose
tolerance will be tested and
some animals will be used to
train graduate students on
experimental procedures
Blood
sampling;
biopsy;
oral
gavage
Rats 63
Standard Format – protocol description
Protocol Description
Enables the CCAC to determine the intent of the
protocol i.e. fundamental research, teaching etc.
Helps validate the PAU
Technical Assistance: 1-805-617-7071 or Toll free: 1-866-998-6710 – WEB ID: 119-759-979
Standard Format – keywords
Keywords
Enable the CCAC to determine what procedures have
been carried out on the animals.
Help validate the Category of Invasiveness.
List of keywords in the instruction document.
List of Keywords
Protocol Description or Keywords
Ideally we would like both as the focus is different
IF protocol description only, ensure sufficient
information about procedures
IF keywords only, ensure enough information about
type of studies
Technical Assistance: 1-805-617-7071 or Toll free: 1-866-998-6710 – WEB ID: 119-759-979
Standard Format – animal genus and species
Animal Genus and Species
Be as specific as possible:
mice – wild or house
birds – chickens, zebra finches, loons
fish – zebrafish, wild salmon, trout
monkeys – rhesus, cynomolgus
Cats and Dogs
Random or purpose-bred
Public concern
Specify in the animal genus and species column
Technical Assistance: 1-805-617-7071 or Toll free: 1-866-998-6710 – WEB ID: 119-759-979
Sortable File for 2011
Standard Format – animal use numbers
Animal Use Numbers
Used in that same calendar year
If animals used in more than one protocol, include the
number of the protocol
Unique Protocol
Number
Number of
Animals Used
Number of
Animals Re-used
Protocol Number
of First Use
100359 20 10 100423
Standard Format – re-used from previous year
Re-used From Previous Year
Unique
Protocol
Number
Animal
Species
Number of
Animals
Used
Number of Animals
Re-used From a
Previous Year
2000349 macaque 5 5 - these animals
have been in the
facility for the past
five years, and are
used for...
CCAC does not require this information
Technical Assistance: 1-805-617-7071 or Toll free: 1-866-998-6710 – WEB ID: 119-759-979
Help Us to Help You
Information on animal use at the local level
Comparison with other institutions
Areas where assistance is needed
Contact
For questions related to the
submission of your AUDF,
please contact:
Wendy Clarence,
Research Assistant, CCAC
wclarence@ccac.ca
Tel. (613) 238 - 4031 ext. 228
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