angiostatin : a novel angiogenesis inhibitor that mediates the suppression of metastases
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Angiostatin : A Novel Angiogenesis Inhibitor That Mediates the Suppression of Metastases by a Lewis Lung Carcinoma Michael S. O ’Reilly , Lars Holmgren , Yuen Shing , Catherine Chen , Rosallnd A. Rosenthal , Marsha Moses, William S. Lane , Yihai Cao, - PowerPoint PPT Presentation
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Angiostatin: A Novel Angiogenesis InhibitorThat Mediates the Suppression of Metastases
by a Lewis Lung Carcinoma
Michael S. O’Reilly, Lars Holmgren, Yuen Shing,Catherine Chen, Rosallnd A. Rosenthal,
Marsha Moses, William S. Lane, Yihai Cao, E. Helene Sage, and Judah Folkman
Cell, Vol. 79, 315-328, October 21, 1994
Lung carcinoma implanted subcutaneously into mice.Allow to grow to 1500 mm3
Removed (or not) and wait 15 daysLook for metastases to lung
Same experiment, but now treat with serum or urine from tumor-bearing animal
Named this protein Angiostatin
Surprise! It’s a fragment of Plasminogen
Named this protein Angiostatin
Surprise! It’s a fragment of Plasminogen
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