ams - stevens-johnson syndrome and toxic epidermal necrolysis adverse drug reactions •...

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis:

Update In Therapeutic Approach

Dr Oh Choon Chiat Associate Consultant

Department of Dermatology Singapore General Hospital

Adverse drug reactions

• Exanthematous

• Fixed drug eruption

• Drug-induced hypersensitivity syndrome (DIHS)/ Drug-related eosinophilia with systemic symptoms (DRESS)

• Epidermal necrolysis: Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN)

What type of drug reaction is this?

a. Drug-Induced Hypersensitivity Reaction b. Exanthematous c. Fixed Drug Eruption d. Stevens-Johnson Syndrome e. Vasculitis

Exanthematous eruptions

• Most common of all cutaneous drug eruptions (~90%) • Limited to the skin • Lesions initially appear on the trunk and spread centrifugally to the

extremities in a symmetric fashion • Erythematous macules and infiltrated papules • Pruritus and mild fever may be present • Skin lesions usually appear more than 2 days after the drug has been

started, mainly around day 8-11, and occasionally persists several days after having stopped the drug

What’s the likely diagnosis?

1. Bullous pemphigoid

2. Erythema migrans

3. Fixed drug eruption

4. Spider bite

5. Vasculitis

Fixed Drug Eruption

• Adverse drug reaction characterized by the formation of a solitary erythematous patch or plaque that will recur at the same site with re-exposure to the drug

• This distinguishing feature is why it’s called “fixed”

• Commonly involved drugs include: phenolphthalein (laxatives) /barbiturates / tetracyclines/ metronidazole/ sulfonamides/ NSAIDs

What is the next best step in management? 1. Consult dermatology

2. Discontinue all non-life-sustaining medications

3. Request a tissue biopsy to confirm suspected diagnosis

4. Consider transfer to burn unit

5. All of the above

HOW TO BREAK BAD NEWS TO A DERMATOLOGIST

Summary

• A detailed medication history is essential in suspected drug reactions

• Document the drug reaction in the patient’s chart with the medication and description of the reaction

• Exanthematous eruptions are the most common of all cutaneous drug eruptions and tend to resolve without sequelae

• Fixed drug eruptions will recur at the same with re- exposure to the drug

Summary

• SJS and TEN are acute life-threatening mucocutaneous reactions characterized by extensive necrosis and detachment of the epidermis and mucosal surfaces

• Consult dermatology at the earliest moment of concern for SJS/TEN

• Cessation of culprit drug/ supportive care of skin and affected organs/ IVIG vs Ciclosporin