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Molecular Oncology Research Center - BARRETOS CANCER HOSPITAL1
This annual report describes the Molecular Oncology Research Center (CPOM) from the Barretos Cancer Hospital, and its research activities for the year 2013.
2013 Annual Report
Molecular Oncology Research Center
Molecular Oncology Research Center - BARRETOS CANCER HOSPITAL2
Index
1) Mission....................................................................................................................................42) Team.......................................................................................................................................43) Research Lines.........................................................................................................................74) Productivity.............................................................................................................................95) Conferences and Congresses................................................................................................176) Science Communication to general public............................................................................277) Supervision of PhD, Master and Initiation to Trainee Fellows..............................................278) Prizes....................................................................................................................................329) Participation in International Networks................................................................................3310) Participation in National Networks.....................................................................................3411) Organization of Conferences and Meetings........................................................................3412) Lectures / Seminars at Conferences and Meetings............................................................3413) Funding...............................................................................................................................3814) Patents................................................................................................................................4415) Jury participation................................................................................................................4416) National and International Collaborations:.........................................................................4717) Molecular Diagnostics Center.............................................................................................4718) Perspectives for 2014.........................................................................................................47
3 Molecular Oncology Research Center – Barretos Cancer Hospital
Introduction
The Molecular Oncology Research Center “Centro de Pesquisa em Oncologia Molecular”
(CPOM) was inaugurated on August 19, 2010, by the former Minister of Health, Dr. José
Temporão. The CPOM is framed at the Institute for Research and Education “Instituto de
Ensino e Pesquisa” (IEP) of Barretos Cancer Hospital, which in conjunction with other
clinical departments of the Hospital, as well as the Department of Clinical Research and
Post-graduation in Oncology, are the basic foundations in developing the future of
oncology medicine - personalized medicine.
The CPOM is installed in the new building of the IEP, with an area of 1,000 m2. The
project design was based on the most modern research centers, emphasizing the
convenience of movement, sharing of technological resources and the supervision of
experience professionals. The complex infrastructure of CPOM counts with state-of-the-
art laboratories of cytogenetics, molecular genetics, and molecular and cellular biology,
allowing the development of different research lines of in the field of molecular oncology.
During 2013, the third year of CPOM, we observed the growing of the projects generated
in the first couple of years, and the increased number of approved grants by Funding
Agencies, as well as the implementation of numerous and varied scientific partnerships.
A steady increased of the number of researchers was also observed during this year.
To evaluate and guide their steps, the CPOM was an External Advisory Board, which
consists of the following members:
- Jorge Reis-Filho (MSKCC, USA)
- Jorge Gomez (NCI, USA)
- Luisa Villa (INCT-CNPq, Brazil)
- Manuel Sobrinho-Simões (IPATIMUP, Portugal)
- Oliver Bogler (MDAnderson, USA)
4 Molecular Oncology Research Center – Barretos Cancer Hospital
1) Mission
To promote knowledge and innovation in order to apply molecular oncology in cancer
control.
- Knowledge of the causes, biological mechanisms and targets,
- Innovation in detection, diagnostic, treatment and prognosis,
- Application in prevention and assistance to patient.
2) Team
Senior Researcher
Adhemar Longatto-Filho, PhD – Coordinator of Post-graduation
André Lopes Carvalho, MD, PhD – IEP Executive Director
Benedito Mauro Rossi, MD, PhD – External Collaborator
Ismael Dale Cotrim Guerreiro da Silva, MD, PhD – External Collaborator
José Humberto Tavares Guerreiro Fregnani, MD, PhD – IEP Scientific Diretor
Luiz Fernando Lopes, MD, PhD – Pediatric Hospital Coordinator
Rui Manuel Reis, PhD – Molecular Oncology Research Center Coordinator
Visitant Professor
Kari J Syrjanen, MD, PhD – University of Turku, Finland
Junior Researcher
Céline Marques Pinheiro, PhD – External Collaborator, FACISB
Cristovam Scapulatempo-Neto, MD, PhD – Department of Pathology Coordinator
Daniel Onofre Vidal, PhD – Researcher
Denise Peixoto Guimarães, MD, PhD – Departament of Endoscopy
Edenir Inêz Palmero, PhD – Researcher
Eduardo Anselmo Garcia, PhD - External Collaborator, FACISB
Fernanda Scarnato de Rosa, PhD - External Collaborator, UNIFEB
Henrique César Santejo Silveira, PhD – Researcher
Lucas Tadeu Bidinotto, PhD - External Collaborator, FACISB
Márcia Maria Chiquitelli Marques Silveira, PhD – Researcher
Marjori Leiva Camparoto, PhD – Researcher
Olga Martinho, PhD - External Collaborator, ICVS/UMinho
5 Molecular Oncology Research Center – Barretos Cancer Hospital
Vinicius de Lima Vazquez MD, PhD – Clinical Diretor.
Post-doc
Adriane Feijó Evangelista, PhD
Ana Carolina Carvalho, PhD
Matias Eliseo Melendez, PhD
Vânia Sanmartino Mariano, PhD
Viviane Silva, PhD
PhD students
Adriana Tarlá Lorenzi
Aline Becker
Lidia Maria Rebolho Batista Arantes
Master students
Camila Martinelli
Carla Aparecida Pinheiro
Flávia Coltri Eguchi
Larisa Kuil
Natalia Campacci
Nathalia Campanella
Paula Roberta Aguiar Pastrez
Taciane Macedo
Vanessa Uzan
Biologists / Bioinformaticians / Technical support
Aline Tansine, PhD
Adriana Cruvinel Carloni (master student)
Alessandra Paulino dos Santos
André Escremim de Paula
André Van Helvoort Lengert
Flávia Escremim de Paula, PhD
Gabriela Carvalho Fernandes (master student)
6 Molecular Oncology Research Center – Barretos Cancer Hospital
Maicon Fernando Zanon da Silva (master student)
Marcela Nunes
Maressa Ferreira Neto, PhD
Raul Torrieri
Renato José da Silva Oliveira (PhD student)
Research Initiation / Trainee
Anna Luiza Silva Almeida Vicente
Cintia Batista de Oliveira
Fernanda Costa Ferreira
Fernanda Cury
Karina Pepineli de Mello
Karla Rodrigues de Assis
Livia Marques dos Santos
Marina Schimidt Carrijo
Manoela Catarina Aguena Souza Ramos
Tereza Victoria de Castilho Niero Simoes
Verônica Crissatti
Weder Pereira de Menezes
Administrative/IT/Comercial
Ednise Woyciechowski –IEP manager
Tamiris Regina Ribeiro de Moraes – Administrative Assistant - CPOM
Marcella Marchioretto – Financial Analyst - EPIT
Osmar Alves – IT support
Raphael Alves Ramos Assunção – Administrative Assistant - Molecular Diagnostic
Amanda Costa – Administrative Assistant - EPIT
Paulo Ferreira – Marketing and Comercial
7 Molecular Oncology Research Center – Barretos Cancer Hospital
3) Research Lines
- Cellular Signaling
One of the hallmarks of cancers is the oncogenic upregulation of the signaling cascades
that govern the transduction of extracellular growth factors to cellular nuclear response.
Among these plethora of players, receptor tyrosine kinases (RTKs) and intracellular
MAPK, PI3KCA/AKT and JAK/STAT pathways, have a crucial impact in cancer
development, behavior and currently, there is also an attractive therapeutic target. Our
group is focused in evaluate the major genetic alterations that disrupt these cellular
circuits, and understand their impact on patient prognosis and therapeutic response.
Additionally, using tumor cell line and primary culture models we intend to understand
their function and biological impact on cancer.
- Biomarkers
We now know that cancer is a disease of the genome and this new vision has introduced
a new paradigm. In this scenario, the genome of the cancer can be more objectively in the
stratification of patients with cancer, leading to the emerging personalized medicine in
oncology. In order to achieve this aim, it is necessary to identify from the myriad of cancer
genomic changes, which ones have a clinical value - biomarkers. The diagnosis based on
the genome, it should present a high sensitivity and specificity, and detection of these
biomarkers should be possible not only in tumor tissue, but also extended to other body
fluids such as plasma, serum, urine, saliva, strokes cavity, allowing so early detection and
the ability to monitor tumor development. With a huge bank of tissues and fluids of cancer
patients in Barretos Hospital of Cancer (CrioBio) and a detailed medical history, our
group intends to validate potential biomarkers known in the Brazilian population, as well
as identify new biomarkers.
- Functional Genomics of Cancer
The genomic science aims to understand how genes and genetic information is organized
within the genome (structural genomics) and how the organization determines its function
(functional genomics). The functional genomics applied to cancer aims to evaluate
systematically and simultaneously, the expression of genes (mRNA), microRNAs or
proteins to a better understanding of the molecular genetic basis governing the process of
carcinogenesis. Our research group intends to use the functional genomics resources for
8 Molecular Oncology Research Center – Barretos Cancer Hospital
transcriptional signatures mRNA and microRNAs expression in order to point out
potential molecular biomarkers of tumor progression. Additionally, using tumor cell line
we can validate the miRNA-mRNA interactions through functional tests using silencing
of miRNAs (using anti-miRNAs or anti-MIRs) and thus assess the impact of these new
biomarkers in the progression cancer.
- Environmental factors and Cancer
The exposure to different types of environmental factors such as: food, occupational
conditions, medications, hormones, radiation, viruses, bacteria, chemical agents, air
pollution and water are intrinsically linked to the occurrence of cancer in exposed
populations. The determination of the potential cancer risk in the exposure to
environmental factors can contribute to public policies and preventive measures.
Therefore, our research group aims to assess populations exposed to chemical or
environmental factors using genetic biomarkers. Considering the susceptibility of each
individual to metabolize carcinogenic agents, we intend to reveal the molecular
mechanisms involved in the resistance to these compounds, polymorphisms, gene-
environment interactions and its implications in carcinogenesis.
- Hereditary Cancer
Several cancers developed in higher than normal frequencies may be related to inherited
genetic alterations, present in predisposed families. Around 10% of most cancer types are
due to the presence of germline mutations, leading to an increased lifetime cancer risk.
The recognition of a hereditary cancer-affected individual is crucial for the identification
of other at-risk family members and their inclusion in cancer risk reduction strategies.
The focus of our research group is to prematurely identify, characterize and analyze,
clinically and molecularly, these at-risk individuals. Genetic modifiers that may
contribute to an increased cancer development risk, such as genetic polymorphisms,
rearrangements, copy number variations are also part of our research work.
- Epigenetics
Epigenetics are related to reversible events that do not produce modification in the
genomic DNA sequence, but rather alters its phenotype, influencing mechanisms related
to gene expression. Methylation is the most common epigenetic event, being a very
9 Molecular Oncology Research Center – Barretos Cancer Hospital
important biologic process involved in gene silencing. The study of hypermethylation can
give vital information on the understanding of carcinogenesis, as well as the evaluation
of its pattern can be used as a biomarker for diagnosis, treatment planning and prognosis
of an individual.
- Pediatric Tumor Biology
Although considered rare, childhood cancer is the leading cause of disease-related
mortality in children. Cancer in the childhood often is more devastating and aggressive
than their counterparts in adults. Despite the progress in cure rates and survival
improvement achieved in the last Decades, there is a group of tumors that still do not
respond to any available standard treatment. Our goal is to apply the knowledge and tools
of molecular biology to clarify and understand the biology and pathogenesis of pediatric
tumors, in order to identify potential biological markers that may support diagnosis and/or
indicate prognosis of pediatric patients. As well, we are looking for the altered
pathways/genes that can be targets for new therapy strategies.
4) Productivity
4.1) Books or Book Chapters
1. de Mello R, Araújo A, Reis RM, Hespanhol V. The role of genetic polymorphisms in
the angiogenesis pathway and non-small cell lung cancer tumor behavior: implications in
risk assessment and clinical outcome. In: Mehta JL, Dhalla NS. (Org.). Biochemical Basis
and Therapeutic Implications of Angiogenesis, Advances in Biochemistry in Health and
Disease, 381-403, 2013.
2. Fregnani JH. Future Strategies for Cervical Cancer Prevention in Developing
Countries: HPV vaccine and Its Implementation around the World. In: Breast and
Gynecological Cancers. An Integrated Approach for Screening and Early Diagnosis in
Developing Countries.1st ed.New York: Springer, 320-329, 2013.
3. Branca M, Longatto-Filho A. A Manual for Cervical Cancer Screening and Control:
Principles, Practice and New Perspectives NOVA Publishers Publishers, New York, 2013.
4. Paixao Becker A, Scapulatempo-Neto C, Neder L, Chimelli L, Reis RM. Pilocytic
Astrocytoma: Anatomic, pathological and molecular aspects. Clinical Management and
Evolving Novel Therapeutic Strategies for Patients with Brain Tumors, InTech, p.127-
143, 2013.
10 Molecular Oncology Research Center – Barretos Cancer Hospital
5. Scapulatempo-Neto C, Costa H. Câncer de esôfago. Manual De Padronização de
Laudos Anátomo Patológicos, 4 edição, Editora Manole, 602-615, 2013.
4.2) Publications in International Journals
1. Abrahão-Machado LF, Jacome AA, Wohnrath DR, Dos Santos JS, Carneseca EC,
Fregnani JH, Scapulatempo-Neto C. HER2 in gastric cancer: Comparative analysis of
three different antibodies using whole-tissue sections and tissue microarrays. World
Journal of Gastroenterology. 6438-46, 2013. IF: 2,594
2. Afonso J, Longatto-Filho A, Martinho O, Lobo F, Amaro T, Reis RM, Santos LL.
RKIP downregulation associates with poor prognosis in bladder cancer patients.
Virchows Archiv. 445-53, 2013. IF: 2.676
3. Amorim R, Martins S, Longatto-Filho,A, Preto A, Baltazar F. Exploiting
monocarboxylate transporters as new molecular targets for colorectal carcinoma therapy.
BMC Proceedings. 7(2), 60, 2013. IF: NA
4. Azevedo MM, Pinheiro C, Yaphe J, Baltazar F (2013). Assessing the Impact of a
School Intervention to Promote Students’ Knowledge and Practices on Correct Antibiotic
Use. International Journal Environmental Research Public Health. 2920-31. IF: 1.998
5. Azevedo MM, Miranda IM, Ricardo E, Silva AP, Pinheiro C, Pina-Vaz C, Rodrigues
AG (2013). Input of University Júnior 2012 to Science Education: a cross study among
Portuguese students. Education Research Journal 50- 58, 2013. IF: NA
6. Benberin V, Bektayeva R, Karabayeva R, Lebedev A, Akemeyeva K, Paloheimo L,
Syrjänen K. Prevalence of H. pylori infection and atrophic gastritis among symptomatic
and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of
serum biomarkers. Anticancer Research. 4595-602, 2013. IF: 1.713
7. Campanella NC, de Oliveira AT, Scapulatempo-Neto C, Peixoto-Guimarães D, Reis
RM. Biomarkers and novel therapeutic targets in gastrointestinal stromal tumors (GISTs).
Recent Patents on Anti-Cancer Drug Discovery. 288-297, 2013. IF: 2.700
8. Campos M, DE Campos SG, Ribeiro GG, Eguchi FC, Silva SR, DE Oliveira CZ, DA
Costa AM, Curcelli EC, Nunes MC, Penna V, Longatto-Filho A. Ki-67 and CD100
immunohistochemical expression is associated with local recurrence and poor prognosis
in soft tissue sarcomas, respectively. Oncology Letters. 1527-1535, 2013. IF: 0.237
11 Molecular Oncology Research Center – Barretos Cancer Hospital
9. Carneseca EC, Mauad EC, Araújo MA, Dalbo RM, Longatto-Filho A, Vazquez VL.
An analysis of cancer survival at a single institution in Brazil over a 10-year period. BMC
Research Notes, 141, 2013. IF: NA
10. Cássio Zequi SD, Fregnani JH, Favaretto RL, Costa WH, Madeira Campos RS,
Fonseca FP, Guimaraes GC, Soares FA, da Cunha IW, Lopes A. The impact of
immunohistochemical expression of nitric oxide synthases on clinical and pathological
features of renal cell carcinoma. World Journal of Urology. 1197-203, 2013. IF: 2.888
11. Carvalho TG, De Carvalho AC, Maia DC, Ogawa JK, Carvalho AL, Vettore AL.
Search for mutations in signaling pathways in head and neck squamous cell carcinoma.
Oncology Reports. 334-40, 2013. IF: 2.297
12. Colleoni JL, Rodrigues LM, Junior GS, Scapulatempo C, Abreu LC, Valenti VE,
Fujiki E, Camargo RC, Oliveira FR, Alves MT, Cohen M. Immunohistochemical analysis
of mechanoreceptors in the human posterior cruciate ligament: association with aging
male. Aging Male. 73-8, 2013. IF: 1.711
13. de Castro Mattos JS, Mauad EC, Syrjänen K, Longatto-Filho A, Haikel RL, Da Costa
Vieira RA, Silva TB, De Barros N. The impact of breast cancer screening among younger
women in the Barretos Region, Brazil. Anticancer Research. 2651-5, 2013. IF: 1.713
14. de Mello RA, Ferreira M, Pires FS, Costa S, Luis M, Pozza DH, Cunha J, Oliveira P,
Hespanhol V, Reis RM. The impact of polymorphic variations in the 5p15, 6p12, 6p21
and 15q25 loci on the risk and prognosis of Portuguese patients with non-small cell lung
cancer. PlosOne. 2013. IF: 3.730
15. de Mello RA, Araújo A, Hespanhol V, Reis RM. Loci identified through genome-
wide association studies and lung cancer risk: is there anything more? Sao Paulo Medical
Journal. 135-6, 2013. IF: NA
16. de Oliveira CM, Fregnani JH, Carvalho JP, Longatto-Filho A, Levi JE. Human
papillomavirus genotypes distribution in 175 invasive cervical cancer cases from Brazil.
BMC Cancer. 357, 2013. IF: 3.333
17. Emerenciano M, Meyer C, Mansur MB, Marschalek R, Pombo-de-Oliveira MS;
Brazilian Collaborative Study Group of Infant Acute Leukaemia. The distribution of
MLL breakpoints correlates with outcome in infant acute leukaemia. British Journal of
Haematology. 224-36, 2013. IF: 4.942
18. Filassi JR, Zonta MA, Trinconi A, Calvagno D, Velame de Oliveira F, Ricci MD,
Baracat E, Longatto-Filho A. Can breast nipple fluid collected with automated aspiration
12 Molecular Oncology Research Center – Barretos Cancer Hospital
and preserved in based-liquid solution improve the cytological samples? Acta Cytologica.
276-80, 2013. IF: 0.693
19. Fregnani JH, Carvalho AL, Eluf-Neto J, Ribeiro Kde C, Kuil Lde M, da Silva TA,
Rodrigues SL, Mauad EC, Longatto-Filho A, Villa LL. A school-based human
papillomavirus vaccination program in Barretos, Brazil: final results of a demonstrative
study. PLoS One. 62647, 2013. IF: 3.730
20. Fregnani JH, Scapulatempo-Neto C, Haikel RL Jr, Saccheto T, Campacci N, Mauad
EC, Longatto-Filho A. Could alarmingly high rates of negative diagnoses in remote rural
areas be minimized with liquid-based cytology? Preliminary results from the RODEO
study team. Acta Cytologica. 69-74, 2013. IF: 0.693
21. Garcia EA, Simões K, Wakamatsu A, Cirqueira SC, Alves VAF, Longatto-Filho, A,
Camargo RS. Pro and Anti-Angiogenic Vascular Endothelial Growth Factors Expression
in Benign and Malignant Thyroid Lesions. Journal of Thyroid Disorders & Therapy, v. 2,
1-6, 2013. IF: NA
22. Giacomazzi J, Koehler-Santos P, Palmero EI, Graudenz MS, Rivero LF, Lima E,
Pütten AC, Hainaut P, Camey SA, Michelli RD, Neto CS, Fitarelli-Kiehl M, Geyer G,
Meurer L, Geiger A, Azevedo MB, da Silva VD, Ashton-Prolla P. A TP53 founder
mutation, p.R337H, is associated with phyllodes breast tumors in Brazil. Virchows
Archiv. 17-22, 2013. IF: 2.676
23. Goss PE, Lee BL, Badovinac-Crnjevic T, Strasser-Weippl K, Chavarri-Guerra Y,
Louis JS, Villarreal-Garza C, Unger-Saldaña K, Ferreyra M, Debiasi M, Liedke PE,
Touya D, Werutsky G, Higgins M, Fan L, Vasconcelos C, Cazap E, Vallejos C, Mohar
A, Knaul F, Arreola H, Batura R, Luciani S, Sullivan R, Finkelstein D, Simon S, Barrios
C, Kightlinger R, Gelrud A, Bychkovsky V, Lopes G, Stefani S, Blaya M, Souza FH,
Santos FS, Kaemmerer A, de Azambuja E, Zorilla AF, Murillo R, Jeronimo J, Tsu V,
Carvalho AL, Gil CF, Sternberg C, Dueñas-Gonzalez A, Sgroi D, Cuello M, Fresco
R, Reis RM, Masera G, Gabús R, Ribeiro R, Knust R, Ismael G, Rosenblatt E, Roth B,
Villa L, Solares AL, Leon MX, Torres-Vigil I, Covarrubias-Gomez A, Hernández A,
Bertolino M, Schwartsmann G, Santillana S, Esteva F, Fein L, Mano M, Gomez H,
Hurlbert M, Durstine A, Azenha G. Planning cancer control in Latin America and the
Caribbean. Lancet Oncology. 391-436, 2013. IF: 25.117
24. Jácome AA, Wohnrath DR, Scapulatempo Neto C, Fregnani JH, Quinto AL,
Oliveira AT, Vazquez VL, Fava G, Martinez EZ, Santos JS. Effect of adjuvant
13 Molecular Oncology Research Center – Barretos Cancer Hospital
chemoradiotherapy on overall survival of gastric cancer patients submitted to D2
lymphadenectomy. Gastric Cancer. 233-238, 2013. IF: 3.989
25. Jácome AA, Wohnrath DR, Scapulatempo Neto C, Carneseca EC, Serrano SV, Viana
LS, Nunes JS, Martinez EZ, Santos JS. Prognostic value of epidermal growth factor
receptors in gastric cancer. A survival analysis by Weibull model incorporationg long-
term survivors. Gastric Cancer. 2013. IF: 3.989
26. Liberman PH, Schultz C, Goffi-Gomez MV, Lopes LF. Speech recognition and
frequency of hearing loss in patients treated for cancer in childhood. Pediatric Blood
Cancer. 1709-13, 2013. IF: 2.353
27. Linhares P, Carvalho BM, Figueiredo R, Reis RM, Vaz R. Early Pseudo-progression
Following Chemoradiotherapy in Glioblastoma Patients: The Value of RANO Evaluation.
Journal of Oncology. 2013. IF: NA
28. Linhares P, Martinho O, Carvalho B, Castro L, Lopes JM, Vaz R, Reis RM. Analysis
of a synchronous gliosarcoma and meningioma with long survival: A case report and
review of the literature. Surgical Neurology International, 2013. IF: NA
29. Lorenzi AT, Fregnani JH, Possati-Resende JC, Neto CS, Villa LL, Longatto-Filho A.
Self-collection for high-risk HPV detection in Brazilian women using the careHPV™ test.
Gynecologic Oncology. 131-4, 2013. IF: 3.929
30. Koskela HM, Syrjänen K, Korkeila EA. Disease outcome of patients with pancreatic
cancer in a cohort treatedoutside clinical trials. Anticancer Research. 5491-4, 2013. FI:
1.713
31. Macedo C, Evangelista AF, Marques MMC, Octacilio-Silva S, Donadi EA,
Sakamoto-Hojo ET, Passos GAS. Autoimmune regulator (Aire) controls the expression
of microRNAs in medullary thymic epithelial cells. Immunobiology. 554-60, 2013. IF:
2.814
32. Martinho O, Silva-Oliveira R, Miranda-Gonçalves V, Clara C, Almeida JR, Carvalho
AL, Barata JT, Reis RM. In vitro and in vivo analysis of RTKs inhibitors efficacy and
identification of its novel targets in glioblastomas. Translational Oncology. 187-96, 2013.
IF: 2.943
33. Martinho O, Simões K, Longatto-Filho A, Jacob CE, Zilberstein B, Bresciani C,
Gama-Rodrigues J, Cecconello I, Alves V, Reis RM. Absence of RKIP expression is an
independent prognostic biomarker for gastric cancer patients. Oncology Reports. 690-6,
2013. IF: 2.297
14 Molecular Oncology Research Center – Barretos Cancer Hospital
34. Martinho O, Pinto F, Granja S, Miranda-Gonçalves V, Moreira MAR, Ribeiro LJF,
di Loreto C, Rosner MR, Longatto-Filho A, Reis RM. RKIP inhibition in cervical cancer
is associated with higher tumor aggressive behavior and resistance to cisplatin therapy.
PLoS One. 8, 2013. IF: 3.730
35. Martino A, Sainz J, Reis RM, Moreno V, Buda G, Lesueur F, Marques H, García-
Sanz R, Ríos R, Stein A, Dumontet C, Gemignani F, Rossi AM, Landi S, Jurado M,
Petrini M, Jamroziak K, Campa D, Canzian F. Polymorphisms in regulators of xenobiotic
transport and metabolism genes PXR and CAR do not affect multiple myeloma risk: a
case-control study in the context of IMMEnSE consortium. Journal of Human Genetics.
155-9, 2013. IF: 2.365
36. Martins S, Garcia EA, Luz MA, Pardal F, Rodrigues M, Longatto-Filho A.
Clinicopathological Correlation and Prognostic Significance of VEGF-A, VEGF-C,
VEGFR-2 and VEGFR-3 Expression in Colorectal Cancer. Cancer Genomics Proteomics.
55-67, 2013. IF: NA
37. Martins S, Amorim R, Reis RM, Pinheiro C, Rodrigues M, Baltazar F, Longatto-Filho
A. A Hospital Based Cohort Study of Colorectal Cancer Cases Treated at Braga Hospital,
Northern Portugal. Journal of Gastrointestinal & Digestive System. 146, 2013. IF: NA
38. Miranda-Gonçalves V, Honavar M, Martinho O, Pires MM, Pinheiro C, Cordeiro M,
Bebiano G, Costa P, Palmeirim I, Reis RM, Baltazar F. Monocarboxylate transporters
(MCTs) in gliomas: expression and exploitation as therapeutic targets. Neuro-Oncology.
172-88, 2013. IF: 6.180
39. Moniz S, Martinho O, Pinto F, Sousa B, Loureiro C, Oliveira MJ, Moita LF, Honavar
M, Pinheiro C, Pires M, Lopes JM, Jones C , Costello JF, Paredes J, Reis RM, Jordan P.
Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and
triggers Rac1-mediated tumour cell invasiveness. Human Molecular Genetics. 84-95,
2013. IF: 7.692
40. Morais-Santos F, Miranda-Gonçalves V, Pinheiro S, Vieira AF, Paredes J, Schmitt
FC, Baltazar F, Pinheiro C (2013). Differential sensitivities to lactate transport inhibitors
of breast cancer cell lines. Endocrine-Related Cancer. 27-38, 2013. IF: 5.261
41. Oliveira RDR, Fontana V, Junta CM , Marques MM, Macedo C, Rassi DM, Passos
GAS, Donadi EA, Louzada-Jr P. Differential gene expression profiles Maio differentiate
responder and non-responder rheumatoid arthritis patients for methotrexate monotherapy
15 Molecular Oncology Research Center – Barretos Cancer Hospital
and methotrexate plus TNF-blocker combined therapy. The Journal of Rheumatology.
1524-32, 2013. IF: 3.690
42. Osório NS, Rodrigues F, Garcia EA, Costa MJ. Drawings as snapshots of student
cellular anatomy understanding. Medical Education, 1120-1121, 2013. IF: 3.546
43. Paugh BS, Zhu X, Qu X, Endersby R, Zhang J, Bax DA, Carvalho D, Reis RM, Onar-
Thomas A, Broniscer A, Wetmore C, Jones C, Zhang J, Ellison DW, Baker SJ. Novel
Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas. Cancer Research.
6219-6229, 2013. IF: 8.650
44. Polli CD, Toledo KA, Franco LH, Mariano VS, Oliveira LL, Bernardes ES, Roque-
Barreira MC, Pereira-da-Silva G. Monocyte Migration Driven by Galectin-3 Occurs
through Distinct Mechanisms Involving Selective Interactions with the Extracellular
Matrix. ISRN Inflammation. 28, 2013. IF: NA
45. Rettori MM, de Carvalho AC, Bomfim Longo AL, de Oliveira CZ, Kowalski LP,
Carvalho AL, Vettore AL. Prognostic significance of TIMP3 hypermethylation in post-
treatment salivary rinse from head and neck squamous cell carcinoma patients.
Carcinogenesis. 20-7, 2013. IF: 5.635
46. Rettori MM, de Carvalho AC, Longo AL, de Oliveira CZ, Kowalski LP, Carvalho
AL, Vettore AL. TIMP3 and CCNA1 hypermethylation in HNSCC is associated with an
increased incidence of second primary tumors. Journal of Translational Medicine. 316,
2013. IF: 3.46
47. Roncaglia MT, Fregnani JH, Tacla M, DE Campos SG, Caiaffa HH, Ab'saber A, DA
Motta EV, Alves VA, Baracat EC, Longatto Filho A. Characterization of p16 and E6
HPV-related proteins in uterine cervix high-grade lesions of patients treated by conization
with large loop excision. Oncology Letters. 63-68, 2013. IF: 0.237
48. Scapulatempo C, Fregnani JH, Campacci N, Possati-Resende JC, Longatto-Filho A.
The significance of augmented high-grade squamous intraepithelial lesion detection on
pap test examination: partial results from the RODEO study team. Acta Cytologica. 489-
94, 2013. IF: 0.698
49. Silva AG, Maschietto M, Vidal DO, Peliçario LM, Velloso ED, Lopes LF, Krepischi
AC, Rosenberg C. Array-CGH as an adjuvant tool in cytogenetic diagnosis of pediatric
MDS and JMML. Medical Oncology. 734, 2013. IF: 2.147
16 Molecular Oncology Research Center – Barretos Cancer Hospital
50. Silva TB, Mauad EC, Carvalho AL, Jacobs LA, Shulman LN. Difficulties in
implementing an organized screening program for breast cancer in Brazil with emphasis
on diagnostic methods. Rural Remote Health. 2013. IF: 0.979
51. Silveira HCS, Carrijo MS, Seidel EH, Scapulatempo Neto C, Longatto Filho A,
Carvalho AL, Reis RM, Saldiva PH. Emissions generated by sugarcane burning promote
genotoxicity in rural workers: a case study in Barretos, Brazil. Environmental Health. 87,
2013. IF: 2.714
52. Sonaglio V, de Carvalho AC, Toledo SRC, Salinas-Souza C, Carvalho AL, Petrilli
AS, de Camargo B, Vettore AL. Aberrant DNA methylation of ESR1 and p14ARF genes
could be useful as prognostic indicators in osteosarcoma. OncoTargets and Therapy. 713-
23, 2013. IF: 2.073
53. Stein MD, Fregnani JH, Scapulatempo C, Mafra A, Campacci N, Longatto-Filho A;
RODEO Study Team From Barretos Cancer Hospital. Performance and Reproducibility
of Gynecologic Cytology Interpretation Using the FocalPoint System: Results of the
Rodeoa Study Team. American Journal of Clinical Pathology. 567-71, 2013. IF: 2.88
54. Trigo G, Martins TG, Fraga AG, Longatto-Filho A, Castro AG, Azeredo J, Pedrosa.
J. Phage Therapy Is Effective against Infection by Mycobacterium ulcerans in a Murine
Footpad Model. PLoS Neglected Tropical Diseases. 2183, 2013. IF: 4.569
55. Valente V, Serafim B R, Oliveira C L, Adorni S F, Torrieri R, Tirapelli C P D,
Espreafico M E, Oba-Shinlo M S, Marie N K S, Paçó-Larson L M, Carloti Jr. G C.
Modulation of HJURP (Holliday Junction-Recognizing Protein) Levels Is Correlated
with Glioblastoma Cells Survival. Plos One 25, 2013. IF: 3.730
56. Vecchiatti SM, Guzzo ML, Caldini EG, Bisi H, Longatto-Filho A, Lin CJ. Iodine
increases and predicts incidence of thyroiditis in NOD mice: Histopathological and
ultrastructural study. Experimental and Therapeutic Medicine. 603-607, 2013. IF: 0.344
57. Viana RC, Scapulatempo-Neto C, Kerr LM, Palmero EI, Marques MMC, Colacoiavo
T, Queiroz Junior AF, Carvalho AL, Siqueira SAC. The interference of cold isquemia
time in the quality of total RNA from frozen tumor samples. Cell & Tissue Banking. 167-
73, 2013. IF: 1.171
58. Vidal DO, Marques MMC, Lopes LF, Reis RM. The Role of miRNAs in
Medulloblastoma. Pediatric Hematology and Oncology. 367-78, 2013. IF: 0.891
59. Vinagre J, Almeida A, Populo H, Batista R, Lyra J, Pinto V, Coelho R, Celestino R,
Prazeres H, Lima L, Melo M, Rocha A, Preto A, Castro P, Castro P, Pardal F, Lopes JM,
17 Molecular Oncology Research Center – Barretos Cancer Hospital
Lara Santos L, Reis RM, Cameselle-Teijeiro J, Sobrinho-Simões M, Lima J, Máximo V,
Soares P. Frequency of TERT promoter mutations in human cancers. Nature
Communications. 26, 2013. IF: 10.015
60. Wang SJ, Patel SG, Shah JP, Goldstein DP, Irish JC, Carvalho AL, Kowalski LP,
Lockhart JL, Holland JM, Gross ND. An Oral Cavity Carcinoma Nomogram to Predict
Benefit of Adjuvant Radiotherapy. JAMA Otolaryngol Head Neck Surgery. 1-6, 2013.
IF: 1.63
4.3) Publications in Brazilian Journals
1. Abud J, Izetti PR, Moreira MA, M, Achatz MIW, Vargas FR, Palmero EI, Cossio SL,
Prolla JC, Ashton PP. Study Group on Hereditary Breast and Colorectal Cancer. CHEK2
1100DELC germline mutation: a frequency study in hereditary breast and colon cancer
Brazilian families. Arquivos de Gastroenterologia. 273-278, 2013. IF: 0.0238
2. Heinke T, Espiríto Santo KS, Longatto Filho A, Stavale JN. Vascular endothelial
growth factor and KIT expression in relation with microvascular density and tumor grade
in supratentorial astrocytic tumors. Acta Cirurgica Brasileira. 48-54, 2013. IF: 0.626
3. Passos-Filho O, Cangussu HC, Lopes RH, Oliveira AT, Vazquez VL, Galvão CN.
Síndrome de Boerhaave: relato de caso. Revista do Colégio Brasileiro de Cirurgiões. 83-
84, 2013. IF: 0.0317
4. Velloso ED, Chauffaille ML, Peliçario LM, Tanizawa RS, Toledo SR, Gaiolla
RD, Lopes LF. Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome
cases: challenges and difficulties in a large and emerging country. Brazilian Journal of
Medical Biological Research. 85-90, 2013. IF: 1.139
5) Conferences and Congresses
5.1) Oral Communications
1. Berardinelli GN, Souza NCN, Scapulatempo-Neto C, Melanni R, Reis RM. Mutational
profile of Colorectal Cancer Patients: Implication in Anti-EGFR Therapies. III Simpósio
em Oncologia Translacional do Hospital de Câncer de Barretos. August 2013, Barretos,
Brazil.
2. Bidinotto LT, MacKay A, Caravina G, Becker A, Viana-Pereira M, Clara C, Jones C,
Reis RM. Profile of genomic alterations of gliomas. XVI Jornada de Patologia do
18 Molecular Oncology Research Center – Barretos Cancer Hospital
A.C.Camargo Cancer Center / VI Encontro Internacional de Patologia Investigativa. 7-
10, 2013. São Paulo, Brazil.
3. Campacci N, Lima JO, Ramadan L, Michelli R, Viana DV, Mauad EC, Haikel
JRR, Rossi, BM, Palmero EI. Identification of at-risk families for hereditary colorectal
cancer through a Brazilian Cancer Prevention Network in a population-based sample. In:
International Society for Gastrointestinal Hereditary Tumours - 5th Biennial Meeting,
2013, Cairns, Australia.
4. de Paula AE, Mendes DRP, Fernandes GC, Berardineli GN, Reis RM, Oliveira JC,
Viana DV, Andrade CEMC, Scapulatempo-Neto C, Palmero EI. Caracterização
Molecular de Famílias em Risco para Câncer Colorretal Hereditário – Importância da
realização do Teste Genético. XXV Congresso Brasileiro de Genética Médica. 11-15,
2013. Florianópolis, Brazil.
5. de Paula AE, Mendes DRP, Fernandes GC, Legnaro CC, Michelli R, Reis RM, Viana
DV, Andrade CEMC, Palmero EI. Caracterização molecular dos genes BRCA1 e BRCA2
em famílias com Risco de Câncer de Mama e Ovário Hereditário. XXV Congresso
Brasileiro de Genética Médica. 11-15, 2013. Florianópolis, Brazil.
6. Guimarães DP, Yamane L, Scapulatempo-Neto C, Alvarenga L, Cunha T, Almodova
E, Fava G, Reis RM. Caracterização Endoscópica de Adenomas Serrilhados Sésseis. XII
Semana Brasileira do Aparelho Digestivo. 24-27 November de 2013. Goiânia, Brazil.
7. Lacerda CF, Carloni AC, Scapulatempo-Neto C, Crema E, de Arruda Henry M,
Rodrigues MA, de Oliveira AT, Guimaraes DP, Reis RM. TP53 Gene Mutations in
Squamous Cells Carcinoma of the Esophagus Associated with Chagasic Megaesophagus.
Global Academic Program Meeting, 2013. Houston, USA.
8. Oliveira-Silva RJ, Martinho O, Berardinelli GN, Viana L, Carvalho AL, Reis RM. The
importance of molecular characterization of head and neck cancer cell lines for the
prediction of anti-EGFR therapies resistance. III Simpósio em Oncologia Translacional
do Hospital de Câncer de Barretos. 29-30 August de 2013, Barretos, Brazil.
9. Silva-Correia J, Pereira H, Yan LP, Miranda-Gonçalves V, Espregueira-Mendes J,
Oliveira AL, Reis RM, Oliveira JM, Reis RL. Development of Anatomical
Silk/Methacrylated Gellan Gum Scaffolds for Controlling Segmental Vascularization in
Meniscus Tissue Regeneration – TERMIS-EU 2013. Istanbul, Turkey.
10. Silva-Correia J, Pereira H, Yan L-P, Miranda-Gonçalves V, Oliveira AL, Oliveira
JM, Reis RM, Espregueira-Mendes J, Reis RL. Novel Silk-based Scaffolds for Meniscus
19 Molecular Oncology Research Center – Barretos Cancer Hospital
Tissue Engineering: The Relevance of Controlling Segmental Vascularization by
Methacrylated Gellan gum Hydrogels – 14th EFORT Congress, 2013. Istanbul, Turkey.
11. Zanon MF, Almeida GC, Matsushita MM, Reis RM, Squire JA, Camparotto ML.
Evaluation of 1p/19q codeletion using FISH analysys in pure and mixed oligodendroglial
tumors at the routine pathology of the Barretos Cancer Hospital-SP, Brazil. 3ª Reunião
Brasileira de Citogenética e IV Simpósio Latino-Americano de Citogenética e Evolução.
26- 29 may 2013. Guarujá, SP, Brazil.
5.2) Posters
1. Almeida M, Portela C, Nabiço R, Ferreira A, Pardal F, Costa S, Ferreira M, Costa P,
Viana-Pereira M, Reis RM. Association of ESR1 polymorphisms with tamoxifen
response in women with estrogen receptor-positive breast cancer. IMPAKT Breast
Cancer Conference, May 2013. Brussels, Belgian.
2. Andrade C, Palmero EI, Viana DV, Michelli R, Fregnani JH. Criteria to screening
endometrial cancer for Lynch Syndrome in a Public Health System. In: 2013 SGO Annual
Meeting on Women s Cancer. 2013, Flórida, USA.
3. Becker A, Bidinotto L, Mackay A, Clara C, Scapulatempo-Neto C, Jones C, Reis RM.
Avaliação de alterações cromossomicas em astrocitomas pilocíticos através da técnica de
array-CGH: Estudo piloto de 4 pacientes do HCB. XXIX Congresso Brasileiro de
Patologia. 13-16 November de 2013, Florianópolis, Brazil.
4. Becker A, Clara C, Scapulatempo-Neto C, Reis RM. Caracetrização
clinicoepidemiológica e construção de TMA de uma série de astrocitomas pilocíticos do
HCB. XXIX Congresso Brasileiro de Patologia. November de 2013, Florianópolis, Brazil.
5. Berardinelli GN, Scapulatempo Neto C, Campanella NC, Melani A, Guimaraes DP,
Lima JP, Reis RM. Study of microsatellite instability (MSI) and mutations of MSI-target
genes in large cohort of Brazilian colorectal cancer patients. Global Academic Program
Meeting. April 2003, Houston, USA.
6. Bezerra F, Cunha M, Miranda-Gonçalves V, Pinheiro C, Baltazar F. Monocarboxylate
transporters as mediators in tumor-endothelial cell crosstalk. XXII Porto Cancer Meeting.
2013, Porto, Portugal.
7. Campacci N, de Lima JO, Rissatti V, de Toledo EMP, Ramadan L, Palmero EI. O uso
de uma ferramenta de baixo custo para rastreamento de Câncer Hereditário. XXV
Congresso Brasileiro de Genética Médica. Jun 2013. Florianópolis, Brazil.
20 Molecular Oncology Research Center – Barretos Cancer Hospital
8. Campanella NC, Scapulatempo-Neto C, de Oliveira AT, Guimarães DP, Reis RM.
Study of microsatellite instability and potential target genes in GISTs. Translating
Molecular Biology into Cancer Treatment. SPSAS – São Paulo School of Advanced
Sciences, Advances in Molecular Oncology. February 2013. São Paulo, Brazil.
9. Campanella NC, Scapulatempo-Neto C, de Oliveira AT, Guimarães DP, Reis RM.
Mutações na região promotora da telomerase reverse transcriptase (TERT) ocorrem em
uma parcela dos GISTs. V Encontro Científico do Hospital de câncer de Barretos. 13-14
Decembre 2013. Barretos, São Paulo, Brazil.
10. Camparotto ML, Castro NS, Gonçalves IZ, Squire JA. Impact of cytogenetic for
evaluation of different diagnostic approach in acute lekemia: a case report. 3º Reunião
Brasileira de Citogenética. May 2013. Águas, Guarujá, São Paulo, Brazil.
11. Carloni AC, Oliveira RJS, Clara C, Camparotto ML, Squire JA, Reis RM.
Cytogenetic and molecular characterization of gliomas primary culture. Translating
Molecular Biology into Cancer Treatment. SPSAS – São Paulo School of Advanced
Sciences, Advances in Molecular Oncology. February 2013. São Paulo, Brazil.
12. Carloni AC, Oliveira R, Bidinotto L, Clara C, Almeida GC, Camparotto ML, Squire
JA, Reis RM. Establishment and cytogentic and molecular characterization of
glioblastomas primary cultures. III Simpósio em Oncologia Translacional do Hospital de
Câncer de Barretos. 29-30 de August 2013. Barretos, Brazil.
13. Carvalho Al, Penna V, Pinheiro C A, Reis RM, Squire J, Camparoto ML. Centrosome
clustering in primary sarcomas cultures and its association with malignant behavior in
tumor”. III Simpósio Internacional de Oncologia Translacional do Hospital de Câncer de
Barretos. 29-30 de August 2013. Barretos, Brazil.
14. Carvalho D, Mackay A, Burford A, Chen LBL, Kozarewa I, Lord C, Ashworth A,
Reis RM, Jones C. Integrated whole genome and RNA sequencing identifies novel
expressed fusion transcripts in paediatric high grade glioma. May 2013. Fort Lauderdale,
Flórida, USA.
15. Costa A, Oliveira MJ, Martinho O, Pinto F, Jordan P, Reis RM. WNK2 as a modulator
of MMP-2 and MMP-9 expression and activity in Gliomas. VI Congresso Nacional da
Associação Portuguesa de Neuro-Oncologia. 15-16 November 2013. Almada, Portugal.
16. Couto E, Portela C, Almeida M, Nabiço R, Ferreira M, Costa S, Costa P, Viana-
Pereira M, Reis RM. Association of SMAD7 single nucleotide polymorphisms with risk
21 Molecular Oncology Research Center – Barretos Cancer Hospital
and prognosis of colorectal cancer in a Portuguese population. ESMO 15th World
Congress on Gastrointestinal Cancer. July de 2013. Barcelona, Spain.
17. Cury FP, Ramos MC, Silveira HC. Assessment of micronuclei frequency in civil
construction workers. III Simposio em Oncologia Translacional do Hospital de Câncer
de Barretos. 29-30 August de 2013, Barretos, Brazil.
18. Cury FP, Ramos MC, Silveira HC. Assessment of micronuclei frequency in civil
construction workers. 59º Congresso Brasileiro de Genética, 2013. 16-19 September 2013.
Águas de Lindóia, Brazil.
19. Cury FP, Ramos MC, Scapulatempo-Neto C, Silveira HC. Assessment of genotoxic
damages in civil construction workers using micronucleus assay. V Encontro Científico
do Hospital de Câncer de Barretos, 2013. July 2013, Barretos, Brazil.
20. de Carvalho AC, Maia DCC, Carvalho AL, Scapulatempo-Neto C, Vettore AL. High
accuracy of microRNAs expression in the detection of lymph node metastasis in patients
with oral squamous cell carcinomas. AACR 104th Annual Meeting 2013. 2013,
Washington, USA.
21. de Carvalho AC, Maia DCC, Carvalho AL, Scapulatempo-Neto C, Vettore AL.
Concordance of pathologic examination and qRT-PCR for microRNA expression in
lymph nodes from oral squamous cell carcinoma patients. 4th World Congress of the
International Academy of Oral Oncology, 2013. Greece.
22. Evangelista AF, Macedo T, Oliveira RJS, Marques MMC. MicroRNA-mRNA
Networks for Identification of Biomarkers for Breast Cancer. III Simpósio em Oncologia
Translacional do Hospital de Câncer de Barretos. 29-30 August de 2013, Barretos, Brazil.
23. Evangelista AF, Macedo T; Oliveira RJS, Marques MMC. MicroRNA-mRNA
networks of identification of biomarkers for breast cancer. International Congress of
Markers in Cancer.7–9 de November de 2013. Brussels, Belgian.
24. Evangelista AF, Macedo T; Oliveira RJS, Marques MMC. Integrative analysis of
microRNAs:mRNA expression for breast cancer biomarker discovery. SELECTBIO
Exosomes and Circulating Biomarkers Summit. 12-13September 2013. San Diego,
California, USA.
25. Fernandes GC, Fonseca TCB, Michelli RAD, Mendes DRP, de Paula AE, Viana DV,
Scapultempo-Neto C, Palmero EI. Associação entre triplo-negatividade para câncer de
mama, história familiar positiva e presença de mutações germinativas nos genes BRCA1
22 Molecular Oncology Research Center – Barretos Cancer Hospital
e BRCA2. XXV Congresso Brasileiro de Genética Médica. 11-15 June 2013.
Florianópolis, Brazil.
26. Fernandes GC, Mendes DRP, de Paula AE, Michelli RAD, Viana DV, Palmero EI.
Padrão heterogêneo de desenvolvimento tumoral em famílias portadoras da mutação
germinativa p.R337H no gene TP53: implicações para o Aconselhamento Genético e
seguimento. XXV Congresso Brasileiro de Genética Médica. 11-15 June de 2013,
Florianópolis, Brazil.
27. Giacomazzi J, Graudenz M, Osorio CA, Koehler-Santos P, Palmero EI, Michelli R,
Fernandes GC, Scapulatempo-Neto C, Achatz MIW, Martel-Planche G, Soares FA,
Caleffi M, Goldim JR, Hainaut P, Camey SA, Ashton-Prolla P. Association between the
founder brazilian TP53 p.R337H mutation and HER2-positive status. In: ASCO Annual
2013 Meeting - Building Bridges to Conquer Cancer, 2013, Chicago, USA.
28. Guimarães DP, Carvalho E, Cunha T, Oliveira K, Viel A, Fava G. Combinação entre
Mitomicina-C e Prótese Plástica Auto-expansivel no Tratamento Endoscópico das
Estenoses Benignas Refratárias à Dilatação Endoscópica: Relato de Caso. XII Semana
Brasileira do Aparelho Digestivo. 24-27 November 2013, Goiânia, Brazil.
29. Lacerda CF, Carloni AC, Scapulatempo-Neto C, Crema E, de Arruda Henry M,
Rodrigues MA, de Oliveira AT, Guimaraes DP, Reis RM. TP53 Gene Mutations in
Squamous Cells Carcinoma of the Esophagus Associated with Chagasic Megaesophagus.
III Simpósio em Oncologia Translacional do Hospital de Câncer de Barretos. 29-30
August de 2013, Barretos, Brazil.
30. Lourenço T, Gonçalves CS, Xavier-Magalhães A, Pinto F, Reis RM, Costa BM.
Relevance of HES1 expression in human gliomas: molecular and clinical correlates. XXII
Porto Cancer Meeting. 11-12 April 2013, Porto, Portugal.
31. Macedo T, Evangelista AF, Marino AFL, Oliveira RJS, Vieira RAC, Longatto AF,
Silva VAO, Vidal DO, Marques MMC. Functional assays of mir-183 and mir-494 in
breast cancer cell lines. III Simpósio em Oncologia Translacional do Hospital de Câncer
de Barretos. 29-30 August de 2013, Barretos, Brazil.
32. Macedo T, Evangelista AF, Marino AFL, Vieira RAC, Longatto AF, Silva VAO,
Vidal DO, Marques MMC. miR-183 and miR-494 as risk biomarkers for breast cancer
development. International Congress of Markers in Cancer. 7–9 November de 2013.
Brussels, Belgian.
23 Molecular Oncology Research Center – Barretos Cancer Hospital
33. Marino ALF, Macedo T, Longatto AF, Kerr LM, Vieira RAC, Evangelista AF,
Silveira HCS, Marques MMC. MicroRNA profiling as a risk biomarker in the
development of breast cancer metastasis. III Simpósio em Oncologia Translacional do
Hospital de Câncer de Barretos. 29-30 August de 2013, Barretos, Brazil.
34. Martinho O, Reis RM. Role of AXL knockdown in the prediction of sunitinib therapy
response in glioblastoma. VI Congresso Nacional da Associação Portuguesa de Neuro-
Oncologia. 15-16 November 2013, Almada, Portugal.
35. Miranda-Gonçalves V, Honavar M, Pires MM, Pinheiro C, Cordeiro M, Bebiano G,
Costa P, Reis RM, Baltazar F. MCT1 plasma membrane expression at hypoxic regions
could be a mediator of cellular aggressiveness in glioblastoma. VI Congresso Nacional
da Associação Portuguesa de Neuro-Oncologia. 15-16 November 2013, Almada, Portugal.
36. Morais-Santos F, Pinheiro C, Vieira A, Paredes J, Schmitt F, Baltazar F. Exploitation
of Monocarboxylate Transporter 1 (MCT1) as target in breast cancer therapy. XXII Porto
Cancer Meeting. 2013, Porto, Portugal.
37. Morais-Santos F, Pinheiro C, Vieira A, Paredes J, Schmitt F, Baltazar F.
Monocarboxylate Transporters as therapeutic targets in breast cancer. Advances in
Molecular Oncology: Translating Molecular Biology into Cancer Treatment. 2013, São
Paulo, Brazil.
38. Morais-Santos F, Pinheiro C, Vieira A, Paredes J, Schmitt F, Baltazar F. Contribution
of monocarboxylate transporters to the aggressive phenotype of breast cancer. 11th
International Congress on Targeted Anticancer Therapies. 2013, Paris, France.
39. Oliveira-Silva RJ, Martinho O, Carvalho AL, Reis RM. Testing a novel irreversible
anti-EGFR drug for head and neck cancer treatment. XLII Reunião Anual da SBBq. May
2013, Foz do Iguaçu, Brazil.
40. Oliveira K, Guimarães DP, Cunha T, Almodova E, Viel A, Scapulatempo-Neto C,
Barro G, Fava G. O Papel da Colonoscopia em Pacientes Submetidos ao Transplante de
Medula Óssea Alogênico com Diagnóstico de Doença do Enxerto Contra Hospedeiro
Agudo. XII Semana Brasileira do Aparelho Digestivo. 24-27 Novembers. 2013, Goiânia,
Brazil.
41. Osório NS, Rodrigues F, Garcia EA, Costa MJ. Medical Students Cell Drawings as
Snapshots of Cellular Anatomy Understanding. Association for Medical Education in
Europe (AMEE). 24-28 August 2023, Prague, Czech Republic.
24 Molecular Oncology Research Center – Barretos Cancer Hospital
42. Pereira MS, Viana-Pereira M, Jones C, Reis RM. SPINT2 hypermethylation – a
common event in high-grade gliomas. Translating Molecular Biology into Cancer
Treatment. SPSAS – São Paulo School of Advanced Sciences, Advances in Molecular
Oncology. February 2013, São Paulo, Brazil.
43. Pereira MS, Viana-Pereira M, Pardal F, Amorim J, Melo-Pires, Pinheiro C, Lopes JM,
Honavar M, Costa P, Pimentel J, Jones C, Reis RM. Unraveling the Biological Role of
SPINT2 in Gliomas. VI Congresso Nacional da Associação Portuguesa de Neuro-
Oncologia, 15-16 November 2013, Almada, Portugal.
44. Pojo M, Gonçalves SC, Xavier-Magalhães A, Fernandes R., Gonçalves T, Rodrigues
AJ, Costa S, Pinto L, Reis R M, Rocha M, Costello JF, Sousa N, Costa B. M. A
Transcriptomic Signature Mediated by HOXA9 Sustains Human Glioblastoma
Aggressiveness, Resistance to Chemotherapy and Glioma Initiation. EACR Summer
Conference: Cancer Genomics. 25-28 June 2013, Cambridge, England.
45. Pojo M, Gonçalves SC, Xavier-Magalhães A, Fernandes R, Gonçalves T, Rodrigues
J, Costa S, Pinto L, Reis RM, Rocha M, Costello J F, Sousa N, Costa B. M. HOXA9
Promotes Glioma Initiation and Sustains Human Glioblastoma Aggressiveness and
Resistance to Therapy. XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting.
11-12 April2013, Porto, Portugal.
46. Ramos MC, Cury FP, Scapulatempo-Neto C, Silveira HC. Análise comparativa para
seleção de Micronúcleos em células esfoliadas da mucosa bucal preparados por citologia
de base liquida. V Encontro Científico do Hospital de Câncer de Barretos, 2013. Barretos,
Brazil.
47. Rodrigues AL, Evangelista AF, Macedo T, Oliveira RJS, Mota AL, Reis RM,
Marques MM. Molecular signatures of microRNAs on human breast cancer cell lines
exposed to Cediranib. III Simpósio em Oncologia Translacional do Hospital de Câncer
de Barretos. 29- 30 August 2013. Barretos, Brazil.
48. Rosa MN, Silva VAO, Tansini A, Jones C, Lima JP, Pianowski LF, Reis RM. In Vitro
Activity of euphol from Euphorbia tirucalli on a large panel of human cancer cell lines.
XLII Reunião Anual da SBBq. May 2013, Foz do Iguaçu, Brazil.
49. Scapulatempo-Neto C, Carlos C, Viana L, Miziara JE, Pereira R, Reis RM.
Frequência de mutação de EGFR e KRAS em carcinoma não pequenas células do pulmão
na população brasileira e sua correlação com marcadores genéticos de ancestralidade.
XXIX Congresso Brasileiro de Patologia. 13-16 November 2013, Florianópolis, Brazil.
25 Molecular Oncology Research Center – Barretos Cancer Hospital
50. Scapulatempo-Neto C, Faria EF, Saber G, Fregnani JH, Záccaro-Silva LC. Achados
histopatológicos de biópsia prostática: Análise da concordância entre a avaliação de um
centro não oncológico e sua revisão em um centro oncológico numa instituição brasileira.
XXIX Congresso Brasileiro de Patologia. 13 -16 November 2013, Florianópolis, Brazil
51. Scapulatempo-Neto C, Stein MD, Fregnani JH, Carvalho TS, Kerr L, Silva SM,
Abrahão-Machado L, Mateus FP, Mafra A, Campacci N, Silva ET, Mauad EC, Longatto-
Filho A. Desempenho do rastreio citológico cérvico-vaginal em pacientes submetidas à
radioterapia pélvica e braquiterapia vaginal, utilizando o sistema computadorizado Focal
Point: Resultado do estudo RODEO. XXIX Congresso Brasileiro de Patologia. 13-16
November 2013, Florianópolis, Brazil.
52. Scapulatempo-Neto C, Watanabe A, Pereira CAA, Vieira RA, Silva ECA, Yamashita
T, Relato de caso: Amiloidose primária da mama formando massa e microcalcificações
suspeitas à mamografia. XXIX Congresso Brasileiro de Patologia. 13-16 November 2013,
Florianópolis, Brazil.
53. Silva ECA, Abrahão-Machado L, Carvalho TS, Souza W, Almeida GC, Matsushita
M, Santana IV, Scapulatempo-Neto C. Carcinoma hepatóide primário do ovário: Um raro
relato de caso. XXIX Congresso Brasileiro de Patologia. 13-16 November 2013,
Florianópolis, Brazil.
54. Silva ECA, Abrahão-Machado L, Santana IV, Scapulatempo-Neto C, Souza W, Silva
SFA. Tumor sólido pseudopapilífero do pâncreas em uma mulher de meia idade: Relato
de um caso com apresentação clínico-patológica incomum. XXIX Congresso Brasileiro
de Patologia. 13-16 November 2013, Florianópolis, Brazil.
55. Silva V, Rosa MN, Tansini A, Lima JP, Jones C, Pianowski LF, Reis RM. Cytotoxic
activity of semi-synthetic ingenol derived from Euphorbia tirucalli on a large panel of
human cancer cell lines. 2013 ASCO Annual Meeting. May 2013, Chicago, USA.
56. Silva VAO, Rosa MN, Tansini A, Lima JP, Jones C, Pianowski LF, Reis RM.
Cytotoxic effect of euphol from Euphorbia tirucalli on a large panel of human cancer cell
lines. 2013 ASCO Annual Meeting. May 2013, Chicago, USA.
57. Silva VAO, Rosa MN, Tansini A, Vazquez V, Pianowski LF, Reis RM. Cytotoxic
effect of euphol and semi-synthetic ingenol derived from Euphorbia tirucalli on human
melanomas cell lines. 8th World Congress of Melanoma. July 2013, Hamburg, Germany.
58. Silva VAO, Rosa MN, Tansini A, Costa AM, Oliveira-Silva R, Martinho O,
Pianowski L, Reis RM. The semi-synthetic ingenol c derived from Euphorbia tirucalli
26 Molecular Oncology Research Center – Barretos Cancer Hospital
induces cell death via autophagy but not apoptosis in human glioma cancer cells. III
Congresso Luso-Brasileiro de patologia experimental (XIII Simpósio Internacional sobre
técnicas experimentais). 23-25 October 2013, Tiradentes, Minas Gerais, Brazil.
59. Silva VAO, Rosa MN, Tansini A, Pianowski LF, Reis RM. In vitro cytotoxic activity
of am11 and semi-synthetic ingenol derived from Euphorbia tirucalli on a large panel of
human cancer cell lines. III Congresso Luso-Brasileiro de patologia experimental (XIII
Simpósio Internacional sobre técnicas experimentais). 23-25 October 2013, Tiradentes,
Minas Gerais, Brazil.
60. Silva VAO, Rosa MN, Tansini A, Costa AM, Oliveira-Silva R, Martinho O,
Pianowski L, F, Reis RM. The semi-synthetic ingenol c derived from Euphorbia tirucalli
induces cell death via autophagy but not apoptosis in human glioma cancer cells. V
Encontro Científico do Hospital de câncer de Barretos . 13-14 Decembre 2013, Barretos,
SP, Brazil.
61. Torrieri R, Lima JP, Reis RM. In silico analysis of the raf kinase inhibitory protein
(RKIP) expression impact in breast cancer patients. III Simpósio em Oncologia
Translacional do Hospital de Câncer de Barretos. 29-30 August 2013, Barretos, Brazil.
62. Xavier-Magalhães A, Gonçalves SC, Lourenço T, Pojo M, Rocha M, Lopes MC,
Crespo I, Rebelo O, Tão H, Moreira R, Pinto AA, Reis RM, Costello JF, Sousa N, Costa
BM. Long Non-Coding RNA HOTAIR is Transcriptionally Activated by HOXA9 and Is
Associated with Poor Prognosis in Glioblastoma. XXII Porto Cancer Meeting & III Porto-
Bordeaux Joint Meeting. 11-12 April 2013, Porto, Portugal.
63. Xavier-Magalhães A, Gonçalves SC, Lourenço T, Pojo M, Rocha M, Lopes MC,
Crespo I, Rebelo O, Tão H, Moreira R, Pinto AA, Reis RM, Costello JF, Sousa N, Costa
BM. Long Non-Coding RNA HOTAIR is Transcriptionally Activated by HOXA9 and Is
Associated with Poor Prognosis in Glioblastoma. Non-coding RNA, epigenetics and
transgenerational inheritance. 11-12April 2013, Cambridge, England.
64. Xavier-Magalhães A, Gonçalves SC, Lourenço T, Pojo M, M, Rocha Lopes M C,
Crespo I, Rebelo O, Tão H, Moreira R. Pinto A A, Reis RM, Costello JF, Sousa N, Costa
BM. Long Non-Coding RNA HOTAIR is Transcriptionally Activated by HOXA9 and Is
Associated with Poor Prognosis in Glioblastoma. SPSAS - Advances in Molecular
Oncology: Translating Molecular Biology into Cancer Treatment. 3-8 February 2013,
São Paulo, Brazil.
27 Molecular Oncology Research Center – Barretos Cancer Hospital
65. Viana DV, Viana-Pereira M, Almeida G, Clara C, Palmero E, Scapulatempo Neto C,
Jones C, Bertuzzo CS, Reis RM. Biallelic mutations in MMR gene in a retrospective
series of CNS tumors. IV Annual IMPPC Conference/1st ICO-IDIBELL Hereditary
Cancer Program Meeting. Hereditary and Familial Cancer In The Personal Genomics
Era.14-15 March 2013, Barcelona, Spain.
66. Volpe FAP, Doretto AS, Rezende FF, Freitas JA, Garcia EA. Public health units as
learning scenario for medical students. Association for Medical Education in Europe
(AMEE). 24 -28 August 2013, Prague, Czech Republic.
67. Zanon MF, Almeida GC, Matsushita MM, Reis RM, Squire JA, Camparotto ML.
Evaluation of 1p/19q codeletion using FISH analysys in pure and mixed oligodendroglial
tumors at the routine pathology of the Barretos Cancer Hospital-SP, Brazil. III Simpósio
em Oncologia Translacional do Hospital de Câncer de Barretos. 29-30 August 2013,
Barretos, Brazil.
6) Science Communication to general public
1. Reis RM, Carvalho AL: Revista Hospital do Futuro, HdF Nº15, Portugal – O Hospital
de Câncer de Barretos.
2. Lacerda CF, de Oliveira AT, Guimaraes DP, Reis RM. Câncer de Esôfago, da Clínica
a Biologia Molecular. Revista Onco& – oncologia para todas as especialidades. Nov/Dec,
2013
3. Palmero EI. Hereditariedade e Câncer de Mama” Revista Onco & – oncologia para
todas as especialidades. Sept/Oct, 2013.
4. Silveira HCS, Lopes LF. Alunos acompanham luta contra o câncer em Hospital de
Barretos. Portal G1, Barretos, 15 July, 2013.
5. Silveira HCS . Concurso de Redação do HC. O Diário, Barretos, 14 July, 2013.
6. Silveira HCS . I Concurso de Redação. Jornal de Barretos, Barretos, 06 July. 2013.
7) Supervision of PhD, Master and Initiation to Trainee Fellows
7.1) PhD
1. Adriana Lorenzi. Valor do teste careHPV de captura híbrida em Unidade Móvel no
rastreio do câncer cervical em áreas rurais e remotas. HCB (Supervision - Longatto Filho,
A.). 2011 – present.
28 Molecular Oncology Research Center – Barretos Cancer Hospital
2. Aline Nazareth de Paiva Paixão Becker. Avaliação da via MAPK na oncogênese dos
astrocitomas pilocíticos. HCB (Supervision – Reis RM, Co-supervision- Scapulatempo-
Neto C). 2012 – present.
3. Filipe Pinto. Learning from the embryo: Understanding early embryonic T gene -
Brachyury - impact in human tumorigenesis. ICVS, Universidade do Minho (Supervision
– Reis RM). 2011-present.
4. Gustavo Berardinelli. Elucidação do impacto molecular e clínico da instabilidade de
microssatélite em pacientes com câncer colorretal esporádico do Hospital de Câncer de
Barretos. HCB (Supervision – Reis RM). 2013 – present.
5. Herlander Jose Resende Marques. Prevalência de vírus Herpes nos Linfomas
Foliculares Influência dos polimorfismos dos sistemas apresentadores de antigénio na
infecção crónica. ICVS, Universidade do Minho. (Supervision - Longatto Filho A). 2008
- 2013.
6. Julieta Alexandra Pereira Afonso. The Biology of Lymphatic Spread of Urothelial
Bladder Cancer. ICVS, Universidade do Minho. (Supervision - Longatto Filho A). 2008
- 2013.
7. Junea Caris de Oliveira. Correlação genotipo-fenotipo em pacientes portadores de
Polipose Adenomatosa Familial. HCB (Supervision – Rossi BM, Co-supervision-
Palmero EI). 2012 – present.
8. Leonado Gabeira Secco. Fatores Prognósticos em Carcinoma Bem Diferenciado da
Tireóide. FMUSP (Supervision – Carvalho AL). 2005-present.
9. Maria Teresa Roncaglia. O valor da captura híbrida para HPV no seguimento de
pacientes com neoplasia intra-epitelial de alto grau submetidas à conização do colo
uterino por cirurgia de alta freqüência. FMUSP (Supervision –Longatto Filho A). 2010-
present.
10. Roberta Targa Stramandinoli. Avaliação da interface osso/implante em mandíbula
de miniporcos irradiados e o uso de biomateriais na osseointegração. FMUSP
(Supervision – Carvalho AL). 2010-present.
11. Sandra Fátima Fernandes Martins. Expression of Colorectal Cancer Metabolic and
Angiogenic Markers: Association with Clinicopathological Characteristics and Impact on
Prognosis. ICVS, Universidade do Minho. (Orientação Longatto Filho L). 2008 - 2013.
29 Molecular Oncology Research Center – Barretos Cancer Hospital
12. Thiago Buosi Silva. Desenvolvimento e validação de nomogramas para estimar os
riscos de câncer de próstata e de câncer de próstata de baixo e alto grau de malignidade.
FMUSP (Supervision – Carvalho AL). 2010-2013.
13. Renato José da Silva Oliveira. Identificação de novos biomarcadores preditivos da
resposta à terapia anti-EGFR em tumores sólidos. HCB (Supervision – Reis RM, Co-
supervision- Carvalho AL). 2011 – present.
14. Flávio Mavignier Cárcano. Estudo da instabilidade de microssatélite, ADAMTSI e
OCT-3/4 nos tumores de células germinativas do testículo e suas associações
prognósticas preditivas nos pacientes submetidos à quimioterapia. Hospital de Câncer de
Barretos (Supervision: Lopes LF). 2012-present.
7.2) Master
1. Adriana Cruvinel. Caracterização Citogenética e Molecular de Linhagens Primárias
de Gliomas. Hospital de Câncer de Barretos (Supervision - Reis RM). 2011-2013.
2. Adriano Jander Ferreira. Catalogação dos pacientes com diagnostico de Sarcoma de
Ewing tratados no Hospital de Câncer de Barretos. Hospital de Câncer de Barretos
(Supervision - Lopes LF). 2011 – 2013.
3. Ana Laura Bordinhão Rodrigues. Avaliação da expressão de microRNAs em
linhagens celulares de carcinoma mamário humano expostas a ação do fármaco
Cediranib. Hospital de Câncer de Barretos (Supervision- Marques, MMC). 2011-2013.
4. Augusto Ludvik Filip Marino. Análise do perfil de expressão diferencial de
microRNAs em carcinomas mamários por microarrays. Hospital de Câncer de Barretos
(Supervision - Marques, MMC). 2011-2013.
5. Camila Maria da Silva Martinelli. Avaliação do perfil de metilação de genes alvo
candidatos em tumores de células germinativas do testículo. Hospital de Câncer de
Barretos (Supervision- Lopes LF, Co-supervision- Vidal DO). 2013 – present.
6. Croider Franco Lacerda. Estudo do gene supressor tumoral, TP53, no carcinoma de
células escamosas do esôfago associado ao megaesôfago chagásico. Hospital de Câncer
de Barretos (Supervision - Reis RM, Co-supervision- Guimaraes DP). 2011-2013.
7. Flávia Coltri Eguchi. Avaliação da superexpressão das proteínas TMPRSS2 e ERG e
a fusão gênica TMPRSS2:ERG em portadores de câncer prostático. Hospital de Câncer
de Barretos (Supervision - Campos, SGP). 2011-2013.
30 Molecular Oncology Research Center – Barretos Cancer Hospital
8. Gabriela Carvalho Fernandes. Identificação de mulheres em risco para câncer de mama
hereditário por mutação nos genes BRCA1 e BRCA2: contribuição dos dados patológicos,
história familiar e modificadores genéticos do risco de câncer. Hospital de Câncer de
Barretos (Supervision - Palmero EI). 2013-2015.
9. Juliana Levy Daher. Aspectos funcionais e emocionais da deglutição e fonação no
paciente com câncer de cabeça e pescoço pré e pós tratamento oncológico Hospital de
Câncer de Barretos. (Supervision - Carvalho AL). 2011-2013.
10. Júlio Cesar Possati Resende. Detecção de lesão intraepitelial cervical de alto grau em
mulheres com citologia de ASC-US E LIEBG: Comparação entre a expressão
imunocitoquímica dos biomarcadores P16/Ki-67 e teste molecular de DNA-HPV de alto
risco. (Supervision – Scapulatempo-Neto, C). 2012-2014.
11. Letícia Rodrigues Cardoso. Síndrome de Dor Miofascial em pacientes portadores de
câncer de cabeça e pescoço. Hospital de Câncer de Barretos (Supervision - Carvalho AL).
2011-present.
12. Leticia dos Santos Yamane. Estudo mutacional dos oncogeneses KRAS e BRAF nas
lesões do cólon e reto. Hospital de Câncer de Barretos (Supervision – Guimaraes DG, Co-
supervision- Reis, RM). 2011 – 2013.
13. Luiz Cesar Záccaro da Silva. Análise crítica da discrepância entre achados
histopatológicos da biópsia prostática realizada em centros não oncológicos e sua revisão
em um centro oncológico. Hospital de Câncer de Barretos (Supervision - Scapualtempo-
Neto C). 2011-2013.
14. Maira DeGiovani Stein. Desempenho diagnóstico da citologia manual versus a
citologia assistida por computador usando BD FocalPoint GS Imaging system em
material preparado em sistema BD SurePath de base líquida. Hospital de Câncer de
Barretos (Supervision -Adhemar Longatto Filho). 2011-2013.
15. Maicon Fernando Zanon da Silva. Avaliação da via de sinalização
FGFR1/PI3K/AKT em carcinomas adenóides císticos. Hospital de Câncer de Barretos
(Supervision – Scapulatempo-Neto C). 2012-2014.
16. Marcelo Simonsen. Comparação da correlação cito-histológica utilizando os
diferentes dispositivos Cytobrush™ e Cervex-Brush Combi™ na coleta de amostras
uterinas para confecção de citologias de base líquida. Hospital de Câncer de Barretos
(Supervision Scapulatempo- Neto C). 2013-2015.
31 Molecular Oncology Research Center – Barretos Cancer Hospital
17. Natalia Campacci. Rastreamento populacional de famílias com predisposição
hereditária de câncer de mama e/ou câncer colorretal. Hospital de Câncer de Barretos
(Supervision -Palmero EI). 2011-2013.
18. Nathália Cristina Campanella. Estudo da instabilidade de microssatélite e potenciais
genes alvos em GISTs. Hospital de Câncer de Barretos (Supervision - Reis RM). 2012-
2013.
19. Taciane Macedo. Estudo funcional de microRNAs associados ao processo de
metástase em linhagens celulares de carcinoma mamário humano. Hospital de Câncer de
Barretos (Supervision - Marques, MMC) 2012- present.
20. Vanessa Regina Maciel Uzan. Perfil de expressão gênica dos RNAs não codificadores
HOTAIR, MALAT1, HULC e BCYRN1 (BC200) em Osteossarcoma. Hospital de Câncer
de Barretos (Supervision- Lopes LF, Co-supervision- Vidal DO). 2013 – present.
21. Marcelo Simonsen. Comparação do desempenho dos dispositivos de coleta de
material cervical Cervex brush e escova endocervical + espátula de Ayre na detecção de
lesões intraepiteliais (Supervision- Scapulatempo-Neto C). 2013- present.
22. Júlio César Possati Ribeiro. Comparação entre o teste molecular COBAS e a co-
expressão de ki-67/p16 na detecção de lesões intra epiteliais de alto grau em pacientes
com diagnóstico de ASC-US e LSIL na citologia cérvico vaginal (Supervision-
Scapulatempo-Neto C). 2012-present.
23. Thiago Rabelo da Cunha. Estudo comparativo entre diferentes parâmetros de
coagulação com plasma de argônio no tratamento da retite actínica. (Supervision-
Guimarães DP). 2012-present.
7.3) Trainee Fellows
1. André de Lima Mota. Avaliação da expressão de VEGF e do seu receptor VEGFR-
1/Flt-1 e VEGFR-2/Flk-1 em linhagens celulares de carcinoma mamário humano
expostas a ação do fármaco Cediranib. Hospital de Câncer de Barretos (Supervision -
Marques MMC).
2. Fernanda de Paula Cury. Análise do potencial risco de câncer na exposição dos
trabalhadores da construção civil a agentes carcinogênicos. HCB (Supervision – Silveira
HC).
3. Graziela Sartori. Caracterização molecular em melanomas acrolentiginosos e das
mucosas. Hospital de Câncer de Barretos (Supervision - Vazquez VL).
32 Molecular Oncology Research Center – Barretos Cancer Hospital
4. Juliana Oliveira de Lima. Rastreamento populacional de famílias com predisposição
hereditária de câncer de mama e/ou câncer colorretal. Hospital de Câncer de Barretos,
HCB. (Supervision - Palmero EI).
5. Lamis Ramadan. Desenvolvimento de estrategias educativas para famílias com
predisposição hereditária ao câncer de mama e/ou câncer colorretal. Hospital de Câncer
de Barretos, HCB. (Supervision - Palmero EI).
6. Talitha Cezareti Blau Fonseca. Identificação de mulheres em risco para câncer de
mama hereditário por mutação nos genes BRCA1 e BRCA2: contribuição dos dados
patológicos, história familiar e modificadores genéticos do risco de câncer. Hospital de
Câncer de Barretos (Supervision - Palmero EI).
7. Verônica Rissati. Validação de novas estratégias para identificação de indivíduos em
risco para câncer hereditário.. Hospital de Câncer de Barretos (Supervision - Palmero EI).
8. Manuela Catarina Aguena souza Ramos. Análise comparativa para seleção de
Micronúcleos em células esfoliadas da mucosa bucal preparados por citologia de base
liquida. Hospital de Câncer de Barretos, HCB. (Supervision - Silveira HC).
8) Prizes
1. IV Octavio Frias de Oliveira Prize in the categorie of Research on Oncology with
Prognostic significance of TIMP3 hypermethylation in post-treatment salivary rinse from
head and neck squamous cell carcinoma patients. Rettori MM, de Carvalho AC, Bomfim
Longo AL, de Oliveira CZ, Kowalski LP, Carvalho AL, Vettore AL. 05 August 2013.
2. Best Scientific Research work at the III Simpósio em Oncologia Translacional do
Hospital de Câncer de Barretos, with The importance of molecular characterization of
head and neck cancer cell lines for the prediction of anti-EGFR therapies resistance.”
Oliveira-Silva, RJ, Martinho O, Berardinelli GN, Viana L, Carvalho AL, Reis RM. 29-
30 August 2013.
3. Honour Mention at the III Congresso Luso-Brasileiro de Patologia Experimental.
Tiradentes, Minas Gerais, with “The semi-synthetic Ingenol C derived from Euphorbia
tirucalli induces cell death via autophagy but not apopotosis in human glioma cancer cells.
Silva, VAO, Rosa MN,Tansini A,Costa AM, Oliveira-Silva R, Martinho O, Pianowski
LF. Reis RM. 23- 25 October 2013.
4. Best Poster at XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting, with
"HOXA9 Promotes Glioma Initiation and Sustains Human Glioblastoma Aggressiveness
33 Molecular Oncology Research Center – Barretos Cancer Hospital
and Resistance to Therapy."Pojo M, Gonçalves SC, Xavier-Magalhães A, Fernandes R,
Gonçalves T, Rodrigues AJ, Costa S;Pinto L, Reis RM, Rocha M, Costello, JF, Sousa N,
Costa BM. Portugal, 2013.
5. Best Poster at V Encontro Científico do Hospital de Câncer de Barretos, with The semi-
synthetic ingenol c derived from Euphorbia tirucalli induces cell death via autophagy but
not apoptosis in human glioma cancer cells. Silva VAO, Rosa MN, Tansini A, Costa AM,
Oliveira-Silva R, Martinho O, Pianowski LF, Reis RM. December, Barretos, Brazil,
2013.
6. Best Scientific Work (Gizele Rozone de Luca Award) at XXV Congresso Brasileiro
de Genética Médica, with “Utilização das unidades móveis e fixa de prevenção para
rastreamento populacional de famílias com predisposição hereditária de câncer de mama”.
Campacci N, Lima JO, Rossati V, Toledo EMP, Ramadan L, Palmero EI. Florianópolis,
Brazil, 2013.
7. Honour Mention at the I Encontro de Jovens Talentos do Hospital de Câncer de
Barretos, with Assessment of genotoxic damages in civil construction workers using
micronucleus assay. Cury FP, Ramos MC, Scapulatempo-Neto C, Silveira HC. Barretos,
Brazil, 2013.
9) Participation in Internacional Networks
1. Carvalho AL, Silveira HC, Reis RM. International Cancer Genome Consortium. 2012-
present.
2. Carvalho AL, Marques MMC, Reis RM, Scapulatempo-Neto C - US-Latin American
Cancer Research Network (USLACRN). 2010-present.
3. Carvalho AL, Mauad EC- WIN - World Innovative Networking, 2010-present.
4. Carvalho AL- INTERCHANGE – Head and Neck Study Group (IARC), 2010-present.
5. Carvalho AL, Silveira HC. The Cancer Genome Atlas (TCGA). 2013 – present.
6. Mauad EC, Carvalho AL, Reis RM, Scapulatempo-Neto C – GAP – Global Academic
Program – Sister Institution Network (MDANderson). 2011-present.
7. Reis RM - IMMEnSE (International Multiple Myeloma rESEarch) consortium – 2010-
present.
8. Reis RM - Société Internationale d'Oncologie Pédiatrique (SIOP) - Brain Tumour
Committee- High Grade Glioma Working Group. 2010-present.
34 Molecular Oncology Research Center – Barretos Cancer Hospital
10) Participation in National Networks
1. Carvalho AL, Scapulatempo-Neto C – GENCAPO – Projeto de Genoma Cabeça e
Pescoço Brasileiro, 2010-present.
2. Palmero EI, Reis RM. Rede Brasileira de Câncer Familiar.
3. Silveira HC – INAIRA - Instituto Nacional de Análise Integrada do Risco Ambiental
(INCT).
11) Organization of Conferences and Meetings
1. Carvalho AL, Fregnani JH, Longatto Filho A, Scapulatempo Neto C, Vidal DO,
Palmero E, Silveira H, Marques MM, Viana L, Serrano SV, Reis RM. III Simpósio
Internacional em Oncologia Translacional do Hospital de Câncer de Barretos, August,
2013.
2. Lopes LF. II Encontro Internacional de Oncologia Pediátrica de Barretos, March, 2013.
12) Lectures / Seminars at Conferences and Meetings
1. Guimarães DP. XII Semana Brasileira do Aparelho Digestivo. Caracterização
Endoscópica de Adenomas Serrilhados Sésseis. 2013, Goiânia, Brazil.
2. Mariano VS. V Jornada de Integração das ligas de Biomedicina. O papilomavírus
humano como agente causador de câncer. 2013, Ribeirão Preto, São Paulo, Brazil.
3. Longatto AF. Patologia molecular en el diagnostico oncológico, Universidad de La
Republica Uruguaya, Screening en Cáncer Cervical: Nuevo Era Nuevos Paradigmas. 16-
17 May 2013, Montevideo, Uruguai.
4. Longatto AF. 18th International Congress of Cytology. Cervical câncer prevention in
Barretos region, Brazil. 26-30 May 2013, Paris, France.
5. Longatto AF. The EUROGIN 2013. Screening: molecular-based strategies careHPV.
3-6 November 2013, Florence, Italy.
6. Longatto AF. VIII Congreso Latinoamericano de Patologia Del Tracto Genital Inferior
y Colposcopia. Prevención de cáncer cervical en Latinoamérica. 13-15 November 2013,
Buenos Aires, Argentina.
7. Longatto AF. VIII Congreso Latinoamericano de Patologia Del Tracto Genital Inferior
y Colposcopia. Diagnóstico citopatológico y molecular en El TGI - Diagnótico citológico
y anatomopatológico de la ZT. 13-15 November 2013, Buenos Aires, Argentina.
35 Molecular Oncology Research Center – Barretos Cancer Hospital
8. Longatto AF. VIII Congreso Latinoamericano de Patologia Del Tracto Genital Inferior
y Colposcopia. HPV. Biologia molecular y respuesta inmune’. Marcadores pronósticos
de La lesión inducida por HPV. 13-15 November 2013, Buenos Aires, Argentina.
9. Lopes LF. XI Congresso de Saúde e Qualidade de Vida do Cone Leste Paulista. Banco
de tumores pediátricos no auxílio a pesquisa tranlacional e a aplicação a prática clínica
da oncologia pediátrica. 2013. UNIVAP-São José dos Campos, São Paulo, Brazil.
10. Lopes LF. II Encontro do Comitê de Sindromes Mielodisplásticas da ABHH. Grupo
Brasileiro de SMD pediátrica: sucessos e dificuldades. 2013, São Paulo, São Paulo, Brazil.
11. Lopes LF. I Encontro Nacional dos Profissionais de Pesquisa Clínica em
Oncopediatria no XIV Encontro Nacional de Grupos Cooperativos. Tumores de células
germinativas. 2013. São Paulo, São Paulo, Brazil.
12. Lopes LF. II Encontro Internacional de Oncologia Pediátrica de Barretos. Tumor de
células germinativas: dados do grupo brasileiro. 2013, Barretos, São Paulo, Brazil.
13. Lopes LF. II Encontro Internacional de Oncologia Pediátrica de Barretos. SMD da
infância: histórico e dados epidemiológicos. 2013, Barretos, São Paulo, Brazil.
14. Lopes LF. 45° Congresso da Sociedade Internacional de Oncologia Pediátrica. 2013,
Hong Kong, China.
15. Lopes LF. III Jornada Latino Americana- Israelense de Hemantologia Pediátrica e 7ª
Renião Científica Anual do Grupo Galop. Tumores de Células Germinativas- Resultados
de TCG 2008. 2013. Montevideo, Uruguai.
16. Lopes LF. Congresso Brasileiro de Hematologia e Hemoterapia da ABHH. Avanços
na Patonense e tratamento da Leucemia Mielomonocitica Juvenil. Brasília, Brazil.
17. Lopes LF. GAP 2013 Meeting. The Brazilian cooperative Group on Pediatric
Myelodyplastic syndrome from 1997 to 2012: is it relevant to improve educational
approach and correct diagnosis. 2013 Houston, USA.
18. Pinheiro C. III International Symposium on Translational Oncology of the Barretos
Cancer Hospital. Therapeutic targeting of cancer metabolism: exploitation of
monocarboxylate transporters.29-30 August 2013, Barretos, Brazil.
19. Palmero EI. III International Symposium on Translational Oncology of the Barretos
Cancer Hospital. The interplay between research and clinics in hereditary cancer, 29-30
August 2013, Barretos, Brazil.
20. Palmero EI. XXV Congresso Brasileiro de Genética Médica. Importância do
diagnóstico molecular para a identificação dos indivíduos em risco. 2013, Florianopolis,
36 Molecular Oncology Research Center – Barretos Cancer Hospital
Brazil.
21. Palmero EI. Ion World 2013 - Next Generation Sequencing: From Bench top to the
Clinic. Applications of Next-Generation Sequencing in Oncology. 2013, São Paulo,
Brazil.
22. Reis RM. I Simpósio de Pesquisa Clínica do Hospital de Câncer de Barretos. Pesquisa
Translacional: o que esperar do future? 29 November 2013, Barretos, Brazil.
23. Reis RM. I Jornada de Cirurgia Hepatobiliopancreática do HUGG. Biologia
Molecular no tratamento Onco-Cirúrgico. 28-30 October 2013, Rio de Janeiro, Brazil.
24. Reis RM. Meeting de Gliomas, Universidade Federal da Bahia (UFBA), Instituto de
Ciências da Saúde (ICS). Biologia Molecular de Gliomas: Impacto Clínico. 23 October
2013, Salvador, Brazil.
25. Reis RM. III Simpósio Internacional de Oncologia Translacional do Hospital de
Câncer de Barretos. The role of RTKs signaling in gliomas. 29-30 August 2013. Barretos,
Brazil.
26. Reis RM. World Innovative Networking (WIN) 2013. Challenges and opportunities
in the implementation of personalized medicine in Brazil. July 2013, Paris, France.
27. Reis RM. XVI Pathology Meeting of A. C. Camargo Cancer Center and VI
International Meeting on Investigative Pathology. The role of RTKs and the downstream
MAPK pathway in glioma biology and therapy. 7-9 August 2013, São Paulo, Brazil.
28. Reis RM. 1er Curso en Patologia Molecular Diagnostica Terapêutica e Investigativa.
Centro de Pesquisa em Oncologia Molecular, Hospital de Câncer de Barretos. 16-17 May
2013, Montevideo, Uruguai.
29. Reis RM. 1er Curso en Patologia Molecular Diagnostica Terapeutica e Investigativa.
Bases Moleculares en el Diagnostico y Terapeutica en Cancer. 16-17 May 2013,
Montevideo, Uruguai.
30. Scapulatempo CN. III International Symposium on translational oncology of The
Barretos Cancer Hospital. Recent genomic discoveries with potential impact in
personalized medicine. 29-30 August. Barretos, Brazil.
31. Scapulatempo CN. Practicas em Patología Molecular. Primeiro Curso em Patologia
Molecular Diagnóstica Terapêutica e Investigativa. 16-17 May 2013, Hospital de Clínicas
de Montevideo, Uruguai.
37 Molecular Oncology Research Center – Barretos Cancer Hospital
32. Scapulatempo CN. Discussão de Casos-Clinicos. Patología Molecular. Primeiro
Curso em Patologia Molecular Diagnóstica Terapêutica e Investigativa. 16-17 May 2013,
Hospital de Clínicas de Montevideo, Uruguai.
33. Scapulatempo CN. Seminário de Lâminas- Citologia. XXIX Congresso Brasileiro de
Patologia. 13-16 November 2013, Florianopolis, Brazil.
34. Scapulatempo CN. Como eu diagnóstico carcinoma escamocelular versus
adenocarcinoma em pequenas amostras de biópsia pulmonar. XXIX Congresso Brasileiro
de Patologia. 13-16 November 2013, Florianopolis, Brazil.
35. Scaputatempo CN. Seminário de Lâminas - Patologia cirúrgica: Armadilhas em
patologia cirúrgica. XXIX Congresso Brasileiro de Patologia. 13-16 November 2013,
Florianopolis, Brazil.
36. Silveira H. III International Symposium on Translacional Oncology. Risk assessment
on occupationally exposed populations. 29-30 August 2013, Barretos, Brazil.
37. Marques MCM. III International Symposium on Translational Oncology of the
Barretos Cancer Hospital. MicroRNAs as biomarkers in breast cancer. 29-30 August
2013, Barretos, Brazil.
38. Marques MM. Controle pos-transcricional da expressão genica por microRNAs.
Universidade Federal de São Carlos. 21 November 2013, São Carlos, Brasil.
39. Vazquez VL. 10ª Conferencia Brasileira de Melanoma- linfadenectomia video
assistida. 2-3 August 2013. Belo Horizonte, Brazil.
40. Vazquez VL. XI Congresso da Sociedade Brasileira de Cirurgia Oncológica-
linfadenectomia video assistida. 17-19 October 2013. São Paulo, Brazil.
41. Vidal DO. II Encontro Internacional de Oncologia Pediátrica de Barretos. Síndrome
Mielodisplásica da Infância: Estudos de Biologia Molecular: revisão da literatura e dados
brasileiros. 22-25 March 2013. Barretos, Brazil.
42. Vidal DO. II Curso Avançado em Citogenômica do Câncer: Abordagem teórico-
prática em Citogenétia e Biologia Molecular aplicada a onco-hematologia. Epigenética
em onco-hematologia. 20–23 November 2013, Fortaleza, Brazil.
43. Vidal DO. II Curso Avançado em Citogenômica do Câncer: Abordagem teórico-
prática em Citogenétia e Biologia Molecular aplicada a onco-hematologia. Epigenética e
Câncer: conceitos teóricos. 20–23 November2013, Fortaleza, Brazil.
38 Molecular Oncology Research Center – Barretos Cancer Hospital
13) Funding
13.1) Governmental Agencies
1. Análise de metilação em câncer de cabeça e pescoço
Funding Agency: FAPESP
CPOM -Hospital de Câncer de Barretos
Duration: 2010-2013
PI: Eloiza Tajara, Membros, André Lopes Carvalho, Matias Melendez
2. Avaliação do papel de microRNAs diferencialmente expressos no controle de invasão
e metástase do câncer de mama
Funding Agency: FAPESP
CPOM -Hospital de Câncer de Barretos
Duration: 2011-2013
PI: Márcia MC Marques
3. Chamada CNPq Nº 014/2011- Caracterização da instabilidade genômica em
glioblastomas: identificação e elucidação de novas vias moleculares em tumores e
culturas primárias”
Funding Agency: CNPq Universal
CPOM -Hospital de Câncer de Barretos
Duration: 2012-2013
PI: Rui M Reis
4. Instituto Nacional de Ciência E Tecnologia para o estudo de papilomaviroses humanas
Agências de Fomento: CNPq - Auxílio financeiro / FAPESP - Auxílio financeiro
CPOM -Hospital de Câncer de Barretos
Duration: 2009 – 2013
PI: Luisa Lina Villa, Membro - Adhemar Longatto Filho
5. Implantação do Centro de Prevenção - Edital FINEP - CT-INFRA - 01/2012
Funding Agency: FINEP
CPOM -Hospital de Câncer de Barretos
Duration: 2012-2013
PI: André L. Carvalho; Adhemar Longatto-Filho
6. Decifrando o papel dos pyknons não-codificantes no câncer colorretal
Funding Agency: SINF-MDAnderson Cancer Center
CPOM -Hospital de Câncer de Barretos
39 Molecular Oncology Research Center – Barretos Cancer Hospital
Duration: 2012-2014
PI: George Calin, Membro; Rui M Reis
7. Avaliação do papel biológico e clínico de alterações nas vias moleculares RAS-MAPK
e PI3K-AKT , em melanomas cutâneos e de mucosa em população brasileira e
comparação com a população estadunidense
Funding Agency: FAPESP/fluxo contínuo – auxílio financeiro.
CPOM-Hospital de Câncer de Barretos
Duration: 2012-2014
PI: Vinicius de Lima Vazquez
8. Transportadores de monocarboxilatos como potenciais alvos terapêuticos em câncer:
estudos de expressão e de inibição em tumores de células germinativas
Funding Agency: CNPq- Universal 14/2013
CPOM-Hospital de Câncer de Barretos
Duration: 2014-2017
PI: Céline Pinheiro
9. Nova abordagem para o tratamento de células de glioblastoma com deleção de MTAP
Funding Agency: CNPq- Universal 14/2013
CPOM-Hospital de Câncer de Barretos
Duration: 2014-2017
PI: Lucas Bidinotto
10. Estudo do papel biológico e terapêutico da Raf kinase inhibitor protein (RKIP) em
GISTs e sua correlação com o fenótipo de instabilidade de microssatélites (MSI)
Funding Agency: CNPq- Universal 14/2013
CPOM-Hospital de Câncer de Barretos
Duration: 2014-2017
PI: Rui Manuel Reis
11. Care HPVTM – Captura Híbrida em unidade móvel para melhoria do programa de
rastreio do câncer cervical em áreas restritas e remotas brasileiras
Funding Agency: PPSUS
CPOM-Hospital de Câncer de Barretos
Duration: 2013-2015
PI: Adhemar Longatto-Filho
40 Molecular Oncology Research Center – Barretos Cancer Hospital
12. BIOPLAT – Plataforma Brasileira para Estudos de Bioprospecção de compostos
naturias com potencial anticâncer em fase pré-clínica
Agência de fomento: FINEP (MCTI/FINEP/MS/SCTIE/DECIT-1302/13)
CPOM-Hospital de Câncer de Barretos
Duration: 2014-2016
PI: Rui Manuel Reis
13. Perfil mutacional de linhagens primárias de glioblastomas
Funding Agency: FAPESP/fluxo contínuo – auxílio financeiro
CPOM-Hospital de Câncer de Barretos
Duration: 2013-2015
PI: Rui Manuel Reis
14. Estudo funcional da modulação dos miRNAs, miR-451 e miR-720, em linhagens
celulares de tumores humanos
Funding Agency: FAPESP/ Projeto de Pesquisa – Regular
CPOM – Hospital de Câncer de Barretos
Duration: 2013-2015
PI: Daniel Onofre Vidal
15. Estudo do efeito antineoplásico de extratos e derivados de Euphorbia tirucalli em
tumores cerebrais e células tronco tumorais cerebrais
Funding Agency: MCTI/CNPq (73/2013)
CPOM-Hospital de Câncer de Barretos
Duration: 2013-2015
PI: Rui Manuel Reis
16. Avaliação do câncer ocupacional e do potencial risco em trabalhadores rurais expostos
a agentes carcinogênicos ambientais e ocupacionais na região de Barretos
Funding Agency: Ministério da Saúde – Chamamento Publico n°20 – Estudos e Pesquisas
Aplicadas em Vigilância em Saúde
Duration: 2013-2015
PI: Henrique César Santejo Silveira
17. The Cancer Genome Atlas (TCGA)
Funding Agency: NIH
Duration: 2013-2014
PI: André Lopes Carvalho
41 Molecular Oncology Research Center – Barretos Cancer Hospital
13.2) Pharmaceutical / Biotechnology Industry
1. Estudo pré-clinico dos potenciais compostos anti-neoplásicos AM10 e AM11.
Industry: Fitomedicamentos Amazônica
CPOM -Hospital de Câncer de Barretos
Duration: 2012-2015
PI: Rui M Reis
2. Tumores de Origem Primária Desconhecida ou Incerta: Identificação através de um
Diagnóstico Molecular Inovador.
Industry: Laboratório Fleury
Duration: 2012-2014
PI: André Carvalho Lopes
3. Métodos moleculares para rastreamente de lesões de colo uterino induzidas por
Papilomavírus humano.
Industry: Laboratório Fleury
Duration: 2012-2014
PI: Adhemar Longatto Filho
13.3) Individual Grants
13.3.1) Technical Support / Research Initiation
1. Beneficiary: Aline Oliveira da Rocha (TT3)
Agency: FAPESP
Duration: 2013-2015
Responsible: Daniel Onofre Vidal
2. Beneficiary: Anna Luiza Almeida (TT3)
Agency: FAPESP
Duration: 2012-2014
Responsible: Vinicius Vazquez
3. Beneficiary: Weder Menezes (TT3)
Agency: FAPESP
Duration: 2013-2015
Responsible: Rui Manuel Reis
4. Beneficiary: Fernanda Cury
42 Molecular Oncology Research Center – Barretos Cancer Hospital
Agency: CNPq
Responsible: Henrique Cesar Santejo Silveira
13.3.2) Master
1. Beneficiary: Augusto Ludvik Filip Marino
Agency: FAPESP
Duration: 2012-2013
Responsible: Márcia MC Marques Silveira
2. Beneficiary: Nathália Cristina Campanella
Agency: FAPESP
Duration: 2012-2013
Responsible: Rui M Reis
3. Beneficiary: Flávia Coltri Eguchi
Agency: FAPESP
Duration: 2012-2013
Responsible: Silvana Campos
4. Beneficiary: Taciane Macedo
Agency: FAPESP
Duration: 2013-2014
Responsible: Márcia MC Marques Silveira
13.3.3) Post-Doc Fellowship
1. Beneficiary: Adriane Feijó Evangelista
Agency: FAPESP
Local: CPOM -Hospital de Câncer de Barretos
Duration: 2012-2014
Responsible: Márcia MC Marques Silveira
2. Beneficiary: Matias Melendez
Agency: CNPq
Duration: 2012-2014
Responsible: André Lopes Carvalho
43 Molecular Oncology Research Center – Barretos Cancer Hospital
13.3.4) Exchange Grants
1. Beneficiary: André van Helvoort Lengert
Agency: St. Jude Children’s Research Hospital
Duration: July 2012 - June 2013
Country: U.S.A.
Responsible: Daniel Onofre Vidal and Luiz Fernando Lopes.
13.3.5) Excelentce in Research Grants
1. Bolsista de Produtividade em Pesquisa 1D
Funding Agency: CNPq
CPOM-Hospital de Câncer de Barretos
Duration: 2010-2013
PI: André Lopes Carvalho
2. Bolsista de Produtividade em Pesquisa 1D
Funding Agency: CNPq
CPOM -Hospital de Câncer de Barretos
Duration: 2011-2014
PI: Adhemar Longatto Filho
3. Bolsista de Produtividade em Pesquisa 1D
Funding Agency: CNPq
CPOM -Hospital de Câncer de Barretos
Duration: 2011-2014
PI: Rui M Reis
13.3.6) Visiting Professor Grant
1. Funding Agency: CNPq
CPOM - Hospital de Câncer de Barretos
Visiting Porfessor: Kari Juhani Syrianny
Duration: 2012-2014
Responsible: Adhemar Longatto-Filho
44 Molecular Oncology Research Center – Barretos Cancer Hospital
14) Patents
Title: Usos de pelo menos um miRNA, kit métodos de diagnóstico de câncer de mama e
métodos para avaliação de risco de metástase.
Identification number: PCT/BR2013/000357
Responsible: Márcia MC Silveira
15) Jury Participartion
15.1) PhD
1. Marques MMC. Danilo Jordão Xavier, Influencia da hiperglicemia sobre perfis de
expressão transcricional de mRNAs e microRNAs em linfócitos de pacientes com
Diabetes Mellitus tipo 2. Departamento de Genética Faculdade de Medicina de Ribeirão
Preto, 2013.
2. Marques MMC: Danielle Calheiros Maia. Avaliação do perfil de expressão de
microRNAs como marcadores prognosticos em tumores iniciais de laringe tratados com
radioterapia exclusiva. Universidade Federal de São Paulo, 2013.
3. Lopes LF. Indhira Dias Oliveira. Estudo de expressão genica nos mecanismos de
manutenção de telomeros e de remodelação óssea em osteossarcoma.CUniversidade
Federal de São Paulo, 2013.
4. Reis RM. Rute Maria Ferreira Lima. Caracetrização Fenotípica de ESP12, uma nova
linhagem de células tumorais de glioblastomas humano, e desenvolvimento de um
modelos in vitro para avaliar a resistência de gliomas e quimioterápicos. Patologia
Humana e Patologia Experimental, Universidade Federal de Bahia, FioCruz, Salvador,
2013.
5. Reis RM. Israel Gomy. Análise da Suscetibilidade ao Câncer Colorretal em Indivíduos
Brasileiros por Genotipagem de Polimorfismos de Nucleotídeo Único Conhecidos.
Fundação Antônio Prudente, 2013.
6. Reis RM. Ana Ines Rebelo Crespo. Genetic imbalances and numerical chromosomal
alterations in glioblastomas as assessed by SNP-arrays and their impacto n gene
expression. Universidade de Coimbra, January, 2013.
7. Vidal DO. Lídia Maria Rebolho Batista Arantes. Metilação do DNA e Biomarcadores
em Câncer de Cabeça e Pescoço. Doutorado em Ciências da Saúde - Faculdade de
Medicina de São José do Rio Preto. 2013.
45 Molecular Oncology Research Center – Barretos Cancer Hospital
15.2) Master
1. Carvalho AL. Carlos Eduardo Goulart Silveira. HPV-16 Como fator preditivo de
recorrência para lesões intraepiteliais do colo do uterino tratadas cirurgicamente. Hospital
de Câncer de Barretos, 2013.
2. Evangelista AE. Fernanda Bueno Barbosa. CNVs em Lúpus Eritematoso Sistêmico.
Faculdade de Medicina de Ribeirão Preto/USP. 2013.
3. Fregnani JH. Maíra Degiovani Stein. Desempenho diagnóstico da citologia cervical
preparada em base líquida, lida manualmente versus a lida de forma automatizada e
assistida por computador. Hospital de Câncer de Barretos, 2013.
4. Fregnani JH. Letícia dos Santos Yamane. Caracterização mutacional dos oncogenes
KRAS e BRAF e análise de MSI nas lesões precursoras do câncer colorretal. Hospital de
Câncer de Barretos, 2013.
5. Fregnani JH. Emilze Mafra de Lima. Saúde oral como fator de risco para neutropenia
febril pós quimioterapia em pacientes com neoplasias hematológicas. Fundação Pio XII
- Hospital de Câncer de Barretos, 2013.
6. Fregnani JH. Fernando Luís Visoni Poliseli. Avaliação do número de cópias do gene
TOP2A e da expressão da sua proteína em leiomiossarcomas uterinos. Hospital A.C.
Camargo, 2013.
7. Garcia EA. Maíra Degiovani Stein. Desempenho diagnóstico da citologia cervical
preparada em base líquida, lida manualmente versus a lida de forma automatizada e
assistida por computador. Hospital de Câncer de Barretos, 2013.
8. Garcia EA. Luana Pimenta Gomes. Avaliação dos fatores de crescimento endotelial
vascular VEGF e de seus principais receptores VEGFR-1 e -2 no processo de cicatrização
com influência da radioterapia em ratos da linhagem Wistar. Faculdade de Medicina da
Universidade de São Paulo, 2013.
9. Guimarães DP. Ana Laura Rodrigue Bordinhão. Avaliação da expressão de micrornas
em linhagens celulares de carcinoma mamário humano expostas a ação do fármaco
Cediranib. Hospital de Câncer de Barretos, 2013.
10. Longatto AF. Carlos Eduardo Mattos da Cunha Andrade. HPV-16 Como fator
preditivo de recorrência para lesões intraepiteliais do colo uterino tratadas cirurgicamente,
Hospital de Câncer de Barretos, 2013.
46 Molecular Oncology Research Center – Barretos Cancer Hospital
11. Lopes LF. Juliana Levy Daher. Análise da qualidade de vida, voz e deglutição no
paciente com câncer de cabeça e pescoço pré e pós tratamento oncológico, Hospital de
Câncer de Barretos, 2013.
12. Palmero EI. Croider Franco Lacerda. Perfil multinacional do gene supressor tumoral
TP53 no carcinoma de células escamosas de esôfago associado ao megaesôfogo
chagásico, Hospital de Câncer de Barretos, 2013.
13. Palmero EI. Henrique de Campos Reis Galvão. Caracterização de pacientes com
Polipose Adenomatosa Familial atendidos no Hospital de Clínicas de Porto Alegre:
enfoque nos achados extracolônicos. Universidade Federal do Rio Grande do Sul. 2013.
14. Pinheiro C. Ana Laura Rodrigues Bordinhão. Avaliação da expressão de mircroRNAs
em linhagem celulares de carcinoma mamário humano expostas a ação do fármaco
Cediranib”, Hospital de Câncer de Barretos, 2013.
15. Reis RM. Thalles Olivi de Almeida. Valor do spect mibi cerebrla na predição da
sobrevida em pacientes portadores de glioblastoma multiforme. Hospital de Câncer de
Barretos, 2013.
16. Scapulatempo CN. Augusto Ludvik Filip Marino. Análise do perfil de expressão
diferencial de micrornas em carcinomas mamários por microarrays, Hospital de Câncer
de Barretos, 2013.
17. Marques MMC. Flávia Coltri Eguchi. Avaliação da superexpressãoda proteina ERG
e da fusão gênica- TMPRSS2: ERG em portadores de câncer prostático, Hospital de
Câncer de Barretos, 2013.
18. Marques MM. Thais Cristine Arns. Identificação de cascatas gênicas com base na
modulação trasncricional de células sangüíneas mononucleares periféricas de pacientes
com diabete mellitus do tipo 1”, Dissertação Mestrado, Faculdade de Medicina de
Ribeirão Preto-USP, Ribeirão Preto, 2013.
19. Vazquez VL. Regina Célia da Silva. Qualidade de vida em pacientes com linfoma
não Hodgkin durante a quimioterapia em regime ambulatorial: Avaliação com o
questionário EORTC-QLQ-C30. Hospital de Câncer de Barretos, 2013.
20. Vidal DO. Bruna Rodrigues Muys. Caracterização da estrutura e regulação dos genes
MGC16121 e CR596471. 2013. Faculdade de Medicina de Ribeirão Preto – USP, 2013.
47 Molecular Oncology Research Center – Barretos Cancer Hospital
16) National and Internacional Collaborations:
16.1 National
- Centro Internacional de Pesquisa e Ensino (CIPE) - Hospital AC Camargo, S. Paulo.
- Faculdade de Medicina da Universidade de São Paulo, S. Paulo.
- INCT-HPV, S. Paulo.
- Instituto de Medicina Integral Professor Fernando Figueira/ Instituto Materno Infantil
de Pernambuco (IMIP), Recife, PE.
- Laboratório de Poluição Atmosférica da Faculdade de Medicina da USP.
- Universidade Federal de Goiás.
- Universidade Federal do Rio Grande do Sul, Porto Alegre
16.2 International
- Harvard School of Public Health - HSPH, Boston, USA.
- Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP),
Porto, Portugal.
- Life and Health Science Research Institute (ICVS), University of Minho, Braga,
Portugal.
- MDAnderson Cancer Center, Houston, USA.
- The Institute of Cancer Research (ICR), Sutton, UK.
- St. Jude Children’s Research Hospital, Memphis, TN, USA.
17) Molecular Diagnostic Center
The Molecular Diagnostics Center (http://hcbdiagnostico.com.br/) is offering to the
Barretos Cancer Hospital patients and external Institutions a variety of tests currently used
in the clinical routine in the following áreas: Cytogenetics, Personalized Medicine and
Oncogenetics.
18) Prespectives for 2014
- Increase the number of publications and projects by researcher;
- Consolidate and structure the research lines and increased the interaction among
researchers;
- Fostering and increase adherence to Journals Club/Scientific Meetings and Meeting of
seniors/junior researchers;
- Animal house facility;
- Consolidate partnerships with national and international partners (academic/industry).
Molecular Oncology Research Center - BARRETOS CANCER HOSPITAL48
MOLECULAR ONCOLOGY RESEARCH CENTER TEAM
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