| 1

Total Knee SystemProduct overview

AMC II™

AMC II™

2 |

Technology | Reliability | VersatilityThe AMC II™ is a clinically proven rotating platform knee system1

offering the surgeon complete flexibility through implant choice and

simple instrumentation.

With over ten years successful clinical use of advanced bearing

technologies, titanium nitride (TiN) ceramic and Biomimetic

Cementless Technology offer a low wear implant solution2,3,4 with

excellent early and long-term fixation4,5,6.

| 3

Achieving excellence through innovation

AMC II™

4 |

TiN: Optimising performanceIncorporating advanced technologies, the AMC II™ knee system has

been designed to provide improved function and longevity.

Titanium nitride (TiN) ceramic is an innovative surface coating

technology allowing patients to enjoy the benefits of a ceramic, low

wearing articulation whilst maintaining the strength and flexibility of

their metal implant2,3,7,8. The coating has been proven to reduce wear

by 98%2.

The ceramicised outer layers minimise exposure of the patient’s joint

space to metal ions, therefore reducing the risk of metal allergies7,8,9,10.

| 5

The only ceramic surface coating with more than 10 years clinical history2,3,7,8

AMC II™

6 |

Biomimetic Cementless TechnologyBridging the gap

AMC II™ uses advanced Biomimetic Cementless Technology to achieve

bone-implant fixation11,12,13,14. This calcium phosphate (CaP) coating

constitutes a microcrystalline structure which maintains substrate surface

roughness providing a large area for bone integration15,16. Its biphasic

composition enhances short and long-term osseointegration while the bone-

like (biomimetic) coating morphology provides a potent capillary effect on

blood, accelerating the implant healing process1,4,5,6,11,12,16,17,18.

| 7

Advanced biomimetic cementless coating technology with more than 20 years of clinical heritage4,5,18

AMC II™

8 |

ReliabilityA highly congruent, rotating platform knee system, the AMC II™

allows for reduced contact stresses and low wear whilst maintaining

joint stability throughout range of motion19,20. A simple, gap balancing

instrumentation philosophy ensures reliable bone cuts and, together

with an anti-lift off feature incorporated into the tibial tray design,

minimises the risk of bearing dislocation21.

| 9

Confidence with longevity

AMC II™

10 |

VersatilityAvailable in both primary and semi-constrained versions, the

AMC II™ knee system provides the surgeon with intra-operative

choice. A single step is required to modify a primary to a semi-

constrained implant option with minimal bone resection.

| 11

Flexibility and choice

©2015 Corin P No I1061 Rev 1 02/2015 ECR 13966

The Corinium CentreCirencester, GL7 1YJt: +44 (0)1285 659 866f: +44 (0)1285 658 960e: info@coringroup.com

www.coringroup.com

Printed on Cocoon 100 which contains 100% total recycled fibre and is produced at a mill which holds the ISO 14001 for Environmental Management Systems. The pulp is bleached using Elemental Chlorine Free processes.

References:

1. Data on file at Corin Group 2009.

2. Pappas MJ, Makris G, Buechel FF. Titanium nitride ceramic film against polyethylene. A 48 million cycle wear test. Clin Orthop Aug 1995; 317:64-70.

3. Streicher RM, Schon R, Semlitsch MF. Tribology and possibilities of optimising the wear properties of metal-on-polyethylene combinations for artificial joints. Biomedizinische Technik 1990; 4.

4. Saxler G, Temmen D, Bontemps G. Medium-term results of AMC unicompartmental knee arthroplasty. The Knee 2004; 11:39-355.

5. Wood PLR, Deakin S. Total ankle replacement. The results in 200 ankles. J Bone Joint Surg [Br] 2003; 85-B:3:334.

6. Massei G, Trisi P, Malchiodi L, Szmukler-Moncler S. Immediately loaded FBR coated PITT-EASY BIO-OSS Implants. A histologic evaluation in 3 patients after 8-12 weeks of function. European Association for Osseointegration 2001; Poster

7. Wisbey A, Gregson PJ, Tuke M. Application of PVD TiN coating to Co-Cr-Mo based surgical implants. Biomaterials 1987; 8:477-480.

8. Coll BF, Jacquot P. Surface modification of medial implants and surgical devices using TiN layers. 15th International Conference on Metallurgical Coatings, San Diego, Ca, USA, 1988.

9. Scarano A, Piattelli M, Vrespa G, Caputi S, Piattelli A. Bacterial adhesion on titanium nitride coated and uncoated implants; an in vivo human study. J Oral Implantol 2003; 29(2):80-5.

10. DOT GmbH internal test report. Data on file Corin Group.

11. Schwarz ML, Kowarsch M, Rose SB, Jani L. Histomorphometrical and mechanical evaluation of various surfaces on titanium test bodies placed into femora of the Göttinger minipig. Can a resorbable CaP coating increase osteointegration? 9th Annual Meeting of the Orthopaedic Research Society 2003; Poster.

12. Szmukler-Moncler S, Becker P, Kunemann P, Nardin M. Capillarity measurement of various FBR/BONIT-coated titanium surfaces. European Association for Osseointegration 2003; Poster.

13. Zeggel P, Becker P. BONIT®. A biomimetic calcium phosphate coating connects bone and implant surfaces. BONEZone Summer 2003.

14. Massei G, Trisi P, Malchiodi L, Szmukler-Moncler S. Immediately loaded FBR-coated PITT-EASY BIO-OSS Implants. A histologic evaluation in 3 patients after 8-12 weeks of function. European Association for Osseointegration 2001; Poster.

15. Zeggel P. Bioactive Calcium phosphate coatings for dental implants. A summarising characterisation of BONIT-FBR. International Magazine of Oral Implantology 1/2000; 51-57.

16. Becker P, Nebe B, Luthen F, Rychle J, Neumann HG. Cellular investigations on electrochemically deposited CaP-composite. 18th European Conference on Biomaterials 2003. Abstract.

17 Broeke RHM. ten, Alves A, Baumann A, Arts JJC, Geesink RGT. Bone reaction to a biomimetic third generation hydroxyapative coating and new surface treatment for the Symax hip system.

18. Schlueter-Brust KU, Kruse S, Bontemps G. Twelve year survivorship after cemented and uncemented medial unicompartmental knee arthroplasty. 15th EFFORT Congress June 2014

19. Atwood SA, Currier JH, Mayor, MB, Collier JP, Van Listers DW, Kennendy FE. Clinical wear measurement on low contact stress rotating platform bearings. J Arthroplasty 2008 App 23(3):431-40.

20. Data on file Corin Group 2008.

21. Dennis DA, Kesmistek RD, Kin RH, Shaman A. Gap bearing versus measured resection technique for total knee arthroplasty. Clin Orthop Relat Res 2010 Jan; 468

100%