alternative therapies in health and medicine - nutrition issue 2015

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ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE A PEER-REVIEWED JOURNAL • VOL. 21, SUPPL. 2 • $14.95 HEPATOPROTECTIVE EFFECTS OF GRAPE SEED PROCYANIDIN B2 IN HEPATIC FIBROSIS • ZINC SUPPLEMENTATION EFFECTIVE FOR METHOTREXATE-INDUCED INTESTINAL DAMAGE • PHYTOMEDICINE- BASED AND QUADRUPLE THERAPIES IN HELICOBACTER PYLORI INFECTION • RED YEAST RICE PLUS BERBERINE FOR VASCULAR AND METABOLIC HEALTH • EXTRACT OF HAWAIIAN TURMERIC: ACTIVITY AGAINST HUMAN COLON CANCER CELLS • COMPLEX NUTRACEUTICAL STRATEGIES: PREVENTING AND MANAGING SEPSIS • RADIOPROTECTANT AND CYTOTOXIC EFFECTS OF SPIRULINA IN RELAPSED VERRUCOUS VULVAR CANCER • CONVERSATIONS—GERARD E. MULLIN, MD, AND JON KAISER, MD • EDITORIAL—NUTRITION

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This is a free sample of Alternative Therapies in Health and Medicine issue "Nutrition Issue 2015" Download full version from: Apple App Store: https://itunes.apple.com/us/app/id850281378?mt=8&at=1l3v4mh Magazine Description: Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat di... You can build your own iPad and Android app at http://presspadapp.com

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Page 1: Alternative Therapies in Health and Medicine - Nutrition Issue 2015

ALTERNATIVE THERAPIESI N H E A L T H A N D M E D I C I N E

A PEER-REVIEWED JOURNAL • VOL. 21, SUPPL. 2 • $14.95

HEPATOPROTECTIVE EFFECTS OF GRAPE SEED PROCYANIDIN B2 IN HEPATIC FIBROSIS • ZINC SUPPLEMENTATION EFFECTIVE FOR

METHOTREXATE-INDUCED INTESTINAL DAMAGE • PHYTOMEDICINE-BASED AND QUADRUPLE THERAPIES IN HELICOBACTER PYLORI

INFECTION • RED YEAST RICE PLUS BERBERINE FOR VASCULAR AND METABOLIC HEALTH • EXTRACT OF HAWAIIAN TURMERIC: ACTIVITY

AGAINST HUMAN COLON CANCER CELLS • COMPLEX NUTRACEUTICAL STRATEGIES: PREVENTING AND MANAGING SEPSIS • RADIOPROTECTANT

AND CYTOTOXIC EFFECTS OF SPIRULINA IN RELAPSED VERRUCOUS VULVAR CANCER • CONVERSATIONS—GERARD E. MULLIN, MD, AND JON

KAISER, MD • EDITORIAL—NUTRITION

Page 2: Alternative Therapies in Health and Medicine - Nutrition Issue 2015

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*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Tel: 805.693.1802 • Fax: 805.693.1806 • CustomerService@ResearchedNutritionals.comwww.ResearchedNutritionals.com | Available only through healthcare professionals

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*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Complete Mitochondrial SupportATP Fuel®

ATP Fuel® starts with the base of our highly acclaimed NT Factor Energy™ phospholipid delivery system for mitochondrial membrane support. Stabilized NADH and CoEnzyme Q10 are incorporated to promote healthy Krebs output.

Lipid Replacement Therapy with a Glyco-

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CoQ10 Significantly Reduces Fatigue in

Intractable Chronic Fatiguing Illnesses and

Chronic Lyme Disease Patients

Garth L. Nicolson, Ph.D., Robert Settineri, M.S. and Rita Ellithorpe, M.D.

The International Journal of Clinical Medicine

ATP FUEL ®

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Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Intractable

Fatigue in Western Blot-Positive ‘Chronic Lyme Disease’ Patients: Preliminary ReportGarth L. Nicolson, Ph.D., Robert Settineri, M.S. and Rita Ellithorpe, M.D.

The Journal of Functional Foods in Health and Disease

ATP FUEL ®

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Research

Published March 28, 2012

Clinical Research

Presented at ILADS Annual ConferenceToronto, Ontario, Canada

ATP Fuel®

Joseph Burrascano Jr., MD“Due to the efficacy & purity of these products, these are some of my favorites”

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Experience the only liposomal glutathione that you squeeze onto a teaspoon and enjoy. No need to mix in juice. Natural orange flavor & GMO-free.

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Page 3: Alternative Therapies in Health and Medicine - Nutrition Issue 2015

Tel: 805.693.1802 • Fax: 805.693.1806 • CustomerService@ResearchedNutritionals.comwww.ResearchedNutritionals.com | Available only through healthcare professionals

CALL 800.755.3402

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Complete Mitochondrial SupportATP Fuel®

ATP Fuel® starts with the base of our highly acclaimed NT Factor Energy™ phospholipid delivery system for mitochondrial membrane support. Stabilized NADH and CoEnzyme Q10 are incorporated to promote healthy Krebs output.

Lipid Replacement Therapy with a Glyco-

phospholipid Formulation with NADH and

CoQ10 Significantly Reduces Fatigue in

Intractable Chronic Fatiguing Illnesses and

Chronic Lyme Disease Patients

Garth L. Nicolson, Ph.D., Robert Settineri, M.S. and Rita Ellithorpe, M.D.

The International Journal of Clinical Medicine

ATP FUEL ®

Peer-Reviewed

Research Published May 2012

Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Intractable

Fatigue in Western Blot-Positive ‘Chronic Lyme Disease’ Patients: Preliminary ReportGarth L. Nicolson, Ph.D., Robert Settineri, M.S. and Rita Ellithorpe, M.D.

The Journal of Functional Foods in Health and Disease

ATP FUEL ®

Peer-Reviewed

Research

Published March 28, 2012

Clinical Research

Presented at ILADS Annual ConferenceToronto, Ontario, Canada

ATP Fuel®

Joseph Burrascano Jr., MD“Due to the efficacy & purity of these products, these are some of my favorites”

PEER-REVIEWED PUBLISHED RESEARCH

Experience the only liposomal glutathione that you squeeze onto a teaspoon and enjoy. No need to mix in juice. Natural orange flavor & GMO-free.

HIGH DOSEEach serving offers:

• 450 mg of reduced glutathione• 50 mg of Vitamin C

HEAT STABLEWe contracted with a third party lab to subject Tri-Fortify™ Orange to the most extreme conditions: 104˚F and 75% humidity for 90 consecutive days. The result: product met and exceeded the nutrient content on the label.

Oral Liposomal Glutathione GelTri-Fortify™ Orange

G

MO FREE

DAIRY FREE

HE

AT STABL

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Page 4: Alternative Therapies in Health and Medicine - Nutrition Issue 2015

Tel: 805.693.1802 • Fax: 805.693.1806 • CustomerService@ResearchedNutritionals.comwww.ResearchedNutritionals.com | Available only through healthcare professionals

CALL 800.755.3402

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Joseph Burrascano Jr., MD“Due to the research basis of these formulations, I think these products would be an important part of a practitioner’s arsenal.”

Healthy Cytokine SupportCytoQuel™ has been developed to promote healthy cytokine activity. Based on the latest published research, CytoQuel™ offers doctors a valuable new tool in the quest for healthy inflammation levels.

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Microbinate™ is formulated to promote a healthy response to today’s vast microbial challenges. Each capsule combines nature’s most potent and well-researched nutrients into one complete product with therapeutic levels of:

( Oregano Extract (30% carvacrol) ( Monolaurin ( Olive Leaf Extract ( Stabilized Allicin (the active ingredient in garlic) ( CurcuWIN™ tumeric extract

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Page 5: Alternative Therapies in Health and Medicine - Nutrition Issue 2015

x ALTERNATIVE THERAPIES, VOL. 21 SUPPL, 2 3Table of Contents

TABLE OF CONTENTSNUTRITION ISSUE VOL. 21, SUPPL. 2

10 Nutrition Andrew W. Campbell, MD

12 Hepatoprotective Effects of Grape Seed Procyanidin B2 in Rats With Carbon Tetrachloride–induced Hepatic Fibrosis Zhenli Wang, MD; Zemin Zhang, MD; Ning Du, MD; Kai Wang, MD; Lei Li, MD

22 Zinc Supplementation Alone Is Effective for Partial Amelioration of Methotrexate-induced Intestinal Damage Nurul S. E. Musa, BSc(Hon); Gordon S. Howarth, PhD; Cuong D. Tran, PhD

33 Phytomedicine-based and Quadruple Therapies in Helicobacter pylori Infection: A Comparative, Randomized Trial Hafiz Muhammad Asif, BEMS, PhD; Syed Faisal Zaidi, MD, PhD; Toshiro Sugiyama, MD, PhD; Naveed Akhtar, PhD; Khan Usmanghani, PhD

40 Red Yeast Rice Plus Berberine: Practical Strategy for Promoting Vascular and Metabolic Health Mark F. McCarty, BA; James H. O’Keefe, MD; James J. DiNicolantonio, PharmD

46 An Ethanol Extract of Hawaiian Turmeric: Extensive In Vitro Anticancer Activity Against Human Colon Cancer Cells Konstantinos Dimas, PhD; Chrisiida Tsimplouli, PhD; Courtney Houchen, MD; Panayotis Pantazis, PhD; Nikos Sakellaridis, MD, PhD; George Th. Tsangaris, PhD; Ema Anastasiadou, PhD; Rama P. Ramanujam, PhD

56 Preclinical Studies Suggest Complex Nutraceutical Strategies May Have Potential for Preventing and Managing Sepsis Mark F. McCarty, BA

68 Radioprotectant and Cytotoxic Effects of Spirulina in Relapsed Verrucous Vulvar Cancer: A Case Report Huriye Senay Kiziltan, MD; Ayse Gunes Bayir, DVM; Ozgur Taspinar, MD; Gul Yucesan, MD; Didem Tastekin, MD; Fatma Cavidan Sonmez, MD; Ganime Coban, MD; Gokhan Kilic, MD; Ali Hikmet Eris, MP; Teoman Aydin, MD; Adem Akcakaya, MD; Alpaslan Mayadagli, MD

w w w . a l t e r n a t i v e - t h e r a p i e s . c o m

EDITORIAL

ALTERNATIVE THERAPIESI N H E A L T H A N D M E D I C I N E

review article

ORIGINAL RESEARCH

case study

Page 6: Alternative Therapies in Health and Medicine - Nutrition Issue 2015

4 ALTERNATIVE THERAPIES, VOL. 21 SUPPL, 2 Table of Contents

73 Gerard E. Mullin, MD: The Influence of the Gut-Brain Axis on Health Interview by Craig Gustafson

77 Jon Kaiser, MD: Supporting Mitochondrial Health With Nutrient Therapy Interview by Craig Gustafson

conversations

ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE (ISSN 1078-6791) is published 6 times per year (January, March, May, July, September, November) by InnoVision Professional Media, 3140 Neil Armstrong Blvd, Suite 307, Eagan, MN, 55121, Tel: (877) 904-7951, Fax: (651) 344-0774. E-mail: [email protected]. Copyright 2015 by InnoVision Professional Media. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage retrieval system without permission from InnoVision Professional Media. InnoVision Professional Media assumes no liability for any material published herein. Before photocopying items, please contact the Copyright Clearance Center, Customer Service, 222 Rosewood Dr, Danvers, MA 01923. Telephone: (978) 750-8400. All statements are the responsibility of the authors. Alternative Therapies in Health and Medicine is indexed in Index Medicus, CINAHL, Science Citation Index-Expanded (SciSearch®), ISI (Institute for Scientific Information) Alerting Services, Current Contents®/Clinical Medicine, EMBASE (Excerpta Medica), and MEDLINE.

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