“all i need is the air that i breathe” review of pulmonary ... · pdf...
TRANSCRIPT
![Page 1: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/1.jpg)
©2015 MFMER | slide-1
“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology
Eric Olson, MD Associate Professor of Medicine College of Medicine Mayo Clinic
2016 Big Sky Pulmonary Conference
![Page 2: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/2.jpg)
©2015 MFMER | slide-2
Disclosures
• None
![Page 3: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/3.jpg)
©2015 MFMER | slide-3
O2
CO2
Atmosphere
Lungs
Heart
Mitochondria
![Page 4: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/4.jpg)
©2015 MFMER | slide-4
Overview: Anatomy
250 million L of air partake in respiration
over a lifetime!
![Page 5: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/5.jpg)
©2015 MFMER | slide-5
Nasopharynx
Velopharynx
Oropharynx
Hypopharynx
Hard palate
Epiglottis
Vocal fold
Esophagus
*
* *
* Tonsil locations
Upper Airway Anatomy
![Page 6: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/6.jpg)
©2015 MFMER | slide-6
Nasal ala Nostril (nares)
Columella
Cartilage (gray)
Bone (tan)
https://www.clinicalkey.com/
![Page 7: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/7.jpg)
©2015 MFMER | slide-7
https://www.clinicalkey.com/
Nasal polyps
Sinusitis
Septal
deviation
![Page 8: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/8.jpg)
©2015 MFMER | slide-8
Friedman M. Otolayngol Head Neck Surg 2002; 127:13
Grading of Tongue-Palate Relationship, Palatine Tonsil Size
![Page 9: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/9.jpg)
©2015 MFMER | slide-9
https://www.clinicalkey.com/
![Page 10: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/10.jpg)
©2015 MFMER | slide-10
Stridor: Sign of Vocal Cord Dysfunction
![Page 11: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/11.jpg)
©2015 MFMER | slide-11
bronchi bronchiole
Conducting airways
• bronchi terminal bronchiole
• lead air to the site of exchange
• respiratory bronchiole alveoli
• site of gas exchange
Respiratory airways
https://www.clinicalkey.com/
Airway Tree: 23 Generations
![Page 12: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/12.jpg)
©2015 MFMER | slide-12
goblet cells cilia
Microscopic view
Cilia beat in coordinated fashion causing mouthward movement of mucous and
trapped inhaled particles
Lining of Conducting Airways
![Page 13: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/13.jpg)
©2015 MFMER | slide-13
Asthma: Airway Wall Findings
Normal Bronchiole Bronchiolar
Smooth Muscle Thickening
![Page 14: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/14.jpg)
©2015 MFMER | slide-14
Asthma: Airway Wall Findings (cont)
Goblet Cell Hyperplasia
Thickened Basement Membrane Eosinophils
![Page 15: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/15.jpg)
©2015 MFMER | slide-15
Bronchiectasis
Airway
Pulmonary
Artery
![Page 16: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/16.jpg)
©2015 MFMER | slide-16
Bronchiectasis
![Page 17: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/17.jpg)
©2015 MFMER | slide-17
Alveoli
Respiratory bronchioles
Terminal bronchiole
https://www.clinicalkey.com/
Pulmonary acinus
![Page 18: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/18.jpg)
©2015 MFMER | slide-18
Centrilobular (smoking-related) Emphysema
TB
RB1
RB3
RB3
RB3
RB3
RB2
AS+AS
Septum
Inflamed
![Page 19: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/19.jpg)
©2015 MFMER | slide-19
Terminal bronchioles
Pulmonary Lobule; Contain 3-6 acini
Acinus: Lung derived from a terminal bronchiole
Pulmonary artery
Interlobular septa Lymphatics; veins
![Page 20: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/20.jpg)
©2015 MFMER | slide-20
Congestive
heart failure
(smooth septal
thickening)
Normal
Lymphangitic
spread of
malignancy
(beaded septal
thickening)
Clinical Application: Causes of Interlobular Septal Thickening
![Page 21: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/21.jpg)
©2015 MFMER | slide-21
alveolus
capillary
pneumocytes
Microscopic view
Alveolar-Capillary Interface
![Page 22: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/22.jpg)
©2015 MFMER | slide-22
Alveolar-Capillary Interface
Alveolus
capillary
lumen
capillary
lumen
Alveolar
macrophage
Type II
pneumocyte
Type I
pneumocyte
Interstitium
Schematic view
Surfactant
![Page 23: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/23.jpg)
©2015 MFMER | slide-23
![Page 24: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/24.jpg)
©2015 MFMER | slide-24
ARDS
![Page 25: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/25.jpg)
©2015 MFMER | slide-25
2 Blood Supplies: Bronchial and Pulmonary
Aird WC. Circ Res 2007;100:174
Airway
bleeding
source
Alveolar
bleeding
source
![Page 26: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/26.jpg)
©2015 MFMER | slide-26
Special Properties of Pulmonary Circulation: Hypoxic Vasoconstriction; Recruitment
Clinical Respiratory Medicine, 4th ed. Spiro SG, Silvestri GA, Agusti A, eds. Elsevier, 2012
Hypoxic
vasoconstriction
Recruitment
![Page 27: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/27.jpg)
©2015 MFMER | slide-27
Pulmonary Lymphatic System
https://www.studyblue.com/notes/note/n/gi-and-metabolism-anatomy/deck/10205673
![Page 28: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/28.jpg)
©2015 MFMER | slide-28
Thoracic Lung Node Stations
Clinical
application:
Lymph node
involvement
important
determinant
in lung cancer
treatment
![Page 29: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/29.jpg)
©2015 MFMER | slide-29
Interim Summary • Air travels 23 airway generations
• Examples of airways disease • Larynx: stridor • Conducting bronchi: asthma, bronchiectasis • Bronchioles: COPD
• Site of gas exchange: alveolus • Impressive area for gas exchange
• 2 arterial supplies to the lung • Bronchial: airways • Pulmonary: alveoli; capable of hypoxic
vasoconstriction, recruitment during exercise
• Lymphatics: filtering system • Critical in lung cancer staging
![Page 30: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/30.jpg)
©2015 MFMER | slide-30
Overview: Physiology
![Page 31: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/31.jpg)
©2015 MFMER | slide-31
Central Control
Ventilation O2, CO2
Exchange
![Page 32: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/32.jpg)
©2015 MFMER | slide-32
Central Respiratory Control
Central
Pacemaker
VRG (I, E)
DRG (I)
Pontine
![Page 33: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/33.jpg)
©2015 MFMER | slide-33
Clinical Respiratory Medicine, 4th ed. Spiro SG, Silvestri GA, Agusti A, eds. Elsevier, 2012
“Wakefulness drive to breathe”
+
![Page 34: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/34.jpg)
©2015 MFMER | slide-34
Response to CO2
• Ventilation 2 to 3 L/min for every 1mmHg PCO2
• Lower the PO2, the brisker the response
• With chronic hypercapnia, ventilatory drive arising from central chemosensors will be lower
30 40 50 60
Ve
nti
lati
on
(L
/min
)
PACO2
PAO2 100
PAO2 55
![Page 35: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/35.jpg)
©2015 MFMER | slide-35
Response to O2
• Markedly increases when PAO2 < 50-60
• Response to hypoxia augmented by PACO2
40 50 70 60
Ve
nti
lati
on
(L
/min
)
PAO2
80 90
PACO2 40
PACO2 50
![Page 36: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/36.jpg)
©2015 MFMER | slide-36
Sleep: Loss of Wakefulness Drive
Central
Pacemaker
Sleep
![Page 37: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/37.jpg)
©2015 MFMER | slide-37
Physiologic Changes in Breathing During Sleep
• Controller of ventilation: CO2
• Respiratory rate: ↔
• Tidal volume: ↓
• Upper airway muscles: ↓
• Ventilation: ↓ (10-15%)
• PCO2: ↑ (3-7 mm Hg)
• SpO2: ↓ (1-3%)
![Page 38: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/38.jpg)
©2015 MFMER | slide-38
Physiologic Changes in Breathing: NREM vs REM
NREM REM
Tidal volume Regular Irregular
Resp rate Regular Irregular
CO2 responsiveness
↔ or ↓ ↓
O2
responsiveness ↔ or ↓ ↓
Accessory muscles
Normal Paralyzed
![Page 39: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/39.jpg)
©2015 MFMER | slide-39
Upper Airway Muscles and Sleep
Tensor palatini (stiffens palate)
Changes in upper airway during sleep leaves an
anatomically challenged pharynx vulnerable to collapse
Tensor Palatini EMG
Awake NREM
Genioglossus (protrudes tongue)
↓ Tonic activity
↓ Negative pressure reflex
![Page 40: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/40.jpg)
©2015 MFMER | slide-40
Clinical Application:
Loss of Accessory Muscle Input in Stage R results in deeper desaturations in COPD, ALS
REM REM REM
![Page 41: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/41.jpg)
©2015 MFMER | slide-41
Sleep and Asthma
• Circadian drop in airway caliber at night
• More dramatic in asthmatics
• More deaths from asthma per hour at night than by day
• Nocturnal symptoms signal suboptimal control
• Mechanism unclear, but contributor may be ↑ parasympathetic bronchoconstrictor input to airways
“Morning dipper” per
peak flows
![Page 42: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/42.jpg)
©2015 MFMER | slide-42
Interim Summary
• Pacemaker for breathing located in the brainstem; composed of multiple neuronal groups
• Pacemaker responds to multiple inputs
• During sleep: • PCO2 is the main ventilatory determinant
• ↓ventilation: • Loss of “wakefulness drive to breathe” • ↓ chemo responsiveness • ↑ upper airway resistance
![Page 43: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/43.jpg)
©2015 MFMER | slide-43
Interim Summary (cont)
• During REM sleep:
• Diaphragm function intact; marked reduction in intercostal muscle activity
• Ventilatory responses to chemical stimuli most blunted
• Clinical significance of these changes:
• Desaturations most severe in patients with lung disease during REM
• Airways narrow during; exaggerated in asthma
![Page 44: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/44.jpg)
©2015 MFMER | slide-44
Central Control
Ventilation O2, CO2
Exchange
![Page 45: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/45.jpg)
©2015 MFMER | slide-45
Physiology of Respiration, 2nd ed. Hlastala MP, Berger AJ, eds. Oxford: Oxford University Press, 2001
![Page 46: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/46.jpg)
©2015 MFMER | slide-46
Inhalation
O2
Physiology of Respiration, 2nd ed. Hlastala MP, Berger AJ, eds. Oxford: Oxford University Press, 2001
![Page 47: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/47.jpg)
©2015 MFMER | slide-47
- - - - - - -
- - - -
- - -
- -
OSA
Collapsing forces (negative pressure +/- anatomic barriers ) >
distending forces (pharyngeal muscles)
![Page 48: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/48.jpg)
©2015 MFMER | slide-48
Clinical Application
Diaphragm Paralysis
Normal Diaphragm paralysis
Chest Abdomen
Symptoms: Dyspnea; orthopnea
Signs: Intolerance of supine positioning; thoracoabdominal paradox
![Page 49: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/49.jpg)
©2015 MFMER | slide-49
Determinants of Inspiratory Volume
• Central drive
• Neuromuscular transmission
• Strength of inspiratory muscles
• Respiratory system compliance
• Airways resistance Work of breathing
![Page 50: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/50.jpg)
©2015 MFMER | slide-50
Compliance
• ∆ Volume/ ∆ Pressure
• ↑ compliance = ↑ distensibility
• Influenced by volume
Low High
Low
![Page 51: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/51.jpg)
©2015 MFMER | slide-51
Respiratory System Compliance: Lung & Chest Wall Components
Compliance influence by lung volume: ↑ lung volume→ ↓ compliance
![Page 52: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/52.jpg)
©2015 MFMER | slide-52
![Page 53: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/53.jpg)
©2015 MFMER | slide-53
Conditions of ↓ Chest Wall Compliance
Scoliosis Obesity
![Page 54: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/54.jpg)
©2015 MFMER | slide-54
Conditions of ↓ Lung Compliance
Pulmonary
fibrosis Pleural
disease
![Page 55: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/55.jpg)
©2015 MFMER | slide-55
Airway Resistance
↑ tube radius → ↓ resistance
Medium-sized bronchi provide most resistance
Airway resistance inversely influence by lung volume: ↑ lung volume→ ↓ resistance
https://www.clinicalkey.com/
![Page 56: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/56.jpg)
©2015 MFMER | slide-56
Condition of ↑ Airway Resistance: COPD
Barnes PJ. N Engl J Med 2000; 343:269
![Page 57: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/57.jpg)
©2015 MFMER | slide-57
Subdivisions of Ventilation
Anatomic dead space Alveolar dead space
Alveolar ventilation (VA)
Amount of ventilation devoted to gas
exchange
Alveolar Ventilation = Total ventilation – Dead space ventilation
Dead space ventilation
Vt
.
![Page 58: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/58.jpg)
©2015 MFMER | slide-58
Normal Lung Ventilation
Tidal volume 500 mL
Anatomic dead space 150 mL
Alveolar gas 3000 mL
Total ventilation 7500 mL/min
Frequency 15 breaths/min
Alveolar ventilation 5250 mL/min
Pulmonary blood flow 5000 mL/min
Dead space ventilation 2250 mL/min
Adapted from: Respiratory Physiology: The Essential, 7th ed. West JB, ed. Lippincott, Williams, and Wilkins, 2007
![Page 59: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/59.jpg)
©2015 MFMER | slide-59
Ventilation Governs PCO2
• PCO2 = VCO2
VA
• PCO2 = alveolar ventilation
• tidal volume and/or
• dead space
CO2 production alveolar ventilation
Hypoventilation results if RR not sufficient to augment VA
![Page 60: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/60.jpg)
©2015 MFMER | slide-60
Causes of Hypercapnia (high PCO2)
• “Won’t breathe”
• ↓ Central drive (drugs; hypothyroidism)
• “Can’t breathe”
• ↓ Neuromuscular transmission (spinal cord injury)
• ↓ Strength of inspiratory muscles (ALS)
• ↓ Respiratory system compliance (pneumonia)
• ↑ Airways resistance (asthma exacerbation)
Bi-level PAP may enhance alveolar ventilation and thus overcome causes of hypoventilation
![Page 61: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/61.jpg)
©2015 MFMER | slide-61
Clinical Application
Symptoms and Signs of Hypoventilation
• Nonspecific, insidious; accentuated by coexistent hypoxia
• Dyspnea not uniformly present!
• CNS effects
• Altered mentation
• Sleep disruption
• Hypersomnolence
• Headache
• Pulmonary hypertension
• Dependent edema
• Orthopnea
• Cor pulmonale
• Cyanosis
• Elevated serum bicarbonate
![Page 62: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/62.jpg)
©2015 MFMER | slide-62
Clinical Application
Evaluation for Cause(s) of Hypoventilation
• ABG: confirmatory test
• Physical exam: emphasis on thoracic, neuro systems
• Pulmonary function tests (maximal respiratory pressures)
• CXR
• Bloods: Thyroid; Ca++; Mg++; PO4; CK; aldolase; Hgb
• Diaphragm studies
• CNS imaging
• PSG
Martin TJ, Sanders MH. Sleep 1995; 18:617
![Page 63: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/63.jpg)
©2015 MFMER | slide-63
Exhalation
+
+
+
+
+ +
+
+
+
+
CO2
Physiology of Respiration, 2nd ed. Hlastala MP, Berger AJ, eds. Oxford: Oxford University Press, 2001
![Page 64: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/64.jpg)
©2015 MFMER | slide-64
Lung Volumes and Capacities
1
6
5
4
3
2
Vo
lum
e (
L)
0
Tidal volume
Residual volume
Functional residual capacity
Vital capacity
Total lung
capacity
↓ with obesity, sleep
![Page 65: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/65.jpg)
©2015 MFMER | slide-65
Obstructive Lung Disease
1
6
5
4
3
2
Vo
lum
e (
L)
0
Tidal
volume
Residual
volume
Functional
residual
capacity
Total
lung
capacity
7
Slower
exhalation
time
![Page 66: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/66.jpg)
©2015 MFMER | slide-66
Restrictive Lung Diseases
1
6
5
4
3
2
Vo
lum
e (
L)
0
Tidal volume
Residual
volume
Functional
residual capacity
Vital
capacity
Total lung
capacity
![Page 67: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/67.jpg)
©2015 MFMER | slide-67
Interim Summary
• Main inspiratory muscle is diaphragm
• Thoracoabdominal paradox and orthopnea (shortness of breath when supine) → diaphragmatic dysfunction
• Alveolar ventilation: balance between inspiratory load and neuromuscular competence
• PCO2 = inadequate alveolar ventilation for metabolic demand
• Causes: • “Won’t breathe:” impaired central drive
• “Can’t breathe:” Dysfunction of breathing apparatus
![Page 68: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/68.jpg)
©2015 MFMER | slide-68
Summary of PFT Interpretation
TLC FEV1 FVC FEV1/FVC
Obstruction
Restriction NL or
![Page 69: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/69.jpg)
©2015 MFMER | slide-69
Central Control
Ventilation O2, CO2
Exchange
![Page 70: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/70.jpg)
©2015 MFMER | slide-70
Pulmonary Gas Exchange
Alveolus
Capillary
Normal
O2 CO2
Diffusion
Terminology V = Ventilation Q = Perfusion
Alveolar-capillary membrane = 0.3 uM
Equilibration < 0.20 sec
![Page 71: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/71.jpg)
©2015 MFMER | slide-71
Diffusion
Flow depends on: -Concentration difference
-Area available for diffusion -Thickness of membrane
Membrane Alveolus Capillary
![Page 72: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/72.jpg)
©2015 MFMER | slide-72
Arterial Oxygen Transport
Alveolus
Capillary
Normal
O2
O2
O2 O2
O2
O2 O2
O2 carried on hemoglobin in red blood
cells
![Page 73: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/73.jpg)
©2015 MFMER | slide-73
Measurements of Oxygen
• PaO2
• Pressure exerted by O2 in blood
• SpO2
• % total hemoglobin bound with O2
O2
O2
O2
Artery Measured by arterial blood gas
Measured by pulse oximetry
![Page 74: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/74.jpg)
©2015 MFMER | slide-74
Oxyhemoglobin Dissociation Curve
0
10
20
30
40
50
60
70
80
90
100
0 20 40 60 80 100 120
PaO2
Satu
rati
on
(%
)
Arterial blood
Venous blood
![Page 75: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/75.jpg)
©2015 MFMER | slide-75
Physiologic Mechanisms of Hypoxemia:
V/Q Mismatch
Capillary
• Example:
• Asthma
• COPD
• Treatment • Bronchodilators • Steroids
Impairment of
“V” due to
airways
obstruction
Alveolus
![Page 76: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/76.jpg)
©2015 MFMER | slide-76
Physiologic Mechanisms of Hypoxemia:
V/Q Mismatch
Capillary
• Example:
• Obesity
• Treatment • Weight loss
Impairment of
“V” due to
collapse of
alveoli
Alveolus
![Page 77: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/77.jpg)
©2015 MFMER | slide-77
Mechanisms of Hypoxemia:
Hypoventilation
• Examples: • “Can’t Breathe”
(dysfunction of respiratory apparatus)
• ALS
• “Won’t Breathe” (depressed respiratory drive)
• Opioids
• Treatment • Bilevel PAP ± O2 • Remove respiratory
depressants
Insufficient
alveolar
ventilation
Capillary
Alveolus
![Page 78: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/78.jpg)
©2015 MFMER | slide-78
Mechanisms of Hypoxemia:
Shunt
• Examples:
• Intracardiac
• Septal defect in heart
• Intrapulmonary
• AVM
• Hepatopulmonary syndrome
• Treatment • Close the defect
Blood bypasses alveoli;
cannot load O2
Alveolus
![Page 79: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/79.jpg)
©2015 MFMER | slide-79
Mechanisms of Hypoxemia:
Diffusion Limitation
• Example:
• Pulmonary fibrosis
• Treatment • Treat underlying
disorder • O2
Alveolus
Capillary
Blood leaving alveolus fails to
reach equilibrium with alveolar
gas
Interstitial
process
![Page 80: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/80.jpg)
©2015 MFMER | slide-80
Mechanisms of Hypoxemia:
Low Inspired Oxygen
• Example:
• High altitude
• Treatment • Descent • O2
Capillary
O2
O2
O2
O2
Alveolus PAO2 too
low to drive
diffusion
![Page 81: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/81.jpg)
©2015 MFMER | slide-81
Clinical Application:
Differentiating Causes of Hypoxemia
• Clinical scenario
• Calculate A-a gradient
• Assess response to oxygen
![Page 82: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/82.jpg)
©2015 MFMER | slide-82
Clinical Application:
Alveolar-arterial (“A-a”) Gradient
• Measure of how well the lungs are oxygenating the blood independent of alveolar ventilation
• PAO2: must be calculated; PaO2 measured by ABG
• PAO2 = (PB – PH2O)(FiO2) – PACO2/R
= (PB – PH2O)(FiO2) – PACO2/R =(760-47)(.21) – 40/0.8
=150 – 50
=100 mm Hg
• A-a gradient = PAO2 – PaO2
= 100 – 90
= 10
![Page 83: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/83.jpg)
©2015 MFMER | slide-83
Summary of Mechanisms of Hypoxemia
Clinical scenario
A-a gradient O2 responsiveness
Low FiO2 altitude; w/o usual O2
Normal Yes
Hypoventilation PCO2 Normal Yes
Diffusion Limitation
Abnormal lung imaging
Increased Yes
Shunt Increased No
V/Q Mismatch Most common
Increased Yes
![Page 84: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/84.jpg)
©2015 MFMER | slide-84
Capillary
O2
O2
O2
O2
Muscle
CO2
CO2
CO2 + H2O ↔ H2CO3 ↔ H+
A. CO2 dissolved in blood: 10%
A
B
B. CO2 attached to hemoglobin: 30%
C: Bicarbonate: 60% CO2
+ HCO3-
C
In lung, HCO3
- converted
back to CO2 and exhaled
Carbonic anhydrase
CO2 Transport
![Page 85: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/85.jpg)
©2015 MFMER | slide-85
Clinical Question
• Why does the depth of desaturation vary between disordered breathing events?
![Page 86: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/86.jpg)
©2015 MFMER | slide-86
Interim Summary
• Alveolus is site of gas exchange
• O2, CO2 cross alveolar-capillary interface via diffusion
• Partial pressure gradient drives the process
• Vast majority of oxygen carried in the blood by hemoglobin
• The S-shaped hemoglobin dissociation curve: • Physiologically advantageous • Governs relationship between SpO2 and PaO2
• SpO2 90% = PaO2 60 mm Hg
![Page 87: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/87.jpg)
©2015 MFMER | slide-87
Interim Summary (cont)
• Mechanisms of hypoxemia
• V/Q mismatch (most common)
• Shunt (unresponsive to supplemental O2)
• Hypoventilation (PCO2)
• Diffusion impairment (abnl lung exam, imaging)
• Low inspired oxygen
• CO2 primarily transported as HCO3-
![Page 88: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/88.jpg)
©2015 MFMER | slide-88
Central Control
Ventilation O2, CO2
Exchange
![Page 89: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/89.jpg)
©2015 MFMER | slide-89
Effects of Obesity on the Respiratory System
• O2 consumption and CO2 production
• ventilatory response to hypoxia and hypercapnia
• ↓ Functional residual capacity • ↓ Respiratory system compliance
• ↑ upper and lower airways resistance
• ↑ V/Q mismatching
• ↓ lung O2 stores (deeper desats with apneas/hypopneas)
![Page 90: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/90.jpg)
©2015 MFMER | slide-90
O2
O2
O2
O2
O2
O2
O2
O2
O2
O2
O2
O2
O2
O2
O2
O2
O2
O2
O2
O2
O2
Lung O2 stores = Lung volume x PAO2
Shepard JW, Jr. Med Clin North Am 1985; 69:1243
![Page 91: “All I Need is the Air That I Breathe” Review of Pulmonary ... · PDF file“All I Need is the Air That I Breathe” Review of Pulmonary Anatomy and Physiology ... • site of](https://reader034.vdocuments.us/reader034/viewer/2022042801/5aac6e477f8b9a2e088cf4f6/html5/thumbnails/91.jpg)
©2015 MFMER | slide-91
• “Before I came here I was confused about this subject. Having listened to your lecture I am still confused. But on a higher level”
Enrico Fermi