ale and brainmap · 2014-05-23 · each foci is modeled by a 3d gaussian distribution x y...

ALE and BrainMap Educational Course on Neuroimaging Meta-Analysis

2014 OHBM Annual Meeting - 8 June 2014

Angie Laird Associate Professor

Department of Physics

Coordinate-Based Results in Neuroimaging StudiesSummary results of functional neuroimaging studies as represented by statistical parametric images

Reported in the literature in the form of stereotactic coordinates

(x,y,z) (x,y,z)(x,y,z)

(x,y,z)

(x,y,z)

(x,y,z)

“ALE and BrainMap” ~ Educa2onal Course on Neuroimaging Meta-‐Analysis ~ 2014 OHBM Annual Mee2ng

BrainMap Database: Archives Peak Coordinates and Metadata

“Quick Author Search”

2,396 papers 11,397 contrasts 91,251 locations

Scribe: submit papers to BrainMap

Sleuth: search papers in BrainMap

GingerALE: perform meta-analyses


“What brain regions are typically activated in a memory task in schizophrenia patients?

BrainMap Scribe


BrainMap Scribe - Screencast


BrainMap Scribe - Behavioral Domain and Paradigm Class


BrainMap Sleuth


BrainMap Sleuth - Screencast


BrainMap Sleuth - Exported Foci


Literature Search: Face Discrimination Studies

BrainMap Database >2K Publications

>10K Experiments

BrainMap Search Criteria: “Face Monitor/

Discrimination” AND “Normal Mapping”

Example Search Result: 2 Experiments Returned from 1 Publication, 8 and 6 Foci Total

Paller et al., “Neural correlates of person recognition”, Learning & Memory, 2003

BrainMap search yielded 396 experiments of healthy controls that participated in a face discrimination task

Whole brain sets of coordinates (foci) from all 396 Face Discrimination experiments visualized

in the BrainMap Sleuth application


Coordinate-Based Meta-Analysis: Activation Likelihood Estimation

BrainMap Database >2K Publications

>10K Experiments

BrainMap Search Criteria: “Face Discrimination”

Search results = 396 sets of coordinates

Meta-Analysis: Where do the foci converge? Reported coordinates are not treated as points

but as centers of probability distributions

Each foci is modeled by a 3D Gaussian distribution

x

y

Activation Likelihood Estimation ALE originally developed by Turkeltaub et

al. (2002); has been adopted by BrainMap and revised and expanded several times (Laird et al., 2005; Eickhoff et al., 2009;

2012; Turkeltaub et al., 2012)

ALE Meta-Analysis: Face DiscriminationCompute ALE scores

Determine statistical significance Threshold final ALE images P<0.05, correctedL R


BrainMap GingerALE

Talairach or MNI


BrainMap GingerALE - Screencast


Mango - Viewing ALE Results


ALE Applications: Paradigm-Based Meta-AnalysesSingle word reading and speech production Object naming of animals and tools n-back working memory Saccades and gaze perception Pain, painful stimulation, and pain empathy Task switching Anticipatory effect of choice Risk, reward, and decision-making Finger tapping Go/No-Go and response inhibition Movement perception, dance, and emotion Text, speech, and metaphor comprehension Aesthetic appraisal Emotional processing Morality, theory of mind, and empathy Regulation of negative affect Episodic encoding and retrieval Swallowing, eating, and drinking Default mode processing Executive function and cognitive control Stressor-evoked blood pressure reactivity Time perception and timing Taste and craving, food and drug cues Phonological processing of Chinese characters and alphabetic words Reflexive reorienting, motor inhibition, and action updating Sublexical speech, speech effectors, phonation and articulation

Numeracy, number processing, and calculation Spatial organization of sound processing Embodiment in language Pain, hyperalgesia, and allodynia Emotional processing and recognition Multi-sensory imagery Motor learning Noun and verb processing Acupuncture needle stimulation Central processing of autonomic function Semantic processing and semantic memory Action imitation and observation Rectal distension

Stuttering, dyslexia, schizophrenia, OCD, depression, ADHD, Alzheimer’s disease, mild cognitive impairment, autism spectrum disorders, bipolar disorder, aphasia, psychosis, addiction, anorexia nervosa, PTSD, tinnitus, TBI, stroke, chronic pain, borderline personality disorder, Huntington’s disease, social anxiety disorder, obesity

Diseases and Disorders

brainmap.org/pubs“ALE and BrainMap” ~ Educa2onal Course on Neuroimaging Meta-‐Analysis ~ 2014 OHBM Annual Mee2ng

Summary

1. Paradigm-Based ALE Meta-Analysis

P<0.05, correctedL R

2. ROI-Based ALE Meta-Analysis

P<0.05, correctedL R

“Meta-analytic connectivity modeling” or “MACM”


Face Perception in Healthy Controls

3. Functional Interpretation of Resting State Networks

• Functional interpretation of networks is problematic given the nature of resting state fMRI data

• Components are typically loosely grouped by anatomy (e.g., “basal ganglia”, “frontal-parietal”, “cerebellar”) or function (e.g., “sensorimotor”, “visual”, “attention”, “default mode”, “executive

• However, a recent neuroinformatics technique that utilized the BrainMap database offers a different approach...

• RSNs: long range, but functionally connected regions that exhibit coherent fluctuations at rest; consistently identified using ICA

• ICA is a popular method of identifying RSNs to study the human connectome

Designed to serve as a resource for data interpretation of ongoing RSN and other human connectome studies (brainmap.org/icns)

Summary


http://brainmap.org/icns

Thank You!

Florida International University: Matt Sutherland, Julio Yanes, Jessica Bartley, Dane Marguglio, Kailey MacNamara, Rob Laird UT Health Science Center San Antonio: Peter Fox, Jack Lancaster, Mick Fox, Angela Uecker, Kim Ray, Cody Riedel Heinrich Heine University: Simon Eickhoff

Acknowledgments

ale and brainmap · 2014-05-23 · each foci is modeled by a 3d gaussian distribution x y...

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