aldavine 5x - lucas meyer cosmetics
TRANSCRIPT
ALDAVINETM 5X
Active ingredients
Algae Polysaccharides Complex
Protect microcapillary integrity-Reduce dark circles and eye puffiness
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Aldavine™ 5X is a calibrated association of 2 unique algae
polysaccharides which protect microcapillary integrity.
CALIBRATED ASSOCIATION OF ALGAE POLYSACCHARIDESAldavineTM 5X is a highly potent cosmetic active ingredient born from the calibrated
association of 2 unique algae polysaccharides. The pollutant-free environment
protected by UNESCO offers optimal growth conditions for the harvest of these high
quality algae. Our biotechnological process makes it possible to create outstanding
and biologically active polysaccharides that clinically demonstrate effectiveness in the
protection of microcapillary integrity.
TARGETTING PRO-INFLAMMATORY MEDIATORS AND MMPSSkin cells sense the aggression of external stress and initiate a cascade of biological
responses. Keratinocytes and fibroblasts produce biochemical mediators in the forms
of VEGF (vascular endothelial growth factor) and PGE2 (prostaglandin E2). PGE
2
targets skin microcapillaries and induces its dilatation (enlargement of diameter) while
the microcapillary hyperpermeability (leakiness) is further encouraged by VEGF. This
phenomenon favors the efflux of leukocytes towards the extracellular matrix (ECM)
where they start secreting enzymes such as elastase and MMPs. Altogether, this
reaction progressively leads to a disorganization of the elastic components of the ECM
thereby weakening its structure. Ultimately, this cascade of events will dramatically
affect the cosmetic appearance of the skin, leading to fine lines and wrinkles, hallmarks
of aging skin, as well as the apparition of dark circles.
By inhibiting VEGF, PGE2, and MMP-2 activity, AldavineTM 5X maintains dermis matrix
integrity for better skin support, preventing fluid leakage and vasodilatation.
Baseline Stressed cells(PMA)
0.2%AldavineTM 5X
+ PMA
0
0.5
1
1.5
2
2.5
3
3.5
4
VE
GF
(n
g/m
L)
79%*Reduction
Baseline Stressed cells(PMA)
0.2%AldavineTM 5X
+ PMA
0
50
100
150
200
250
300
350
400
450
PG
E2 (
ng
/mL
)
70%*Reduction
0.1% 0.2% 0.3% 0.5%0
5
10
15
20
25
30
35
40 37%
3%
16%
25%
Inh
ibit
ion
of
MM
P-2
acti
vit
y (
%)
AldavineTM 5X
EffEct of aldavinEtm 5x on vEgf synthEsis by kEratinocytEs
EffEct of aldavinEtm 5x on pgE2
synthEsis by kEratinocytEs EffEct of aldavinEtm 5x on mmp-2 activity
* p<0.01 * p<0.01
Galactans from Asparagopsis armata are obtained from a patented culture technique.
Fucans from Ascophyllum nodosum are depolymerized following a proprietary biotechnological process.
PROTECTING AGAINST PHOTO-AGING
Preventive action
Test protocol
Volunteers applied 1% AldavineTM 5X or placebo 2x/day for 7 days. Microcirculation was
measured on D0, then UV exposure, then re-measured 5 hrs later.
Curative action
Test protocol
Volunteers were exposed to UV rays, then applied 1% AldavineTM 5X or placebo.
Microcirculation was measured 2 hrs later.
AldavineTM 5X normalizes the excessive increase of microcirculation caused by UV exposure, thus preventing premature aging.
REDUCTION OF DARK CIRCLESTest protocol
Volunteers applied 1% AldavineTM 5X or placebo 2x/day for 28 days. Evaluation of red
blood cell concentration (TIVI index) and evaluation of skin colorimetric parameter b*
was done at D0 and D28.
AldavineTM 5X decreases the intensity of dark circles and brightens the eye contour.
REDUCTION OF EYE PUFFINESSTest protocol
Volunteers applied 0.5% AldavineTM 5X + 0.5% LanachrysTM 2B PF or placebo 2x/day
for 28 days. Evaluation of the eye puffiness volume by fringe projection at D0 and D28.
The combination of AldavineTM 5X and LanachrysTM 2B PF clearly reduces eye puffiness and improves the appearance for an overall youthful and radiant look!
Baseline 0
0.05
0.1
0.15
0.2
0.25
0.3
0.35
Mic
rocir
cu
lati
on
(m
W/c
m.°
C)
67%Reduction
Placebo 1%AldavineTM 5X
Irradiated (1 MED)Non-irradiated
Baseline Placebo 1%AldavineTM 5X
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9 74%Reduction
Mic
rocir
cu
lati
on
(m
W/c
m.°
C)
Irradiated (1 MED)Non-irradiated
Placebo 0.5% AldavineTM 5X +0.5% LanachrysTM 2B PF
-7
-6
-5
-4
-3
-2
-1
0
D28
-D0
(m
m3)
-0.3
-6
prEvEntivE action
post-uv ExposurE action
Aldavine™ 5X visibly reduces dark circles and eye puffiness.
D28 D2810
10.5
11
11.5
12
+4%
+12%
b*
para
mete
r
1% AldavineTM 5X Placebo
a b* parameter e appearance of
dark circles
variation of dark circlE bluE color (b*) comparEd to basElinE
Evaluation of EyE puffinEss volumE variation aftEr 28 days
Placebo 1% AldavineTM 5X
100% of subjects show reduction in the appearance of dark circles!
Placebo 1% AldavineTM 5X -8
-7
-6
-5
-4
-3
-2
-1
0
D28
-D0
Red
blo
od
cells
co
ncen
trati
on
(a.u
.) -1
-7
tivi indEx variation (rEd blood cElls concEntration)
6X Better!
D0 D28
Clear reduction of eye puffiness
Features and benefitsProduct descriptionINCI NAME
HydrogenatedStarchHydrolysate(1)(and)Water(2)(and)AscophyllumNodosumExtract(3)(and)AsparagopsisArmataExtract(4)
CAS68425-17-2(1),7732-18-5(2),84775-78-0(3),174393-71-6(4)
EINECS 270-337-8(1),231-791-2(2),283-907-6(3),-(4)
APPEARANCEYellowishtransparentliquid
FORMULATION AldavineTM5Xshouldbeincorporatedattheendoftheformulationatatemperatureof<40°C.
DOSAGE 0.2-1%
OPTIMUM pH 4-8
APPLICATIONS
-Anti-aging-Sensitiveskin-Puffyeyes-Eyecare-Concealer-Anti-inflammatory-Men’scare
-Photodamage-Telangiectasia-Actinicelastosis-Acne-After-suncare-Rosacea
CHINA-COMPLIANT
FEATURES BENEFITS
2naturalpolysaccharidesobtainedfrommarinebiotechnology
Naturalandsustainableorigin
Has3cellularmechanisms:-VEGF-PGE
2
-MMP-2
Providesasynergisticeffectformaximalresults
Strongclinicalresults Fastandeffectivevisibleresultsondarkcirclesandeyepuffiness
Multi-functional Canbeusedasanti-aging,forsensitiveskin,andeyecare
This brochure is not intended for consumers and neither this brochure nor any extract thereof shall be used in order to commercialize products to consumers. No drawing, photograph or other extract derived from this brochure shall be used by any person without our prior written approval. As well, no claim with respect to the ingredient referred to in this brochure shall be made by any person without our prior written approval, even though the claim is set forth in this brochure. The person using the ingredient referred to in this brochure in the formulation of finished products is solely responsible for ensuring that the use made of the ingredient, the finished products marketed to consumers, their packaging, labeling and advertising materials and the claims made with respect to the finished products and the ingredient comply with all applicable laws and regulations. We hereby disclaim any warranty of suitability of the ingredient referred to in this brochure for any purpose. Any prospective user of the ingredient shall himself determine the suitability of the ingredient for his intended use and, as the case may be, obtain the required regulatory approvals for the commercialization of his finished products.
Age-defying eye cream
REDUCTION OF SIGNS OF AGING AND SKIN SENSITIVITY Positive feedback from 56 volunteers who have wrinkles and dry sensitive skin, after
using a formulation with 0.4% AldavineTM 5X for 28 days, 2x/day.
Using AladavineTM 5X in a cosmetic formulation provides the skin with the tools it needs to protect and maintain the integrity of its microcapillaries.
0 20 40 60 80 100
58%
59%
68%
70%
71%
84%
Reduced tingling sensation
Improved resiliency
Smoothing effect
Immediate relief
Skin comfort
Improved elasticity
Positive opinion (%)
INGREDIENTS INCI NAMES %
A Water Water qsp
HydramolTGLTM Polyglyceryl-3Laurate 2.00
TinovisADE SodiumAcrylatesCopolymer(and)HydrogenatedPolydecene(and)PPG-1Trideceth-6
1.00
B UconFluidAP PPG-14ButylEther 1.50
SchercemolDISMTM DiisostearylMalate 2.50
d-Delta-RichTocopherols Tocopherol 0.05
SoftfocusBPD-500w HDI/TrimethylolHexyllactoneCrosspolymer(and)Silica
2.50
C Neo-mekkingsM16 Phenoxyethanol(and)Methylparaben(and)Ethylparaben(and)Butylparaben(and)Propylparaben(and)Isobutylparaben
1.00
Aldavine™5X HydrogenatedStarchHydrolysate(and)Water(and)AscophyllumNodosumExtract(and)AsparagopsisArmataExtract
0.20
ChroNOline™ Glycerin(and)Water(and)Dextran(and)CaprooylTetrapeptide-3
1.00
Lanachrys™2BPF ButyleneGlycol(and)Water(and)ChrysanthellumIndicumExtract
0.05
Hydriame™ Water(and)Glycosaminoglycans(and)SclerotiumGum(and)ChitosanGlycolate(and)SodiumHydroxide
2.00
ParfumAmnesio Fragrance 0.20
D TinovisGTC Acrylates(and)Beheneth-25MethacrylateCopolymer 0.50
NaOH(solution10%) SodiumHydroxide qspL
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LUCAS MEYER COSMETICS S.A.S.
ZA les Belles Fontaines99 route de Versailles91160 Champlan - France T: +33 (0)1 69 10 69 69 - F: +33 (0)1 69 10 69 70
LUCAS MEYER COSMETICS CANADA INC.
Place de la cité, tour Belle Cour 2590, boul. Laurier, #650 Québec (Québec) G1V 4M6 CanadaT: +1 418 653-6888 - F: +1 418 653-6005