aines en ingles

8/10/2019 Aines en Ingles

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Autonomous University of Tlaxcala School of

Integrative activity.

Pharmacokinetics and Pharmacodynamics o

Michelle Alison Ochoa

Jessica Fernanda Lp

Jorge Daniel Campos

Leobardo Flores Cuah

Jess Antonio Snche


2/25

Dialogue------------------ Leobardo y A

Alison: Hi good morning Leobardo: Hello

Alison: Sorry that medication can recommend me is that myhurts and I'm swollen.

Leobardo: I recommend an NSAID

Alison: A NSAIDs, What is an NSAID?

Leobardo: Do not look worry you'll explain ...


3/25

Fernanda:

Introduccin. Los antiinflamatorios no esteroideos comparten

actividades teraputicas y efectos colaterales, su mecanismo

est mediado por la inhibicin de la Ciclooxigenasa (COX 1 y 2

encargada de la biosntesis de prostaglandinas. Casi tantiinflamatorios no esteroideos utilizados en la actualidad, in

actividades de la ciclooxigenasa 1 constitutiva y la ciclooxig

inducida en el sitio de la inflamacin. Mtodo. Para lo

investigacin se busc informacin principalmente en journa

complementndose con la de libros, artculos y pginas web. Co

Los AINEs se presentan como un grupo farmacolgico su

heterogneo en lo que a estructuras qumicas se refiere. Sin emba

ellos comparten un principio de accin fundamental, el bloqu

sntesis de prostaglandinas a travs de la inhibicin de la

ciclooxigenasa.


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Fernanda:

Pharmacokinetics

Pharmacokinetics is the branch of pharmacology that studies the

processes to which a drug is submitted by its passage through the

body. Try to explain what happens to a drug from the time it is used

until complete elimination from the body.

The detailed stepwise traversing the drug in the body, the study are

grouped LADME acronym:

Release of the active ingredient.

Absorption of it.

Distribution by the body.

Metabolism.

Excretion of the drug or the waste that remains the same.


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6/25

Ferananda:

NSAIDs

Nonsteroidal antiinflammatory

drugs (NSAIDs) are a diverse

group of mainly anti-inflammatory

drugs, analgesics and antipyreticsgroup, thereby reducing the

symptoms of inflammation, pain

and fever.


7/25

Jesus:

Mechanism of Action

Activation of phospholipase A2 in response to various stimuli, hydroly

membrane phospholipids releasing arachidonic acid in cytoplasm. Thserves as a substrate for two enzmicas pathways: cyclooxygenase a

lipoxygenase. By way of COX prostaglandin (PG) H2, which stimulat

formation of various prostanoids generated, including various prosta

thromboxane A2.

Of particular importance in anti-inflammatory therapy was the identifidifferent forms of the cyclooxygenase enzyme: cyclooxygenase-1 (C

cyclooxygenase-2 (COX-2). COX-1 is an enzyme involved in the ove

homeostasis and is present in most tissues and organs. COX-2 is no

tissues, appears only in the presence of certain stimuli. By way of lipo

leukotrienes, lipoxins and other products are formed.


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Mechanism of Action


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Jesus:

Inflammation

The inflammatory process involves a series ofevents that can be triggered by various stimuli

(infectious agents, ischemia, antigen-antibody

interactions).

Which will be five signs of inflammation:

Blush: Redness mainly due to the phenomena

of increased pressure by vasodilation.

Tumor: Increased interstitial fluid and edema

formation.


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Heat: Temperature increase

Pain: Symptom subjective in nature while the rest a

an objective nature

Loss of function: Changes caliber vascular flow and

in vascular permeability.


11/25

Leobardo

Pain:Almost always inflammatory drugs

are classified as mild analgesics.

Pain that accompanies inflammation

and tissue injury results from perhaps

local stimulation of pain fibers and

increased sensitivity to it.


12/25

Leobardo

Fever:

The fever may result from

infection or tissue injury

sequel, inflammation, graft

rejection, cancer or other

pathogens pictures.


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Pharmacodynamics

The main action of all NSAIDs is inhibition of

cyclooxygenase. Inhibiting the synthesis of

prostaglandins and thromboxanes NSAID

would be responsible for their therapeutic

activity and various toxic effects of this class

of drugs.

The fundamental action of NSAIDs areessentially threefold: - Relieve pain for their

analgesic actions Reduce inflammation for

their anti-inflammatory actions Reduce fever

antipyretic actions.

Leobardo


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Alison

Analgesic Action

And a peripheral effect is related to the

inhibition of prostaglandin synthesis in the

place where it is perceived. All NSAIDs

inhibit the cyclooxygenase activity. They

prevent sensitization of nociceptors. As will

be useful in pain with acute or chronic

inflammatory component, such as renal

colic pain or bilar.


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16/25

Alison

Anti-Inflammatory Action

NSAIDs also act directly or indirectly modifyingother inflammatory mediators. This ability of

NSAIDs peripherally to block or inhibit any or all

mediators of inflammation factors. The reducing

inflammation with NSAIDs often brings clinical

improvement for important periods of time. In

dentistry, NSAIDs frequently indicated for relief

of mild to moderate pain of dental origin and

subsequent dental procedures


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Daniel

Ibuprofen

First member of the family of propionic acid

NSAIDs, their pharmacokinetics in plasma

proteins absorbed reached 90% plasma at

30 minutes dental indications concentrations

processes, presentations are 200,400,600

and 800 mg and 200 mg suspensions their

dosage one capsule every 6 to 8 hour dose6-11 months is 10 ml of 12 to 23 months and

12.5 ml of 2-5 years is 15 ml trade names

are tabalon, actron, motrin, advil not for

hypertensive patients


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Ketorolac

Ketorolac is to treat short-term pain (posttraumatic,

postoperative) pharmacokinetics bound to plasma

protein 99% is metabolized in the liver via renal

excretion is 92% and the rest by feces indicated for

dental processes (not as antipyretic) presentations

tablet 10 mg, 1 ml ampoules their dosage 10 mg

tablet every 4 to 6 hours not to exceed 20 mg

ampule every 4-6 hours. dolac Supradol tradenames, mavidol.


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Hypersensitivity


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Pregnancy and lactation


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coagulation defects


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Renal impairment


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Cardiac disorders


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Gastric Pathology


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Conclusion

NSAIDs are a group of commonly used in clinical practi

variety of indications drugs. In general, NSAIDs should

short cycles and lowest doses possible, always within r

effectiveness, and monitoring specifically digestive,

cardiovascular, renal, hepatic and hematologic complicEach patient may respond to a specific NSAIDs, while a

require a different product, however the best benefit r

ibuprofen.

Fernanda

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