agmapure® from genabolix

GREEN AGMATINE SULFATE

BOOST YOUR CELLS TO ENERGY

www.agmapure.com [email protected]

http://www.agmapure.com/

WHAT IS AGMAPURE®


AGMAPURE® IS A REGISTERED BRAND OF GENABOLIX

A POPULAR SUPPLEMENT FOR SPORTS NUTRITION

THE UNIQUE GREEN AGMATINE SULFATE IN THE MARKET

TOP-HIGH-QUALITY

PURER AGMATINE SULFATE NATURAL FERMENTED

Agmapure® has top-high-quality purer agmatine sulfate produced by natural biotransformation process.

Agmapure® provides the edge in the fiercely competitive and rapidly growing markets of energy, sports performance, and cognitive achievement.

As the quality is at the core of everything, Agmapure® has no residues of harmful substances and Insure the environment safety and healthy.


AGMAPURE® Recently Agmatine has gained wide interest as a breakdown metabolite of Arginine with a multitude of physiological functions. Agmatine sulfate, the commonly used stable salt of Agmatine, is a promising supplement rapidly drawing the attention of the athletic performance market. Currently, Agmapure® is the unique Green Agmatine sulfate in sports nutrition market. It’s high purity,produced by natural biological process and away from the neurohazard impurity Arcaine,which exists in almost all the other brands of Agmatine sulfate.

AGMAPURE®

ULTIMATE PUMPS

INTRA-WORKOUT ENERGY

NEUROPROTECT SUPPORT

NOOTROPIC BOOST NOOTROPIC BOOST

ANALYESIC EFFECT

Multi-Pronged Benefits Facilitates a wide range of healthy functions

Agmapure® & Increased Pumps ULTIMATE PUMPS

As a competitive inhibitor of all nitric oxide synthase isoenzymes, Agmapure® stimulates some types of Nitric Oxide Synthase (NOS) and acts directly on endothelial cells to increase the NOS, which induces them to cause vasodilatation, specifically iNOS and nNOS, leading to increased blood flow to the muscle experienced by acting as a competitive inhibitor. Agmapure® is a definite contributor to an overall good looking muscular physique lead to a full look to the muscle and increase muscle pumps: agmatine may improve nutrient partitioning, leading to more muscle glycogen stored and consequently more water retained in the muscle

As an imidazoline receptor agonist, also showing insulin-like effect that may help improve insulin response through enhanced insulin production which is a key to a leaner, harder, more muscular body in bodybuilding circles.

Agmatine enhances results gained from gym visits in multiple ways. First, it increases nitric oxide production.Nitric oxide optimizes glucose transportation and stabilizes glucose muscle concentrations during exercise, prolonging the onset of fatigue. Increasing glucose content has shown in clinical studies to reduce exercise time to exhaustion.

Physiological concentrations of agmatine activated vessel relaxation via α-2 AR and G-proteins and this was partially dependent on vascular NO synthesis. Agmatine relaxed the vessels at 100 times lower concentration as compared to arginine and thus making it a physiologically relevant agonist at α-2 AR binding site.

Santhanam A.V. Raghaven and Madhu Dikshit. Pharmacological Research. 2004,5,397-414. Thomas W. Balon, Jerry L. Nadler, et al. Journal of Applied Physiology. 1997,82,359-363. Foster C, Costill DL, Fink WJ, et al. Medicine and Science in Sports. 1979, 11,1-5 Tushar V. Gadkari, Natalie Cortes, Kumpal Madrasi,et al. Nitric Oxide. 2013,35,65–71

INTRA-WORKOUT ENERGY

Agmapure® & Anti-oxidant As a known antioxidant, Agmapure® aid the body in shedding unwanted free-radicals that have built up during the course of normal daily activities lead to more free radical buildup than with the average person. It helps to keep entire body in a better state of health by limiting the activity of glutamate, over excitation of the brain.

Agmantine Sulfate can prevent excitotoxicity which can occur when using too much Sunifiram, Unifiram, Modafinil or other similar nootropic supplements. Removal of free radicals, toxins, and other poisons can help to keep not only the brain but the entire body in a better state of health.

Cardiovascular Benefits Agmapure® have cardiovascular benefits Due to its stimulation of NOS. It has a potential hypotensive benefit that may help aid in cardiovascular health. This hypotensive role is beneficial for bodybuilders or athletes that use stimulants or hormone based compounds that may cause elevations.

AGMATINE PROTECTS MICROGLIA FROM LPS-INDUCED INJURY

The influence of agmatine on nitric oxide production, norepinephrine release and related receptor systems indicate its potential cardioprotective benefits associated with these mechanisms as well.

Not only can agmatine directly and immediately support healthy cardiovascular function, but it may protect related systems to promote future health and stability should challenges arise.

body in bodybuilding circles.

Representative western immunoblots. Twenty-four hours after lipopolysaccharide (LPS) microinjection into the corpus callosum, protein was obtained from ipsilateral cortical tissue. IL=interleukin; iNOS=inducible nitric oxide synthase; TNF=tumor necrosis factor. Soo Kyung Ahn , Samin Hong, Yu Mi Park. Life Sciences 2012, 91: 1345–1350


Wang WP, Iyo AH, Miguel-Hidalgo J, Regunathan S, Zhu MY. Brain Res. 2006, 1084, 210–216.

body in bodybuilding circles. Yang XC, Reis DJ. J Pharmacol Exp Ther. 1999, 288, 544–549.

Agmapure® & Improved Insulin Response As an imidazoline receptor agonist, Agmapure® also showing insulin-like effect that may help improve insulin response through enhanced insulin production which is a key to a leaner, harder, more muscular body in bodybuilding circles.

body in bodybuilding circles. Agmatine significantly lengthened exercise time before athletes were immobilized by exhaustion. Researchers note effects seem strongest when agmatine is supplemented within 30 minutes prior to exercise.

body in bodybuilding circles. Agmatine is the only molecule known to scientists with the capability to induce antizyme. This enhances cell growth and homeostasis and is proven to increase cell count per unit of surface area by 10-17%.

body in bodybuilding circles. Argmatine stimulates pituitary hormone secretion, including growth hormone. Raising growth hormone maximizes the speed and size of muscle growth. It’s also proven to improve muscle strength by 24-61.2%

Sener A, Lebrun P, Blachier F, Malaisse W. Biochem Pharmacol. 1989, 38, 327–30. 2.Joseph Satriano, Carolyn J Kelly, Roland C Blantz. Kidney International. 1999,56,1252-1253. 3. Kazuhiro Tanahashi and Antonios G. Mikos. Journal of Biomedical Materials Research Part A.2003,67,448-457. 4.Satya P. Kaira, Edward Pearson, Abhiram Sahu, Pushpa S. Kalra. Neuroscience Letters. 1995,194, 165-168. 5.Dennis R. Taaffe, Leslie Pruitt, Jennifer Reim, Raymond L. Hintz, Gail Butterfield, Andrew R. Hoffman, Robert Marcus. Journal of Clinical Endocrinology and Metabolism. 1994, 79, 1361-1366

ANALGESIC EFFECT

AGMAPURE® & ANALGESIC EFFECT

Agmapure® has potential to modulate pain sensitivity due to its ability to inhibit hyperalgesia (increased sensitivity to pain) and its neuroprotective activity. Therefore, it may potentiate the effects of analgesics used during recovery from injury in sports training. It offers a plethora of health benefits for athletes, elderly individuals, and people suffering from drug addiction or chronic pain. It can boost your workouts by making you more inclined to work.

DELIVERY OF TWO LOWER AGMATINE DOSES ALSO COMPLETELY INHIBITED FENTANYL SELF-ADMINISTRATION


Agmatine-mediated attenuation of fentanyl self-administration. Time course of fentanyl self-administration for mice receiving i.c.v. treatments of saline (A) or agmatine (10 nmol/5 μl) (B) given the day before the first self-administration sessions and every 2 days for 16 days. Responses represent lever presses on one of two bars. The first bar (active lever) delivers 70 μl of fentanyl (10 μg/ml) (triangles). Pressing the control lever results in no reward and is indicative of non-specific activity (circles).Mice did not respond differently for food-maintained responding under either the saline or agmatine conditions (C). Carrie L. Wade b, Daniel J. Schuster c, Kristine M. Domingo, et al. European Journal of Pharmacology. 2008, 587：135–140。


Effect ofintrahippocampal(i.h.)administration of agmatine on(A)thermal hyperalgesia, (B)coldallodynia and (C)mechanical hyperalgesia in neuropathic rats. The study confirms the role of sigma(s1 and s2) receptors within hippocampus in the antinociceptive effect of agmatine against the neuropathic pain in rats. Nandkishor Ramdas Kotagale, Saurabh Haridas Shirbhate,Pradeep Shukla, et al. European JournalofPharmacology 2013, 714, 424–431

INTRAPERITONEAL AND INTRAHIPPOCAMPAL ADMINISTRATION OF AGMATINE ATTENUATES NEUROPATHIC PAIN

AGMATINE INHIBITS THE ESCALATION OF INTRAVENOUS MORPHINE SELF-ADMINISTRATION


Agmatine inhibited the escalation of intravenous morphine (Mor) self-administration in respect to the nose-poke response (Panel A) and morphine intake Rui-Bin Su , Wei-Ping Wang, Xin-Qiang Lu, et al. Pharmacology, Biochemistry and Behavior. 2009, 92, 676–682

NOOTROPIC BOOST Agmapure® & Nootropic Effect AGMATINE AFFORDS NEUROPROTECTION AGAINST CORTICOSTERONE EFFECTS BY A MECHANISM


Effect of agmatine (0.1 mg/k/day, p.o.) in mice chronically (21 days) treated with corticosterone on astroglial morphology in the hippocampus. Andiara E. Freitas. Javier Egea, Izaskun Buendia, et al. Mol Neurobiol 2016, 53, 3030–3045.

Agmapure® has a decidedly Nootropic effect that can help those looking to achieve a mental edge, whether it is in the gym or in day to day life. It can also help support a healthy mood, anti-anxiety and antidepressant properties, and also stack well with other Nootropic supplements.

UNIQUE ADVANTAGES

Agmapure® has reliable craft to produce high-purity agmatine. Agmapure® has NO bad breath and bacterial vaginosis. Agmapure® produced by natural biological process with medium of water utilization systems. The reaction conditions basically lie in the active enzyme, and finally there isn’t any hazard byproduct.

QUALITY IS AT THE CORE OF EVERYTHING WE DO

NEUROPROTECT SUPPORT

SOLID FOUNDATION & TECHNICAL COOPERATION

Agmapure® & Neuroprotective Role Agmapure® is a neurotransmitter due to its antioxidant effect and its prevention of over excitation by glutamate. Agmatine influences brain function in a variety of ways. It inhibits hyperalgesia which protects against brain injury and neuron damage. It also enhances motoneuron and nerve recovery and is used to treat facial nerve damage because it accelerates healing and results in more complete nerve rehabilitation.

PROTECTIVE EFFECT OF AGMATINE ON OGD-INDUCED CYTOTOXICITY OF ASTROCYTES

Agmatine attenuated the oxygen-glucose deprivation (OGD)-induced cell death in primary-cultured cortical astrocytes. It also protected cells subjected to OGD followed by restoration (OGD-R).


Won Taek Leea, Samin Hongc, Sung Hwan Yoon, et al.brain research 2009, 1281,64-70.

body in bodybuilding circles. Agmapure® has a validated reference standard and assay method proving efficacy and safety for athletes. Agmapure® has established long and steady technical cooperative relations with universities, research institutes, which promote the upgrade of our products


We always follow up on a regular basis the reaserch progress of Agmatine, collect and invent various methods of biosynthesis and analysis to upgrade our products and consumer experiences for better safety and stability We has combined experience in the fields of diplomacy , government and industry and technology. We are developing new scientific research basis and new functions below the premise that assures quality.

NO HARMFUL RESIDUES

THE PROCESS IS GREEN AND SAFE,WITHOUT INTRODUCING IN ANY UNWANTED AND UNKNOW IMPURITY


No matter how accurately the process parameters are set and controlled, the byproduct Arcaine (1, 4-diguanidinobutane, CAS#: 544-05-8), a harmful chemical, always remains in the final Agmatine product unavoidably. During the process of preparation of Agmatine Sulphate, the amino group of the product Agmatine Sulphate can also react with S-Methylisothiourea to produce a small quantity of Arcaine Sulphate as byproduct because of the material adding method and competitive reaction speed, which is very difficult to control in organic process. But for the biotransformation process of AGMAPURE®, the specificity of the utilized enzyme is in high efficiency, so there is no byproduct produced during the process.

MAXIMUM PURITY & SPECIAL BIOFERMENT TECHNOLOGY

In the biotransformation process of AGMAPURE®, the system utilizes water as medium, the reaction conditions basically lie in the active enzyme, and finally there isn’t any hazard byproduct. So it’s quite convenient to control and won’t bring up any concern about environmental pollution.

Microbe Seed Culture Medium

Fermentation Medium

Fermentation Process

SAFETY & DOSAGE


Many athletic professionals and scientific researchers promote agmatine as a safe, reliable sports enhancement supplement.According to a number of studies, it appears that Agmatine is safe even in relatively high doses. While there have been relatively few studies conducted thus far, they have not shown any side effects to be associated with this supplement. This does not mean to jump in and start taking the supplement at the highest dosage possible. In fact, your dose should be determined by the reasons for taking the supplement in the first place. The generally accepted daily dosage range for Agmatine is anywhere between 250 mg and 2.5 grams. some studies even suggest that the amount of amino acid that reaches muscle tissue during heavy resistance training may be as much as doubled when supplementing with adequate amounts of Agmatine. Therefore, For most people, the usual agmatine dosage consists of 500mg twice daily. Some prefer to take 500mg pre workout, and then another 500mg dose after they finish their routine.Some way to use agmatine supplement is about 30-45 minutes before a workout.

TIPS

For those looking to take this supplement more for its benefits upon the mind, or for analgesic effects, then it can be divided into smaller administrations throughout the day.It would probably be beneficial to consult with a qualified professional that has experience with dietary supplements so that you can skip all of the guess work.

Although there isn’t enough research to determine an official recommended dose, human studies have successfully used dosages between 1.3-2.6g per day. This dosing range seems to be effective and well tolerated.

However, many clinically-proven doses refer to injection and not oral supplementation. To increase mental sharpness and alleviate anxiety, 6.4-40 mg per kg body weight is a typical dose for oral supplementation. But, according to some experts, agmatine’s effects are not dose-dependent and follow a “bellcurve” pattern. Consequently, exceeding 6.4 mg per kg body weight is usually not necessary.

Scientists assert agmatine is best absorbed on an empty stomach or with a small meal. Avoid consuming agmatine with a large protein source because it competes for chemical transporters which have limited availability in the intestines.

Most study participants had no side effects from taking agmatine sulfate, but it’s fair to say most people can safely take up to 2.6g agmatine sulfate per day without side effects. All gastrointestinal side effects did stop immediately following the end of treatment. Diabetics or people with hypotension should consult their doctor before using agmatine sulfate because of how agmatine affects blood pressure.

CAUTION

ANTI-DIABETES MEDICATIONS

Agmatine may lower blood glucose. In those whose blood sugar is not well-controlled this could be a good thing. However, care should be taken when used along with other antidiabetes drugs such as glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), and rosiglitazone (Avandia).

At least in rats, Agmatine lowers blood pressure. In humans with high blood pressure this could be a good thing. However, care should be taken when used along with other blood-pressure lowering medications such as captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), as well as many others.

ANTI-HYPERTENSIVE ( BLOOD PRESSURE) MEDICATIONS

AGMAPURE®

ONE OF THOSE RARE COMPOUNDS THAT APPEAR TO PROVIDE REAL,COMPREHENSIVE MIND-BODY SUPPORT

body in bodybuilding circles.c

Human clinical studies support the role of agmatine in maintaining physical comfort amidst direct challenges within the spine, and evidence suggests benefits for peripheral systems as well. In addition, research with alternative experimental models suggests great promise for agmatine to benefit CNS-related systems within the brain. Just the range of these potential helps is enough to consider at least trying it and seeing what effects it will have on you personally. The idea of being able to protect the brain, relieve pain, and help increase insulin production and response from a single supplement does sound extraordinary. Agmantine is also very promising for regular users of Glutamatergic Ampaine nootropics that want to protect the brain against excitatory neurotoxicity. This supplement is continuing to be researched for its possible anti-aging and life extension or longevity promoting benefits. Besides those functions, agmatine also increases overall mental well-being. It also relieves symptoms of drug withdrawal. It has successfully reduced alcohol, opioid, and morphine dependency in past studies. Because of this, agmatine might become a primary treatment for drug-rehab patients in the future.

AGMAPURE® FOR FUTURE

body in bodybuilding circles.c

Agmatine is found in its highest concentrations within central nervous system tissues, and what this really means, primarily, is the brain. It's also important to note that orally ingested agmatine has been shown to cross the blood-brain barrier to contribute to our agmatine stores. So, when we think of our brain—our mind—we think of mood and cognition. Agmatine have the potential to promote the health and functioning of organs and systems that are dependent on normal neurotransmission. That means the brain, the central nervous system and really, the entire body, as the health and function of our nervous system can impact comfort and performance from head to toe. We know from animal research that agmatine is found concentrated within the hippocampus and prefrontal cortex, areas associated with learning and memory. Preliminary studies suggest that supplemental agmatine may promote healthy performance in these areas. While the data here is limited, the evidence is quite encouraging and we'll see a lot more focus on agmatine's potential to support cognition and age-related cognitive maintenance in the future.

agmapure® from genabolix

Health & Medicine