aging & cancer
DESCRIPTION
AGING & CANCER. Gene loss. DNA Repair. Proteasome. telomare. STOP CYCLE/AGING. ENVIRONMENTAL STRESS. mutation silencing and expressing gene. CANCER. Aging as a catabolic malfunction and “Garbage Catastrophe”. Young and clean. Old and Dirty. Oxidative damage. Oxidative damage. - PowerPoint PPT PresentationTRANSCRIPT
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AGING AGING & & CANCERCANCER
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telomareSTOP CYCLE/AGINGSTOP CYCLE/AGING
CANCERCANCER
Proteasome
DNA Repair
Gene loss
ENVIRONMENTAL ENVIRONMENTAL
STRESSSTRESS
mutation
silencing and expressing gene
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Oxidative damage
Proteosomal
degradation
Oxidative damage
Proteosomal
degradation
Oxidized and
cross-linked
proteins
Oxidized and
cross-linked
proteins
(Lipofuscin)
Young and clean Old and Dirty
“Garbage
catastrophe”
Anti-aging Reversing the catastrophe
Aging as a catabolic malfunction
and
“Garbage Catastrophe”
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telomareSTOP CYCLE/AGINGSTOP CYCLE/AGING
CANCERCANCER
Proteasome
DNA Repair
Gene loss
ENVIRONMENTAL ENVIRONMENTAL
STRESSSTRESS
mutation
silencing and expressing gene
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ENVIRONMENTAL FACTORENVIRONMENTAL FACTOR
Nutrition excess calories cancers of colon, rectum, stomach,
breast, ovaries excess fat consumtion obesity
cigaretes 1/3 of cancer deaths Cancers of lung, pancreas, mouth,
larynx, liver, alchohol esophagus and bladder
occupation 5% of cancerdeaths cancers of lung, bladder, stomach, blood, liver, bones, skin
Radiation 3% /xray, uv, isotop blood and skin
Other drug, virus, bacteri various
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Cancer cells
Normal and Cancer cells contrast in their proliferation capacity
Normal cells
Limited number of divisions
Permanent growth arrest/senescence
Unlimited number of divisions
Tumor
Vs
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CANCER NEED MORE ENERGYCANCER NEED MORE ENERGY
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environmental stressenvironmental stress
p53, HSF
ApoptosisApoptosisrepair mechanism,
protecting cell
necroticnecrotic
CancerCancer
healty nutrient/suplement
HSF, HO-1, NOS,
P45OR (GENE
PROTECTOR)
interaction of genes between stressor and food cause cancer