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Advances in C–H Functionalization

247th American Chemical Society National MeetingDallas 17th-19th March 2014

Foreword

For over half a century the teaching and practice of organic chemistry has revolved around the classification of compounds according to their functional groups. A basic precept of all introductory organic chemistry texts is the contrast between the selective reactivity of functional groups (alcohols, amines, esters…) and the “inert” C–H and C–C bond framework of organic molecules. However, the logic of chemical synthesis is evolving. Over the past two decades there has been an explosive growth in the development of methods for the C–H Functionalization and the application of these technologies for the synthesis of complex targets such as natural products, pharmaceutical agents and organic materials. Today, a large and carried number of site- and stereoselective C–H Functionalization methods are available that operate with a level of precision and predictability required for the synthesis of complex molecular scaffolds. These tools can significantly streamline chemical strategies by rendering functional group interconversion steps redundant, with the C–H bond being considered an effective synthon for both C–C and C–hetereoatom moieties.

This symposium brings together many of the leading practitioners in this field from across the globe to really highlight the broad scope of applications for this science. From novel methodologies, via the streamlining of strategies toward natural products and pharmaceutical targets to the discovery of new building blocks and polymerization techniques for organic polymers, all these applications and investigations are highlighted in this Symposium.

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Chemoselective and tunable silver-catalyzed aminations.J. M. Schomaker – UW Madison

Site-selective C-H functionalization based on common functional groups.G. Dong – UT Austin

Complex alkaloid synthesis.M. Movassaghi – MIT

Development of iridium pincer complexes as catalysts for enantioselective atom-transfer C–H functionalization reactions.S. B. Blakey – Emory University

Metalloradical catalysis for stereoselective C–H amination.P. X. Zhang – U South Florida

Synthesis of heterocyclic scaffolds using Pd- and Ni-catalyzed C-H arylations.D. Kalyani – St Olaf’s College

Catalytic oxidative annulations involving C-H functionalization.H. Lam – University of Nottingham

Ir-promoted, Pd-catalyzed direct arylation of unactivated arenes.L. J. Durak, J. C. Lewis* – U Chicago

Low-temperature, transition-metal-free intramolecular amination of arene C-H bonds.L. Kurti*, D. H. Ess, H. Gao, Q. Xu – UT Southwestern

Title and Authors

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Contributing Speakers SessionMonday 17th March. Presiding: M. Movassaghi

Advances in C–H Functionalization3

Contributing Speakers SessionMonday 17th March. Presiding: J.-Q. Yu

Catalytic hydrocarbon oxidation.T. Strassner,* D. Munz – TU Dresden

Direct, intermolecular, sterically-controlled, acylation of aromatics via iridium-catalyzed C-O and C-H bond activation.N. A. Serratore, G. T. Hoang, C. J. Douglas* – U Minnesota

Silole-containing compounds influence on direct arylation.C. Scott*, M. Bisen, C. Liu – Southern Illinois University

New opportunities with NHC organocatalysis: β-sp3 C–H activation of saturated ester and beyond.Y. Chi - NTU

Strategies to study and enable non-directed C–H functionalization in the presence of Lewis basic heterocycles.H. A. Malik,* B. L. Taylor, J. R. Kerrigan, J. E. Grob, K. N. Houk, J. Du Bois, L. G. Hamann and A. Patterson - Novartis

Late stage C-H functionalization of nitrogen-containing complex natural products via intermolecular rhodium-carbenoid insertion.J. He, L. G. Hamann, H. M. L. Davies* and R.E. Beckwith* - Novartis

New electrophilic amination reagents for transition metal catalyzed C-H aminations.M. H. Emmert – Worcester Polytechnic Institute

Origins of regioselectivity in template-directed palladium-catalyzed C–H bond activation.B. L. Taylor, S. Ahlquist, P. Liu and K. N. Houk* - UCLA

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Total synthesis of hebispeptin A and B via palladium-catalyzed C-H arylation.G. Chen – Penn State U266.4:20


Generation of molecular complexity via intermolecular allylic C–H alkylations.J. M. Howell, W. Liu, A. J. Young and C. M. White* – UI-Urbana-Champaign

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Challenging assumptions: C–H functionalization logic in natural product synthesis.P. S. Baran - TSRI

Addressing challenges in late stage C-H functionalization of pharmaceutically relevant substrates.L. Hamann - Novartis

C-H coupling for synthetic biomolecules and nanocarbons.K. Itami – Nagoya University

Rhodium and cobalt-catalyzed functionalization of formyl C-H bonds.V. M. Dong – UC Irvine

Rapid assembly of heterocycles by C-H bond functionalization.J. A. Ellman – Yale University

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Tuesday 18th March. Presiding: H. M. L. Davies


Invited Speakers Session

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Tuesday 18th March. Presiding: D. Morton

C–H bond functionalization by the introduction of a temporary functional group.J. F. Hartwig – UC-Berkeley

Site-selective C-H functionalization by means of metal carbene-induced C-H insertion.H. M. L. Davies – Emory University

C-H functionalization as an enabling technology for drug discovery.T. Cernak - Merck

Development of direct C-H amination reactions.S. Chang - KAIST

Ligand-accelerated C-H activation reactions: New synthetic disconnections.J.-Q. Yu - TSRI

New activation modes for aliphatic Pd-catalyzed C–H bond functionalization.M. J. Gaunt – University of Cambridge

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Contributing Speakers SessionWednesday 19th March. Presiding: S. B. Blakey


Synthesis of benzobisthiazole and thiazolothiazole derivatives via C-H functionalization.J. L. Bon, S. R. Marder* and S. B. Blakey* - Emory and GA Tech

Redox-neutral α-oxygenation of amines.M. T. Richers, A. Y. Platonova, M. Breugst, K. N. Houk,* D. Seidel* - UCLA and Rutgers

Designing immobilized dirhodium carbenoid catalysts for high activity and enantioselectivity.N. A. Brunelli, K. M. Chepiga, Y. Fang, H. M. L. Davies,* C. W. Jones* - Emory and GA Tech

Ruthenium(IV) porphyrin catalyzed nitrene sp3 and sp2 C-H bond insertion using phosphoryl azides as nitrene source.W. Xiao, C. Zhou, C. Che* - The University of Hong-Kong

Palladium-catalyzed direct arylation of cyclopropanes: Facile access to spiro 3,3’-cyclopropyl oxindoles.C. L. Ladd, D. Sustac Roman, A. B. Charette* - University of Montreal

Mechanistic behavior of Ir(ppy)3 in organic reactions.J. J. Devery, J. J. Douglas, J. D. Nguyen, R. A. Flowers, C. R. Stephenson* - U-Michigan

Mechanistic details of the Au(I)-catalyzed asymmetric cyclopropenation of internal alkyne with diazo carbenes.S. Chen, H. M. Davies,* J. F. Briones, D. G. Musaev* - Emory University

TBAF-promoted Pd-catalyzed direct arylation of 5-iodouracil nucleosides.Y. Liang, J. Gloudeman, O. Akinniyi, S. F. Wnuk* - FIU

Toward practical C-H borylation with base metal catalysts.N. P. Mankad,* T. J. Mazzacano, G. W. Waldhart – UI-Chicago

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Chemo- and regioselective C(sp3)-H arylation of unactivated allylarenes via a deprotonative cross-coupling process.N. Hussain, G. Frensch, J. Zhang, P. Walsh* - U-Pennsylvania

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Advances in C–H Functionalization 8


Invited Speakers Profiles

Huw Davies - Emory UniversityHuw M. L. Davies received his B. Sc. degree from University College Cardiff, Wales and his Ph. D degree from the University of East Anglia. After a post-doctoral position at Princeton University, he joined the faculty at Wake Forest University. After being promoted to full professor he moved to the University at Buffalo, the State University of New York where he held the positions of UB Distinguished Professor and Larkin Professor of Organic Chemistry. In 2008 he moved to Emory University as the Asa Griggs Candler Professor of Organic Chemistry.Professor Davies’ research emphasizes the development of new enantioselective synthetic methods and their applications in total synthesis and drug discovery.

Sukbok Chang - KAIST UniversitySukbok Chang obtained a B. S. degree in 1985 from Korea University and his M. S. in 1987 from KAIST under the direction of Sunggak Kim. In 1996 he completed a Ph.D. working under the direction of Eric N. Jacobsen at Harvard University. In 1996 Sukbok moved to Caltech as a Postdoctoral Fellow under the direction of Robert H. Grubbs. In 1998, Sukbok joined the faculty at Ewha Womans University as an Assistant Professor. In 2002 Sukbok moved to KAIST as a Professor and in 2012 became the Director of the IBS-Center for Catalytic Hydrocarbon Functionalization.His independent research focuses on the development of novel chemical transformations with an emphasis on C–H bond activation, methane functionalization and catalytic selective defunctionalization.

Tim Cernak - MerckTim Cernak was born in Montreal, Canada in 1980. He completed a B.Sc. at UBC Okanagen before returning to Montreal in 2002 to pursue PhD studies on the total synthesis of palau’amine with James Gleason at McGill University. In 2007 he began postdoctoral studies with Tristan Lambert at Columbia University. These involved the development of catalytic heterocyclization reactions. Since 2009, he has been a member of the Medicinal Chemistry Team at Merck & Co., Rahway, NJ. His research interests include medicinal chemistry, catalysis and C–H activation.

Phil Baran - The Scripps Research InstitutePhil Baran obtained a B. A. degree in 1997 from New York University. In 2001 he completed a Ph.D. working under the direction of K. C. Nicolaou at The Scripps Research Institute. In 2001 Phil moved to Harvard University as an NIH Postdoctoral Fellow under the direction of E. J. Corey. In 2003, Phil joined the faculty at The Scripps Research Institute as an Assistant Professor and has risen through the ranks to become the Darlene Shiley Chair in Chemistry in 2013. His independent research focuses on the pursuit of the total synthesis of a broad scope of complex molecules. To this end the discovery and development of novel reactions is often required with a particular emphasis on atom, step and redox-economy.

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Lawrence Hamann - NovartisLawrence G. Hamann received his Ph.D. in Organic Chemistry from the University of Michigan in 1991 before joining Ligand Pharmaceuticals, where he helped discover some of the first known nonsteroidal modulators of nuclear hormone receptors. Moving to Bristol-Myers Squibb in 1999, he led drug discovery programs targeting cardiovascular and metabolic disease, sarcopenia, hepatitis C, and HIV, yielding multiple clinical development candidates, including the FDA approved DPP4 inhibitor Onglyza (saxagliptin) for type 2 diabetes and the HCV NS5A inhibitor daclatasvir, currently in phase III. Since 2008, he has been Executive Director and Head of Early Discovery Chemistry at Novartis Institutes for BioMedical Research in Cambridge, MA, working closely with the Developmental and Molecular Pathways biology group to identify and validate novel drug targets, including those for orphan diseases.

Matthew Gaunt - Cambridge UniversityMatthew Gaunt graduated from the University of Birmingham with Honours in 1995. He moved to the University of Cambridge to carry out his graduate studies as a Wellcome Trust Scholar with Dr. Jonathan B. Spencer, finishing in 1999. Following this he was awarded a prestigious GlaxoWellcome Fellowship that he took to the University of Pennsylvania to work with Prof. Amos B. Smith. He returned to the UK in 2001 to work with Prof. Steven Ley as a Junior Research Fellow at Magdalene College, and was also awarded a Ramsay Memorial Fellowship.He began his independent research career in 2003 at the University of Cambridge. In 2006 he was appointed Lecturer in Organic Chemistry, and a Philip & Patricia Brown Next Generation Fellow at the University of Cambridge. In 2010 he was promoted to Reader in Chemical Synthesis. In 2012 he was promoted to Professor.

Jonathan Ellman - Yale UniversityJonathan Ellman obtained a B. S. degree in 1984 from MIT, and a PhD degree from Harvard University in 1989, working under the direction of David A. Evans. In 1989, Jonathan moved to UC-Berkeley as an NSF Postdoctoral Fellow to work with Peter G. Shultz. In 1992, Jonathon joined the Department of Chemistry at UC-Berkeley as an Assistant Professor. In 1997 Jonathan was promoted to Associate Professor and in 1999 Full Professor at UC-Berkeley. In 2010 Jonathan became a Professor of Pharmacology at Yale University. His independent research efforts are focused on the development of efficient, systematic chemical tools to establish protein function through the design and synthesis of small molecule libraries. In addition, a major emphasis is placed on the development of practical and general new synthetic methods, in particular, methods for the asymmetric synthesis of amines and the development of synthetic applications of C-H activation.

Vy Dong - UC IrvineVy Dong graduated magna cum laude from UC Irvine where she majored in chemistry and completed an honor’s project with Larry Overman. After graduation, she joined David MacMillan’s group at UC Berkeley, and then moved with his group to Caltech to complete her doctoral studies. Her Ph.D. thesis featured variants of the zwitterionic-Claisen rearrangement and a total synthesis of erythronolide B. As an NIH postdoctoral fellow, Vy pursued training in organometallic and supramolecular chemistry with Robert Bergman and Kenneth Raymond back at Berkeley. She began her independent academic career at the University of Toronto, where she was promoted with tenure and named the Adrian Brook Professor. After six years in Canada, Vy returned to the United States to assume a professorship at her alma mater, UC Irvine. Professor Dong’s research team aims to solve challenges in organic synthesis through the study and design of catalytic methods.

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Jin-Quan Yu - The Scripps Research InstituteJin-Quan Yu earned his B.S. in Chemistry in 1987, at East China Normal University, Shanghai, his M.S. in Organic Chemistry in 1990, at the Guangzou Institute of Chemistry and his Ph.D. in 1999, at Cambridge University, under the direction of Prof. JB Spencer. Dr. Yu completed his postdoctoral fellowship at Harvard University in 2002, under the direction of Prof. EJ Corey. From 2003 Dr. Yu was a Royal Society Research Fellow at the University of Cambridge, and from 2004 he held the position of Assistant Prof. in the Department of Chemistry at Brandeis University. In 2007 he began his position as a Tenured Associate Prof. at The Scripps Research Institute, and in August of 2010 he was promoted to Full Professor in the Department of Chemistry, TSRI. In 2013 he became the Frank and Bertha Hupp Chair of Chemistry.

Kenichiro Itami - Nagoya UniversityKenichiro Itami obtained his undergraduate degree in 1994 from Kyoto University. In 1998 he completed a Ph.D. working under the direction of Yoshihiko Ito at Kyoto University. In 1998 he was a JSPS Research Fellow, with a sabbatical in the lab of Jan-E. Backvall. In 1998, Ken joined the faculty at Kyoto University as an Assistant Professor. In 2005 Ken moved to Nagoya University as Professor of Chemistry. In 2010 he became Director of the WPI-Institute for Transformative bio-Molecules.His independent research focuses on the development of new synthetic methods, strategies, and concepts to solve challenging synthetic problems for realizing ideal chemical synthesis and for generating as-yet unexplored molecules of significant interest.

John Hartwig - UC BerkeleyJohn Hartwig obtained a B. A. degree in 1986 from Princeton University. In 1990 he completed a Ph.D. working under the direction of Richard A. Anderson and Robert Bergman at UC-Berkeley. In 1990 John moved to MIT as an American Cancer Society Postdoctoral Fellow. In 1992, John joined the faculty at Yale University as an Assistant Professor and rose through the ranks to Irénée Dupont Professor of Chemistry. In 2006 John moved to the University of Illinois at Urbana-Champaign as the Kenneth L. Reinhart Jr. Professor. In 2011 John moved to UC-Berkeley as the Henry Rapoport Chair in Organic Chemistry. His independent research focuses on the discovery and understanding of new reactions of organic compounds catalyzed by transition metal complexes. These findings result from a combination of organic synthesis, organometallic synthesis and mechanistic analysis of catalytic systems.

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Contributing Speakers Profiles

Nicholas Brunelli - Ohio State UniversityNicholas Brunelli received his PhD in Chemical Engineering from Caltech in 2010, supported through the NSF Graduate Research Fellowship. His materials characterization background provided the basis for him to transition into catalysis based research during his postdoctoral appointment at Georgia Institute of Technology from 2010. In 2013 he worked with Prof. Huw Davies and Chris W. Jones as a Postdoctoral Fellow at Emory University, on the immobilization of dirhodium carbenoid catalysts and creating a mechanistic understanding of the catalytic cycle, including catalyst deactivation. In 2014 he joined the faculty at Ohio State University as an Assistant Professor. His independent research revolves around the specific design and control of active catalytic sites.

Jennifer Bon - Emory UniversityJen is from Fairfax, Virginia and earned her B. S. in chemistry from James Madison University working with Drs. Ben DeGraff and Scott Lewis. She is currently finishing her PhD with Dr. Simon Blakey at Emory University working to develop new C-H functionalization techniques to cross couple heterocycles.

Simon Blakey - Emory UniversitySimon Blakey obtained a B. Sc. degree in 1997 from the University of Auckland. In 2002 he completed a Ph.D. working under the direction of Ian Paterson at the University of Cambridge. In 2002 Simon moved to Caltech as a Postdoctoral Fellow under the direction of David MacMillan. In 2005, Simon joined the faculty at Emory University as an Assistant Professor and is now an Associate Professor. His independent research focuses on the development of chemical reactivity, catalysis and synthetic strategy, focusing on problems with potential for broad societal impact, from drug discovery to materials science.

Gong Chen - Penn State UniversityDr. Gong Chen is currently an assistant professor of chemistry in the department of chemistry of the Pennsylvania State University. His research is focused on the synthetic and biological studies of complex carbohydrates and peptides, and the development of new synthetic methods. Dr. Chen obtained his BS degree from Nanjing University in China in 1998. He got his Ph.D. degree in Organic Chemistry at Columbia University with Prof. Dalibor Sames in 2004. After his postdoctoral training at Memorial Sloan-Kettering Cancer Center with Prof. Samuel Danishefsky, he started his independent academic career at Penn State in 2008. In 2011, he received the CAREER award from the National Science Foundation.

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Jim Devery - University of Michigan at Ann ArborJames was born in Buffalo, NY and grew up in southeastern Pennsylvania. He completed his B.S. in Chemistry at Lehigh University in 2006. After graduation, he stayed at Lehigh to pursue his Ph.D. under Prof. Robert Flowers, which was completed in 2013. He is currently participating in a teaching postdoctoral fellowship at the University of Michigan and a research postdoctoral fellowship under Prof. Corey Stephenson.

Robin Chi - NTU-SingaporeRobin Chi obtained a B. S. degree in 2002 from the Hong Kong Baptist University. In 2007 he completed a Ph.D. working under the direction of Samuel H. Gellman at UW-Madison. In 2007 Robin moved to UC-Berkeley as a Postdoctoral Fellow to work with Jean M. J. Fréchert. In 2009, Robin joined the faculty at the Nanyang Technological University, Singapore as an Assistant Professor. His independent research focuses on the development of effective organocatalysis and synthesis, with applications in synthesis/modification/manufacturing of pharmaceuticals, bioactive compounds, Chinese medicines, fine chemicals, and functional polymer materials. A particular focus is to realize effective synthesis through the creation of new basic activation modes, and through the development of better reaction controls.

Shentan Chen - Emory UniversityShentan Chen did his Ph.D study with Dr. Chisholm and Dr. Bursten at the Ohio State University. He then moved to PNNL for a postdoc working with Dr. Roger Rousseau and Dr. Michel Dupuis. After that Shentan joinedthe Musaev group at Emory University as a postdoc in May, 2013. Shentan’s research interests focus on theoretical studies on the electronic structure and reactivity of transition metal complexes with applications to energies, electrochemistry, catalysis and materials.

Guangbin Dong - University of Texas at AustinDr. Guangbin Dong received his B.S. degree from Peking University and completed his Ph.D. degree in Chemistry from Stanford University with Prof. Barry M. Trost. In 2009, He joined the group of Prof. Robert H. Grubbs at California Institute of Technology, as a postdoctoral researcher. His expertise is in the field of organic synthesis, catalysis, organometallics and medicinal chemistry. His future research interests lie at the development of powerful chemical tools for addressing questions of biological importance.

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Jing He - NovartisJing He received her BS in chemistry from the University of Science and Technology of China in 2007. She conducted her graduate research at Boston College under the supervision of Prof. Marc Snapper, working on synthetic applications of iron-stabilized cyclobutadiene complex. In November 2012, with the receipt of a Presidential Postdoctoral Research Fellowship, she joined Novartis Institutes for BioMedical Research. She is currently working on late stage C-H functionalization of natural products and pharmaceuticals under the joint direction of Dr. Rohan E. J. Beckwith and Prof. Huw M. L. Davies (Emory University).

Marion Emmert - Worcester Polytechnic InstituteMarion H. Emmert received her Diploma at the University of Freiburg (Germany), where she carried out research in the laboratory of Bernhard Breit. She pursued her Ph.D. at the University of Münster (Germany) working with Gerhard Erker.Following postdoctoral work at the University of Michigan with Melanie Sanford as a DFG (German Research Foundation) and NSF CCI CENTC Postdoctoral Fellow, she joined the faculty at Worcester Polytechnic Institute (WPI) in 2011 as Assistant Professor of Chemistry, with a joint appointment in the WPI Department of Mechanical Engineering since 2012. Research in the Emmert group focuses on the development of new, sustainable processes. The group is developing transition-metal catalyzed C-H bond functionalizations and catalysts for aerobic oxidations at low oxygen concentrations.

Christopher Douglas - University of MinnesotaChristopher Douglas obtained a B. S. degree in 1999 from the University of Minnesota with research supervision from Richard P. Hsung. In 2005 he completed a Ph.D. working under the direction of Larry E. Overman at UC-Irvine. In 2005 Chris moved to Caltech as an NIH Postdoctoral Fellow to work with Robert Grubbs. In 2007, Chris joined the faculty at the University of Minnesota as an Assistant Professor. His independent research focuses on the development of new synthetic methods and on finding solutions to a variety of synthesis problems, with a particular emphasis on carbon-carbon sigma bond activation.

Jennifer Howell - University of Illinois at Urbana-ChampaignJennifer Howell received her B.S. in chemistry from the California State University at Chico in 2006. She conducted her graduate research at Colorado State University under the supervision of Prof. John Wood, completing in 2012. In 2012, she joined the group of Christina White as Postdoctoral Fellow at the University of Illinois-Urbana Champaign.

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László Kürti - University of Texas - SouthWesternLászló Kürti received his Diploma from Lajos Kossuth University with Professor Sándor Antus and his masters at the University of Missouri-Columbia, with Professor Michael Harmata. He received his Ph.D. (2006) with Professor Amos B. Smith III at the University of Pennsylvania. In 2006 he undertook postdoctoral studies in the group of E. J. Corey at Harvard. In September 2010, László joined the faculty at UT Southwestern Medical Center, Dallas Tx as an Assistant Professor in the Department of Biochemistry.The Kürti group focuses on the development of powerful new methods for the expedient enantioselective assembly of highly functionalized biaryls, heterocycles and carbocycles.

Dipannita Kalyani - St Olaf’s CollegeDipannita Kalyani obtained an A. B. degree in 2003 from Bryn Mawr College, an M. A. from Bryn Mawr College in 2003, and a Ph.D. working under the direction of Melanie S. Sanford at the University of Michigan, Ann Arbor in 2008. In 2009 Dipannita moved to the University of Illinois at Urbana Champaign as Postdoctoral Fellow to work with Scott Denmark. In 2011, Dipannita returned to the Sanford group as a postdoc. In 2011 Dipannita joined the faculty at St. Olaf College as an Assistant Professor. Her independent research efforts center around the development of new methods for the construction of C-C bonds using transition metal catalysts. Specifically interest focuses on the development of methods for the palladium (and nickel) catalyzed arylation and alkylation of C-H bonds.

Nusrah Hussain - University of Pennsylvania Nusrah Hussain obtained a B.A. in Chemistry as a Distinguished Scientist Scholar from Bard College in 2009. Currently, she is a fifth year graduate student in Patrick Walsh group at University of Pennsylvania. During the past four years, the focus of her graduate research at Penn comprises new reaction development with particular emphasis on chemoselectivity, regioselectivity and metal-catalyzed reactions.

Carolyn Ladd - University of MontrealA native Albertan, Carolyn Ladd obtained her B.Sc. in Chemistry from the University of Calgary in 2011. She then moved across the country to pursue her M.Sc. in the Charette Group at the Université de Montréal. After a rewarding M.Sc, she decided to continue her graduate studies, and is currently a 1st year Ph.D student under the supervision of André B. Charette. Her research interests include C–H functionalization, cyclopropanes, green chemistry and catalysis.

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Yong Lian - Florida International UniversityYong Liang was born in Beijing, China, in 1985. He received his B.S. and M.S. in Organic Chemistry at the Shaanxi Normal University in 2007 and 2010 respectively, where he carried out graduate research on the base promoted cyclization of isoflavone with 3-amino-5-hydroxypyrazole under the guidance of Dr. Zunting Zhang. In 2010, he began his Ph.D. studies at the Florida International University, joining the research group of Professor Stanislaw Wnuk. This doctoral research focused on developing of novel approaches for the synthesis of carbon-5 modified pyrimidine nucleosides. His interests include novel synthetic method development, palladium-catalyzed carbon-carbon bond formation for synthesis of biologically active molecules, and organogermanium chemistry.

Jared Lewis - University of ChicagoJared Lewis obtained a B. S. degree in 2002 from the University of Illinois at Urbana Champaign. In 2007 he completed a Ph.D. working under the direction of Jonathan Ellman and Robert Bergman at UC-Berkeley. In 2007 Jared moved to Caltech as an NIH Postdoctoral Fellow to work with Frances H. Arnold. In 2011, Jared joined the faculty at the University of Chicago as an Assistant Professor. His independent research focuses on the development of new catalysts for a variety of key chemical transformations. Small molecule transition metal catalysts, enzymes, and artificial metalloenzymes are being explored toward this end and comprise the three major areas of emphasis within the group.

Hon Lam - University of NottinghamHon Wai Lam obtained an MChem degree in chemistry in 1998 from the University of Oxford, and a PhD degree from the University of Nottingham in 2001, working under the direction of Gerald Pattenden. In January 2002, Hon moved to Harvard University as a GlaxoSmithKline Postdoctoral Fellow to work with David A. Evans. In October 2003, Hon joined the School of Chemistry at the University of Edinburgh as a Lecturer, where he started his independent research around the development of new synthetic methodology, enantioselective catalysis, and natural product synthesis. Hon was promoted to Senior Lecturer in 2009, and to Reader in 2012. Hon took up the GSK Chair of Sustainable Chemistry at the School of Chemistry, University of Nottingham in October 2013.”

Hasnain Malik - NovartisHasnain A. Malik his B.S. degree from Lehigh University in 2005, where he conducted his undergraduate research with Prof. Ned D. Heindel. In 2010 he earned his Ph.D. from the University of Michigan, Ann Arbor under the direction of Prof. John Montgomery, working on strategies for regio- and enantiocontrol in Ni-catalyzed reductive couplings. Following a year as a Postdoctoral Fellow with Prof. Mark Lautens at the University of Toronto, he moved to the Department of Global Discovery Chemistry at the Novartis Institutes for BioMedical Research, Inc. (NIBRI) in Cambridge, Massachusetts. As a Presidential Postdoctoral Fellow in NIBRI, he has worked with Dr. Andrew W. Patterson, Dr. Lawrence G. Hamann, Professor K. N. Houk, and Professor J. Du Bois on a collaborative industrial–academic study toward solving challenges in C–H functionalization in the pharmaceutical setting. Hasnain will join NIBRI as a Research Investigator in April, 2014.

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Matthew Richers - RutgersMatthew T. Richers obtained his B.Sc. in chemistry at The College of New Jersey in 2009. Currently, he is pursuing a Ph.D. in organic chemistry at Rutgers University in the laboratory of Prof. Daniel Seidel. His research focuses on developing methodologies for redox-neutral amine alpha-functionalization.

Mo Movassaghi - Massachusetts Institute of TechnologyMohammad Movassaghi (Mo) carried out his undergraduate research with Prof. Paul A. Bartlett at UC-Berkeley completing with honors in 1995. Mo began his graduate studies in organic chemistry in 1995 at Caltech with Prof. Andrew G. Myers, moved to Harvard University with Prof. Myers in 1998, and completed his PhD studies in 2001 as a Roche Predoctoral Fellow. He then joined Prof. Eric N. Jacobsen’s group at Harvard University as a Damon Runyon–Walter Winchell Foundation postdoctoral fellow. In 2003, Mo joined the faculty at MIT where his research group focuses on the total synthesis of complex alkaloids in concert with the discovery and development of new reactions for organic synthesis.

Neal Mankad - University of Illinois at ChicagoNeal P. Mankad was an undergraduate at MIT (S.B. 2004) and performed research with Prof. Joseph P. Sadighi, focusing on copper(I) alkyl and hydride complexes supported by N-heterocyclic carbene ligands. Neal then performed graduate work as an NSF Graduate Research Fellow at Caltech (Ph.D. 2010) under the supervision of Prof. Jonas C. Peters, studying N2 activation by iron complexes as well as multielectron redox chemistry of copper complexes. After serving as an NIH postdoctoral fellow (2010-2012) in the laboratories of Prof. F. Dean Toste at UC-Berkeley studying multielectron redox chemistry of catalytically relevant gold complexes, Neal began his independent career as an assistant professor at UIC in 2012.

Jennifer Schomaker - University of WisconsinJennifer began her research career at Dow Chemical in the Organic Chemicals and Polymer Lab and later moved to Agricultural Chemicals Process Research where she participated in the route selection and scale-up campaigns for two new herbicides. She obtained her Ph.D. with Professor Babak Borhan at Michigan State University in 2006, then moved to Berkeley as an NIH postdoctoral fellow in the labs of Professor Robert G. Bergman and F. Dean Toste. She joined the faculty at UW-Madison in 2009, where her research focuses on catalyst-controlled chemoselectivity, new reactivity for first-row transition metals and the application of allene aziridination to the synthesis of complex molecules.

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Buck Taylor - UCLABuck Taylor is an NIH Postdoctoral Fellow at UCLA, where he works with Prof. Kendall N. Houk to study organometallic reaction mechanisms using compu-tational methods. His research focuses on Pd-catalyzed C–H functionalization and Ru-catalyzed olefin metathesis reactions. In 2012 he completed his Ph.D. at UC Irvine, where he worked with Prof. Elizabeth Jarvo on the development of Ni-catalyzed stereospecific cross-coupling methods. Buck is a native of Port-land and received his B.A. from Willamette University, where he conducted research with Prof. Sarah Kirk.

Thomas Strassner - TU DresdenThomas Strassner obtained his PhD with P.v.R. Schleyer at the FAU Erlangen-Nürnberg in 1994. After a lectureship at the TU Dresden (1995/96) he was a postdoctoral research associate with Ken Houk at the UCLA (1997/98). He was appointed as an Associate Professor at the TU Dresden in 2004. Research in his group is based upon synthetic organometallic chemistry, in particular the synthesis of late–transition metal NHC complexes. Topics include research on catalytic CC coupling reactions and on the activation and functionalization of C-H (alkanes like methane or propane) and Si-H bonds (hydrosilylation). His recent interests include catalysis in new ionic liquids and the photophysical properties of metal-organic complexes for use in OLEDs. Computational methods are employed to understand the electronic structure and reactivity of the metal-organic compounds as well as the reaction mechanisms involved in catalytic reactions.

Colleen Scott - Southern Illinois UniversityColleen Scott received her Bachelor degree in Chemistry (cum laude) in 1998 from Auburn University. She went on to obtain her Ph.D. in 2005 from the University of Pittsburgh, under the guidance of Dr. Craig Wilcox. Her thesis focused on the development of methods for the synthesis of organic and supramolecular compounds. Dr. Scott took a position as a Post-Doctoral Assistant at Southern Illinois University where she remains. In 2010, she was hired as an Assistant Professor in the Department of Chemistry and Biochemistry. Dr. Scott’s research focuses on the design and synthesis of organic small molecules and polymeric materials with desired properties and functions for application in the technological advancement of the biomedical field.

Peter Zhang - University of South FloridaPeter Zhang obtained a B. S. degree in 1985 from Anhui Normal University and his M.S. in 1988 from Beijing Normal University. In 1996 he completed a Ph.D. working under the direction of B. B. Wayland at the University of Pennsylvania. In 1996 Peter moved to MIT as a Postdoctoral Fellow under the direction of Stephan Lippard. In 1999 Peter joined the group of Stephan Buchwald as a Postdoctoral Fellow. In 2001, Peter joined the faculty at University of Tennessee as an Assistant Professor. In 2006 Peter joined the faculty of the University of South Florida as an Associate Professor and has risen through the ranks to become a Professor in Chemistry.His independent research focuses on developing 1e catalytic approaches to harness the vast potential of radical reactions for stereoselective construction of molecular structures.

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