advanced synthetic reaction

8/10/2019 Advanced Synthetic Reaction

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https://en.wikipedia.org/wiki/Sulfuric_acidhttps://en.wikipedia.org/wiki/Triphenyl_phosphinehttps://en.wikipedia.org/wiki/Boronhttps://en.wikipedia.org/wiki/Zinchttps://en.wikipedia.org/wiki/Tinhttps://en.wikipedia.org/wiki/Triflatehttps://en.wikipedia.org/wiki/Iodidehttps://en.wikipedia.org/wiki/Bromidehttps://en.wikipedia.org/wiki/Leaving_grouphttps://en.wikipedia.org/wiki/Organopalladiumhttps://en.wikipedia.org/wiki/Functional_grouphttps://en.wikipedia.org/wiki/Tetrakis(triphenylphosphine)palladium(0)https://en.wikipedia.org/wiki/Palladiumhttps://en.wikipedia.org/wiki/Beta-hydride_eliminationhttps://en.wikipedia.org/wiki/Reductive_eliminationhttps://en.wikipedia.org/wiki/Transmetallationhttps://en.wikipedia.org/wiki/Oxidative_additionhttps://en.wikipedia.org/wiki/Reaction_mechanismhttps://en.wikipedia.org/wiki/Biphenylhttps://en.wikipedia.org/wiki/Iodobenzenehttps://en.wikipedia.org/wiki/Styrenehttps://en.wikipedia.org/wiki/Vinyl_chloridehttps://en.wikipedia.org/wiki/Bromobenzenehttps://en.wikipedia.org/wiki/Carbon-carbon_bondhttps://en.wikipedia.org/wiki/Organometallic_compoundhttps://en.wikipedia.org/wiki/Catalysthttps://en.wikipedia.org/wiki/Hydrocarbonhttps://en.wikipedia.org/wiki/Organic_chemistry


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https://en.wikipedia.org/wiki/Stille_cross_couplinghttps://en.wikipedia.org/wiki/Negishi_couplinghttps://en.wikipedia.org/wiki/Sonogashira_couplinghttps://en.wikipedia.org/wiki/Heck_reactionhttps://en.wikipedia.org/wiki/Kumada_couplinghttps://en.wikipedia.org/w/index.php?title=Cassar_reaction&action=edit&redlink=1https://en.wikipedia.org/wiki/Gilman_reagenthttps://en.wikipedia.org/wiki/Castro-Stephens_couplinghttps://en.wikipedia.org/wiki/Cadiot-Chodkiewicz_couplinghttps://en.wikipedia.org/wiki/Gomberg-Bachmann_reactionhttps://en.wikipedia.org/wiki/Ullmann_reactionhttps://en.wikipedia.org/wiki/Glaser_couplinghttps://en.wikipedia.org/wiki/Wurtz_reactionhttp://www.qlabtech.com/https://en.wikipedia.org/wiki/Palladiumhttps://en.wikipedia.org/wiki/Nickelhttps://en.wikipedia.org/wiki/Oxygen


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http://en.wikipedia.org/wiki/File:Suzuki_Reaction_Scheme.pnghttps://en.wikipedia.org/wiki/File:Fagnou_fluoroarene_coupling.pnghttp://en.wikipedia.org/wiki/File:Suzuki_Reaction_Scheme.pnghttps://en.wikipedia.org/wiki/File:Fagnou_fluoroarene_coupling.pnghttp://en.wikipedia.org/wiki/Tetrakis(triphenylphosphine)palladium(0)http://en.wikipedia.org/wiki/Catalysthttp://en.wikipedia.org/wiki/Palladiumhttp://en.wikipedia.org/wiki/Coupling_reactionhttp://en.wikipedia.org/wiki/Organotrifluoroboratehttp://en.wikipedia.org/wiki/Boronic_esterhttp://en.wikipedia.org/wiki/Boronic_esterhttp://en.wikipedia.org/wiki/Halideshttp://en.wikipedia.org/wiki/Triflatehttp://en.wikipedia.org/wiki/Pseudohalidehttp://en.wikipedia.org/wiki/Biphenylhttp://en.wikipedia.org/wiki/Styrenehttp://en.wikipedia.org/wiki/Olefinhttp://en.wikipedia.org/wiki/Organic_synthesishttp://en.wikipedia.org/wiki/Nanomaterial-based_catalysthttp://en.wikipedia.org/wiki/Palladiumhttp://en.wikipedia.org/wiki/Halidehttp://en.wikipedia.org/wiki/Vinylhttp://en.wikipedia.org/wiki/Arylhttp://en.wikipedia.org/wiki/Boronic_acidhttp://en.wikipedia.org/wiki/Vinylhttp://en.wikipedia.org/wiki/Arylhttp://en.wikipedia.org/wiki/Organic_reactionhttps://en.wikipedia.org/wiki/Coupling_reaction#cite_note-17https://en.wikipedia.org/wiki/Electron_deficiencyhttps://en.wikipedia.org/wiki/Carbon-hydrogen_bond_activationhttps://en.wikipedia.org/wiki/Keith_Fagnouhttps://en.wikipedia.org/wiki/Halogenoarenehttps://en.wikipedia.org/wiki/CuTChttps://en.wikipedia.org/wiki/Liebeskind%E2%80%93Srogl_couplinghttps://en.wikipedia.org/wiki/Liebeskind%E2%80%93Srogl_couplinghttps://en.wikipedia.org/wiki/Fukuyama_couplinghttps://en.wikipedia.org/wiki/Buchwald-Hartwig_reactionhttps://en.wikipedia.org/wiki/Buchwald-Hartwig_reactionhttps://en.wikipedia.org/wiki/Hiyama_couplinghttps://en.wikipedia.org/wiki/Suzuki_reaction


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http://en.wikipedia.org/wiki/File:Heck_Reaction_Mechanism.svghttp://en.wikipedia.org/wiki/File:Heck_Dieck_1974.svghttp://en.wikipedia.org/wiki/File:Heck_Reaction_Mechanism.svghttp://en.wikipedia.org/wiki/File:Heck_Dieck_1974.svghttp://en.wikipedia.org/wiki/Stille_reactionhttp://en.wikipedia.org/wiki/Boronic_acidhttp://en.wikipedia.org/wiki/Suzuki_couplinghttp://en.wikipedia.org/wiki/Alkynehttp://en.wikipedia.org/wiki/Sonogashira_couplinghttp://en.wikipedia.org/wiki/Wacker_processhttp://en.wikipedia.org/wiki/Potassium_carbonatehttp://en.wikipedia.org/wiki/Reductive_eliminationhttp://en.wikipedia.org/wiki/Reductive_eliminationhttp://en.wikipedia.org/wiki/%CE%A0_complexhttp://en.wikipedia.org/wiki/Beta-hydride_eliminationhttp://en.wikipedia.org/wiki/Torsional_strainhttp://en.wikipedia.org/wiki/Syn_additionhttp://en.wikipedia.org/wiki/%CE%A0_complexhttp://en.wikipedia.org/wiki/Oxidative_additionhttp://en.wikipedia.org/wiki/Triphenylphosphinehttp://en.wikipedia.org/wiki/Palladium(II)_acetatehttp://en.wikipedia.org/wiki/In_situhttp://en.wikipedia.org/wiki/Catalytic_cycle


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http://en.wikipedia.org/wiki/File:StillereactionGeneralScheme.pnghttp://en.wikipedia.org/wiki/File:Heck_amino.svghttp://en.wikipedia.org/wiki/File:StillereactionGeneralScheme.pnghttp://en.wikipedia.org/wiki/File:Heck_amino.svghttp://en.wikipedia.org/wiki/Reductive_eliminationhttp://en.wikipedia.org/wiki/Transmetalationhttp://en.wikipedia.org/wiki/Oxidative_additionhttp://en.wikipedia.org/wiki/Palladiumhttp://en.wikipedia.org/wiki/Organic_reductionhttp://en.wikipedia.org/wiki/Catalytic_cyclehttp://en.wikipedia.org/wiki/Reaction_mechanismhttp://en.wikipedia.org/wiki/Organotinhttp://en.wikipedia.org/wiki/Oxidationhttp://en.wikipedia.org/wiki/Solventhttp://en.wikipedia.org/wiki/Dehydrationhttp://en.wikipedia.org/wiki/Air-free_techniquehttp://en.wikipedia.org/wiki/Oxygenhttp://en.wikipedia.org/wiki/Sulfurhttp://en.wikipedia.org/wiki/Fluorinehttp://en.wikipedia.org/wiki/Carbonhttp://en.wikipedia.org/wiki/Triflatehttp://en.wikipedia.org/wiki/Pseudohalidehttp://en.wikipedia.org/wiki/Iodinehttp://en.wikipedia.org/wiki/Brominehttp://en.wikipedia.org/wiki/Chlorinehttp://en.wikipedia.org/wiki/Halidehttp://en.wikipedia.org/wiki/Organic_chemistryhttp://en.wikipedia.org/wiki/Palladiumhttp://en.wikipedia.org/wiki/Halidehttp://en.wikipedia.org/wiki/Organotin_compoundhttp://en.wikipedia.org/wiki/Organotin_compoundhttp://en.wikipedia.org/wiki/Chemical_reaction


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http://en.wikipedia.org/wiki/File:Stille_Reaction_Mechanism.pnghttp://en.wikipedia.org/wiki/Triphenylarsinehttp://en.wikipedia.org/wiki/Tris(dibenzylideneacetone)dipalladium(0)http://en.wikipedia.org/wiki/Ammonium_chloridehttp://en.wikipedia.org/wiki/Ammonium_chloridehttp://en.wikipedia.org/wiki/Ureahttp://en.wikipedia.org/wiki/Mannitolhttp://en.wikipedia.org/wiki/Green_chemistryhttp://en.wikipedia.org/wiki/Palladium-on-carbonhttp://en.wikipedia.org/wiki/Donor_numberhttp://en.wikipedia.org/wiki/Manganesehttp://en.wikipedia.org/wiki/Copperhttp://en.wikipedia.org/wiki/Lithium_chloridehttp://en.wikipedia.org/wiki/Dioxanehttp://en.wikipedia.org/wiki/Dimethylformamidehttp://en.wikipedia.org/wiki/HMPT


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http://en.wikipedia.org/wiki/File:Sonogashira_Cross-Coupling_Reaction.svghttp://en.wikipedia.org/wiki/File:StilleCouplingGreenish.pnghttp://en.wikipedia.org/wiki/File:Sonogashira_Cross-Coupling_Reaction.svghttp://en.wikipedia.org/wiki/File:StilleCouplingGreenish.pnghttp://en.wikipedia.org/wiki/Attention_deficit_hyperactivity_disorderhttp://en.wikipedia.org/wiki/Schizophreniahttp://en.wikipedia.org/wiki/Tourette_syndromehttp://en.wikipedia.org/wiki/Tourette_syndromehttp://en.wikipedia.org/wiki/Alzheimer%27s_diseasehttp://en.wikipedia.org/wiki/Parkinson%27s_diseasehttp://en.wikipedia.org/wiki/Altiniclinehttp://en.wikipedia.org/wiki/Tazarotenehttp://en.wikipedia.org/wiki/Sonogashira_couplinghttp://en.wikipedia.org/wiki/Sonogashira_coupling#cite_note-Development-1http://en.wikipedia.org/wiki/Vinyl_halidehttp://en.wikipedia.org/wiki/Arylhttp://en.wikipedia.org/wiki/Alkynehttp://en.wikipedia.org/wiki/Catalysthttp://en.wikipedia.org/wiki/Palladiumhttp://en.wikipedia.org/wiki/Carbon%E2%80%93carbon_bondhttp://en.wikipedia.org/wiki/Organic_synthesishttp://en.wikipedia.org/wiki/Cross-coupling_reaction


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http://en.wikipedia.org/wiki/File:Sonogashira_Mechanism_english_V.1.pnghttp://en.wikipedia.org/wiki/Reductive_eliminationhttp://en.wikipedia.org/wiki/Trans-cis_isomerizationhttp://en.wikipedia.org/wiki/Acetylidehttp://en.wikipedia.org/wiki/Transmetallationhttp://en.wikipedia.org/wiki/Rate-limiting_stephttp://en.wikipedia.org/wiki/Oxidative_additionhttp://en.wikipedia.org/wiki/Vinylhttp://en.wikipedia.org/wiki/Arylhttp://en.wikipedia.org/wiki/Reaction_mechanism


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http://en.wikipedia.org/wiki/File:Reactivity_in_Sonogashira_Cross-Coupling.svghttp://en.wikipedia.org/wiki/Solventhttp://en.wikipedia.org/wiki/Diethylaminehttp://en.wikipedia.org/wiki/Triethylaminehttp://en.wikipedia.org/wiki/Aminehttp://en.wikipedia.org/wiki/Diethylaminehttp://en.wikipedia.org/wiki/Bis(triphenylphosphine)palladium(II)_chloridehttp://en.wikipedia.org/wiki/In_situhttp://en.wikipedia.org/wiki/Triphenylphosphine_oxidehttp://en.wikipedia.org/wiki/Triphenylphosphine_oxidehttp://en.wikipedia.org/wiki/Triphenylphosphinehttp://en.wikipedia.org/wiki/Phosphinehttp://en.wikipedia.org/wiki/Aminehttp://en.wikipedia.org/wiki/Pre-catalysthttp://en.wikipedia.org/wiki/Dppfhttp://en.wikipedia.org/wiki/Dppphttp://en.wikipedia.org/wiki/Dppehttp://en.wikipedia.org/wiki/Ligandhttp://en.wikipedia.org/wiki/Bidentatehttp://en.wikipedia.org/wiki/Ligandhttp://en.wikipedia.org/wiki/Zerovalent


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http://en.wikipedia.org/wiki/File:Copperfree1.tifhttp://en.wikipedia.org/wiki/Sonogashira_coupling#cite_note-Recent_Advances-4http://en.wikipedia.org/wiki/Sonogashira_coupling#cite_note-Copper-free-8http://en.wikipedia.org/wiki/Sonogashira_coupling#cite_note-Copper-free-8http://en.wikipedia.org/wiki/Inerthttp://en.wikipedia.org/wiki/Oxidationhttp://en.wikipedia.org/wiki/Glaser_couplinghttp://en.wikipedia.org/wiki/Sonogashira_coupling#cite_note-11


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http://en.wikipedia.org/wiki/File:Hartwig1.pnghttp://en.wikipedia.org/wiki/File:Buchwaldhartwig.pnghttp://en.wikipedia.org/wiki/File:Application_of_Sonogashira.svghttp://en.wikipedia.org/wiki/File:Hartwig1.pnghttp://en.wikipedia.org/wiki/File:Buchwaldhartwig.pnghttp://en.wikipedia.org/wiki/File:Application_of_Sonogashira.svghttp://en.wikipedia.org/wiki/File:Hartwig1.pnghttp://en.wikipedia.org/wiki/File:Buchwaldhartwig.pnghttp://en.wikipedia.org/wiki/File:Application_of_Sonogashira.svghttp://en.wikipedia.org/wiki/Anilinehttp://en.wikipedia.org/wiki/Secondary_aminehttp://en.wikipedia.org/wiki/Diethylaminehttp://en.wikipedia.org/wiki/Argonhttp://en.wikipedia.org/wiki/Metathesishttp://en.wikipedia.org/wiki/Oxidative_additionhttp://en.wikipedia.org/wiki/Organic_redox_reactionhttp://en.wikipedia.org/wiki/D_orbitalhttp://en.wikipedia.org/wiki/Total_synthesishttp://en.wikipedia.org/wiki/Natural_producthttp://en.wikipedia.org/wiki/Nucleophilic_aromatic_substitutionhttp://en.wikipedia.org/wiki/Goldberg_reactionhttp://en.wikipedia.org/wiki/Reductive_aminationhttp://en.wikipedia.org/wiki/Nucleophilic_substitutionhttp://en.wikipedia.org/wiki/Nucleophilic_substitutionhttp://en.wikipedia.org/wiki/Palladium-catalyzed_coupling_reactionshttp://en.wikipedia.org/wiki/Catalysishttp://en.wikipedia.org/wiki/Palladiumhttp://en.wikipedia.org/wiki/Carbon%E2%80%93nitrogen_bondhttp://en.wikipedia.org/wiki/Organic_chemistryhttp://en.wikipedia.org/wiki/Chemical_reaction


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http://en.wikipedia.org/wiki/File:BHASecondgenchiral.pnghttp://en.wikipedia.org/wiki/File:BHASecondgenexamples.pnghttp://en.wikipedia.org/wiki/File:BHAFirstgenexamples.pnghttp://en.wikipedia.org/wiki/File:BHASecondgenchiral.pnghttp://en.wikipedia.org/wiki/File:BHASecondgenexamples.pnghttp://en.wikipedia.org/wiki/File:BHAFirstgenexamples.pnghttp://en.wikipedia.org/wiki/File:BHASecondgenchiral.pnghttp://en.wikipedia.org/wiki/File:BHASecondgenexamples.pnghttp://en.wikipedia.org/wiki/File:BHAFirstgenexamples.pnghttp://en.wikipedia.org/wiki/Buchwald%E2%80%93Hartwig_amination#cite_note-Buchwald_5-24http://en.wikipedia.org/wiki/Chelate_effecthttp://en.wikipedia.org/wiki/1,1%27-Bis(diphenylphosphino)ferrocenehttp://en.wikipedia.org/wiki/BINAP


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http://en.wikipedia.org/wiki/File:BHAHetarylamide.pnghttp://en.wikipedia.org/wiki/File:BHAThirdgenscope.pnghttp://en.wikipedia.org/wiki/File:BHAHetarylamide.pnghttp://en.wikipedia.org/wiki/File:BHAThirdgenscope.pnghttp://en.wikipedia.org/wiki/Ammoniahttp://en.wikipedia.org/wiki/Ferrocenehttp://en.wikipedia.org/wiki/Biphenylhttp://en.wikipedia.org/wiki/Phosphatehttp://en.wikipedia.org/wiki/Carbonatehttp://en.wikipedia.org/wiki/Hydroxide


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http://en.wikipedia.org/wiki/File:BHAether.pnghttp://en.wikipedia.org/wiki/File:BHAammonia.pnghttp://en.wikipedia.org/wiki/File:BHAether.pnghttp://en.wikipedia.org/wiki/File:BHAammonia.pnghttp://en.wikipedia.org/wiki/Ullmann_condensationhttp://en.wikipedia.org/wiki/Etherhttp://en.wikipedia.org/wiki/Alcoholhttp://en.wikipedia.org/wiki/Buchwald%E2%80%93Hartwig_amination#cite_note-Buchwaldsilyl-35http://en.wikipedia.org/wiki/Buchwald%E2%80%93Hartwig_amination#cite_note-benzophenoneimine-33http://en.wikipedia.org/wiki/Buchwald%E2%80%93Hartwig_amination#cite_note-benzophenoneimine-33http://en.wikipedia.org/wiki/Anilinehttp://en.wikipedia.org/wiki/Iminehttp://en.wikipedia.org/wiki/Benzophenone


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http://en.wikipedia.org/wiki/File:Kumada_General_Mechanism.pnghttp://en.wikipedia.org/wiki/File:BHAenolates.pnghttp://en.wikipedia.org/wiki/File:Kumada_General_Mechanism.pnghttp://en.wikipedia.org/wiki/File:BHAenolates.pnghttp://en.wikipedia.org/wiki/Vinylhttp://en.wikipedia.org/wiki/Arylhttp://en.wikipedia.org/wiki/Alkylhttp://en.wikipedia.org/wiki/Catalystshttp://en.wikipedia.org/wiki/Transition_metalhttp://en.wikipedia.org/wiki/Grignard_reagenthttp://en.wikipedia.org/wiki/Carbon%E2%80%93carbon_bondhttp://en.wikipedia.org/wiki/Cross_coupling_reactionhttp://en.wikipedia.org/wiki/Organic_chemistryhttp://en.wikipedia.org/wiki/Nickelhttp://en.wikipedia.org/wiki/Copper


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