advanced squamous cell carcinoma of the lung is the time now?
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Advanced Squamous Cell Carcinoma of the Lung Is the Time Now?. Program Goals. Introduction. Parsing Lung Cancer to Optimize Patient Management. Recommendations From NCCN NSCLC Guidelines. Recommendations From NCCN NSCLC Guidelines (cont). - PowerPoint PPT PresentationTRANSCRIPT
Advanced Squamous Cell Carcinoma of the Lung
Is the Time Now?
Program Goals
Introduction
Parsing Lung Cancer to Optimize Patient Management
Recommendations From NCCN NSCLC Guidelines
Recommendations From NCCN NSCLC Guidelines (cont)
Nab-paclitaxel vs Solvent-based Paclitaxel in First-line
ChemotherapyEfficacy Results
Second-line Therapy Options Are Limited in Advanced NSCLC
Targetable Molecular Alterations in Nonsquamous Advanced NSCLC
Potential Targetable Molecular Alterations in Advanced NSCLC,
SCC
SWOG S1400: Lung-MAP Study
Antibody Therapy in Advanced NSCLC, Including SCC
REVELStudy Design
REVEL: PFS
REVELForest Plot of PFS by Histologic Subgroup
REVELForest Plot of OS by Histologic Subgroup
REVELBleeding-related AEs
Phase 3 Trials of Cetuximab in Advanced NSCLC
SQUIREStudy Design
SQUIREForest Plot of OS by Subgroup
SQUIREExploratory Analysis of EGFR H-Score
SQUIRE: AEs
Role of CTLA-4 in the Immune Response
Role of PD-1/PD-L1 in the Immune Response
Immune System in Carcinogenesis
Ipilimumab + Chemotherapy in Advanced NSCLCDesign of Phase 2 Trial
Ipilimumab + Chemotherapy in Advanced NSCLC
Results
Ipilimumab + ChemotherapyHistology Subgroup Analysis
Phase 1 Study of Nivolumab in Heavily Pretreated Pts With
Advanced NSCLCHistology Subgroup Analysis
Recurrent NSCLC, SCC Single-agent Nivolumab Therapy
Relationship Between PD-L1 Tumor Status and Response to MK-3475
Pretreated Advanced NSCLC
Clinical Development of Some PD-1/PD-L1 Immune Checkpoint
Inhibitors
First-line MK 3475 in Advanced NSCLC
Study Design
First-line MK 3475 in Advanced NSCLC
Efficacy Results
ASCO PerspectiveDefining Clinically Meaningful Outcomes in Lung
Cancer Clinical Trials
Summary: Advanced NSCLC, SCC
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