adult neurogenesis in the female mouse hypothalamus ... · pdf filetvx ,pdjhvuhvxowlqjiurph...
TRANSCRIPT
Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreadingprocess.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in anymedium provided that the original work is properly attributed.
Copyright © 2016 the authors
This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version.
Research Article: New Research | Integrative Systems
Adult neurogenesis in the female mouse hypothalamus: Estradiol and high fat dietalter the generation of newborn neurons expressing estrogen receptor #
Estradiol and diet alter generation of new ER# neurons in adult female hypothalamus
Elizabeth P. Bless1, Jane Yang1, Kalpana D. Acharya1, Sabin A. Nettles1, Fair M. Vassoler2, Elizabeth M. Byrnes2
and Marc J. Tetel1
1Neuroscience Program, Wellesley College, Wellesley, MA 02481, USA2Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, Grafton, MA01536, USA
DOI: 10.1523/ENEURO.0027-16.2016
Received: 11 February 2016
Revised: 22 August 2016
Accepted: 23 August 2016
Published: 29 August 2016
Author Contributions: EPB, EMB and MJT designed research; EPB, JY, KDA, SAN and FMV performedresearch; EPB, KDA, SAN, FMV, EMB and MJT analyzed data; EPB, EMB and MJT wrote the paper
Funding: NIDDKR01 DK61935
Funding: NIDDKRe-entry Award
Conflict of Interest: Authors report no conflict of interest.
Correspondence should be addressed to Marc J. Tetel, Neuroscience Program, Wellesley College, 106Central Street, Wellesley, MA 02481. E-mail: [email protected]
Cite as: eNeuro 2016; 10.1523/ENEURO.0027-16.2016
Alerts: Sign up at eneuro.org/alerts to receive customized email alerts when the fully formatted version of thisarticle is published.
α
α α
α
α
Fgf10
Fgf10
e.g.
e.g.
α α
α
α
α
α
α
α
α
α
α
μ
μ μ μ
μ μ
μ
α
Δ
Δ Δ
ΔΔ
t
α
α
α
α
α
α
α
α
α α
α
α
α
α
α
α
α
Fgf10
Fgf10
Bcl2,
BDNF, capsase3, CNTF IkappaB
α
α
α
α
α
α
α
α
α
α
α
α
α α
α
α
α
e.g.
α
α
Fgf10
Fgf10
Fgf10
α α
α
α
α
α
α
α
α
α
α
α
α
Fgf10
α 97
1
Data Structure Type of Test p values a Normally distributed ANOVA 0.022 b Normally distributed ANOVA 0.002 c Normally distributed ANOVA 0.001 d Normally distributed ANOVA 0.002 e Normally distributed ANOVA 0.003 f Normally distributed ANOVA 0.003 g Normally distributed Tukey’s HSD post hoc 0.026 h Normally distributed Tukey’s HSD post hoc 0.021 i Normally distributed Tukey’s HSD post hoc 0.001 j Normally distributed ANOVA 0.02 k Normally distributed ANOVA 0.019 l Normally distributed ANOVA 0.044 m Normally distributed Tukey’s HSD post hoc 0.11 n Normally distributed Tukey’s HSD post hoc 0.15 o Normally distributed Tukey’s HSD post hoc 0.15 p Normally distributed Tukey’s HSD post hoc 0.11 q Normally distributed ANOVA 0.023 r Normally distributed ANOVA 0.014 s Normally distributed ANOVA 0.04 t Normally distributed Tukey’s HSD post hoc 0.152 u Normally distributed Tukey’s HSD post hoc 0.14 v Normally distributed Tukey’s HSD post hoc 0.145 w Normally distributed Tukey’s HSD post hoc 0.096 x Normally distributed ANOVA 0.043 y Normally distributed ANOVA 0.054 z Normally distributed ANOVA 0.048 aa Normally distributed ANOVA <0.001 bb Normally distributed Tukey’s HSD post hoc 0.014 cc Normally distributed Tukey’s HSD post hoc 0.002 dd Normally distributed Tukey’s HSD post hoc <0.001 ee Normally distributed Tukey’s HSD post hoc 0.02 ff Normally distributed Tukey’s HSD post hoc <0.001 gg Normally distributed Student’s t-test 0.027