adprt reaction
DESCRIPTION
ADPRT Reaction. NAD +. eEF2 diphthamide residue. nicotinamide. ADP-ribosylated eEF2 diphthamide residue. ADPRT Reaction. O. O. CH. 3. O. CH. N. CH. 3. NH. 3. H. N. +. 2. 2. CH. ADP-ribosyl-eEF-2. CH. N. 3. +. 3. H. N. +. N. 2. CH. CH. 3. 2. CH. H. O. 2. O. - PowerPoint PPT PresentationTRANSCRIPT
ADPRT Reaction
+
:N N
CH2 CH NH C
O
CH2 CH2 CH C O NH2
N(CH3)3 O
N
NH2
O
OH HO
CH2 O P O P O O
O-
O
O- H2C O
OH HO
O
N
N N
N
H2N
+
+
N
NH2
O
O
OH HO
CH2 O P O P O O
O-
O
O- H2C O
OH HO
O
N
N N
N
H2N
N N
CH2 CH NH C
O
CH2 CH2 CH C O NH2
N(CH3)3 +
eEF2 diphthamide residueNAD+
nicotinamide
ADP-ribosylated eEF2 diphthamide residue
ADPRT Reaction
HO
-
-
-
O
ONH
NN(CH2)2
NH2H N
CH3CH3
CH3+COC+
NHNH2 NH
H
np
ck
ADP-Ribosylation of eEF-2 by ETAADP-Ribosylation of eEF-2 by ETA
ADP-ribosyl-eEF-2ADP-ribosyl-eEF-2
nicotinamidenicotinamide
N
O
NH2
OHOH
OHOH NH2
O
N
N N
NCH2
P O-O
O
O
O-O P
OCH2 O
+CH3
CH3
CH3O
H2NN
PROTEINCH2
N N
H
NADNAD++
eEF2eEF2
O
NH2
+
O
NCH2
O
P-O O
O
O
-O OP
CH2 O
N
N N
N
NH2OH
OH
OHOH
N N
CH2 PROTEIN
NH2N
O CH3
CH3
CH3+
:
H