adecade of progress - naspghan · pediatric gastroenterology, hepatology and nutrition is to:...

November 13–15, 2008

Sheraton San Diego Hotel & Marina San Diego, CA

SPECIAL SINGLE TOPIC SYMPOSIUM

THE GUT MICROBIOME IN DEVELOPMENT, HEALTH AND DISEASE

November 12, 2008

THE NASPGHAN–CDHNF PARTNERSHIP:A CLINICAL & SCIENTIFIC CONFERENCE

A Decade of Progress

REGISTRATION BROCHURE

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Dear Colleague:

We invite you to attend “The NASPGHAN–CDHNF Partnership: A Decade of Progress” meeting to be held at the beautiful SheratonSan Diego Hotel & Marina in San Diego, California from Thursday through Saturday November 13th–15th, 2008. The planning committee,including B Li, Brent Polk, Laurie Fishman, John Pohl, Steven Schwarz, Alan Leichtner and Karen Murray, has put together an outstandingprogram that will engage the interest of clinicians, academics, and trainees alike.

The meeting will be preceded by a special, NIH–funded, one day symposium entitled “The Gut Microbiome in Development, Healthand Disease” to be held on Wednesday, November 12th. A host of international experts in the field will review biologic and technologicadvances in the rapidly evolving field of the intestinal microbiome, how it is acquired in newborns, the mechanisms by which it interactswith the mucosal immune system, its relation to specific diseases (inflammatory bowel disease, obesity), and its modification by pre–,pro– and antibiotics. The intent of the symposium is to provide interested professionals (including young investigators and trainees)with a state–of–the–art overview of this exciting and rapidly involving discipline.

The NASPGHAN–CDHNF meeting will begin on Thursday, November 13th with a “Challenges in Nutrition” Postgraduate Course,focused entirely on pediatric nutrition. The five modules include: Parenteral Nutrition, Obesity and the Gastroenterologist, Vitaminand Minerals Potpourri, Allergy Prevention and Diet, and Enteral Feeding. The talks will be concise and will be followed by rapid–firequestions. Participants will have the option to purchase tickets to eight case-based “Learning Lunches”, a popular learning format ledby Postgraduate Course speakers.

The main portion of the NASPGHAN–CDHNF meeting begins the evening of Thursday, November 13th with a poster session and reception and concludes Saturday evening with a celebration dinner. An outstanding and diverse faculty has been assembled for theplenary session (CDHNF highlights, career vignettes, state-of-the-art, year-in-review formats), 5 research abstract oral presentationsand 3 poster sessions (covering basic science, clinical investigation, and clinical practice vignettes), 10 concurrent clinical modules, and new case-based Clinical Challenge Luncheons (with pre– and post– tests). The clinical modules have been redesigned to include a 30–minute case–based panel (and audience) discussion.

Indeed, this year’s NASPGHAN–CDHNF Partnership Meeting will be a fabulous event, sure to meet the multiple clinical, research andtraining needs of our diverse membership.

We look forward to seeing you in sunny San Diego!

Cordially,

John A. Barnard, MD William F. Balistreri, MD B Li, MDPresident, NASPGHAN President, CDHNF President-Elect, NASPGHANColumbus, Ohio Cincinnati, OH Milwaukee, Wisconsin

ORGANIZING COMMITTEEWilliam Balistreri, MD (CDHNF President) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CDHNF Anniversary

John Barnard, MD (NASPGHAN President) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Program Advisor

Laurie Fishman, MD (Chair, Professional Education Committee) . . . . . . . . . . . . . . . . . . . . NASPGHAN Postgraduate Course, Co-Director

Alan Leichtner, MD (Chair, Training Committee) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Teaching and Tomorrow Program

Ivor Hill, MD (NASPGHAN Secretary-Treasurer) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Meeting Budget

Nicola Jones, MD, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Single topic symposium, Co-Chair

B Li, MD (NASPGHAN President-Elect) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Program Committee Chair

Jenifer Lightdale, MD (Chair, Endoscopy Committee) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Video Learning Center

Karen Murray, MD (Chair, Professional Development Committee) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Professional Development Program

John Pohl, MD (Professional Education Committee) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . NASPGHAN Postgraduate Course, Co-Director

D. Brent Polk, MD (Chair, Research Committee) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Scientific Program

Steven Schwarz, MD (Chair, Clinical Care & Quality Committee) . . . Clinical Practice Forum, Clinical Vignette Posters, Billing & Coding

Philip Tarr, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Single topic symposium – Co-chair

Menno Verhave, MD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CDHNF Anniversary

NASPGHAN National Office . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Meeting oversight, logistics, planning

HOTEL INFORMATION

SHERATON SAN DIEGO HOTEL & MARINA–1380 Harbor Island DriveSan Diego, CA 92101

PHONE: 619-291-2900

FAX: 619-692-2337

HOTEL RESERVATIONS

HOTEL RESERVATION DEADLINE –

September 22, 2008

SINGLE/DOUBLE – $209.00Special NASPGHAN room rate. Applicable taxes will beadded. ( US rate subject to change based on currentexchange rates)

CHECK-IN TIME – 3:00 pm

CHECKOUT TIME – 12:00 noonTo obtain the special NASPGHAN room rates,register ONLINE via the NASPGHAN website.

www.naspghan.org

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http://www.naspghan.org

REGISTRATION

PRE-REGISTRATION DEADLINE –October 14, 2008

�Register by mail, fax or the Internet.

�Visit (www.naspghan.org) to register online.

�Alternately, mail or fax the registration form located on page 16 of this brochure to the NASPGHAN National Office.

�Meeting confirmations, tickets and badges will be mailed 3 weeks prior to the meeting.

�After October 14, all fees will increase by $50 per category.

MEETING OBJECTIVES AND CME INFORMATION

MISSION STATEMENT –

The education mission of the North American Society forPediatric Gastroenterology, Hepatology and Nutrition is to:

�Advance understanding of normal development, physiology and pathophysiology of diseases of the gastrointestinal tract, liver and nutrition in children.

�Improve professional competence, quality of care, and patient outcomes by disseminating knowledge through scientific meetings, professional and public education.

Our activities, education, and interventions will strive touse Adult Learning Methods (ALM) designed to improvecompetence, practice performance, and patient outcomes in measurable ways. These educational activities will betargeted to pediatric gastroenterologists, physicians withan expertise in pediatric gastroenterology, hepatology andnutrition, subspecialty fellows in pediatric gastroenterology,and nurses specializing in pediatric gastroenterology, hepatology and nutrition.

CME INFORMATION

NASPGHAN is accredited by the Accreditation Council forContinuing Medical Education to provide continuing medicaleducation for physicians. This activity has been approved forAMA PRA Category 1 Credit(s)TM. Physicians should only claimcredit commensurate with the extent of their participation inthe activity.

FACULTY DISCLOSUREIn order to ensure independence, objectivity and scientificrigor in all activities and in accordance with the ACCME,ANCC and ACPE Standards for Commercial Support; allthose in a position to control the content of an educationalactivity are required to disclose their relevant financial relationships. This includes indicating that one has nothing to disclose. Disclosure information will be distributed to the activity attendees.

AMERICANS WITH DISABILITIES ACTIn compliance with the Americans with Disabilities Act of1990, NASPGHAN will make all reasonable effort to accommodate persons with disabilities. ContactNASPGHAN in order to make arrangements.

NASPGHAN NATIONAL OFFICE

PO BOX 6

FLOURTOWN, PA 19031

TELEPHONE: 215.233.0808

FAX: 215.233.3918

EMAIL: [email protected]

WEBSITE: WWW.NASPGHAN.ORG

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mailto:[email protected]

Single Topic ConferenceTHE GUT MICROBIOME IN DEVELOPMENT, HEALTH AND DISEASE

WEDNESDAY, NOVEMBER 12, 2008

COURSE DIRECTORS: NICOLA JONES, MD, PHD & PHIL TARR, MDNowhere in human biology are basic concepts changing more rapidly than in our understanding of the human microbiome. Compellingevidence indicates that the gut microbiota play extensive roles in normal development, health and disease. In few areas of science haveso many different worthwhile opportunities for study appeared simultaneously. Therefore, the aims of this meeting are to outline theclinical importance of the gastrointestinal microbiome and to teach young investigators the skills to move this burgeoning field forward.

LEARNING OBJECTIVES:Review the latest opportunities to study the gut microbiomePresent evidence for the role of the intestinal microbiota in the developing immune system and various intestinal & non-intestinal diseases

INTRODUCTION TO THE MICROBIOME

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8:00am–8:15am IntroductionNicola Jones, MD, PhD, The Hospital for Sick Children, Toronto and Phil Tarr, MD, Washington University, St. Louis

8:15am–9:00am Understanding Complex MicrofloraClara Long Davis, PhD, Stanford University

9:00am–9:30am The Human Microbiome Project: Preparing for the Challenges & OpportunitiesElaine J Mardis, PhD, Genome Sequencing Center, Washington University, St. Louis

9:30am–10:00am The Canadian Microbiome Project

10:00am–10:30am Break

THE MICROFLORA IN INFLAMMATORY BOWEL DISEASES

10:30am–11:15am Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune SystemWendy Garrett, MD, PhD, Dana Farber Cancer Institute, Brigham and Women's Hospital, Harvard School of Public Health

11:15am–12:00pm The Intestinal Microflora in Crohn’s DiseaseDaniel Frank, PhD, University of Colorado

12:00pm–12:30pm Question & Answer Session / Discussion Period / Future Directions

12:30pm–2:00pm Lunch / Breakout Sessions for Young Investigators Focusing on Training and Career Development OpportunitiesFaculty panel

THE ROLE OF THE MICROFLORA IN DEVELOPMENT

2:00pm–3:00pm KEYNOTE SPEAKER –The Role of the Human Childhood Intestinal Microbiota in Asthma and other Allergic DisordersBengt Björkstén, MD, PhD, Karolinska Institute

3:00pm–3:45pm Microbes and the Newborn IntestineAllan Walker, MD, Massachusetts General Hospital and Harvard Medical School


4:15pm–4:30pm Break

4:30pm–4:45pm The Role of the Gut Microbiota in Enteric NeurobiologySteven M Collins, MBBS, McMaster University, Hamilton, Ontario, Canada

4:45pm–5:15pm The Role of Bacteroides Fragilis Polysaccharide in Modulating Vertebrate Immune ResponseSarkis K Mazmanian, PhD, California Institute of Technology


5:45pm Research Support for the Microbiome

Wrap Up / Final Agenda

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Challenges inNutrition:A Postgraduate CourseTHE NASPGHAN-CDHNF PARTNERSHIP: A DECADE OF PROGRESS

THURSDAY, NOVEMBER 13, 2008

8:00am–8:10am INTRODUCTION

8:10am–9:10am MODULE A – REDUCING THE COMPLICATIONS OF PARENTERAL NUTRITION Moderators: John Pohl, MD and Dana Ursea, MD

Long chain omega–3 fatty acid (LCOFA): Does it prevent cholestasis?Beth Carter, MD, Texas Children’s Hospital

Learning Objectives: 1. Present the evidence that LCOFA reduces cholestasis2. Identify the mechanisms whereby LCOFA may work3. Discuss the approval status of LCOFA and other fish-oil based lipid formulations

On the line: Preventing catheter sepsisJeffrey Rudolph, MD, Cincinnati Children's Hospital Medical Center

Learning Objectives: 1. Discuss the mechanisms of line sepsis – why infection with gut bacteria?2. Discuss techniques of preventing line sepsis, including ethanol and antibiotic locks3. Characterize timing of line placement and line type to prevent line-related sepsis

Anticipating long-term nutritional complications of TPNMaria Mascarenhas, MD, Children’s Hospital of Philadelphia

Learning Objectives: 1. Characterize micronutrient deficiencies in children receiving parenteral nutrition2. Discuss medical complications of the lack of lipid emulsions or essential fatty acids3. Identify the need for iron infusions in children receiving parenteral nutrition

9:10am–9:20am RAPID–FIRE QUESTIONS

9:20am–9:40am BREAK

9:40am–10:40am MODULE B – EFFECTS OF ENTERAL FEEDINGS ON THE INFANT GUTModerators: Laurie Fishman, MD and Michelle Pietzak, MD

Does formula composition change motility?Samuel Nurko, MD, Children’s Hospital, Boston

Learning Objectives: 1. Discuss formula type (casein and whey-based, soy, hydrolyzed) and its effect on motility2. Discuss osmotic load in formula and the effect on motility3. Discuss formula lipid content and its effect on motility

How does enteral feeding affect the intestinal microbiomeEytan Wine, MD, The Hospital for Sick Children, Toronto

Learning Objectives: 1. Outline the acquisition of the normal infant intestinal microflora2. Discuss how macronutrients affect the microflora3. Discuss implications of altered microflora on later health

Are you what you eat? The effect of infant diet on later health Susannah Huh, MD, Children’s Hospital, Boston

Learning Objectives: 1. Discuss association between infant growth and later health outcomes, including

obesity, cardiovascular disease, and cognition2. Discuss association between infant feeding practices and later health outcomes3. Discuss how pregnancy and infant dietary composition may affect lifelong health

10:40am–10:50am RAPID–FIRE QUESTIONS


11:00am–12:00pm MODULE C – OBESITY AND THE GASTROENTEROLOGISTModerators: Sandeep Gupta, MD and John Pohl, MD

The role of genes and hormones Matthias Tschoep, PhD, University of Cincinnati

Learning Objectives: 1. Describe what is new in the research front on the genetics of obesity2. Discuss the interactions between obesity-related hormones (leptin, ghrelin)3. Describe the effect of gastric bypass on obesity-related hormones

Managing metabolic syndrome Stavra Xanthakos, MD, Cincinnati Children's Hospital Medical Center

Learning Objectives: 1. Define the metabolic syndrome2. Identify associated gastrointestinal complications, including hepatic disease3. Describe medications used for treatment

How does obesity and non-alcoholic fatty liver disease (NAFLD) affect chronic liver disease?Simon Horslen, MD, Seattle Children’s Hospital

Learning Objectives: 1. Describe the effect of NAFLD on chronic viral hepatitis2. Characterize the effect of NAFLD on autoimmune hepatitis3. Identify other hepatic diseases that can mimic NAFLD

12:00pm–12:10pm RAPID–FIRE QUESTIONS

12:10pm–1:40pm NUTRITION LEARNING LUNCHES (separate registration required)

LONG CHAIN OMEGA–3 FATTY ACIDS AND CHOLESTASIS /LONG TERM COMPLICATIONS OF TPNModerator: Dana Ursea, MDBeth Carter, MD and Maria Mascarenhas, MD

CENTRAL LINE SEPSIS PREVENTION / IRON AND INFLAMMATIONModerator: David Easley, MDJeffrey Rudolph, MD and Richard Grand, MD

VITAMIN D AND INFLAMMATIONModerator: Jane Balint, MDFrancisco Sylvester, MD

OBESITY GENES AND HORMONES / METABOLIC SYNDROMEModerator: Sandeep Gupta, MDMatthias Tschoep, PhD and Stavra Xanthakos, MD

OBESITY AND CHRONIC LIVER DISEASE / VITAMIN E AND LIVER DISEASEModerator: John Pohl, MDSimon Horslen, MD and Ronald Sokol, MD

DIET AND ALLERGIC DISEASE PREVENTION / FETAL ORIGINS OF DISEASEModerator: Kathy Chen, MDFrank Greer, MD and Susanna Huh, MD, MPH

FOOD LABELING / ELIMINATION DIETSModerator: Kevin Kelly, MDAmir Kagawalla, MD, and Vanessa Ludlow, RD

FORMULA COMPOSITION AND MOTILITY / INFANT MICROBIOMEModerator: Daniel Gelfond, MDSamuel Nurko, MD, MPH and Eytan Wine, MD

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1:40pm–2:40pm MODULE D–VITAMIN AND MINERAL POTPOURRIModerators: John Pohl, MD and Jane Balint, MD

Does inflammation interfere with iron?Richard Grand, MD, Children’s Hospital, Boston

Learning Objectives: 1. Review the physiology of iron homeostasis (including role of hepcidin)2. Describe the changes in iron homeostasis in states of inflammation (e.g. IBD)3. Characterize treatment strategies, including intravenous iron infusion

Vitamin D – It’s not just for the bonesFrancisco Sylvester, MD, Connecticut Children’s Medical Center

Learning Objectives: 1. Review vitamin D metabolism and causes of deficiency2. Describe the role of vitamin D chemoprophylaxis in colon cancer3. Describe the role of vitamin D in inflammation4. Describe the relationship of vitamin D to insulin metabolism in type II diabetes mellitus

Can vitamin E help in liver disease?Ronald J. Sokol, MD, The Children’s Hospital, Denver

Learning Objectives: 1. Discuss the use of vitamin E in the treatment of childhood NAFLD2. Review vitamin E metabolism and clinical manifestations of deficiency3. Describe supplementation in cystic fibrosis, steatohepatitis, and � lipoproteinemia


2:50pm–3:10pm BREAK

3:10pm–4:10pm MODULE E – ALLERGY PREVENTION AND DIETModerators: Laurie Fishman, MD and Kevin Kelly, MD

Can diet prevent food allergies?Frank Greer, MD, University of Wisconsin

Learning Objectives: 1. Identify infants at high risk for the development of food allergies2. Characterize evidence for the hygiene theory and for use of pre-/probiotics3. Describe the delayed timing of food introduction to prevent food-related allergies

The successful elimination diet for eosinophilic esophagitis (EE)Amir Kagalwalla, MD, University of Illinois, Chicago

Learning Objectives: 1. Discuss the merits of dietary treatment in preventing sequelae such as fibrosis in EE2. Compare directed vs. empiric food elimination diet to diagnose and treat food allergies3. Identify the psychological and nutritional effects of the elimination diet

The food-labeling act and its effect on food-restricted diets Vanessa Ludlow, RD, Children’s Hospital, Boston

Learning Objectives: 1. Describe the purity of gluten-free foods in the U.S. in relationship to threshold2. Characterize food labeling and the food-labeling act3. Describe the level purity of cow milk antigen-free food in relationship to threshold


4:20pm–4:30pm WRAP–UP / ADJOURN

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A Clinical & Scientific ConferenceTHE NASPGHAN–CDHNF PARTNERSHIP: A Decade of Progress

Friday, November 14, 2008 continued . . .

THURSDAY, NOVEMBER 13, 2008

5:00pm–7:00pm POSTER SESSION I / OPENING RECEPTION

FRIDAY, NOVEMBER 14, 2008

8:00am–9:50am NASPGHAN/CDHNF PLENARY SESSION IModerators: William Balistreri, MD and John Barnard, MD

8:00am WELCOMEJohn Barnard, MD

8:05am CDHNF: A DECADE OF PROGRESSGeorge Ferry, MD, Baylor College of MedicinePast President, CDHNF

8:20am CDHNF INVESTIGATOR AWARDS / CAREER VIGNETTESDavid Rudnick, MD, Washington University, St. LouisNeera Gupta, MD, University of California, San Francisco

8:50am ABSTRACT PRESENTATIONS

9:20am BASIC SCIENCE YEAR-IN-REVIEW Eric Sibley, MD, Stanford UniversityEditor, Journal of Pediatric Gastroenterology and Nutrition


10:30am–12:00pm NASPGHAN/CDHNF PLENARY SESSION IIModerators: D. Brent Polk, MD and B Li, MD

10:30am MEETING UPDATEB Li, MD

10:35am ABSTRACT PRESENTATIONS

11:05am IMPROVING OUTCOMES VIA MAINTENANCE OF CERTIFICATION–FROM THE AMERICAN BOARD OF PEDIATRICS GASTROENTEROLOGY SUBBOARDChris Dickinson, MD, University of Michigan

11:20am CDHNF DRIVING THE AAP eQIPP MODULE ON GERDJenifer Lightdale, MD, Children’s Hospital, Boston

11:35am CLINICAL SCIENCE YEAR-IN-REVIEW William Balistreri, MD, Cincinnati Children’s Hospital Medical CenterEditor, Journal of Pediatrics

12:00pm–2:00pm POSTER SESSION II

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2:00pm–3:30pm CONCURRENT SESSION I

CONTROVERSIES IN TREATMENT OF CHRONIC HEPATITIS Moderators: Jean Molleston, MD and Latifa Yeung, MD

Management of hepatitis B: Who, how and with what? Michael Narkewicz, MD, The Children’s Hospital, Denver

Learning Objectives: 1. Discuss the current indications for treatment of chronic hepatitis B2. Describe the diagnostic approach to drug-resistant hepatitis B3. Discuss current therapy (including multi-drug) for treatment of hepatitis B

Management of hepatitis C: What you can see and what you don’t! Kathleen Schwarz, MD, Johns Hopkins University

Learning Objectives: 1. Discuss the current indications for treatment of hepatitis C in children2. Describe current treatment regimens for hepatitis C infection3. Review the potential treatment side effects

Infectious hepatitis – non A-E: How the unalphabetized attack Karen Murray, MD, Children’s Hospital and Regional Medical Center, Seattle

Learning Objectives: 1. Discuss the epidemiology of non A-E viral hepatitis in neonates 2. Discuss the epidemiology of non A-E viral hepatitis in the adolescent3. Describe the epidemiology of non A-E hepatitis in acute liver failure

AUTOIMMUNITY AND THE DIGESTIVE TRACTModerators: Wallace Crandall, MD and James Lopez, MD

Autoimmunity: PathophysiologyTroy Torgerson, MD, Children’s Regional Medical Center, Seattle

Learning Objectives: 1. Provide the current diagnostic criteria for autoimmunity in general2. Describe the genetic basis for autoimmune enteropathy and IPEX3. Describe the current testing (including genetic) for various autoimmune enteropathies

Autoimmune enteropathy: Clinical presentation and treatment Harland Winter, MD, Massachusetts General Hospital for Children

Learning Objectives: 1. Review the clinical presentation of autoimmune enteropathies2. Describe the utility of serological testing3. Characterize the current treatment regimens for this disorder

Autoimmune hepatitis: Update Deborah Freese MD, Mayo Clinic

Learning Objectives: 1. Discuss the incidence, pathophysiology, and diagnosis of type l and type ll

autoimmune hepatitis and the overlap syndromes2. Review new therapeutic options for treatment in children3. Identify treatment options for recurrence post liver transplantation

RESEARCH INTEREST GROUP & ORAL ABSTRACT PRESENTATION

STATE-OF-THE-ART LECTURES

Food Allergy, Probiotics and Gastrointestinal EosinophilaBengt Björkstén, MD, PhD, Karolinska Institute and Glenn Furuta, MD, The Children’s Hospital, Denver, CO

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3:30pm–5:00pm CONCURRENT SESSION II

NEW CLINICAL UPDATESModerators: Ann Scheimann, MD and John Thompson, MD

Eosinophilic esophagitis (EE): TIGERS Consensus 2007 Chris Liacouras, MD, Children’s Hospital of Philadelphia

Learning Objectives: 1. Review the consensus re: histologic criteria for diagnosis of EE 2. Discuss the food-elimination diet and its practical aspects3. Compare the efficacy of various steroid preparations (including treatment of relapses)

Celiac disease – What’s new? Ed Hoffenberg, MD, The Children’s Hospital, Denver

Learning Objectives: 1. Discuss a new celiac disease test : antibodies to deamidated gliadin peptide2. Discuss what to do with the diabetic child with evidence of celiac disease3. Review new food labeling laws

NAFLD: A supersized liver Miriam Vos, MD, Emory University, Atlanta

Learning Objectives: 1. Discuss histologic and radiographic diagnostic criteria2. Review the treatment options (metformin, UDCA and vitamin E)3. Identify the effect of bariatric surgery on prevention and/or reversal of NAFLD

ADVANCED ENDOSCOPIC TECHNIQUESModerators: Marsha Kay, MD and Petar Mamula, MD

Capsule endoscopy: State-of-the-art in childrenStan Cohen, MD, Children’s Center for Digestive Healthcare, Atlanta

Learning Objectives: 1. Review capsule endoscopy procedures and competency requirements2. Describe the current indications for capsule endoscopy in children3. Identify new types of capsule endoscopy and future pediatric uses

Endoscopic Botox in pediatrics: Not just for the 40+ crowd Samuel Nurko, MD, MPH, Children’s Hospital, Boston

Learning Objectives: 1. Describe the mechanism, duration of action and technique of injection of botulinum toxin2. Review the technique and results for cricopharyngeal achalasia, achalasia and pyloric

dysfunction3. Review the technique and results for anal achalasia and Hirschsprung’s disease

Single and double-balloon enteroscopy: Are they ready for prime time? Bradley Barth, MD, Children’s Medical Center of Dallas

Learning Objectives: 1. Discuss emerging techniques in enteroscopy2. Review current clinical trials3. Identify potential clinical indications in pediatrics and limitations of technique and

equipment

ORAL ABSTRACT PRESENTATIONS

6:00pm TRAINING PROGRAM DIRECTORS’ MEETING

PRACTIONERS’ FORUM

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Saturday, November 14, 2008 continued . . .

SATURDAY, NOVEMBER 15, 2008

7:00am–9:00am POSTER SESSION III/CONTINENTAL BREAKFAST

8:30am–10:00am CONCURRENT SESSION III

NEW NASPGHAN GUIDELINES: THE CURRENT STATUSModerators: Barbara Kaplan, MD and Steven Schwarz, MD

Pediatric GERD Colin Rudolph, MD, PhD, Children’s Hospital of Wisconsin

Learning Objectives: 1. To review new evidence-based recommendations for the diagnosis of pediatric GERD 2. To describe changes in symptom-based diagnostic and management approaches for

pediatric GERD

3. To discuss changes in practice recommended in new pediatric GERD guidelines

H. pylori infection in children Nicola Jones, MD, PhD, The Hospital for Sick Children, Toronto

Learning Objectives: 1. Identify revised consensus on diagnostic testing for H. pylori infection2. Characterize antibiotic resistance and use of H. pylori antibiotic sensitivity testing3. Review the current combined antibiotic and PPI treatment regimens

Cyclic vomiting syndrome B Li, MD, Children’s Hospital of Wisconsin Gisela Chelimsky, MD, Rainbow Babies & Children’s Hospital

Learning Objectives: 1. Identify revised definition of cyclic vomiting syndrome 2. Discuss consensus on the diagnostic approach to and disorders that mimic CVS3. Review new therapeutic options including abortive and prophylactic approaches

MANAGEMENT OF PORTAL HYPERTENSION Moderators: Frederick Watanabe, MD and Harpreet Pall, MD

Complications of portal hypertension Vicky Ng, MD, The Hospital for Sick Children, Toronto

Learning Objectives: 1. Provide a definition of portal hypertension (including Doppler imaging)2. Describe mediators involved in the pathogenesis of portal hypertension3. Characterize the clinical manifestations of portal hypertension

Medical management of varicesSimon Ling, MD, The Hospital for Sick Children, Toronto

Learning Objectives: 1. Review strategies for the identification of children at high risk of varices2. Review the prophylaxis of variceal hemorrhage3. Review the medical treatment of children with acute variceal hemorrhage

Non-medical management of portal hypertension Naveen Mittal, MD, Children’s Medical Center, Dallas

Learning Objectives: 1. Review current shunting techniques used to treat portal hypertension2. Management of post-shunt complications3. Review role of transplant in portal hypertension


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Saturday, November 14, 2008 continued . . .

10:30am–12:00pm CONCURRENT SESSION IV

AERODIGESTIVE APPROACHES TO DYSPHAGIA AND ASPIRATIONModerators: Colin Rudolph, MD, PhD and Khalid Khan, MD

The evaluation and management of children with feeding disorders Richard Noel, MD, PhD, Medical College of Wisconsin

Learning Objectives: 1. Review normal progression of swallowing skill acquisition / changes in anatomy2. Review assessment of swallowing in infants and young children with dysphagia3. Review video swallow study – no penetration or aspiration 4. Discuss management of this child in the context of his/her therapies, feeding skills,

growth, and respiratory issues

Evaluation and management of pulmonary complications of feeding and/or gastroesophageal refluxAjay Kaul, MD, Cincinnati Children’s Hospital Medical Center

Learning Objectives: 1. Discuss differential diagnosis2. Review and discuss investigations for silent aspiration, decreased pharyngeal and vocal

fold sensation and aspiration, role of bronchoscopy, impedance, high resolution CT3. Management from gastrointestinal perspective: dietary changes, oral motor therapy,

acid blockade, gastrostomy tube

Evaluation and management of a child with anatomic abnormalities of the aerodigestive tractRachel Rosen, MD, Children’s Hospital, Boston

Learning Objectives: 1. Discuss airway anatomic anomalies (laryngeal cleft/TEF, paralyzed vocal cord)2. Identify gastrointestinal anatomic anomalies (esophageal atresia/TEF, gastric

pull-up procedure)3. Describe the clinical impact of GER(D), eosinophilic esophagitis, vomiting, feeding

intolerance4. Identify ENT concerns regarding above

POST-TRANSPLANT GASTROINTESTINAL COMPLICATIONS Moderators: Daniel Kamin, MD and Philip Rosenthal, MD

The GI manifestations of graft-versus-host disease (GVHD) William Berquist, MD, Lucile Packard Children’s Hospital, Palo Alto

Learning Objectives: 1. Review the causes, time course and clinical presentation of GVHD2. Describe the endoscopic and histologic manifestations and treatment3. Describe extraintestinal manifestations of GVHD (hepatic) and treatment

Post-transplant lymphoproliferative disease (PTLD): An updateEstella Alonso, MD, Children’s Memorial Hospital, Chicago

Learning Objectives: 1. Review PTLD and its changing incidence and clinical presentations in children2. Describe the radiographic, biopsy, and PCR testing to confirm PTLD3. Discuss the treatment options for PTLD

Intestinal transplant and gut motilitySamuel Kocoshis, MD, Cincinnati Children’s Hospital Medical Center

Learning Objectives: 1. Review the changes in motility in the transplanted and rejected intestine2. Describe testing modalities used to confirm dysmotility3. Discuss available treatment options for dysmotility in transplanted bowel (including

treatment of sepsis)


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13 Saturday, November 14, 2008 continued . . .

12:00pm–1:30pm NEW CLINICAL CHALLENGE LUNCHEONS (REGISTRATION REQUIRED)

These are new interactive, case-based luncheons – participants may submit a case in advancedirectly to the moderators. The format will involve: a pre-test and post-test (same) – withaggregate results provided to participants, cover 4–6 case scenarios, and provide an in–depthdiscussion of evidence base areas of controversy (e.g. pro vs. con), clinical reasoning and decision-making, and a rationale approach in the absence of definitive evidence or consensus guidelines.

ALLERGIC BOWEL DISEASE Moderator: Qian Yuan, MD, PhDJohn Kerner, MD, Lucile Packard Children’s Hospital, Palo AltoSandeep Gupta, MD, Riley Children’s Hospital, Indianapolis

THERAPEUTIC APPROACHES TO IRRITABLE BOWEL SYNDROME: WE FEEL YOUR PAIN Moderator: Christopher Jolley, MDAdrian Miranda, MD, Children’s Hospital of WisconsinNader Youssef, MD, Atlantic Health System, Morristown, NJ

EVALUATING NEONATAL LIVER FAILURE Moderator: Grzegorz Telega, MDRobert Squires, MD, Children’s Hospital of PittsburghNada Yazigi, MD, Cincinnati Children’s Hospital Medical Center

POLYPS AND POLYPOSIS SYNDROMESModerator: Steven Erdman, MDThomas Attard, MD, University of NebraskaSherry Huang, MD, UC-San DiegoCarol Durno, MD, Mt. Sinai Hospital, Toronto

HOW BEST TO TREAT NONACID REFLUX?Moderator: Judith O’Connor, MDHayat Mousa, MD, Nationwide Children’s Hospital, Columbus OHRachel Rosen, MD, Children’s Hospital, Boston

MANAGING COMPLICATIONS OF GERD Moderator: David Gremse, MDEric Hassall, MD, University of British Columbia Vasu Tolia, MD, Pediatric GI Center, Detroit

MANAGING GI COMPLICATIONS OF CYSTIC FIBROSISModerator: Ashish Patel, MDJohn Pohl, MD, Scott and White Hospital, Temple, TXSarah Jane Schwarzenberg, MD, Minnesota Children’s Hospital

BILIARY DISEASE: STONES AND GROANS IN THE UPPER RIGHT QUADRANT Moderator: Miguel Saps, MDJames Heubi, MD, Cincinnati Children’s Hospital Medical Center Sonia Michail, MD, Children’s Medical Center, Dayton

METABOLIC LIVER DISEASE: WHEN TO CONSIDER THE DIAGNOSIS & HOW TO MAKE ITModerator: Shikha Sundaram, MDBinita Kamath, MD, Children’s Hospital of PhiladelphiaSaul Karpen, MD, Texas Children’s Hospital

REFRACTORY CONSTIPATION: WHERE DOES IT STOP?Moderator: Bankole Osuntokun, MDRina Sanghavi, MD, Children’s Medical Center, DallasManu Sood, MD Children’s Hospital of Wisconsin

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1:30pm–3:00pm CONCURRENT SESSION V

INFLAMMATORY BOWEL DISEASE (IBD) – CLINICAL SCENARIOS: HOW DO YOU TREAT? Moderators: Paul Rufo, MD and Maria Oliva Hemker, MD

How do we manage a patient with IBD until mercaptopurines becomes therapeutic? William Faubion, MD, Mayo Clinic, Rochester

Learning Objectives: 1. Review thiopurine metabolism and current therapeutic monitoring2. Identify bridging treatment approaches3. Discuss complications of use of thiopurines (pancreatitis, lymphoma, infection)

How do we best manage the patient with refractory Crohn disease? Ted Denson, MD, Cincinnati Children’s Hospital Medical Center

Learning Objectives: 1. Define the “refractory Crohn” patient, including “steroid-dependent” and “resistant”2. Describe the use of methotrexate and infliximab for treatment of refractory patients3. Review the therapeutic options for steroid-refractory hospitalized patient

(cyclosporine, tacrolimus, infliximab, surgery)4. Review the rescue therapies in those failing to respond to biologics (adalimumab,

thalidomide)

How do we best manage the patient with refractory ulcerative colitis? Athos Bousvaros, MD, Children’s Hospital, Boston

Learning Objectives: 1. Define the “refractory UC” patient2. Describe the use of methotrexate and infliximab for treatment of refractory patients3. Review the therapeutic options for steroid-refractory hospitalized patient

(cyclosporine, tacrolimus, infliximab, surgery)4. Review the rescue therapies in those failing to respond to biologics (adalimumab,

thalidomide)

ANTIBIOTIC THERAPY IN GASTROINTESTINAL DISEASE: WHAT’S THE EVIDENCE? Moderators: John Udall, MD and Mary Zachos, MD

Antibiotics and Inflammatory Bowel Disease (IBD) Anne Griffiths, MD, The Hospital for Sick Children, Toronto

Learning Objectives: 1. Review the use of antibiotics as initial therapy and for perianal disease in IBD2. Characterize the evidence base for antibiotic use in fistula and stricture formation3. Describe the evidence for usage of pre- / probiotics for treatment of IBD

Antibiotics and irritable bowel syndrome (IBS) Mark Pimentel, MD, Cedars Sinai Medical Center

Learning Objectives: 1. Describe the pathophysiology of post-infectious IBS2. Identify antibiotic regimens currently being studied in the treatment of IBS3. Discuss the evidence for use of pre- / probiotics for treatment of IBS

Clostridium difficile: How do you treat the patient with relapsing disease? Michael Farrell, MD, Cincinnati Children's Hospital Medical Center

Learning Objectives: 1. Define the incidence of relapsing C. difficile infections in hospitalized patients2. Identify the current effective antibiotic regimens for relapsing C. difficile infection3. Discuss non-antibiotic regimens, including probiotics, IVIG, and cholestyramine


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3:15pm–4:45pm CONCURRENT SESSION VI

BILLING AND CODING 101, 102 Moderators: Leo Heitlinger, MD and Roxanne Hecht, MD

Kathleen Mueller, McVey AssociatesLearning Objectives: 1. Describe billing codes for new endoscopic procedures2. Describe billing codes for newly established gastrointestinal disease3. Provide examples of complex patients that would stimulate mulitple billing codes

EDUCATION 2008: IS SIMULATION THE NEW WAVE?Moderator: B Li, MD

Laurie Fishman, MD, Alan Leichtner, MD and Jeffrey Burns, MD, Children's Hospital BostonLearning Objectives: 1. Review the use of simulation in the context of adult learning principles2. Identify endoscopic simulation products and studies that evaluate competence3. Discuss application of simulation techniques to training in pediatric gastroenterology

RESEARCH MENTORING, CAREER DEVELOPMENT AND METHODOLOGY WORKSHOP Moderators: Mitchell Cohen, MD and David Rudnick, MD, PhD

Pat Robuck, PhD, MPH, D. Brent Polk, MD, PhD and Rob Squires, MDLearning Objectives: 1. Review current NIH and non-NIH funding opportunities for junior faculty2. Discuss career development strategies for both basic and clinical/translational faculty 3. Interactive question & answer session for both basic, clinical/translational research faculty

5:00pm BUSINESS MEETING – NASPGHAN/CDHNF AWARDS CEREMONY

7:00pm CDHNF 1OTH ANNIVERSARY CELEBRATION DINNER

NASPGHAN/CDHNF Conference / November 13–15, 2008 / San Diego, California

Registration FormRegistration Deadline: October 14, 2008

After October 14, fees for the NASPGHAN/CDHNF Conference and the Single Topic Symposium will increase by $50 per category

Register on-line at www.naspghan.org (please print clearly)

First Name Last Name

Address

City State Zip Country

Phone Fax

Email (very important)

SINGLE TOPIC SYMPOSIUM – THE GUT MICROBIOME IN DEVELOPMENT, HEALTH & DISEASE Wednesday, November 12, 2008

CHECK YOUR MEMBER TYPE FEE AMOUNT OWED

Member A $100

Non-member B $175

Trainee/Fellow Member C $50

APGNN Member D $50

Non-Member Nurse E $75

Non-Member Trainee F $75

NASPGHAN–CDHNF CHALLENGES IN NUTRITION POSTGRADUATE COURSEThursday, November 13, 2008


Member G $275

Non-member H $375

Trainee/Fellow Member I $175

APGNN Member J $175

Non-Member Nurse K $225

Non-Member Trainee L $225


Member N $300

Non-member O $400

Trainee/Fellow Member P $200

APGNN Member Q $200

Non-Member Nurse R $250

Non-Member Trainee S $250

Student / Resident T $50

NASPGHAN – CDHNF NUTRITION LEARNING LUNCHES (SELECT ONE)Thursday, November 13, 2008 You must be registered for the Challenges in Nutrition Postgraduate Course to attend a Learning Lunch

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ADDITIONAL Saturday, November 15, 2008

ADDITIONAL – INDICATE CHOICES FEE AMOUNT OWED

Billing and Coding 101, 102 V No Charge

Extra Tickets for Saturday CDHNFDinner Celebration – Adults W $75

Extra Tickets for Saturday CDHNFDinner Celebration – Child X $20

Additional Registration Information�

NASPGHAN – CDHNF CONFERENCE NOVEMBER 13–15, 2008

SEE PAGE 6 FOR TITLES $50 (INDICATE CHOICE) AMOUNT OWED

First Choice M

Second Choice M

Third Choice M

NEW CLINICAL CHALLENGE LUNCHEONS (SELECT ONE)Saturday, November 15, 2008 You must be registered for the NASPGHAN/CDHNFConference to attend a Clinical Challenge Luncheon

GRAND TOTAL $

SEE PAGE 13 FOR TITLES $50 (INDICATE CHOICE) AMOUNT OWED

First Choice U

Second Choice U

Third Choice U

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What’s included:Single Topic Symposium– Registration fees include continental breakfast and lunch on Wednesday, coffee breaks, and the program book.

NASPGHAN–CDHNF Challenges in Nutrition Postgraduate Course– Registration fees include Postgraduate course syllabus, continental breakfast, and coffee breaks.

NASPGHAN–CDHNF Conference– Registration fees for the Conference include the wine and cheese reception on Thursday evening, lunch on Friday, continental breakfast on Saturday morning, coffee breaks, the CDHNF Dinner Celebration on Saturday evening and the meeting program.

Cancellation and Refund:Requests for refunds must be submitted in writing and be received in the National Office by October 17, 2008. No refund requests will be accepted after that date. Registration badge and receipt must accompany request. Approved refunds will be issued after the meeting.

Payment Information:MasterCard Visa American Express

Credit Card #:__________________________________ Verification Code #:_______ Expiration Date:_____________

Make checks (drawn on a US bank in US funds) payable to NASPGHAN:Mail or Fax completed form to:NASPGHANPO Box 6, Flourtown, PA 19031Fax: 215.233.3918

Contact NASPGHAN National Office for further information:Phone: 215.233.0808 Fax: [email protected] www.naspghan.org

NASPGHAN ID 84–126–4996

NASPGHAN/CDHNF Conference / November 13–15, 2008 / San Diego, California

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