“Adaptive rejuvenation as the basis of the therapeutic effect of the

systemic ozone therapy”

E.I.Nazarov, Odessa

Slide 1

• My report is devoted to a new approach to the mechanism of the course of systemic ozone therapy. This approach was the result of attempts to find an answer to the two questions:

• First: Why during the course of ozone therapy the patient's condition periodically improves and worsens and

• Second question: Why does the therapeutic effect of ozone therapy if achieved persist for 3 to 6 months?

• The modern theory of ozone therapy can not explain these features of ozone. Let us consider two examples.

The correct course of ozone therapy !

Dissatisfied with the treatmentWithout changesGood health Bad feeling

Before course

After course

Slide 2

Slide 2

• This slide shows schematically the dynamics of patient's psycho-somatic state throughout the six AHT- O3 procedures and during the next eight months after the completion of the course. This slide represents a successful course of therapy because for 6 months the patient enjoys the result of treatment.

Wrong course of ozone therapyWhat is the reason that some courses of treatment result in a steady

improvement in the patient's condition and psycho-emotional upsurge, and other courses are ineffective?

Dissatisfied with the treatmentWithout changesGood health Bad feeling

Before course

After course

Slide 3

Slide 3

• On this slide the unsuccessful course of ozone therapy is schematically shown. The course failed because the patient received only a minor and short-term improvement at his health.

• What is the reason for achieving the different effectiveness from the standard course of systemic ozone therapy and how do we make the course results predictable? To study this we use the generally accepted quality of life questionnaire Medical Outcomes Study-Short Form, SF-36.

Health related quality of life was studied in random sample of 2156 men and 2769 women aged 45-69 years, according with SF-36 is an indicator of overall health status. (Manchuk VT, Nadtochiy LA Condition and tendencies of health formation of the

indigenous population of the North and Siberia // Siberian Scientific Medical Journal. - 2010. - V. 30. -No. 03.)

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Slide 4

• After a successful course of ozone therapy, patients oftenly say "I am 10 or 20 years younger." This led us to the idea of assessing the subjective age of the patient during treatment. In order to the this we use the results of a statistical analysis of the dependence of the quality of life on age. We chose the parameter of physical role functioning (PRF).

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The dynamics of the physical role function (PRF) of the SF-36 questionnaire during the AHT-O3 course and after the course completion. The study involved six patients with stage 2 hypertension (men aged 64 to 72 years)

course ofAHT-O3

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Slide 5

• In this slide you can see that during the course of ozone therapy there is a fluctuation at the physical well-being of patients. Then throughout the 18 weeks after therapy the achieved value of the studied parameter is preserved. After then spontaneous worsening of the patients' condition takes place.

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rejuvenationcourse ofAHT-O3

withdrawal syndrome

Dynamics of the average calculated age of a group of patients during the course of ozone therapy and after the completion of the course

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Slide 6

• If we calculate the subjective age of the patients we get the following graphic. In fact this is the patient's adaptive age graphic. In this graph we can distinguish three periods: 1) fluctuations in the adaptive age during the course of procedures, 2) the period of adaptive rejuvenation, and 3) the period of development of the ozone withdrawal syndrome

Dependence of the remission time on age after the course of ANT-O3 (6-10 procedures, ozone dose 27 μg / kg). The calculation is based on

a medical history of 58 patients suffering from hypertension, diabetes, rheumatoid arthritis, hepatitis C. The age of patients is 47-

84 years.

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Slide 7

Slide 7

• The duration of remission caused by the course of ozone therapy depends on the age of the patient. The duration of remission is about 6 months at 50 years and about 3 months at 80 years.

The dynamics of the level of Cortisol in the blood of six patients (41-64 years old) in control, during the course of AHT-O3 procedures (dose 27μg/kg, every other day) and within five months after completion of the course.

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Slide 8

• We use the term adaptive rejuvenation in order to emphasize the generalized nature of the processes in the patients' body. Depending on the nature of the underlying disease of the patient we observe a reduction in blood pressure for hypertensive patients or a decrease in glucose concentration for diabetics and so on. It is obvious that we are dealing with the effect of ozone on some integrating system of the body. The real candidate for this role is the hormonal system. This is evident from the dramatic dynamics of the level of cortisol during the course of ozone therapy.

The normalized level of Cortisol in the blood of six patients (41-64 years old) in control, during the course of AHT-O3 procedures (dose 27μg/kg, every other day) and within five months after completion of the course.

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Slide 9

• The same results are presented in a normalized form. Normalization is carried out to average level of the control. It can be seen that the course of ozone therapy initiates abrupt changes in the level of cortisol in all patients. One month after the completion of the course the level of the hormone stabilizes at a new level. The concentration of cortisol in the blood returns to the baseline level for several months.

The normalized level of Cortisol in the blood of six patients (41-64 years old) in control, during the course of AHT-O3 procedures (dose 27μg/kg, every other day) and within one months after completion of the course.

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Slide 10

• The following slide shows the dynamics of cortisol in the blood in a more detailed form. The arrows mark the end of the course of AHT- O3 procedures. It can be seen that the influence of the course of procedures on the concentration of the hormone is highly individual. The micro-quantity of ozone introduced into the blood causes a pronounced change in the hormonal status of the patient's body. How does ozone affect the level of the hormone and how does the body maintain a new hormonal status for several months?

Ozone as a physiotherapeutic agent

According to the widely used terminology, study of natural or preformed natural factors (for example: mud, mineral waters as well as electric and magnetic fields and so on) is a subject of a separate section of medicine the - physiotherapy. From this point of view, ozone is the preformed form of the natural factor - oxygen.

Slide 11

Slide 11

• In order to give an answer to this question we must think about the existing theoretical basis of physiotherapy. Why physiotherapy? Because this medical specialty is focused on the study of natural and preformed natural factors. Ozone is a preformed natural oxygen factor. On this basis in a number of countries ozone therapy is accepted as a kind of physiotherapy.

In accordance with the theoretical views of physiotherapy, ozone, like other natural

factors, causes a systemic compensatory-adaptive reaction in the body, the

basis of which is a conditioned-unconditioned reflex with its neurohumoralcomponent. As can be seen from the illustration, the structures of the intermediate brain and brain stem play the leading role in the organization of the compensatory-adaptive reaction. The most important of these is the hypothalamic-pituitary complex integrating the influence of external and internal factors on the organism and forming an adaptive response.

Noveltyfactor Slide 12

Slide 12

• Physiotherapy teaches us that under the influence of curative natural factors a compensatory-adaptation reaction develops. This reaction based on conditioned unconditioned reflexes with neurohumoral component

O3

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• . That is the organism behaves like a Pavlov’s dog. First we develop a conditioned reflex to ozone during ozone therapy and then the role of a reinforcing factor is played by the products of ozonolysis of the blood. Over time the conditioned reflex decays and a new course of ozone therapy is needed to resume it. Physiotherapy teaches us also that the formation of a conditioned reflex occurs in the hypothalamic-pituitary complex. Thus the course of systemic ozonotherapy can be considered completed if the hypothalamic-pituitary complex stops the formation of a conditioned reflex to ozone.

How to control the dynamics of the compensatory-adaptive

reaction of the body during the course of ozone therapy?

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Slide 15

• Let us turn to a simplified scheme for the functioning of the hormonal system. The central element of this system is the hypothalamic-pituitary complex which through the feedback system controls the activity of the adrenal thyroid and gonads glands. In the posterior and anterior part of the hypothalamus there are nuclei regulating the activity of the sympathetic and parasympathetic nervous system respectively.

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The sympathetic nervous system increases the rhythm of the heart

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sympathetic nervous system increases the rhythm of the heart

The parasympathetic nervous system slows down the rhythm of the heart

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In real conditions the work of these systems together makes the heart rhythm unstable.

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• Thus analyzing changes in the rhythm of the heart we obtain indirect information about the work of the hypothalamic-pituitary complex.

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• This slide shows the appearance of the cardio-intervalogram characteristic for the young and the elderly. Spectral analysis of the cardio-intervalogram allows us to evaluate the parameters of activity of the sympathetic parasympathetic and hormonal systems.

Screenshot of the working program O3Test. Left intervalogram, right spectrum of intervalogram and calculated adaptive characteristics of the patient's

state of health. Slide 20

We have created a hardware-software complex called O3Test which allows non-invasive rapid monitoring of the patient's adaptive age during the course of ozone therapy. The data collection time is only 5 minutes and can be performed during the AHT- O3 procedure. O3Test is integrated with O3Navigator.

Original records of cardio intervals during the course of AHT-O3 (dose 30 mkg/kg). That is the course of

procedures leads to a patient's rejuvenation.

Slide 21

Original records of cardio intervals (left) dynamics of the normalized level of monocytes, eosinophils,

basophils, neutrophils and calculated adaptive age (right) during the course of AHT-O3 (dose 30 mkg/kg)

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Slide 22

• The quantitative adaptation at age can be determined by the O3Test program. The dashed line indicates the dynamics of the calculated adaptive growth during the course of procedures. As we have already said adaptive rejuvenation reflects a generalized process of activation of the patient's homeostasis. For example, we have led the dynamics of the parameters of white blood to mean values of the norm.

Original records of cardio intervals (left) dynamics of the normalized level of monocytes, eosinophils,

basophils, neutrophils and calculated adaptive age (right) during the course of AHT-O3 (dose 30 mkg/kg)

Slide 23

Slide 23

• The O3Test program allows demonstrating the characteristics of the adaptation system to the patient thereby making him a conscious participant in the treatment process.

late repeatedcourse

The slide shows a screen shot of the running program. This is a usual dynamics of the patient's adaptation age during the course of ozone therapy and for several months after the completion of the course. Demonstration of this example should motivate the patient to resume the course of ozone therapy. Slide 24

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In conclusion we will demonstrate the mechanical metaphor of the ozone therapy course in the form of a

pendulum oscillation. Health is balance. Disease is a deviation from balance.

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First procedure.The procedure of ozone therapy removes the system of homeostasis from the state

of the disease.

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The pendulum moves

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Second procedure

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This is a state of health. But the pendulum has inertia and can not stop in

this state

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The pendulum, by inertia, moves to the opposite side. This is also a disease.

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Third procedure of ozone therapy

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The pendulum moves

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Fifth procedure of ozone therapy

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The pendulum, in balance state, but by inertia, moves to

the opposite side

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It is illness too

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Sixth procedure of ozone therapy

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course of treatment completed

Treatment of the patient is strictly individual. For another patient, you may need 10-16 oscillations of the pendulum until it stops. If the

doctor stops the treatment before pacifying the pendulum, then the goal of treatment is not achieved.

conclusions1) Ozone is an preforming natural factor and in accordance with the theoretical basis of physiotherapy is the factor that causes the conditioned-unconditioned adaptive reflex. This reflex decays for several months and requires a repeated course of ozonotherapy for resumption. 2) Fluctuations in the state of health of the patient during the course of ozone therapy are associated with the restructuring of the hormonal system.3) The restructuring of the hormonal system is normotropic and leads to an adaptive rejuvenation of the patient.4) The duration of the compensatory-adaptive reaction is determined by the duration of the conditioned reflex to ozone and decreases with age from 6 months in 50 years to 3 months in 80 years.5) For a successful course of systemic ozone therapy, constant monitoring of the status of the patient's adaptation system should be carried out. Criterion for the completion of the course of procedures is a sharp decrease in the patient's adaptable age.

We must remember the Latin proverb.

MEDICINA CURATA, NATURA PROCURA

Our task is only to shift, with the help ofozone, the system of homeostasis to astate of balance. Everything else will bedone by the body itself

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Thanks for attention

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