A D A M T . W R I G H T M O B I L E : 8 5 8 - 3 4 2 - 3 8 4 4 • A D A M . T . W R I G H T @ G M A I L . C O M

PROFILE Driven research scientist with a thorough engineering background and leadership skills. Experience concurrently managing multiple projects with a number of research groups. Motivated to problem-solve novel technologies and contribute to an innovative team in an industry environment.

EDUCATION University of California, San Diego La Jolla, CA Doctor of Philosophy in Bioengineering, 2010 Master of Science in Bioengineering, 2005

University of California, Davis Davis, CA Bachelor of Science in Biological Systems Engineering, 2003

EXPERIENCE

Becton Dickinson Biosciences La Jolla, CA Life Science Research and Reagents, Technology Development Senior Scientist June 2014 to present • Contributed to the evaluation and implementation of innovative technologies for

biomedical research applications. • Coordinated collaborative relationships with consumers, key opinion providers, and

synergistic industry and academic partners to develop customized research solutions. • Contributed to development, analysis, and marketing of novel fluorescent probes.

o Evaluated newly developed fluorophores for various research applications. o Involved in product development and commercial launch of new reagents.

University of California, San Diego La Jolla, CA Department of Bioengineering – Cardiac Mechanics Research Group Advisor: Andrew D. McCulloch Postdoctoral Researcher April 2010 to December 2013 • In collaboration with several research groups, studied cardiac electrophysiological

alterations associated with cellular structural changes and mechanical abnormalities. o Investigated the phenotype of genetically modified animal models of

arrhythmogenic heart disease. o Implemented optical mapping, immunofluorescence, and electron microscopy

to probe the cellular mechanisms underlying altered electrophysiology.

Graduate Student Researcher October 2003 to April 2010 Ph.D. dissertation: The Effects of Cytoskeletal Disruption and Mechanical Load on Cardiac Conduction • Developed an experimental platform to optically measure action potential propagation

and make electrophysiological measurements in various cardiac tissue preparations. o Designed and constructed a macroscopic imaging system for low intensity,

high-speed fluorescence measurement. o Integrated custom software in several programming environments for image

acquisition and analysis.

Ardea Biosciences San Diego, CA Independent Consultant Fall 2008 • Assembled instrumentation and implemented a standard operating procedure for use

of a plethysmometer for pharmacological animal research.

SCIENCE & ENGINEERING SKILLS

Laboratory Experience: Epifluorescence and confocal microscopy, advanced multiplexed imaging, quantitative image analysis, immunocytochemistry, immunohistochemistry, flow cytometry, mammalian cell isolation and culture, PCR, ELISA, gel electrophoresis, bioinstrumentation, optics design, circuitry, cardiac pacing, ECG acquisition and analysis, small and medium size animal surgical techniques.

Software/Programming Experience: MATLAB/Octave, ImageJ, LabVIEW, R, MetaMorph/MetaXpress, LASX, AutoCAD, Visual Basic, and Microsoft Office. Experience with Windows, Mac and Unix environments, as well as SGE for analysis of large data sets on high-performance computing clusters.

A D A M T . W R I G H T P a g e 2

TEAMWORK & LEADERSHIP EXPERIENCE

Collaborated with many multidisciplinary research groups in academia and industry: • Worked with dynamic teams to evaluate novel technologies. • Contributed to several grants and journal publications. • Worked with visiting academics to establish cooperative research endeavors. Mentored and advised students and co-workers: • Instructed and assisted bioengineering courses. • Oversaw the progression of research projects conducted by several visiting and

undergraduate students. • Advised a senior design research team as a graduate student.

PUBLICATIONS& POSTERS

S.L. Suarez, A.A. Rane, A. Munoz, A.T. Wright, S.X. Zhang, R.L. Braden, A. Almutairi, A.D. McCulloch, K.L. Christman, Intramyocardial injection of hydrogel with high interstitial spread does not impact action potential propagation. Acta Biomater, 2015. Aug. S1742-7061(15)30048-9

A.T. Wright, E. Pfeiffer, A. Edwards, J. Stowe, K. McNall, J. Tan, I. Niesman, H. Patel, D. Roth, J.H. Omens, A.D. McCulloch, Caveolae in Ventricular Myocytes are Required for Stretch-Dependent Conduction Slowing. J Mol Cell Cardiol. 2014 Nov;76:265-74.

R.C. Lyon, V. Mezzano, A.T. Wright, E. Pfeiffer, J. Chuang, K. Banares, A. Castaneda, K. Ouyang, L. Cui, R. Contu, Y. Gu, S.M. Evans, J.H. Omens, K.L. Peterson, A.D. McCulloch, F. Sheikh, Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. Hum Mol Genet, 2014. 23(5): 1134-50

T. Tang, N.C. Lai, A.T. Wright, M.H. Gao, P. Lee, T. Guo, R. Tang, A.D. McCulloch, H.K. Hammond, Adenylyl cyclase 6 deletion increases mortality during sustained β-adrenergic receptor stimulation, J Mol Cell Cardiol, 2013. Apr 12;60C:60-67

P. Meng, A. Irturk, R. Kastner, A. McCulloch, J. Omens, and A. Wright, GPU Acceleration of Optical Mapping Algorithm for Cardiac Electrophysiology, Conf Proc IEEE Eng Med Biol Soc, August 2012

R.W. Mills, A.T. Wright, S.J. Narayan, A.D. McCulloch, The effects of wall stretch on ventricular conduction and refractoriness in the whole heart, in P. Kohl, F. Sachs, M.R. Franz (eds) Cardiac Mechano-Electric Coupling & Arrhythmias Second Edition. Elsevier Saunders (2011)

B.K. Lim, D. Xiong, A. Dorner, T.J. Youn, A. Yung, T.I. Liu, Y. Gu, N.D. Dalton, A.T. Wright, S.M. Evans, J. Chen, K.L. Peterson, A.D. McCulloch, T. Yajima, K.U. Knowlton, Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest, 2008. 118(8): 2758-70

A.E. Zemljic-Harpf, J.C. Miller, S.A. Henderson, A.T. Wright, A.M. Manso, L. Elsherif, N.D. Dalton, A.K. Thor, G.A. Perkins, A.D. McCulloch, R.S. Ross, Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol, 2007. 27(21): 7522-37

A. Wright, J. Martin, J. Rohrer, Incorporation of BD Horizon™ BV421 and BD Horizon™ BV480 immunofluorescence reagents improves immunofluorescence microscopy (poster). American Association of Immunologists; European Congress of Immunology; BDB Tech Fair, 2015.

A. Wright, J. Martin, J. Rohrer, Incorporation of BD Horizon™ BV421 and BD Horizon™ BV480 immunofluorescence reagents improves imaging High Content Analysis (poster). High Content Analysis, 2015

A.T. Wright, I.R. Niesman, D.M. Roth, H.H. Patel, J.H. Omens, A.D. McCulloch, The Role of Caveolae and Membrane Conformation in Load-Induced Ventricular Conduction Slowing (poster). Biophysical Society Conference, 2012

A.T. Wright, J.H. Omens, A.D. McCulloch, Ventricular epicardial conduction slowing in the pressure loaded isolated murine heart (poster). Experimental Biology Conference, 2008

A.T. Wright, A.E Zemljic-Harpf, J.H. Omens, R.S. Ross, A.D. McCulloch, Structural Defects and Increased Mechanical Load Promote Arrhythmias in the Isolated Murine Heart (poster). Gordon Research Conference, 2007

A.T. Wright, J.C. Martin, S.Evans, A.D. McCulloch, Cardiac Optical Mapping of Neonatal Mice (poster). Biophysical Society Conference, 2006