acute gastroenteritis v. 2.0: oral rehydration therapy (ort) · 2019-07-12 · acute...
TRANSCRIPT
Last Updated: June 2015
Next Expected Review: June 2020
For questions concerning this pathway,
contact: [email protected]© 2015, Seattle Children’s Hospital, all rights reserved, Medical Disclaimer
Discharge Instructions· Continue ORT at home for 4-
6 additional hours; then
resume regular diet, or
lactose free formula if
predominantly formula fed
· ED Acute Gastroenteritis
discharge instructions and
ORT worksheet
· Lactobacillus for 5 days
Phase Change
Acute Gastroenteritis v. 2.0: Oral Rehydration Therapy (ORT)
!Routine testing
for stool pathogens
not recommended
NoYes
Passed oral
challenge
(if attempted);
Educate and
prepare for
discharge
Moderate Dehydration (5-10%)· Prolonged capillary refill (>2 seconds)
· Abnormal skin turgor ('tenting' or
inelastic skin)
· Tachypnea
Overt Shock
(Dehydration >10%)
Minimal (<5%) to No
Dehydration· Educate on prevention
of dehydration
Initial ORT Challenge · 5 mL q 5 mins if <10 kg
· 10 mL q 5 mins if ≥10 kg
!Antimicrobials
not recommended
PHASE I (ED/Urgent Care): ORT
Yes No
Give Ondansetron if
Moderately Dehydrated· Consider holding if diarrhea is chief
complaint
Begin ORT
Inclusion Criteria· Vomiting and/or diarrhea of recent onset not due
to chronic disease, with or without fever, nausea,
or abdominal pain
Exclusion Criteria· Patient < 3 months of age
· Toxic appearance (consider sepsis)
· Diarrhea >7 days (consider chronic disease, bacterial
enteritis)
· Bloody diarrhea (consider HUS)
· Comorbid conditions (Medically Complex Children
(MCC), renal failure, cardiac disease)
· Bilious emesis (consider bowel obstruction)
· On diuretic therapy
· Hyponatremia (<130 mEq/L) or Hypernatremia
(>155 mEq/L)
· Acute surgical abdomen
Hold ORT for 20
minutes· Then restart ORT
at initial rate
Increase ORT· 10 mL q 5 mins if <10kg
· 20 mL q 5 mins if ≥10kg
· Assess in 30-60 mins
!Anti-diarrheal
agents are not
recommended
Off
Pathway
Emesis after
initial ORT?
Continued
emesis?
Reassess after
20 min
Failed oral
challenge
(if attempted)
Consider oral
challenge
Continue
to
Phase II
Executive Summary Explanation of Evidence Ratings
Test your knowledge Summary of Version Changes
Citation Information
· Continue ORT at home for 4-
6 additional hours; then
resume regular diet, or
lactose free formula if
predominantly formula fed
Discharge Criteria· Clinical status improved
· Tolerating ORT or regular diet
· Adequate family teaching
· Follow-up established
Last Updated: June 2015
Next Expected Review: June 2020
For questions concerning this pathway,
contact: [email protected]© 2015, Seattle Children’s Hospital, all rights reserved, Medical Disclaimer
Acute Gastroenteritis v. 2.0: IV or NG Rehydration
Check vital signs· Check BP, HR, RR
· Evaluate heart and lung sounds
!Consider
myocarditis if
patient deteriorates
after fluid boluses
PHASE II (ED/Urgent Care):
IV or NG Rehydration
No, does not
meet discharge
criteria
Yes, meets
discharge
criteria
IV
Involve caregiver and patient in
decision to hydrate with IV or NG
Recheck Vital
Signs; Re-examine
Off
Pathway Discharge Instructions· Continue ORT at home for 4-6
additional hours; then resume
regular diet, or lactose free
formula if predominantly
formula fed
· ED Acute Gastroenteritis
discharge instructions and
ORT worksheet
· Lactobacillus for 5 days
Re-examine Exclusion Criteria· Patient < 3 months age
· Toxic appearance (consider sepsis)
· Diarrhea > 7 days (consider chronic
disease, bacterial enteritis)
· Bloody diarrhea (consider HUS)
· Comorbid conditions (MCC, renal failure,
cardiac disease)
· Bilious emesis (consider bowel obstruction)
· On diuretic therapy
· Hyponatremia (<130 mEq/L) or
Hypernatremia (>155 mEq/L) (if
electrolytes checked)
· Acute surgical abdomen
Urgent Care Transfer
Criteria:
· Not tolerating ORT following 2
nd IV/NG bolus (send by
BLS)
· Need for a 3rd
IV/NG bolus (send by BLS)
· Overt shock (IV access, bolus started, ALS transport)
· Worsening clinical status **Continue treatment as outlined by pathway while awaiting transport**
1st IV Fluid Bolus· NS 20 mL/kg over 30-60 mins (Max dose: 1,000 mL)
· Upon initiation of IV, check electrolytes
· Consider ondansetron if not already given or tolerated
2nd IV Fluid Bolus· NS 20 mL/kg over 30-60 mins
Recheck Vital Signs; Re-examine
· If improved, consider returning to ORT
!Consider
checking
blood glucose
1st NG Fluid Bolus· Pedialyte 20 mL/kg over 60 mins (Max dose: 600 mL)
· Consider ondansetron if not already given or tolerated
2nd NG Fluid Bolus· Pedialyte 20 mL/kg over 60 mins
Recheck Vital Signs; Re-examine
· If improved, consider returning to ORT
NG
Admit on
AGE
pathway
Evaluate for Discharge· Clinical status improved
· IV or NG fluids not required
· Tolerating ORT or regular diet
· Adequate family teaching
· Follow-up established
Phase
Change
Continue to
Phase III
· Upon initiation of IV, check electrolytes
· Consider ondansetron if not already given or tolerated
Executive Summary Explanation of Evidence Ratings
Test your knowledge Summary of Version Changes
Citation Information
· Continue ORT at home for 4-6
additional hours; then resume
regular diet, or lactose free
formula if predominantly
formula fed
Last Updated: June 2015
Next Expected Review: June 2020
For questions concerning this pathway,
contact: [email protected]© 2015, Seattle Children’s Hospital, all rights reserved, Medical Disclaimer
Discharge Instructions· Continue ORT, or
· Resume regular diet, or
lactose free formula if
predominantly formula fed
· Acute Gastroenteritis And
Oral Rehydration Therapy
handout (PE636)
· Lactobacillus for 5 days
Acute Gastroenteritis v. 2.0: Inpatient Management
Admit on AGE powerplan· Start IV D5 NS + 20 mEQ KCL/liter OR
NG Pedialyte at maintenance rate
· Assess need for additional NS or
Pedialyte bolus
Assess at 0800 (or after 4 hours of IV/NG
fluids if admitted between 0800-1600)
· Vomiting: ≤1 episodes in the past 4 hours?
· Intake > Output?
Continue maintenance IV/NG fluids· IV: Replace ongoing stool and emesis
losses with NS 1:1 every 4 hours
· NG: Replace ongoing stool and emesis
losses with Pedialyte 1:1 every 4 hours
ORT or Regular Diet Challenge· Discontinue IV or NG fluids
· ORT: 5 mL q 5 mins if <10kg; 10 mL q 5 mins if
≥10kg, or resume regular diet (lactose-free formula if
predominently formula fed)
· Reassess after 20 minutes
· Send prescription for Lactobacillus GG
Discharge Criteria
· Sufficient rehydration as
indicated by weight gain OR
normal respiratory rate,
capillary refill, and skin turgor
· IV or NG fluids not required
· Tolerating ORT or regular diet
· Adequate family teaching
· Follow-up established
!Consider secretory
diarrhea if there is
copious output in the
absence of oral intake
PHASE III: INPATIENT MANAGEMENT
No, not ready for
oral challenge
Yes, ready for
oral challenge
Ready
for ORT
No emesis,
evaluate for
discharge
Yes, RN notifies
MD when
discharge
criteria are met
!Antimicrobials
not recommended
Reassess for switch to ORT every 4
hours
Not ready
for ORT
YesNo
Increase ORT/ Diet· 10 mL q 5 mins if <10kg
· 20 mL q 5 mins if ≥10kg
· Assess in 30-60 mins
Hold ORT for 20
minutes· Then restart ORT
at initial rate
Continued
emesis
> 48 hrs
Consider other
diagnoses
!Anti-emetics are
not recommended
outside of the ED /
Urgent Care
Emesis after
initial ORT?
Emesis
No emesis
Executive Summary Explanation of Evidence Ratings
Test your knowledge Summary of Version Changes
Citation Information
· Resume regular diet, or
lactose free formula if
predominantly formula fed
Return to Phase I
Return to Phase IContinue to Dehydration
Categories
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Return to Phase III
Return to Phase IIIGo to Oral Feeding Page 2
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Executive Summary
Continue to Pg 2
Executive Summary
Continue to Pg 3Return to Pg 1
Executive Summary
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Acute Gastroenteritis (AGE) Citation
Title: Acute Gastroenteritis (AGE) Pathway
Authors:
· Seattle Children’s Hospital
· James O’Callaghan
· Sabreen Akhter
· Elizabeth Austin
· Bryan Dryer
· Sara Fenstermacher
· Jeffrey Foti
· Kristi Klee
· Michael Leu
Date: June 2015
Retrieval Website: http://www.seattlechildrens.org/pdf/acute-gastroenteritis-pathway.pdf
Example:
Seattle Children’s Hospital, O’Callaghan J, Akhter S, Austin E, Dryer B, Fenstermacher S, Foti J,
Klee K, Leu MG. 2015 June. Acute Gastroenteritis (AGE) Pathway. Available from: http://
www.seattlechildrens.org/pdf/acute-gastroenteritis-pathway.pdf
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Self-Assessment
· Completion qualifies you for 1 hour of Category II CME credit. If you are taking this self-assessment as a
part of required departmental training at Seattle Children’s Hospital, you MUST logon to Learning Center.
(1) Which one of the following is NOT an exclusion criteria?
a) toxic appearance
b) bloody diarrhea
c) rotavirus infection
d) diarrhea for more than 7 days
e) bilious emesis
(2) Which of the following statements concerning probiotics is/are TRUE?
a) probiotics are considered adjunctive therapy.
b) probiotics may be more effective for rotavirus diarrhea, compared to all-cause diarrhea
c) yogurt is considered a good source of probiotics
d) a and b
e) a and c
f) b and c
g) all of the above
(3) The historical BRAT diet (consisting of bananas, rice, applesauce, and toast) is unnecessarily restrictive.
a) true
b) false
(4) Which of the following statements is/are TRUE concerning the clinical assessment of dehydration in AGE?
a) Prolonged capillary refill time, abnormal skin turgor, and respiratory rate are the best individual examination
measures
b) A normal bicarbonate concentration may be useful in ruling out dehydration
c) Acute body weight change is considered the gold standard measure of dehydration
d) It is recommended that the history and physical examination be the primary basis for the diagnosis of AGE
e) all of the above
(5) Which of the following discharge criteria are TRUE?
a) tolerating ORT and/or regular diet
b) tolerating BRAT diet
c) medical follow up is available via telephone or office visit
d) a and b
e) a and c
f) b and c
g) all of the above
(6) Ondansetron has been shown to be a safe and effective therapy in hospitalized children.
a) true
b) false
(7) Which of the following is(are) the recommended diet(s) to prevent or limit dehydration?
a) BRAT diet
b) clear liquid diet
c) Paleo diet
d) regular diet
e) a and b
f) a and d
g) b and d
h) a, b, and d
(8) Which of the following liquids are appropriate for use in oral rehydration therapy?
a) Pedialyte®
b) Gatorade©
c) Gatorade© with added salt, in the ratio of 1L Gatorade© + 1 tbsp salt
d) a and b
e) a and c
f) all of the above
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Answer Key
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Evidence Ratings
To Bibliography
This pathway was developed through local consensus based on published evidence and expert
opinion as part of Clinical Standard Work at Seattle Children’s. Pathway teams include
representatives from Medical, Subspecialty, and/or Surgical Services, Nursing, Pharmacy, Clinical
Effectiveness, and other services as appropriate.
When possible, we used the GRADE method of rating evidence quality. Evidence is first assessed
as to whether it is from randomized trial or cohort studies. The rating is then adjusted in the
following manner (from: Guyatt G et al. J Clin Epidemiol. 2011;4:383-94.):
Quality ratings are downgraded if studies:
· Have serious limitations
· Have inconsistent results
· If evidence does not directly address clinical questions
· If estimates are imprecise OR
· If it is felt that there is substantial publication bias
Quality ratings are upgraded if it is felt that:
· The effect size is large
· If studies are designed in a way that confounding would likely underreport the magnitude
of the effect OR
· If a dose-response gradient is evident
Guideline – Recommendation is from a published guideline that used methodology deemed
acceptable by the team.
Expert Opinion – Our expert opinion is based on available evidence that does not meet GRADE
criteria (for example, case-control studies).
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Summary of Version Changes
· Version 1.1 (11/08/2011): Go Live
· Version 1.2 (07/28/2014): Administrative update
· Version 2.0 (06/17/2015): Periodic review; updated literature search,
recommendations, and pathway tools
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Medical Disclaimer
Medicine is an ever-changing science. As new research and clinical experience broaden our
knowledge, changes in treatment and drug therapy are required.
The authors have checked with sources believed to be reliable in their efforts to provide
information that is complete and generally in accord with the standards accepted at the time of
publication.
However, in view of the possibility of human error or changes in medical sciences, neither the
authors nor Seattle Children’s Healthcare System nor any other party who has been involved in
the preparation or publication of this work warrants that the information contained herein is in
every respect accurate or complete, and they are not responsible for any errors or omissions or
for the results obtained from the use of such information.
Readers should confirm the information contained herein with other sources and are
encouraged to consult with their health care provider before making any health care decision.
Bibliography
Identification
Screening
Eligibility
Included
Flow diagram adapted from Moher D et al. BMJ 2009;339:bmj.b2535
Literature Search Strategy
Search Methods, Acute Gastroenteritis, Clinical Standard Work
Studies were identified by searching electronic databases using search strategies developed and executed
by a medical librarian, Susan Klawansky. Searches were performed in November 2014 in the following
databases – on the Ovid platform: Medline and Cochrane Database of Systematic Reviews; elsewhere:
Embase, Clinical Evidence, National Guideline Clearinghouse, TRIP and Cincinnati Children’s Evidence-
Based Care Recommendations. Retrieval was limited to 2007 to current, ages 0-18, and English language.
In Medline and Embase, appropriate Medical Subject Headings (MeSH) and Emtree headings were used
respectively, along with text words, and the search strategy was adapted for other databases as appropriate.
Concepts searched were gastroenteritis, dysentery, enteritis, adenoviridae infections, rotavirus infections or
rotavirus. All retrieval was further limited to certain evidence categories, such as relevant publication types,
index terms for study types and other similar limits. Additional articles were identified by team members and
added to results.
To Bibliography, Pg 2
129 records identified
through database searching
1 additional records identified
through other sources
130 records after duplicates removed
130 records screened 84 records excluded
34 full-text articles excluded,
5 did not answer clinical question
6 did not meet quality threshold
1 outdated relative to other included study
19 duplicates
3 other
46 records assessed for eligibility
12 studies included in pathway
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Bibliography
Return to Pg 1
1. Diarrhoea and vomiting in children. Diarrhoea and vomiting caused by gastroenteritis: diagnosis, assessment and
management in children younger than 5 years. National Collaborating Centre for Women's and Children's Health.
http://www.ncbi.nlm.nih.gov/books/NBK63844/. Updated 2009.
2. Carter B, Fedorowicz Z. Antiemetic treatment for acute gastroenteritis in children: An updated cochrane
systematic review with meta-analysis and mixed treatment comparison in a bayesian framework. BMJ Open.
2012;2(4).
3. Fedorowicz Z, Jagannath VA, Carter B. Antiemetics for reducing vomiting related to acute gastroenteritis in
children and adolescents. Cochrane Database of Systematic Reviews. 2011;9.
4. Freedman SB, Ali S, Oleszczuk M, Gouin S, Hartling L. Treatment of acute gastroenteritis in children: An
overview of systematic reviews of interventions commonly used in developed countries. Evid Based Child Health.
2013;8(4):1123-1137. Accessed 20130723; 11/27/2014 12:34:04 PM. http://dx.doi.org/10.1002/ebch.1932.
5. Guarino A. Albano F. Ashkenazi S. Gendrel D. Hoekstra JH. Shamir R. Szajewska H. European Society for
Paediatric Gastroenterology, Hepatology,and Nutrition.European Society for Paediatric Infectious Diseases.
European society for paediatric gastroenterology, hepatology, and Nutrition/European society for paediatric
infectious diseases evidence-based guidelines for the management of acute gastroenteritis in children in europe. J
Pediatr Gastroenterol Nutr. 2008;46(Suppl 2):S81-122. Accessed 20080507; 11/27/2014 12:34:04 PM. http://
dx.doi.org/10.1097/MPG.0b013e31816f7b16.
6. MacGillivray S, Fahey T, McGuire W. Lactose avoidance for young children with acute diarrhoea. Cochrane
Database of Systematic Reviews. 2013;10.
7. National GC. Best evidence statement (BESt). Use of Lactobacillus rhamnosus GG in children with acute
gastroenteritis. http://www.guideline.gov/
content.aspx?id=33576&search=%22acute+gastroenteritis%22+and+(child*+or+pediatr*+or+paediatr*);.
8. National GC. Evidence-based care guideline for prevention and management of acute gastroenteritis (AGE) in
children aged 2 months to 18 years. http://www.guideline.gov/
content.aspx?id=35123&search=%22acute+gastroenteritis%22+and+(child*+or+pediatr*+or+paediatr*);.
9. National GC. Oral rehydration therapy (ORT) in children. http://www.guideline.gov/
content.aspx?id=38900&search=%22acute+gastroenteritis%22+and+(child*+or+pediatr*+or+paediatr*);.
10. Seattle Children’s Hospital, O’Callaghan J, Beardsley E, Black K, Drummond K, Foti J, Klee K, Leu MG, Ringer
C. 2011 September. Acute Gastroenteritis (AGE) Pathway.
11. Szajewska H, Guarino A, Hojsak I, et al. Use of probiotics for management of acute gastroenteritis: A position
paper by the ESPGHAN working group for probiotics and prebiotics. J Pediatr Gastroenterol Nutr . 2014;58(4):531-
539.
12. Szajewska H, Ruszczynski M, Kolacek S. Meta-analysis shows limited evidence for using lactobacillus
acidophilus LB to treat acute gastroenteritis in children. Acta Paediatr. 2014;103(3):249-255. Accessed 20140211;
11/27/2014 12:34:04 PM. http://dx.doi.org/10.1111/apa.12487.
13. Szajewska H, Skorka A, Ruszczynski M, Gieruszczak-Bialek D. Meta-analysis: Lactobacillus GG for treating
acute gastroenteritis in children--updated analysis of randomised controlled trials. Aliment Pharmacol Ther.
2013;38(5):467-476. Accessed 20130813; 11/27/2014 12:34:04 PM. http://dx.doi.org/10.1111/apt.12403
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