acteiœdomiiologica

Advisory Panel, page V

Contents Vol. 77, page VIAuthors' Index, page XI

Subject Index, page XV

Printed in Denmark

by Bogtrykkeriet Forum

Copenhagen

Advisory Panel

Dr. Asbjorn Aakvaag. Oslo, Norway.Prof. Kurt Ähren, Göteborg, Sweden.Prof. M. Apostolakis. Thessialoniki, Greece.Dr. J. Arends, Copenhagen, Denmark.Prof. G. Asboe-Hansen, Copenhagen,Denmark.Dr. Arne Attramadal, Oslo, Norway.Prof. C. Barker Jorgensen, Copenhagen,Denmark.Dr. Peter Berle, Wiesbaden, Germany.Prof. G. Bettendorf, Hamburg, Germany.Prof. Knut Bjoro, Oslo, Norway.Prof. Werner Blunck, Hamburg, Germany.Dr. L. M. Boot, Amsterdam, The Netherlands.Dr. Albert Burger, Genève, Switzerland.Dr. Hans Biirgi, Bern, Switzerland.Dr. Eroi Cerasi, Stockholm, Sweden.Dr. A. de la Chapelle, Helsinki, Finland.Prof. L. Korsgaard Chrlstensen, Hellerup,Denmark.

Dr. P. A. Desaulles, Basle, Switzerland.Prof. E. Diczfalusy, Stockholm, Sweden.Prof. Bengt Engfeldt, Stockholm, Sweden.Prof. Jörgen Falck Larsen, Hellerup, Denmark.Prof. Sture Falkmer, Umeâ, Sweden.Prof. D. J. Finney, Edinburgh, Scotland.Prof. Heinz Frahm, Hamburg, Germany.Dr. Harald M. M. Frey, Oslo, Norway.Prof. E. R. Froesch, Zürich, Switzerland.Dr. Petter Fylling, Oslo, Norway.Prof. Carl Gemzell, New York, USA.Prof. F. C. Greenwood, Honolulu, USA.Prof. Franz Gross, Heidelberg, Germany.Dr. Harry N. Haugen, Oslo, Norway.Prof. Chr. Hedinger, Zürich, Switzerland.Prof. H. Hortung, Helsinki, Finland.Prof. Anders Hulth, Malmö, Sweden.Prof. Bernt Hökfelt, Malmö, Sweden.Dr. Svend G. Johnsen, Copenhagen,Denmark.Prof. Alfred Jost, Paris, France.Prof. Peter W. Jungblut, Wilhelmshaven,Germany.Prof. H. J. Karl, München, Germany.

Prof. R. Knuppen, Lübeck, Germany.Prof. J. Kracht, Giessen, Germany.Dr. K. Liewendahl, Helsinki, Finland.Prof. Jan Lindsten, Stockholm, Sweden.Dr. B. P. Lisboa, Hamburg, Germany.Dr. Jan-Gustaf Ljunggren, Stockholm,Sweden.Prof. H. Maske, Wien-Liesing, Austria.Dr. R. Neher, Basle, Switzerland.Dr. Karl Olof Nilsson, Malmö, Sweden.Dr. Nils Norman, Oslo, Norway.Prof. P. G. W. J. van Oordt, Utrecht,The Netherlands.Prof. Jörgen Pedersen, Copenhagen,Denmark.Prof. A. Pekkarinen, Turku, Finland.Dr. Risto Pelkonen, Helsinki, Finland.Prof. Sykkö Pesonen, Helsinki, Finland.Prof. A. Prader, Zürich, Switzerland.Dr. Peter Rasmussen, Copenhagen, Denmark.Prof. K. B. Ruf, Genève, Switzerland.Dr. Helmuth Schmidt, Wiesbaden, Germany.Prof. Herbert Schriefers, Ulm/Donau,Germany.Dr. Björn Sjögren, Göteborg, Sweden.Prof. W. Staib, Düsseldorf, Germany.Dr. Werner Stauffacher, Bern, Switzerland.Dr. R. van Strik, Rotterdam, The Netherlands.Prof. K. F. Stoa, Bergen, Norway.Prof. H.-D. Taubert, Frankfurt am Main,Germany.Prof. H. Thomas, Ulm/Donau, Germany.Prof. Niels A. Thorn, Copenhagen, Denmark.Dr. lb Transbol, Hellerup, Denmark.Prof. M. B. Vallotton, Genève, Switzerland.Prof. T. Vanha-Perttula, Kuopio, Finland.Prof. Weiert Velie, Oslo, Norway.Dr. J. van der Vies, Oss, The Netherlands.Prof. H. K. A. Visser, Rotterdam,The Netherlands.Prof. J. H. Vogt, Oslo, Norway.Prof. K. D. Voigt, Hamburg, Germany.Dr. Peter Wahlberg, Mariehamn, Finland.Prof. Otto Walaas, Oslo, Norway.Prof. K. F. Weinges, Homburg/Saar, Germany.

Contents Vol. 77

HYPOTHALAMUS

Corbin ., Upton G. V., Mabry C. C. and Hollingsworth D. R.: Diencephalic in¬volvement in generalized lipodystrophy: rationale and treatment with the neuro-

leptic agent pimozide. 209Galloway D. B., Cotta Y., Pelletier J. and Terqui M.: Circulating luteinizing hor¬

mone and testosterone response in rams after luteinizing hormone releasing hor¬monetreatment. 1

Gamier P. E„ Chaussain J.-L., Binet E., Schlumberger A. and Job ].-C: Effect ofsynthetic luteinizing hormone-releasing hormone (LH-RH) on the release ofgonadotrophins in children and adolescents. VI. Relations to age, sex and puberty 422

Griffiths E. C. and Hooper K. C: Peptidase activity in different areas of the rat

hypothalamus. 10Griffiths E. C, Hooper K. C, Jeffcoate S. L. and Holland D. T.: The presence

of peptidases in the rat hypothalamus inactivating luteinizing hormone-releasinghormone (LH-RH). 435

Haag E., Aakvaag ., Sand T. and Torjesen P. .: The gonadotrophin responseto synthetic gonadotrophin-releasing hormone in males in relation to age, dose,and basal serum levels of testosterone, oestradiol-17/5 and gonadotrophins

....

625Visser T. J., Docter R. and Hennemann G.: Radioimmunoassay of thyrotrophin

releasing hormone (TRH). 417

PITUITARY

Atkinson R. L., Jr., Dimond R. C, Howard W. J. and Earll J. M.: Unsuccessfultreatment of acromegaly with medroxyprogesterone acetate. 19

Aubert M. L., Grumbach M. M. and Kaplan S. L.: Heterologous radioimmuno¬assay for plasma human prolactin (hPRL): values in normal subjects, puberty,pregnancy and in pituitary disorders. 460

Böhmer T., Berdal P. and Hangen . .: Transsphenoidal subtotal hypophys-ectomy in the treatment of acromegaly. 477

Fahrer M., Gruñeiro L., Rivarola M. and Bergedá C: Levels of plasma growthhormone in children with congenital heart disease. 451

Johnson S. E., Norman N. and Sjaastad 0.: Decreased arginine-induced HGHresponse during L-dopa therapy in Parkinsonian patients. 686

Landers E. and Wagner W. C: Adrenalectomy and pituitary LH in oophorecto-mized suckledrat. 498

Lucke C, Höffken . and Morgner K. D.: L-dopa induced growth hormone secre-

tion. Comparison with insulin tolerance test, arginine infusion and sleep in¬duced GH-secretion. 241

Qazi M. H., Romani P. and Diczfalnsy E.: Discrepancies in plasma LH activitiesas measured by radioimmunoassay and in in vitro bioassay. 672

Russell J. T., Hansen E. E. and Thorn . .: Calcium and stimulus-secretioncoupling in the neurohypophysis. III. Ca2+ ionophore (A-23187)-induced releaseof vasopressin from isolated rat neurohypophyses. 443

Russell J. T., Warberg J. and Thorn . .: Calcium and stimulus-secretioncoupling in the neurohypophysis. IV. Effect of N-ethylmaleimide on 45Ca2+transport and vasopressin release by isolated rat neurohypophyses. 691

Schillinger E. and Gerhards E.: Effects of pituitary hormones and corticosteroneon lipolysis in hypophysectomized rats. 502

Torjesen P. ., Sand T., Norman N., Trygstad O. and Foss I.: Isolation of LH,FSH and TSH from human pituitaries after the removal of HGH. 485

Valotaire Y. and Duval J.: Opposite effects of androgens and oestrogens on ratpituitary thymidine kinase activity. 509

Van Damme M.-P., Robertson D. M. and Diczfalnsy E.: An improved in vitro bio¬assay method for measuring luteinizing hormone (LH) activity using mouse

Leydig cell preparations. 655Verjans H. L., de Jong F. //., Cooke . ., van der Molen . J. and Eik-Nes

. B.: Effect of oestradiol benzoate on pituitary and testis function in the normaladult male rat. 636

Verjans H. L., Eik-Nes K. B., Aafjes J. H., Veis F. M. J. and van der Molen H J.:Effects of testosterone propionate, 5a-dihydrotestosterone propionate and oestra¬diol benzoate on serum levels of LH and FSH in the castrated adult male rat 643

Zachmann M„ Völlmin J. A. and Zagalak M.: Urinary steroid dynamics after a

single dose of metyrapone. 221

THYROID

Agerbœk H.: The hormone synthesis of hyperfunctioning thyroid nodules ineuthyroid patients. 53

Bernal J. and Escobar del Rey F.: Inhibition by propylthiouracil of the extra-

thyroidal formation of triiodothyronine from thyroxine. 276Glinoer D., Puttemans N., Van Herle A. J.. Camus M. and Ermans A. M.:

Sequential study of the impairment of thyroid function in the early stage ofsubacute thyroiditis. 26

Gray H. W., Thomson J. A. &: Stuart Kennedy J.: Remission ol lamilial goitroushypothyroidism. 257

Joasoo A. and Murray L P. C: The effect of epinephrine on the uptake of 1S1Iby the rat thyroid, with particular reference to the trapping process. 35

joasoo A. and Murray L P. C: The effect of epinephrine on thyroid hormonesynthesis in the rat. 43

Jolin T. and Tarin M. J.: Thyroidal ,'"I turnover in adult male rats at differenttimes of the sameday. 82

Rapitola J., Schüllerová M., Schreiberová O., Vilimovská D. and Josifko M.: Rela¬tion of TSH concentration in blood to the radioactive rubidium e8Rb uptake in

the thyroid gland of rats: evidence of TSH regulatory effect on thyroid glandbloodflow. 266

Kirkegaard C., Friis T. and Siersbcek-Nielsen K.: Measurements of serum triiodo-thyronine by radioimmunoassay. 71

Kolendorf K., Siersbœk-Nielsen ., Molhohn Hansen J. and Friis T.: Evaluationof thyroid status with the "effective thyroxine ratio" (E.T.R®). 250

Monaco F., Grimaldi S., Scitncio G. and Andreoli M.: Isolation of desialylated andlow-iodinated thyroglobulin in an experimental rat thyroid tumour. 517

Wägar G.: Effect of actinomycin D on TSH-induced stimulation of thyroidalprotein synthesis in the rat. 64

PARATHYROID

Ponthier Jr. R. L. and Rice B. F.: Hypercalcaemia of neoplasia, parathyroid hor¬mone and vitamin D: studies in parabiosis. 527

Scurry M. T. and Pauk G. L.: Renal tubular localization of parathyroid hormoneinduced urinary cyclic adenosine 3',5'-monophosphate. 282

PANCREAS

Annable L., Bangham D. R., Salokangas A. A. and Storring P. L.: The first inter¬national standard for glucagon. 705

Bansal D. D., Bajaj J. S. and Vallance-Owen J.: Application of wick chromato¬graphy to the radioimmunoassay of peptide hormones and other polypeptides

.

. IllCorrali R. J., Hunter W. M.. Campbell I. W., Harrower A. D. B., Duncan L. J. P.

and Clarke B. F.: Reversal by insulin treatment of abnormal growth hormonepattern in newly diagnosed diabetes mellitus. 115

Goes G. and Berend K.: Plasma glucose, insulin and free fatty acids during long-term corticosteroid treatment in children. 699

Hoist J. J. and Aasted B.: Production and evaluation of glucagon antibodies forradioimmunoassay. 715

Keymolen-Jardini V.. Mouawad E., Claeys-De Clercq P., Van Laer E., Levin S.and Borkowski .: Glucose metabolism in traumatic brain injury. 103

Lostroh A. ].: Diabetogenic hormones (human choriosomatomammotrophin andovine growth hormone): anti-insulin action in hypophysectomized rats. 96

LIVER

Ghraf R., Lax E. R., Hoff H.-G. and Schriefers .: Regulation of the activities ofthe enzymes involved in the metabolism of steroid hormones in rat liver: theeffect of 19-nortestosterone and the influence of cyproterone acetate on theaction of testosterone and 5a-dihydrotestosterone. 287

Hillier A. P.: Antagonistic effects of dinitrophenol and cyanide on hepaticthyroxine deiodination. 122

Malier Mansour A. and Nass S.: RNA synthesis in rat liver after cortisol treat¬ment: a possible mitochondrial-nuclear relationship. 298

Thaler-Dao H. and Breuer H.: Gonadal factors regulating the activity of the 17/?-hydroxysteroid oxidoreductase in rat liver. 727

ADRENALS

Manthorpe R., Helin G., Kofod B. and Lorenzen L: Effects of glucocorticoid on

connective tissue of aorta and skin in rabbits. Biochemical studies on collagen,glycosaminoglycans, DNA and RNA. 310

Osterman P. 0.: Light synchronization of the Orcadian rhythm of plasma 11-

hydroxycorticosteroids in man. 128Williams K.: Defective steroidal synthesis by adrenal tissue: the control of gene

expression causing loss of active steroidogenic enzymes. 325

OVARIES

Curtis-Prior P. B., Brewer H. F. N., Temple N. J., Ross L. and Field D. .: In¬vestigations into the effects of cyclical rhythm and hormonal contraception on

serum fat-mobilizing activity, glycerol, cholesterol and blood glucose. 337De Jong F. H., Baird D. T. and van der Molen . J.: Ovarian secretion rates of

oestrogens, androgens and progesterone in normal women and in women withpersistent ovarian follicles. 575

Herlitz ., Hamberger E., Rosberg S. and Akrén K.: Cyclic AMP in isolatedcorpora lutea of the rat: influence of gonadotrophins and prostaglandins. 737

Nilsson L.: Acute effects of gonadotrophins and prostaglandins on the metabolismof isolated ovarian follicles from PMSG-treated rats. 540

Nilsson L., Rosbcrg S. and Ahrén .: Characteristics of the cyclic 3',5'-AMP for¬mation in isolated ovarian follicles from PMSG-treated immature rats afterstimulation in vitro with gonadotrophins and prostaglandins. 559

Senior . E.: Changes in the concentrations of oestrone and oestradiol in the peri¬pheral plasma of the domestic hen during the ovulatory cycle. 588

UTERUS

Egert D. and Maass H.: Progesterone in the uterus. I. On the question of pro¬gesterone metabolism in the uterus of normal rats. 135

Egert D., Jonat W. and Maass H.: Progesterone in the uterus. II. On the questionof in vitro metabolism of progesterone by the uterus of normal rats. 150

Egert D. and Maass H.: Progesterone in the uterus. III. On the question of pro¬gesterone metabolism in the uterus of pregnant rats. 160

PREGNANCY

Choong C. H. and Raeside J. I.: Chemical determination of oestrogen distributionin the foetus and placenta of the domesticpig. 171

Christensen ., Froyshov D. and Fylling P.: Hormone and enzyme assays inpregnancy. IV. The human chorionic somatomammotrophin, placental cystine-aminopeptidase, progesterone and the urinary oestrogens in pregnancies com¬

plicated with essential hypertension, mild or severe pre-eclampsia. 344Geyer . and Riebschläger M.: Effect of pregnancy on cytoplasmic and mito-

chondrial enzymes in human and animal myometrium.

368Pasqualini J. R., Sumida C. and Gelly C: Studies on the mechanism of formation

of [3H]aldosterone macromolecule complexes in the foetal guinea pig kidney . . 356

TESTES

Aakvaag A. and Stremme S. B.: The effect of mesterolone administration to nor¬

mal men on the pituitary-testicular function. 380Comhaire F., Mattheeuws D. and Vermeiden .: Testosterone and oestradiol in

dogs with testicular tumours. 408Mahoudeau J. ., Delasalle A. and Bricaire H.: Secretion of dihydrotestosterone

by human prostate in benign prostatic hypertrophy. 401McMahon M. J.. Butler A. V. J. and Thomas G. H.: Testosterone metabolism in

cultured hyperplasia of the human prostate.

784Smals A. G. H., Kloppenborg P. W. C. and Benraad T. J.: Body proportions and

androgenicity in relation to plasma testosterone levels in Klinefelter's syndrome 387Smals A. G. H., Kloppenborg P. W. C. and Benraad T. J.: The effect of short and

long term human chorionic gonadotrophin (HCG) administration on plasmatestosterone levels in Klinefelter's syndrome. 753

Smals A. G. H., Kloppenborg P. W. C, Lequin R. M. and Benraad T. J.: Theeffect of oestrogen administration on plasma testosterone, FSH and LH levels inpatients with Klinefelter's syndrome and normalmen. 765

Titohimaa P. and Söderström K.-O.: Weight gain and [3H] thymidine incorporationin accessory sex glands of castrated male rats after physiological doses oftestosterone. 597

MISCELLANEOUS

Bell N. H.: Evidence for a separate adenylate cyclase system responsive to beta-adrenergic stimulation in the renal cortex of the rat. 604

Hughes P. C. R. and Tanner J. M.: The effect of a single neonatal sex hormoneinjection on the growth of the rat pelvis. 612

Nozawa S, Kurihara S., Tsutsui F. and Watanabe K.: The effects of oestrogenson the lysosomes of rat vaginal epithelium: a histochemical study. 193

Roy S. K., Setty B. S., Chandra H. and Kar A. B.: The effect of efferent ductligation on the uptake of 65Zn by the epididymis and vas deferens of rhesusmonkeys (Macaca mulatta). 186

Sogbesan A. 0., Kwaku Adadevoh B. and Dada . .: The uptake of certainsteroid hormones by intact human erythrocytes

—

the influence of haemoglobingenotype. 794

Authors' Index

Aafjes J. H., 643Aakvaag ., 380, 625Aasted ., 715Adadevoh . ., 794Agerbœk ., 53Ahrén ., 559, 737Andreoli M., 517Annable L., 705Atkinson R. L., Jr., 19Aubert M. L., 460

Baird D. T., 575Bajaj J. S., IllBangham D. R., 705Bansal D. D., IllBell N. H, 604Benraad T. J., 387, 753, 765Berdal P., 477Berend K., 699Bergadá G, 451Bernal J., 276Binet E„ 422Borkowski ., 103Breuer ., 727Brewer H. F. ., 337Bricaire ., 401Butler . V. J., 784Böhmer T., 477

Campbell I. W., 115Camus M., 26Chandra H., 186Chaussain J.-L., 422Choong C. H, 171Christensen ., 344Clayes-De Clercq P., 103Clarke B. F., 115Comhaire F., 408Cooke . ., 636Corbin ., 209Corrali R. J., 115Cotta Y., 1Curtis-Prior P. ., 337

Dada . ., 794Delasalle ., 401

Diczfalusy E., 655, 672Dimond R. G, 19Docter R., 417Duncan L. J. P., 115Duval J., 509

Earll J. M., 19Egert D., 135, 150, 160Eik-Nes K. B., 636, 643Ermans A. M., 26Escobar del Rey F., 276

Fahrer M., 451Field D. ., 337Foss L, 485Friss T., 71, 250Frayshov D., 344Fylling P., 344

Gács G, 699Galloway D. B., 1Garnier P. E., 422Gelly G, 356Gerhards E., 502Geyer H., 368Ghraf R., 287Glinoer D., 26Gray H. W., 257Griffiths E. G, 10, 435Grimaldi S., 517Grumbach M. M., 460Gruiieiro L., 451

Hamberger L., 737Hansen E. L., 443Hansen J. M., 250Harrower A. D. B., 115Haug E., 625Haugen H. N., 477Helin G, 310Hennemann G., 417Herlitz H, 737Hillier A. P., 122Hoff H.-G., 287Holland D. T., 435Hollingsworth D. R., 209Holst J. J., 715

Hooper K. G, 10, 435Howard W. J., 19Hughes P. C. R., 612Hunter W. M., 115Höffken B., 241

Jeffcoate S. L., 435Joasoo ., 35, 43Job J.-C, 422Johnson S. E., 686Jolin T., 82Jonat W., 150de Jong F. H., 575, 636Josifko M., 266

Kapitola J., 266Kaplan S. L., 460Kar A. B., 186Kennedy J. S., 257Keymolen-Jardini V., 103Kirkegaard G, 71Kloppenborg P. W. G, 387, 753, 765Kofod -B., 310Kurihara S., 193Kolendorf K., 250

Landers E., 498Lax E. R., 287Lequin R. M., 765Levin S., 103Lorenzen L, 310Lostroh A. J., 96Lucke G, 241

Maass H., 135, 150, 160Mabry C. G, 209Mahoudeau J. ., 401Mansour A. M., 298Manthorpe R., 310Mattheeuws D., 408McMahon M. J., 784van der Molen H. J., 575, 636, 643Monaco F., 517Morgner K. D., 241Mouawad E., 103Murray I. P. G, 35, 43Molholm Hansen J., 250

Nass S., 298Nilsson L., 540, 559Norman N., 485, 686Nozawa S., 193

Osterman P. O., 128

Pasqualini J. R., 356Pauk G. L., 282Pelletier J., 1Ponthier R. L. Jr., 527Puttemans N., 26

Qazi M. H., 672Raeside J. L, 171Rice B. F., 527Riebschläger M., 368Rivarola M., 451Robertson D. M., 655Romani P., 672Rosberg S., 559, 737Ross L., 337Roy S. K., 186Russell J. T., 443, 691

Salokangas . ., 705Sand T., 485, 625Schillinger E., 502Schlumberger ., 422Schreiberová O., 266Schriefers ., 287Schüllerová M., 266Scuncio G, 517Scurry M. T., 282Senior B. E., 588Setty B. S., 186Siersbaek-Nielsen K., 71, 250Sjaastad O., 686Smals A. G. H., 387, 753, 765Sogbesan A. O., 794Starring P. L., 705Stramme S. B., 380Sumida G, 356Söderström K.-O., 597

Tanner J. M., 612Tarin M. J., 82Temple N. J., 337Terqui M., 1Thaler-Dao H., 727Thomas G. H., 784Thomson J. ., 257Thorn . ., 443, 691Torjesen . ., 485, 625Trygstad O., 485Tsutsui F., 193Tuohimaa P., 597

Upton G. V., 209

Vallance-Owen J., IllValotaire Y., 509Van Damme M.-P., 655Van Herle A. J., 26Van Laer E., 103Veis F. J. M., 643Verjans H. L., 636, 643Vermeulen ., 408Vilimovská D., 266

Visser T. J„ 417Völlmin J. ., 221

Wagner W. C, 498Warberg J., 691Watanabe K., 193Williams K., 325Wägar G.. 64

Zachmann M., 221Zagalak M., 221

Subject Index

ACCESSORY SEX ORGANSof castrated male rats; weight gain and

thymidine incorporation afterphysiological doses of testosterone, 597

ACROMEGALYplasma growth hormone levels following

oral administration of L-dopa, 241unsuccessful treatment with

medroxyprogesterone acetate, 19treatment; transsphenoidal subtotal

hypophysectomy, 477

ACTINOMYCIN Deffect on nuclear RNA polymerase

in the rat liver, 298effect on TSH-induced stimulation of

thyroid protein synthesis in rats, 64

ADAPTATION SYNDROMEinflammatory process in subacute

thyroiditis, 26

ADENOSINE 3',5'-MONOPHOSPHATEsee CYCLIC AMP

ADENYLATE CYCLASEsystem responsive to beta-adrenergic

stimulation in the renal cortexof the rat, 604

ADIPOSE TISSUEadrenal and pituitary regulation of

lipolysis in rats, 502

ADRENAL CORTEXadrenalectomy and pituitary LH in

oophorectomized suckled rats, 498aldosterone macromolecule complexes;

formation in foetal guinea pigkidney, 356

congenital adrenocortical hyperplasia;defective steroidal synthesis, 325

defective steroidal synthesis byhuman adrenal tissue, 325

hormone secretion; urinary steroiddynamics after a single dose ofmetyrapone, 221

ADRENALECTOMYeffect on pituitary LH in

oophorectomized suckled rats, 498

ADRENALINEeffect on lipolysis in

hypophysectomized rats, 502effect on uptake of 131I by the

rat thyroid, 35effect on thyroid hormone synthesis

in the rat, 43

ALDOSTERONEformation of aldosterone macromolecule

complexes in foetal guinea pigkidney, 356

AMINOACIDSiodo-aminoacids in the rat thyroid;

effects of adrenaline on thyroidhormone synthesis, 43

ANABOLIC STEROIDS19-nortestosteronc; effect on the

regulation of steroidogenic enzymesin the rat liver, 287

ANDROGENICITYin Klinefelter's syndrome; relation to

plasma testosterone level, 387

ANDROGENSeffect on rat pituitary thymidine kinase

activity, 509ovarian secretion of androgens in

normal women and in women withpersistent ovarian follicles, 575

3et-ANDR0STANEDI0Leffect on rat pituitary thymidine kinase

activity, 509

ANDROSTENEDIONEovarian secretion in normal women and

in women with persistent ovarianfollicles, 575

ANTI-ANDROGENScyproterone acetate; effect on the

regulation of steroidogenic enzymesin the rat liver, 287

ANTIGLUCAGON ANTIBODIESproduction and evaluation for

radioimmunoassay, 715

ANTI-INSULIN ACTIONof diabetogcnic hormones in

hypophysectomized rats, 96

ANTI-THYROID COMPOUNDSinhibition by propylthiouracil of

extrathyroidal formation ofT8 from T4, 276

AORTAeffect of glucocorticoids on connective

tissue of rabbit aorta, 310

ARGININEdecreased arginine-induced HGH

response during L-dopa therapy inParkinsonian patients, 686

growth hormone secretion followingarginine infusion, 241

BENIGN PROSTATICHYPERTROPHY

secretion of 5a-dihydrotestosteroneby the human prostate, 401

testosterone metabolism in culturedhyperplasia of the human prostate, 784

BLOODintact human erythrocytes; uptake of

certain steroid hormones, 794

BLOOD CIRCULATIONin thyroid glands of rats;

TSH regulation, 266

BLOOD VESSELSeffect of glucocorticoids on connective

tissue of the rat aorta, 310

BODY PROPORTIONSin Klinefelter's syndrome; relation to

plasma testosterone level, 387

BRAINdiencephalic involvement in generalized

lipodystrophy, 209traumatic brain injury in man:

effect on glucose metabolism, 103

CALCIUMhypercalcaemia of neoplasia,

parathyroid hormone and vitamin D;studies in parabiosis, 527

stimulus-secretion coupling in theneurohypophysis; Ca?+ ionophore-induced release of vasopressin fromisolated rat neurohypophyses, 443

stimulus-secretion coupling in theneurohypophysis; effect of N-ethyl-maleimide on 45Ca2+ transport andvasopressin release from isolated rat

neurohypophyses, 691

CARBOHYDRATESmetabolism in isolated ovarian follicles

from PMSG-treated immaturerats, 540

CATECHOLAMINESadrenaline; effect on lipolysis in

hypophysectomized rats, 502adrenaline; effect on the Tg uptake by

the rat thyroid, 35adrenaline; effect on thyroid hormone

synthhesis in the rat, 43

CHOLESTEROLeffect of menstrual cycle rhythm and

hormonal contraception on serum

cholesterol, 337

CHORIONIC GONADOTROPHINeffect on plasma testosterone levels in

Klinefelter's syndrome, 753

CHROMATOGRAPHYapplication of wick chromatography

to RIA of peptide hormones andother polypeptides, 111

CHROMOSOMESthe control of gene expression causing

loss of active steroidogenic enzymesin human adrenal tissue, 325

CHRONOBIOLOGYcircadian rhythm of androgen secretion

in male rats, 597light synchronization of the circadian

rhythm of plasma 11-OHCSin man, 128

thyroidal 13II turnover in rats atdifferent times of the same day, 82

COAGULATING GLANDSof castrated rats; effects of physiological

doses of testosterone on weight gainand thymidine incorporation, 597

COLLAGENbiochemical studies on connective tissue

of rabbit aorta and skin, 310

CONGENITAL ADRENOCORTICALHYPERPLASIA

the control of gene expressioncausing loss of active steroidogenicenzymes, 325

CONNECTIVE TISSUEeffects of glucocorticoids on connective

tissue of rabbit aorta and skin;biochemical studies on collagen, glyc-osaminoglycans, DNA and RNA, 310

CONTRACEPTION (HORMONAL)effects on serum fat-mobilizing activity,

glyccrol, cholesterol andblood glucose, 337

CORTICOSTEROIDSaldosteronc macromolecule complexes;

formation in foetal guinea pigkidneys, 356

circadian rhythm of plasma 11-OHCSin man; light synchronization, 128

corticosterone; effect on lipolysis inhypophysectomized rats, 502

long-term corticosteroid treatment inchildren; effects on plasma insulin,glucose and free fatty acids, 699

prednisone; effect on connective tissueof rabbit aorta and skin, 310

urinary steroid dynamics after a singleoral dose of metyrapone, 221

CORPUS LUTEUMcyclic AMP in isolated corpora lutea of

the rat; influence of gonadotrophinsand prostaglandins, 737

CORTICOTROPHINACTH-deficient patients; urinary

steroid dynamics after a single oraldose of metyrapone, 221

effect on lipolysis in hypophysectomizedrats, 502

releasing hormone in lipodystrophy, 209

CORTISOLcircadian variation of plasma 11-OHCS

in man; light synchronization, 128effect on aldosterone macromolecule

complexes in foetal guinea pigkidney, 356

effect on RNA synthesis in rat liver;a possible mitochondrial-nuclearrelationship, 298

suppression of oestrogen effects on

lysosomal enzymes of the rat vaginalepithelium: a histochemical study, 193

CYANIDEantagonistic effect on hepatic thyroxine

deiodination, 122

CYCLIC AMPcharacteristics of cyclic AMP formation

in isolated ovarian follicles fromPMSG-trcated immature rats, 559

cyclic AMP in isolated corpora lutea ofthe rat; influence of gonadotrophinsand prostaglandins, 737

dibutyryl cyclic AMP; effect on

lipolysis in hypophysectomizedrats, 502

dibutyryl cyclic AMP: effect on

metabolism of isolated ovarianfollicles. 540

renal tubular localization of parathyroidhormone-induced urinary cyclicAMP, 282

CYPROTERONE ACETATEinfluence on the regulation of steroido¬

genic enzymes in the rat liver, 287influence on thymidine kinase activity

in rat hypophyses, 509

CYTOPLASMIC ENZYMESin human and animal myometrium, 368

DEHYDROEPIANDROSTERONEovarian secretion in normal women and

in women with persistent ovarianfollicles, 575

DEIODINATIONantagonistic effects of dinitrophenol

and cyanide on hepatic thyroxinedeiodination, 122

DEXAMETHASONElong-term treatment in children;

effects on plasma glucose, insulinand free fatty acids, 699

DIABETES MELLITUSabnormal growth hormone pattern in

newly diagnosed diabetes;reversal by insulin treatment, 115

DIABETOGENA HORMONESanti-insulin action in

hypophysectomized rats, 96

DIIODOTYROSINEin "hot" thyroid nodules in euthyroid

patients, 53in the rat thyroid;

effect of adrenaline, 43

5ct-DIHYDR0TEST0STER0NEeffect on rat pituitary thymidine kinase

activity, 509effect on serum levels of LH and FSH

in castrated male rats, 643modifying action on the sexual

differentiation of steroidogenicenzymes in rat liver, 287

secretion by human prostate in benignprostatic hypertrophy, 401

DINITROPHENOLantagonistic effect on hepatic thyroxine

deiodination, 122

DNAbiochemical studies on DNA in

connective tissues of rabbit aortaand skin, 310

"EFFECTIVE THYROXINE RATIO"evaluation of thyroid status in patients

with normal or abnormal thyroidfunction, 250

ENZYMESadenylate cyclase system responsive to

beta-adrenergic stimulation inthe renal cortex of the rat, 604

cytoplasmic and mitochondrial enzymesin human and animal myometrium;effect of pregnancy, 368

17/î-hydroxysteroid oxidoreductase inrat liver; gonadal factors regulatingthe activity, 727

lysosomal enzymes of the rat vaginalepithelium; effects of oestrogens;a histochemical study, 193

oxidoreductase (17/?-OH-steroid) inrat liver; gonadal factors regulatingthe activity, 727

peptidases; LH-RH-inactivating pep-tidases in the rat hypothalamus, 435

peptidases; oxytocin-inactivatingpeptidases in different areas ofthe rat hypothalamus, 10

placental cystine-aminopeptidaseactivity in complicated pregnancy, 344

steroidogenic enzymes in human adrenaltisue; the control of gene expressioncausing los of activity, 325

steroidogenic enzymes in rat liver;modifying action of androgens, an

anabolic steroid and an anti-androgenon the sexual differentiation ofthe enzyme activities, 287

thymidine kinase activity in rathypophyses; opposite effects ofandrogens and oestrogens, 509

EPIDIDYMISuptake of e5Zn in the Rhesus monkey;

effect of efferent duct ligation, 186

ERYTHROCYTESuptake of certain steroid hormones in

intact human erythrocytes; influenceof haemoglobin genotype, 794

ETHIDIUM BROMIDEeffect on RNA synthesis in rat liver, 298

ETHINYLOESTRADIOLeffect on plasma testosterone, F'SH and

LH in Klinefelter's syndrome andin normal men, 765

N-ETHYLMALEIMIDEeffect on 45Ca2+ transport and

vasopressin release by isolated rat

neurohypophyses, 691

FATadrenal and pituitary regulation of

lipolysis in rats, 502generalized lipodystrophy;

rationale and treatment, 209

FAT-MOBILIZING ACTIVITYin serum; effects of menstrual cycle

rhythm and hormonalcontraception, 337

FATTY ACIDSfree fatty acids during long-term corti-

costeroid treatment in children, 699

FOETAL ENDOCRINOLOGYaldosterone macromolccule complexes;

formation in guinea pig kidneys, 356distribution of oestrogens in the

pig foetus and placenta;chemical determination, 171

FOLLICLE STIMULATINGHORMONE

acute effects on cyclic AMP-formationand on the metabolism of isolatedovarian follicles from PMSG-treatedimmature rats, 540, 559

in hypophysis and serum of male ratstreated with oestradiol benzoate, 636

in normal men treated withLH/FSH-RH, 625

in normal men treated withmesterolone, 380

isolation of FSH from human hypo¬physes after removal of HGH, 485

levels in Klinefelter's syndrome andin normal men;effect of ethinyloestradiol, 765

release in children and adolescents;effect of LH-RH, 422

serum levels in castrated male rats;effects of testosterone, 5a-dihydro-testosterone and oestradiol, 643

GENETICShaemoglobin genotypes; influence on

uptake of certain steroid hormones byintact human erythrocytes, 794

the control of gene expression causingloss of active steroidogenic enzymesin human adrenal tissue, 325

GESTAGENSmedroxyprogesterone acetate; unsuc¬

cessful treatment of acromegaly, 19

GLUCAGONantibodies for radioimmunoassay;

production and evaluation, 715First International Standard;

preparation and nature, 705

GLUCOSEblood glucose; effects of menstrual

cycle rhythm and hormonalcontraception, 337

metabolism in traumatic brain injuryin man, 103

plasma glucose during long-term corti-costeroid treatment in children, 699

GLYCEROLeffects of menstrual cycle rhythm and

hormonal contraception on the serum

level, 337

GLYCOSAMINOGLYCANSbiochemical studies on connective

tissues of rabbit aorta and skin, 310

GOITREremission of familial goitrous

hypothyroidism, 257

GONADOTROPHINSacute effects on cyclic AMP-formation

and on the metabolism of isolatedovarian follicles from PMSG-treatedimmature rats, 540, 559

effects on cyclic AMP in isolatedcorpora lutea of the rat, 737

HCG; effect on plasma testosteronelevels in Klinefelter's syndrome, 753

in hypophysis and serum of male ratstreated with oestradiol benzoate, 636

LH and testosterone response in rams

following LH-RH administration, 1LH bioasay using mouse Leydig cell

preparations, 655LH in vitro bioasay, comparison with

radioimmunoasay, 672LH radioimmunoassay; comparison with

an in vitro bioassay method, 672release in children and adolescents;

effect of LH-RH, 422serum FSH and LH in castrated male

rats treated with testosterone, 5a-dihydrotestosterone or oestradiol, 643

serum FSH and LH in normal men

treated with LH/FSH-RH, 625

GROWTHretardation in children with

congenital heart disease, 451

GROWTH HORMONEabnormal growth hormone pattern in

newly diagnosed diabetes mellitus;reversal by insulin, 115

acromegaly; unsuccessful treatment withmedroxyprogesterone acetate, 19

decreased arginine-induced HGHresponse during L-dopa therapy inParkinsonian patients, 686

effect on lipolysis in hypophysectomizedrats, 502

isolation of FSH, LH and TSH fromhuman pituitaries after removal ofHGH, 485

ovine GH; anti-insulin action inhypophysectomized rats, 96

plasma HGH levels following oralL-dopa administration, insulintolerance test, arginine infusion andsleep, 241

plasma HGH levels in children withcongenital heart disease, 451

plasma HGH in patients with traumaticbrain injury, 103

HAEMOGLOBINuptake of certain steroid hormones by

intact human eythrocytes; influenceof haemoglobin genotype, 794

HEARTcongenital heart disease;

levels of plasma growth hormonein children, 451

HEXOESTROLeffect of a single neonatal injection on

the growth of the rat pelvis, 612

HUMAN CHORIONICGONADOTROPHIN see

CHORIONIC GONADOTROPHIN

HUMAN CHORIONICSOMATOMAMMOTROPHIN see

SOMATOMAMMOTROPHIN

HUMAN PLACENTALLACTOGEN HORMONE see

SOMATOMAMMOTROPHIN

11-HYDROXYCORTICOSTEROIDSlight synchronization of the circadian

rhythm of plasma 11-OHCSin man, 128

17-HYDROXYSTEROIDOXIDOREDUCTASE

in rat liver; gonadal factors regulatingthe activity, 727

HYPERCALCAEMIAof neoplasia, parathyroid hormone and

vitamin D; studies in parabiosis, 527

HYPERTENSIONsomatomammotrophin; placental

cystine-aminopeptidase, progesteroneand oestrogens in pregnancies compli¬cated with esential hypertension, 344

HYPERTHYROIDISM"effective thyroxine ratio";

evaluation of thyroid status, 250

HYPOPHYSECTOMYlipolysis in hypophysectomized rats;

adrenal and pituitary regulation, 502transsphenoidal subtotal hypophysec-

tomy in treatment of acromegaly, 477

HYPOPHYSIS (ANTERIOR LOBE)disorders; values of plasma human

prolactin, 460FSH and LH in hypophysis and in

serum in male rats treated withoestradiol benzoate, 636

function; urinary steroid dynamics aftera single oral dose of metyrapone, 221

gonadotrophin secretion followingLH/FSH-RH in normal men, 625

growth hormone secretion followingoral stimulation with L-dopa, 241

hormones; effects on lipolysis in rats, 502hypophysectomy (transsphenoidal sub¬

total) in treatment of acromegaly, 477isolation of FSH, LH and TSH after

removal of HGH, 485pituitary-testicular function in normal

men; effect of mesterolone, 380prolactin; plasma values in normal

subjects, puberty, pregnancy andpituitary disorders, 460

release of gonadotrophins in childrenand adolescents; effect of LH-RH, 422

secretion of LH after LH-RH in rams, 1

thymidine kinase activity in rathypophyses; opposite effects ofandrogens and oestrogens, 509

HYPOPHYSIS (POSTERIOR LOBE) see

NEUROHYPOPHYSIS

HYPOTHALAMUSdiencephalic involvement in generalized

lipodystrophy, 209LH-RH administration in rams; effects

on LH and testosterone production, 1LH-RH; effect on gonaddotrophins,

testosterone and oestradiol innormal men, 625

LH-RH; effect on release ofgonadotrophins in children andadolescents, 422

LH-RH; inactivation by peptidases inthe rat hypothalamus, 435

oxytocin-inhibiting peptidases in differ¬ent areas of the rat hypothalamus, 10

peptidases in the rat hypothalamusinactivating LH-RH, 435

thyrotrophin releasing hormone;radioimmunoassay, 417

HYPOTHYROIDISM"effective thyroxine ratio";

evaluation of thyroid status, 250remission of familial goitrous

hypothyroidism, 257

ICSH see LUTEINIZING HORMONE

IMMUNOLOGYglucagon antibodies for RIA;

production and evaluation, 715heterologous RIA for plasma human

prolactin, 460measurement of serum T:! in man

by RIA, 71RIA of LH in plasma; comparison with

an in vitro bioassay method, 672RIA of thyrotrophin releasing

hormone, 417wick chromatography applied to RIA

of peptide hormones and otherpolypeptides, 111

INSULINanti-insulin action of diabetogenic hor¬

mones in hypophysectomized rats, 96insulin tolerance test; effect on growth

hormone secretion, 241plasma insulin during long-term corti-

costeroid treatment in children, 699treatment in newly diagnosed diabetes

in young men; reversal of the ab¬normal growth hormone pattern, 115

INTERNATIONAL STANDARDSFirst International Standard for

Glucagon; preparation and nature, 705

IODINEdeiodination of thyroxine by the liver;

antagonistic effects of dinitrophenoland cyanide, 122

iodo-aminoacids in the rat thyroid;effects of adrenaline, 43

low-iodinated thyroglobulin in an

experimental rat thyroid tumour, 517thyroidal iodide organification in

familial goitrous hypothyroidism, 257thyroidal 1311 turnover in rats at

different times of the same day, 82uptake of 1311 by the rat thyroid;

effect of adrenaline, 35

IONOPHORECa2+ ionophore (A-23187); induction

of vasopressin release from isolated rat

neurohypophyses, 443

ISOPROTERENOLeffect on adenylate cyclase activity in

rat renal cortex, 604

KIDNEYSaldosterone macromolecule complexes;

formation in foetal guinea pigkidneys, 356

a separate adenylate cyclase systemresponsive to beta-adrenergicstimulation in the renal cortex ofthe rat, 604

renal tubular localization of parathyroidhormone induced urinary cyclicAMP, 282

KLINEFELTER'S SYNDROMEbody proportions and androgenicity

in relation to plasma testosteronelevels, 387

plasma testosterone, FSH and LHlevels; effect of ethinyloestradiol, 765

plasma testosterone levels; effect ofshort- and long-term HCGadministration, 753

L-DOPAgrowth hormone secretion following

oral stimulation with 500 mgL-dopa, 241

therapy in Parkinsonian patients;decreased arginine-induced HGHresponse, 686

LEUCINEincorporation into rat thyroid proteins;

effect of actinomycin D, 64

LEYDIG CELLSbioassay of luteinizing hormone using

mouse Leydig cell preparation, 655

LIGHT SYNCHRONIZATIONof the circadian rhythm of plasma

11-OHCS in man, 128

LIPODYSTROPHYdiencephalic involvement in generalized

lipodystrophy; treatment withpimozide, 209

LIPOLYSISin hypophysectomized rats;

adrenal and pituitary regulation, 502

LIVERhepatic thyroxine deiodination;

antagonostic effects of dinitrophenoland cyanide, 122

RNA synthesis in rat liver aftercortisol: A possible mitochondrial-nuclear relationship, 298

"steroid hormone enzymes" in rat liver;modifying action of androgens,19-nortestosterone and cyproteroncacetate on the sexaul differentiationof the enzyme activities, 287

LUTEINIZING HORMONEacute effects on cyclic AMP-formation

and on the metabolism of isolatedovarian follicles from PMSG-treatedimmature rats, 540, 559

bioassay; an improved method usingmouse Leydig cell preparations, 655

bioassay; an in vitro method comparedwith radioimmunoassay, 672

content in hypophyses ofoophorectomized suckled rats, 498

effect on cyclic AMP in isolatedcorpora lutea of the rat, 737

isolation from human hypophyses afterthe removal of HGH, 485

LH in normal men treated withLH/FSH-RH; age variations, 625

LH in normal men treated withmesterolone, 380

LH in plasma of normal men andKlinefelter patients; effect ofethinyloestradiol, 765

LH release in children and adolescents;effect of LH-RH, 422

radioimmunoassay; comparison with an

in vitro bioassay method, 672releasing hormone; effects on

gonadotrophins, testosterone andoestradiol in normal men, 625

releasing hormone; inactivation by pep¬tidases in the rat hypothalamus, 435

releasing hormone in generalizedlipodystrophy, 209

secretion in rams afterLH-RH-treatment, 1

serum levels in castrated male rats;effects of testosterone, 5«-dihydro-testosterone and oestradiol, 643

MEDROXYPROGESTERONEACETATE

unsuccessful treatment of acromegaly, 19

MENSTRUATIONmenstrual cycle in normal women;

ovarian secretion of oestrogens,progesterone and androgens, 575

menstrual cycle rhythm; influence uponserum fat-mobilizing activity, glycerol,cholesterol and blood glucose, 337

MESTEROLONEeffect on pituitary-testicular function

in normal men, 380

1 a-METHYL-5a-DIHYDRO-TESTOSTERONE see MESTEROLONE

METYRAPONEurinary steroid dynamics after a

single oral dose of metyrapone, 221

MITOCHONDRIAL ENZYMESin human and animal myometrium;

effect of pregnancy, 368

MONOIODOTYROSINEin "hot" thyroid nodules in euthyroid

patients, 53in the rat thyroid;

effect of adrenaline, 43

MYOMETRIUMcytoplasmic and mitochondrial enzymes

in human and animal myometrium;effect of pregnancy, 368

NEUROHYPOPHYSIScalcium and stimulus-secretion coupling

in the neurohypophysis; Ca2+ iono-phore-induced release of vasopressinfrom isolated rat neurohypophyses, 443

calcium and stimulus-secretion couplingin the neurohypophysis; effect ofN-ethylmaleimide on 45Ca2+ trans¬port and vasopressin release fromisolated rat neurohypophyses, 691

vasopressin release in isolated ratneurohypophyses, 443, 691

NEUROLEPTIC AGENTSpimozide; treatment of generalized

lipodystrophy, 209

NEUROLOGYParkinson's disease;

decreased arginine-induced HGHresponse during L-dopa therapy, 686

OESTRADIOLdistribution in foetus and placenta of

the pig; chemical determination, 171

effect on aldosterone macromoleculecomplexes in foetal guinea pigkidneys, 356

effect on lysosomal enzymes of the ratvaginal epithelium;a histochemical study, 193

effect on oxytocin-inhibiting peptidasesin rat hypothalamus, 10

effect on rat pituitary thymidinekinase activity, 509

effect on serum levels of LH and FSHin castrated male rats, 643

plasma levels during the ovulatorycycle of the domestic hen, 588

plasma levels in dogs with testiculartumours, 408

serum and pituitary gonadotrophinsin male rats treated withoestradiol benzoate, 636

serum and testis tissue testosterone inmale rats treated with oestradiolbenzoate, 636

serum oestradiol in normal men treatedwith LH/FSH-RH, 625

OESTRIOLeffect on lysosomal enzymes of the rat

vaginal epithelium; a histochemicalstudy, 193

OESTROGENSdistribution in foetus and placenta of

the pig; chemical determination, 171effect on activity of 17/i-hydroxysteroid

oxidoreductase in the rat liver, 727effect on lysosomal enzymes of the rat

vaginal epithelium; a histochemicalstudy, 193

effect on rat pituitary thymidine kinaseactivity, 509

ethinyloestradiol; effect on plasmalevels of testosterone, FSH and LHin Klinefelter's syndrome and innormal men, 765

hexoestrol; effect of a single neonatalinjection on the growth of the rat

pelvis, 612ovarian secretion of oestrogens in

normal women and in women withpersistent ovarian follicles, 575

plasma oestrogens during the ovulatorycycle of the domestic hen, 588

treatment; influence upon "effectivethyroxine ratio", 250

urinary oestrogens in pregnanciescomplicated with hypertension andpre-eclampsia, 344

OESTRONEdistribution in foetus and placenta of

the pig; chemical determination, 171plasma oestrone during the ovulatory

cycle of the domestic hen, 588

OVARIECTOMYadrenalectomy and pituitary LH in

oophorectomized suckled rats, 498effete on oxytocin-inhibiting peptidases

in rat hypothalamus, 10

OVARIEScorpora lutea of the rat;

effects of gonadotrophins andprostaglandins on cyclic AMP, 737

isolated ovarian follicles fromPMSG-treated immature rats;acute effects of gonadotrophins andprostaglandins on the formation ofcyclic AMP and on the metabolism ofcarbohydrates and proteins, 540, 599

OVULATIONplasma oestrone and oestradiol during

the ovulatory cycle of the domestichen, 588

OXIDOREDUCTASE17/?-hydroxysteroid oxidoreductase in

rat liver; gonadal factors regulatingthe activity, 727

OXYTOCINoxytocin-inhibiting peptidases in

different areas of the rat

hypothalamus, 10

PANCREASglucagon; preparation and nature of

First International Standard, 705

PARABIOSISparabiotic studies on hypercalcaemia

of neoplasia, parathyroid hormoneand vitamin D, 527

PARATHYROIDShormone; effect on adenylate cyclase

activity in rat renal cortex, 604hypercalcaemia of neoplasia, para¬

thyroid hormone and vitamin D, 527renal tubular localization of parathyroid

hormone-induced urinary cyclicAMP, 282

PARKINSON'S DISEASEdecreased arginine-induced HGH

response during L-dopa therapy inParkinsonian patients, 686

PELVISgrowth in rats; effect of a single

neonatal sex hormone injection, 612

PEPTIDASE ACTIVITYin different areas of the rat

hypothalamus, 10in rat hypothalamus;

inactivation of LH-RH, 435

PEPTIDE HORMONESwick chromatography applied to RIA

of polypeptides, 111

PERTECHNETATEtrapping by the rat thyroid;

effect of adrenaline, 35

PIMOZIDEtreatment of generalized

lipodystrophy, 209

PLACENTAoestrogen distribution in the placenta

and foetus of the pig; chemicaldetermination, 171

placental cystine-aminopeptidase inpregnancies complicated withhypertension and pre-eclampsia, 344

PLACENTAL LACTOGEN see

SOMATOMAMMOTROPHIN

PMSG see PREGNANT MARES'SERUM GONADOTROPHIN

POLYPEPTIDESapplication of wick chromatography to

RIA of peptide hormones and otherpolypeptides, 111

PREDNISOLONElong-term treatment in children;

effects on plasma glucose, insulinand free fatty acids, 699

PREDNISONEeffect on connective tissues of rabbit

aorta and skin, 310

PRE-ECLAMPSIAsomatomammotrophin, placental

cystine-aminopeptidase, progesteroneand oestrogens, 344

PREGNANCYcystine aminopeptidase in pregnancies

complicated with hypertension andpre-eclampsia, 344

"effective thyroxine ratio" in pregnantwomen, 250

essential hypertension; somatomammo¬trophin, placental cystine-aminopepti¬dase, progesterone and oestrogens, 344

hormone and enzyme assays inpregnancy; IV, 344

oestrogen distribution in the foetusand placenta of the pig; chemicaldetermination, 171

oestrogen excretion in pregnanciescomplicated with hypertension andpre-eclampsia, 344

pre-eclampsia; somatomammotrophin,placental cystine-aminopeptidase,progesterone and oestrogens, 344

progesterone in pregnancies complicatedwith hypertension andpre-eclampsia, 344

progesterone metabolism in the uterusof the pregnant rat, 160

prolactin values in plasma duringpregnancy, 460

somatomammotrophin in pregnanciescomplicated with hypertension andpre-eclampsia, 344

PREGNANT MARES'SERUM GONADOTROPHIN

acute effects of gonadotrophins andprostaglandins on the formation ofcyclic AMP and on the metabolismof isolated ovarian follicles fromPMSG-treated immature rats, 540, 559

PROGESTERONEin pregnancies complicated with

hypertension and pre-eclampsia, 344metabolism of progesterone in the

uterus of non-pregnant and pregnantrats, 135, 150, 160

ovarian secretion of progesterone innormal women and in women withpersistent ovarian follicles, 575

PROLACTINovine prolactin; anti-insulin action in

hypophysectomized rats, 96plasma human prolactin; heterologous

RIA and values in normal subjects,in puberty, pregnancy and pituitarydisorders, 460

PROPRANOLOLeffect on adenylate cyclase activity in

rat renal cortex, 604

PROPYLTHIOURACILinhibition of the extrathyroidal

formation of T3 from T4, 276

PROSTAGLANDINSacute effects on the formation of cyclic

AMP and on the metabolism ofisolated ovarian follicles fromPMSG-treated immature rats, 540, 559

effect of prostaglandins on cyclic AMPin isolated corpora lutea of the rat, 737

PROSTATEbenign prostatic hypertrophy; secretion

of 5a-dihydrotestosterone by thehuman prostate, 401

benign prostatic hypertrophy;testosterone metabolism in tissuecultures, 784

of castrated rats; effects ofphysiological doses of testosterone on

weight gain and thymidineincorporation, 597

PROTEIN-BOUND IODINEin the early stage of subacute

thyroiditis, 26in the male rat at different times of

the same day, 82

PROTEINSmetabolism of isolated ovarian follicles

from PMSG-treated immaturerats, 540

thyroid protein synthesis in rats;effect of actinomycin D on theTSH-stimulation, 64

PUBERTYplasma human prolactin during

puberty, 460release of gonadotrophins in children

and adolescents; effect of LH-RH, 422

RADIOIMMUNOASSAYSglucagon antibodies for RIA;

production and evaluation, 715heterologous RIA of plasma human

prolactin, 460of LH in plasma; comparison with an

in vitro bioassay method, 672of peptide hormones and other

polypeptides; application of wickchromatography, 111

of serum T3 in man, 71of thyrotrophin releasing hormone, 417

'RELEASING HORMONES"CRF in generalized lipodystrophy, 209LH-RH administration in rams; effects

on LH and testosterone production, 1LH-RH; effect on gonadotrophin

release in sex hormone treatedcastrated male rats, 643

LH-RH; effect on release of gonadotro¬phins in children and adolescents, 422

LH-RH; effect on serum

gonadotrophins, testosterone andoestradiol in normal men, 625

LH-RH in generalizedlipodystrophy, 209

LH-RH; inactivation by peptidases inthe rat hypothalamus, 435

TRH; radioimmunoassay, 417

RIFAMPICINeffect on RNA synthesis in rat liver, 298

RNAbiochemical studies on RNA in

connective tissues of rabbit aortaand skin, 310

control of gene expression causing lossof active steroidogenic enzymes inhuman adrenal tisue, 325

incorporation of 3H-uridine into RNAin rat thyroid; effect ofactinomycin D, 64

synthesis in rat liver after cortisol:A possible mitochondrial-nuclearrelationship, 298

RUBIDIUM86Rb uptake in rat thyroid; relation to

TSH concentration in the blood, 266

SEMINAL VESICLESof castrated rats; effects of physiolo¬

gical doses of testosterone on weightand thymidine incorporation, 597

SEMINOMASplasma levels of testosterone and

oestradiol in dogs with testistumours, 408

SERTOLI CELL TUMOURSplasma levels of testosterone and

oestradiol in dogs with testistumours, 408

SEX DIFFERENCESin rat plevis size; effect of a single

neonatal sex hormone injection, 612release of gonadotrophins in children

and adolescents; effect of LH-RH, 422

SEXUAL DIFFERENTIATIONof the activities of steroidogenic

enzymes in the rat liver; modifying

action of androgens, an anabolicsteroid and an anti-androgen, 287

SIALIC ACIDdesialylated thyroglobulin in an

experimental rat thyroid tumour, 517

SKELETONeffect of a single neonatal sex hormone

injection on the growth of the ratpelvis, 612

SKINconnective tissue of rabbit skin;

biochemical studies and effect ofprednisone, 310

SLEEPsleep-induced growth hormone

secretion, 241

SOMATOMAMMOTROPHINanti-insulin action in

hypophysectomized rats, 96in pregnancies complicated with

hypertension and pre-eclampsia, 344

SOMATOTROPHINsee GROWTH HORMONE

STANDARD PREPARATIONSFirst International Standard for

glucagon; preparation and nature, 705

STEROIDOGENIC ENZYMESin rat liver and in human adrenals,

287, 325

99mTc04" see PERTECHNETATE

SUCKLINGadrenalectomy and pituitary LH in

oophorectomized suckled rats, 498

TESTEScontent of testosterone in rats treated

with oestradiol benzoate, 636function; effect of mesterolone

administration to normal men, 380Klinefelter's syndrome; effect of HCG

on plasma testosterone levels, 753

Klinefelter's syndrome;effect of oestrogens on plasmatestosterone, FSH and LH, 765

Klinefelter's syndrome; plasma levelsof testosterone, 387, 753, 765

Leydig cell preparations;in vitro bioassay of LH, 655

ligation of efferent ducts; effect on

uptake of 65Zn in Rhesus monkeys, 18'pituitary-testicular function in normal

men; effect of mesterolone, 380transplantable Leydig cell tumour of

the Fischer rat; hypercalcaemiaproducing action, 527

tumours in dogs; plasma levels oftestosterone and oestradiol, 408

TESTOSTERONEeffect of a single neonatal injection on

the growth of the rat pelvis, 612effect of HCG on plasma levels of

testosterone in Klinefelter'ssyndrome, 753

effect of physiological doses on weightgain and thymidine incorporation inaccessory sex glands of castratedmale rats, 597

effect on rat pituitary thymidinekinase activity, 509

effect on serum levels of LH and FSHin castrated male rats, 643

metabolism in cultured hyperplasia ofthe human prostate, 784

modifying action on the sexualdifferentiation of the activities ofsteroidogenic enzymes in rat liver, 287

ovarian secretion of androgens innormal women and in women withpersistent ovarian follicles, 575

plasma levels in benign prostatichypertrophy, 401

plasma levels in dogs with testiculartumours, 408

plasma levels in Klinefelter's syndrome,387, 753, 765

plasma levels in normal men treatedwith mesterolone, 380

plasma levels in normal men treatedwith oestrogens, 765

production by mouse Leydig cellpreparations; bioassay of LH, 655

production in rams after LH-RHadministration, 1

serum testosterone in male rats treatedwith oestradiol benzoate, 636

serum testosterone in normal men

treated with LH/FSH-RH, 625

TETRAHYDRO COMPOUNDSurinary steroid dynamics after a single

oral dose of metyrapone, 221

THYMIDINEincorporation in accessory sex glands

of castrated male rats after physio¬logical doses of testosterone, 597

thymidine kinase activity in rat

hypophyses; opposite effects ofandrogens and oestrogens, 509

THYROGLOBULINisolation of desialylated and

low-iodinated thyroglobulin in an

experimental rat thyroid tumour, 517

THYROIDblood flow in rat thyroid;

TSH regulation, 266familial hypothyroidism;

occurrence and remission, 257function; evaluation by "effective

thyroxine ratio", 250function in the early stage of subacute

thyroiditis; sequential study ofthe impairment, 26

hormone synthesis in hyperfunctioningnodules in euthyroid patients, 53

hormone synthesis in the rat;effect of adrenaline, 43

iodine trapping process;effect of adrenaline, 35

protein synthesis in the rat;effect of actinomycin D on theTHS-induced stimulation, 64

uptake of 1311 by the rat thyroid;effect of adrenaline, 35

tumour; isolation of desialylated andlow-iodinated thyroglobulin in an

experimental rat thyroid tumour, 517

THYROIDITISsubacute thyroiditis; sequential study

of the impairment in the early stageof the disease, 26

THYROTROPHINconcentration in the blood of rats;

relation to 86Rb uptake by thethyroid, 266

isolation from human hypophyses afterthe removal of HGH, 485

regulatory effect on thyroid blood flowin rats, 266

stimulation of thyroid protein synthesisin rats; effect of actinomycin D, 64

TRH; radioimmunoassay, 417

THYROXINEevaluation of thyroid status with

"effective thyroxine ratio", 250extrathyroidal conversion to Ta;

inhibition by propylthiouracil, 276hepatic thyroxine deiodination;

antagonistic effects of dinitrophenoland cyanide, 122

in "hot" thyroid nodules in euthyroidpatients, 53

in rat thyroid; effect of adrenaline, 43serum levels in the early stage of

subacute thyroiditis, 26therapy; remission of familial goitrous

hypothyroidism, 257

TRIHYDROXYPREGNANEDIONEurinary steroid dynamics after a single

oral dose of metyrapone, 221

TRIHYDROXYPREGNANONEurinary steroid dynamics after a single

oral dose of metyrapone, 221

TRIIODOTHYRONINEformation of T3 from T4;

inhibition by propylthiouracil on theextrathyroidal formation, 276

hepatic deiodination of T3antagonistic effects of dinitrophenoland cyanide, 122

T3 in "hot" thyroid nodules ineuthyroid patients, 53

T3 in human serum;measurement by RIA, 71

T3 resin uptake levels in the early stageof subacute thyroiditis, 26

TUMOURSexperimental rat thyroid tumour;

isolation of desialylated andlow-iodinated thyroglobulin, 517

testicular tumours in dogs; testosteroneand oestradiol plasma levels, 408

transplantable Leydig cell tumour ofthe Fischer rat; hypercalcaemiaproducing action, 527

URIDINEincorporation into RNA in rat thyroids;

effect of actinomycin D, 64

UTERUSmyometrium; cytoplasmic and

mitochondrial enzymes; effect ofpregnancy, 368

progesterone metabolism in uterus ofpregnant and non-pregnant rats,135, 150, 160

VAGINAlysosomal enzymes of rat vaginal

epithelium; effects of oestrogens;a histochemical study, 193

VASCULAR SYSTEMplasma HGH in children with

congenital heart disease, 451

VAS DEFERENSuptake of ß' in the Rhesus monkey;

effect of efferent duct ligation, 186

VASOPRESSINCa2+ ionophore-induced release of

vasopressin from isolated rat

neurohypophyses, 443release from isolated rat

neurohypophyses ;effect of N-ethylmaleimide, 691

VIRILISMcontrol of gene expression causing loss

of active steroidogenic enzymes inhuman adrenal tissue, 325

VITAMIN Dhypercalcaemia of neoplasia, para¬

thyroid hormone and vitamin D, 527

WICK CHROMATOGRAPHYapplication to RIA of peptide hormones

and other polypeptides, 111

ZINCuptake of 65Zn by epididymis and vas

deferens of the Rhesus monkey;effect of efferent duct ligation, 186