CURRICULUM VITAE

Jennifer Man-Fan Wan

PERSONAL PROFILE

Jennifer Man-Fan Wan (BSc., Ph.D. and BM in Traditional Chinese Medicine) Associate ProfessorFood and Nutritional Sciences Division,The School of Biological Sciences, 5S16 kadorrie Biological Science Building The University of Hong Kong, Hong Kong SAR.Tel: 22990838. jmfwan@hku.hk

ACADEMIC APPOINTMENTS

Associate Professor (2007-present)School of Biological Sciences, The University of Hong Kong,

China.Visiting Professor (2018-present)

Ocean University, Shanghai, China.Visiting Professor (2018-present)

Zhejiang Gongshang University, China.Associate Professor (1993-2007)

Zoology department, The University of Hong Kong, China.Instructor of Medicine (1990-1993),

Department of Medicine, New England Deaconess Hospital, Harvard Medical School, USA.Research Associate (1998-1990)

Department of Surgery, New England Deaconess Hospital, Harvard Medical School, USA. Post-doctoral fellow (1987-1988)

Department of Surgery, New England Deaconess Hospital, Harvard Medical School, USA.

EDUCATION

1999-2003 Bachelor degree in Traditional Chinese Medicine. Beijing University of

Traditional Chinese Medicine, Beijing, China1984-1987 Ph.D. University of Southampton, Southampton, England1981-1983 B.Sc. (Hons upper second), Biology and Chemistry. University of

London, England.

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Research notable contribution to knowledge in the field: Major contributions are in the fields of Proteomics, Cancer Biology, Antioxidants, Chinese Medicine, Dietary Lipids and Cancer, Nutrition and Immunology.

(i) Research and development with proteomic technology for biomarkers discovery:My significant contribution goes to environmental research in the discovery of novel proteins as “biomarkers of toxicity” by proteomic and monoclonal antibodies technology. We have identified the “biomarkers of toxicity” of harmful algal bloom, which is a series matter for marine toxicology for human food. We are presently purifying the antibody raised against T1 to differentiate specifically the toxic algae from the non-toxic algae.

(ii) Chinese Medicine Research in Cancer Biology:We were the first to publish the detailed anticancer mechanisms of polysaccharide peptide (PSP), an extract of the Chinese Medicinal mushroom Yun zhi (Coriolus versicolor, spp). Flow cytometry and cDNA arrays technology were used to identify the cell cycle kinetics, cell death and apoptotic pathways in which PSP exhibits its treatment effect on human leukemia. PSP is currently used in China as adjuvant therapy. Our data show that PSP does not exert cytotoxic effect on normal healthy human cells thus further supports its potential development as chemotherapeutic drug in the west. An RGC grant ($736,000) was received in 2003.

(iii) Dietary Lipids and Cancer Research: During earlier research success (at the Harvard Medical School, USA and later HKU), I have made significant contributions to the relationship of dietary lipids and breast cancer. Detailed anticancer mechanisms (cell proliferation and cell death) on how omega-3 fish oil can retard breast cancer growth have been published. Mathematical models have been developed by us to express the mechanistic influence of the omega-3 and omega-6 fatty acids on cancer cells progression through the Go/G1 phase, DNA S phase, and G2/M mitotic phase of the cell cycle.

(v) Nutrition, Immunity, and Inflammation Research: Nutrition and Immunity is closely linked. My earlier published nutritional papers receive increasing citations (over 40 citations in this area in some). Significant contributions in the areas: (i) Specific nutrients for hospital nutrition, (ii) oxidative stress and dietary antioxidant (ii) lipids and immune function as well as (iii) shock and burn and (iv) nutrition and cytokines.

(vi) Natural products and antiagingNatural compounds from food and Chinese Medicine can prevent aging through at least the free radical and oxidative stress pathway. We are

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interested in understanding the mechanism of natural compounds mitochondrial redox reaction and antiaging mechanisms such as membrane repair, cell death and apoptosis etc.

Research Projects

1. Proteomics Technology development: biomarkers discovery in marine toxic algae, diseases (Kidneys, inflammation, liver cancer) and malnutrition effect on brain development. 2. Chinese Medicine: oxidative stress, Anticancer, immunomodulatory and anti-inflammatory effect of Chinese medicinal herbs.3. Nutrition and cancer research4. Ultrasound and sonoporation induced cell membrane damage and cell death.

Research Grants Funded: Small Project Fund, HKU (PI). $33,240 (2016-2017). Metagenomic

analysis of the effect of dietary extra-virgin olive oil on the intestinal microbiota of rats with liver fibrosis

Small Project Fund, HKU (PI). $72,800 (2015-2016): “Temporal Proteomic Analysis of the Apoptosis Mechanisms of Polysaccharopeptides derived from Coriolus versicolor on Human Leukemic HL-60 Cell”.

Seed Funding Programme for Basic Research, HKU (PI). $67,300 (2014-2015): “The protective mechanisms of dietary extra virgin olive on liver fibrosis: ass spectrometry-based proteomics and lipidomic approach for molecular fingerprinting”.

Small project funding, HKU (PI). $80,000 (2012-2014): “High-speed-cell-sorting by flow cytometry to dissect the cell cycle arrest and apoptosis pathways of sonoporated-human promyelocytic leukemia cells”.

Innovation and Technology Support Programme, HK, (Co-PI) $999,925 (2011-2012). “Advanced ultrasound micro-imaging array research platform fro real-time in-situ apoptosis imaging”.

Innovation and Technology Support Programme, HK, (Co-PI) $264,110 (2011-2012).

Seed Funding for Strategic Research Theme, HKU (Co-PI), $1000,000 (2005-2006): “Strategic research theme group on cancer”.

RGC, HKU (PI) $736,000 (2003-2006):” The Anticancer Mechanisms of Polysaccharide Peptide PSP derived from the Chinese Medicinal fungus Coriolus versicolor on Human leukemia and Human Normal T-lymphocytes”.

Teaching

Taught courses included: Food Toxicology, Food Chemistry, Introduction to Food and Nutrition Science, Diet and Disease, Food

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Toxicology, Funfunctional Food, Clinical Nutrition and Public Health Nutrition. Two capstone courses: Directed studies Food and Nutritional Science and Food and Nutritional Science Internship as well as the postgraduates course “ Nutraceuticals”.

Editorial of the following journalso Nature Partner Journal of Food Science (Associate Editor)o Scientific Report o Clinical Nutrition and Metabolismo Journal of Functional Foodo Chinese Medicine

University Service

Member representation of the Equal Opportunity. Member of Human Research Ethics Committee.

Faculty of Science Service

Oral chairman of Ph.D. examination Academic Advisor Director, Course Coordinator for the MSc in the field of Food Industry:

Management & Marketing.

Departmental Service

Deputy Course Coordinator: Major/Minor curriculum for Food and Nutritional Sciences, School of Biological Sciences.

Member of the Teaching Committee of SBS: representative for Food and Nutritional Sciences Major/Minor

Coordinator for Food and Nutritional Science Biological Sciences at Science Corner for Open Day.

Course coordinator: BIOL 2534 Clinical Nutrition, BIOL 4201 Public Health Nutrition, BIOL6006 Advanced Topics in Nutraceuticals. BIOL 4962 FNS Internship

Capstone coordinator: BIOL4962 Nutrition and Public Heath Assessment in Cambodia: a capstone Experience.

Member of the Recruitment Committee for selection of Associate/Assistant Professor in Food and Nutritional Science in the School of Biological Science.

Member of the Joint FHRC, PTP & Search Committee for Professor to the Food and Nutrition Sciences Major 2016.

Faculty advisor, academic advisor and course selection advisor for Food and Nutritional Science Major/Minor

Interviewer for JUPAS interviews for HKALE applicants applied for admission to 6901 BSc (3 year) program

Coordinator for SBS Information Day 2016

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Coordinator of Faculty of Science undergraduate’s admission promotion plan for the Long and Short visit to SBS.

Community Engagement

Serving on external advisory bodies Member of the Expert Committee in Food Safety – an external

advisory body of the HK SAR government. Advisor of the Hong Kong Nutrition Association Committee Member of the Modernized Chinese Medicine

International Association Chairperson of the Hong Kong Food Science and Technology

Association Chairperson of the Guangdong Hong Kong Science and technology

Research and Innovation Society Chairperson of the Hong Kong Hakka Research Society

PUBLICATIONS

Papers Published in International Journals:

1. Han Feng, Shijie Zhang, Lifeng Gui, Mengcheng Ruan, Na Li, Hongyu Zhang, Zhiguo Liu, Jennifer MF Wan and Hualin Wang. Polysaccharide extracted from Phellinus linteus improves insulin sensitivity in a high-fat high-fructose diet feeding mice model. 2018 in press. Carbohydrate Polymers.

2. Wang Hualin, Sit Wat-Hung, Tipoe George Lim, Liu Zhiguo & Wan Jennifer Man-Fan. Comparative proteomic analysis of fibrotic liver of rats fed high fat diet contained lard versus corn oil. Clinical Nutrition, 2017. 36: p.198-208.

3. Lee YY, Crauste C, Wang H, Wan Jennifer Wan and Lee JCY. Extra virgin olive oil reduced polyunsaturated fatty acid and cholesterol oxidation in rodent liver: Is this accounted for hydroxytryrosol-fatty acid conjugation? Chemical Research Toxicology, 70: 121-135, 2016.

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4. Hualin Wang, Jennifer Man-Fan Wan (2015). Sang Huang De Yao Yong Jia Zhi Yan Jiu Jin Zhan. Lishizhen Medicine and Materia Medical Research 2015, 26 (11): 2747-2750.  doi: 10.3969/j.issn.1008-0805.2015.11.073.

5. Ruen Shan Leow, Jennifer Wan and Alfred CH Yu (2015). Membrane blebbing as a recovery manoeuvre in site-specific sonoporation mediated by targeted microbubbles. J. of the Royal Society Interface. DOI: 10.1098/reif.2015.0029.

6. Wang H, Sit WH, Wan JMF (2014). Differential protective effects of extra virgin olive oil and corn oil in liver injury: A proteomic study. Food and Chemical Toxicology 74: 131-138.

7. Hu Y, Wan JMF, Yu ACH (2014). Cytomechanical perturbations during low intensity ultrasound pulsing. Ultrasound in Medicine & Biology. 40(7): 1587-1598.

8. Chen X, Leow RS, Hu Y, Wan JMF, Yu ACH (2014). Single-site sonoporation disrupts actin cytoskeleton organisation. J R. Soc. Interface Interface vol. 11, no. 95, art. 20140071.

9. Wang H, Zhang J, Sit WH, Lee CYJ, Wan JMF (2014). Cordyceps cicadae induces G2/M cell cycle arrest in NHCC97H human hepatocelluar carcinoma cells: a proteomic study. Chinese Medicine. 9:(15) 1-12.

10. Hu Y, Wan JMF, Yu ACH (2013). Membrane perforation and recovery dynamics in microbubble-mediated sonoporation. Ultrasound in Medicine and Biology. vol. 39, no. 12, pp. 2393-2405.

11. Zhong W, Chen X, Jiang P, Wan JMF, Qin P, Yu ACH (2013). Induction of endoplasmic reticulum stress by sonoporation: linkage to mitochondria-mediated apoptosis initation. Ultrasound in Medicine and Biology. vol. 39, no. 12, pp. 2382-2392.

12. Wan LYM, Woo CSJ, Allen KJ, Turner PC, Wan JMF, El-Nezami H (2013). Individual and combined effects of Fusarium toxins on the mRNA expression of proinflammatory cytokines in swine jejunal epithelial cells. Toxicology letters. 220: 238-246.

13. Hu Y, Zhong W, Wan JMF, Yu ACJH (2013). Ultrasound can modulate neuronal development: Impact on neurite growth and cell body morphology. Ultrasound in Medicine and Biology, 39:915-925.

14. Jiang P, Wan JMF, Cilieborg MS, Sit WH, Sangild PT (2013). Premature delivery reduces intestinal cytoskeleton, metabolism, and stress response proteins in newborn formula-fed pigs. Journal of Paediatric Gastroenterology and Nutrition, 56:615-622.

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15. Jiang P, Jensen ML, Cileborg MS, Thymann T, Wan JMF, Sit WH, Tipoe GL and Sangild PT (2012). Antibiotics increase gut metabolism and antioxidant proteins and decrease acute phase response and necrotizing enterocolitis in preterm neonates. PLOS ONE (www.plosone.org) volume 7: e44929:1-11.

16. Wang H, Wu G, Park HJ, Jiang PP, Sit WH, VanGriensven LJLD, Wan JMF (2012). Protective effect of Phellinus Linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis. Chinese Medicine 7:23.

17. Jiang P, Wan JMF, Sit WH, Lee CL, Schmidt M, Sangild PT (2011). Enteal feeding in utero induces marked intestinal structural and funcational proteome changes in pig fetuses. Pediatric Research. 69(2): 123-128.

18. Zhong W, Sit WH, Wan JM, Yu AC. (2011) Sonoporation induces apoptosis and cell cycle arrest in human promyelocytic leukemia cells. Ultrasound Med Biol. 37(12):2149-59.

19. Wong LL, Fan ST, Man K, Sit WH, Jiang PP, Jor IW, Lee CY, Ling WL, Tam KT, Wan JM. (2011) Identification of Liver Proteins and Their Roles Associated with Carbon Tetrachloride-Induced Hepatotoxicity. Hum Exp Toxicol. 30(9):1369-81.

20. Jiang PP, Sangild PT, Siggers JL, Sit WH, Lee CL, Wan JM. (2011) Bacterial Colonization Affects the Intestinal Proteome of Preterm Pigs Susceptible to Necrotizing Enterocolitis. Neonatology Pediatr Res. 69(2):123-8.

21. Lee CL, Jiang P, Sit WH, Yang X, Wan JM. (2010) Regulatory properties of polysaccharopeptide derived from Coriolus versicolor and its combined effect with ciclosporin on the homeostasis of human lymphocytes. J Pharm Pharmacol. 62(8):1028-36.

22. Wan JM, Sit WH, Yang X, Jiang P, Wong LL. (2010) Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells. Chin Med. 27(5):16-26.

23. Lee CY, Sit WH, Fan ST, Man K, Jor IW, Wong LL, Wan ML, Tan-Un KC, Wan JM. (2010) The cell cycle effects of docosahexaenoic acid on human metastatic hepatocellular carcinoma proliferation. Int J Oncol. 36(4):991-8.

24. Ding WJ, Yan SL, Zeng YZ, Li WH, Duan A, Zheng TE, Liu M, Tan CE, Teng X, Wan J. (2009) Insufficient Activity of MAPK Pathway Is a Key Monitor of Kidney-Yang Deficiency Syndrome. J. Altern. Complement

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Med. 15(6):653-60.

25. Lee CL, Sit WH, Jiang PP, So IWY, Wan JMF (2008). Polysaccharopeptide mimics ciclosporin-mediated Th1/Th2 cytokines balance for suppression of actiavated human T cell proliferation by MAPKp38 and STATS pathways. Journal of Pharmacy and Pharmacology. 60(11) 1491-1499.

26. Jiang P, Siggers JLA, Ngai, HHY, Sit WH, Sangild PT, Wan JMF. (2008). The small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feeding. Journal of Nutrition 138(10): 1895-1901.

27. Jiang PP, Sangild PT, Sit WH, Ngai HH, Xu R, Siggers JL, Wan JM. (2009) Temporal proteomic analysis of intestine developing necrotizing enterocolitis following enteral formula feeding to preterm pigs. J Proteome Res. 8(1):72-81.

28. Ding WJ, Zeng YZ, Li WH, Zhang TE, Liu WW, Teng XK, Ma YX, Yan SL, Wan JMF, Wang MQ (2009). Identification of linkage disequilibrium SNPs from kidney-yang deficiency syndrome pedigree. American Journal of Chinese Medicine. 37(3)427-438.

29. Wan JM, Sit WH, Louie JC (2008). Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30. International Journal of Oncology 32(3): 689-99.

30. Ngai Heidi Hoi-Yee, Sit Wai Hung, Jiang Ping-Ping, Visith Thongboonkerd, Wan Jennifer Man Fan (2007). Markedly increased urinary preprohaptoglobin and haptoglobin in passive Heymann nephritis: a differential proteomics approach. J Proteome Research 6: 3313-20.

31. Ngai HH, Sit WH, Jiang PP, Xu RJ, Wan JM, Thongboonkerd V. (2006) Serial changes in urinary proteome profile of membranous nephropathy: implications for pathophysiology and biomarker discovery. J Proteome Res. 5(11): 3038-47.

32. Chan LL, Sit WH, Lam PK, Hsieh DP, Hodgkiss IJ, Wan JM, Ho AY, Choi NM, Wang DZ, Dudgeon D. (2006) Identification and characterization of “Biomarker of toxicity” from the proteome of Paralytic Shellfish toxin (PST)-producing dinoflagellates Alexandrium tamarense (Dinophycae). Proteomics 6: 654-666.

33. Cheuk-Lun Lee, Ping-Ping Jiang, Wai-Hung Sit and Jennifer Man-Fan Wan. (2006). The culture duration affects the immunomodulatory and anticancer effect of polysaccharopeptide derived from Coriolus versicolor. Enzyme and Microbial Technology. 38: 14-21.

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34. Jennifer Man-Fan Wan , Wai-Hung Sit, Cheuk-Lun Lee, Kelvin Hoi-Man Fu and Daniel Kwong-On Chan, Protection of Lethal Toxicity of Endotoxin by Salvia miltiorrhiza BUNGE is via Reduction in Tumor Necrosis Factor Alpha Release and Liver Injury (2006). International Immunopharmacolog 6: 750-758.

35. Chan LL, Hodgkiss IJ, Lam PK, Wan JM, Chou HN, Lum JH, Lo MG, Mak AS, Sit WH, Lo SC. (2005) Use of 2-DE to differentiate morphospecies of Alexandrium minutum, a paralytic shellfish poisoning toxins (PST)-producing dinoflagellate of Harmful Algal Blooms. Proteomics 5: 1580-1593.

36. Chan LL, Hodgkiss IJ, Wan JM, Lum JH, Mak AS, Sit WH, Lo SC. (2004) Proteomic study of a model causative agent of harmful algal blooms, Prorocentrum triestinum II: the use of differentially expressed protein profiles under different growth phases and growth conditions for bloom prediction. Proteomics. 4(10):3214-26.

37. Cheng Le Le, Yang Xiao Tong, Mi Ke, Wan Jennifer Man Fan, Yang Qing Yao. Colorimetric detection of total Triterpene contents in Fruiting Bodies and spores of Ganoderma Lucidum (Leyss.Ex Fr) Karst (2005). Mycosystema Vol: 24 p. 317-320.

38. Lee L, Yang XT and Wan JMF. (2006) The culture duration affects the immunomodulatory and anticancer effect of polysaccharopeptide derived from Coriolus versicolor. Enzyme and microbial technology 38: 14-21.

39. Kumar D. Siava Sundara Kumar, Lau Chak Sing, SS, Wan Jennifer MF, Yang Dan, Hyde Kevin D. Immunomodulatory compounds from Pestalotiopsis leucothes, an endophytic ungus from Tripterygium wilfordii (2005). Life Sciences 78:147-156.

40. Lau CS, Fanya Zeng, Chung-Chau Hon, Wai-Hung Sit, Ken Yan-Ching Chow, Raymond Kin-Hi Hui, Ivy Ka-Man Law, Victor Wai-Lap Ng, Frederick Chi-Ching Leung and Jennifer Man-Fan Wan. (2005) Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray. International Journal of Oncology 27(2)513-23

41. Cheuk-Lun Lee, Ping-Ping Jiang, Wai-Hung Sit and Jennifer Man-Fan Wan. (2007) Proteome of Human T lymphocytes with Treatment of Cyclosporine and Polysaccharopeptide: Analysis of Significant Proteins that Manipulate T cells Proliferation and Immunosuppression. International Immunopharmacology 7(10): 1311-24.

42. Hui K.P.Y., Sit W.H. and Wan J.M.F. (2005) Induction of S phase cells arrest and caspase activation by polysaccharide peptide (PSP) isolated from coriolus versicolor enhanced the cell-cycle-dependent activity and

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apoptotic cell death of Doxorubicin and Etoposide but not Cytarabine in HL-60 cells. Oncology Reports. 14(1): 145-165.

43. Heidi H.Y. Ngai, W. H. Sit and Jennifer M.F. Wan. (2005) The nephroprotective effects of the Herbal Medicine Preparation, WH30+, on the chemical-induced acute and chronic renal failure in rats. The American Journal of Chinese Medicine 33(3): 491-500.

44. Xiaotong Yang, Wai-Hung Sit, Daniel Kwong-On Chan, Jennifer Man-Fan Wan. (2005) The Cell Death Process of the Anticancer Agent Polysaccharide-peptide (PSP) in Human Promyelocytic Leukemic HL-60 Cells. Oncology Reports 13(6): 1201-1221.

45. Chan L.L., Hodgkiss I.J., Lam P.K.S., Wan J.M.F., Chou N.H., Lum J.H.K., Lo M.G.Y., Mak A.S.C., Sit W.H. and Lo S.C.L. (2005) Use of 2-DE to differentiate morphospecies of Alexandrium minutum, a paralytic shellfish poisoning toxins (PST)-producing dinoflagellate of Harmful Algal Blooms. Proteomics 5: 1580-1593.

46. Chan L.L., Hodgkiss I.J., Wan J.M.F., Lum J.H.K., Mak A.S.C., Sit W.H. and Lo S.C.L. (2004) Proteomic study of a model causative agent of harmful algal blooms, Prorocentrum triestinum II: The use of differentially expressed protein profiles under different growth phases and growth conditions for bloom prediction. Proteomics 4: 3214-3226.

47. Yang Xiatong-Tong, Wan JMF, Ke MI and Feng HQ. (2003) The quantification of (1,3)-b-Glucan in edible and medicinal mushroom polysaccharides by using limulus G test. Mycosystema 22 (2): 296-302.

48. Chung-Yung Jetty Lee and Jennifer Man-Fan Wan. (2002) Immunoregulatory and Antioxidnat performance of a-tocopherol and selenium on human lymphocytes. Biological Trace Element Research 86(2): 123-135.

49. Chiu LCM, Ooi V, Wan J MF. (2001) Eicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression I human leukemic K-562 cells. International Journal of Oncology 19: 845-849.

50. Chiu L, Ooi VE and Wan JMF (2000) Induction of apoptosis by dietary polyundsaturated fatty acids in human leukemic cells is not associated with DNA fragmentation. International Journal of Oncology 17: 789-796.

51. Lee J and Wan JMF. (2000) Vitamin E supplementation improves cell-mediated immunity and oxidative stress of Asian Men and Women. Journal of Nutrition  130(12): 2923-27.

52. Pang ZJ, Chen Y, Zhou M, Wan J (2000). Efect of polysaccaride krestin on glutathione peroxidase gene expression in mouse peritonela macrophages. British HOurnal of Biomedical Sciences, 57(2): 130-136.

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53. Chiu LCM and Wan JMF. (1999) Induction of apoptosis in HL-60 cells by eicosapentaenoic acid (EPA) is assoicated with downregulation of bcl-2 expression. Cancer Letters 145: 17-27.

54. Pang ZJ, Chen Y, Zhou M and Wan J. (1999) The effect of polysaccharide krestin on nitric oxide production in mouse peritoneal macrophages. Medical Science Research 27(5): 299-302.

55. Pang ZJ, Zhou M, Chen Y, Wan J (1999). Macrophage colony-stimulating factor redcues tert-butylhydroperoxide induced oxidative injury to monocytes/macrophages. Atherosclerosis. 147(1) 33-40.

56. Wan, JMF and WH. Sit. Mechanisms of Yun Zhi Control of Tumor Cell Proliferation. p244-246 Adanced Research in PSP. International Symposium on Chinese Medicine, The University of Hong Kong. The Hong Kong Assication for Health Care Ltd. Publisher, 1999.

57. Lee J. Wan JMF. Immunostimulatory Efficiency of YunZhi and Quercetin, p151-152. International Symposium on Chinese Medicine, The University of Hong Kong. Adanced Research in PSP. The Hong Kong Assication for Health Care Ltd. Publisher, 1999.

58. Wan JMF , Grimble R. (1998) Diurnal Factors Influence the Metabolic Response to Endotoxins. Nutrition Research 18: 265-272.

59. Pang ZJ, Zhou M, Chen Y and Wan J. (1998) A Protein-bound Polysaccharide Synergistic with Lipopolysaccharide Induces Nitric Oxide Release and Antioxidant Enzyme Activities in Mouse Peritoneal Macrophages. American Journal of Chinese Medicine 26(2): 133-141.

60. Zhou M, Chen Y, Liu S, Ding Z, Pang Z, and Wan J. (1998) The effect of tert-butyl hydroperoxide on peritoneal macrophages and the protective effect of protein-bound polysaccharide administered intraperitoneally and orally. American Journal of Chinese Medicine 26(3-4): 301-310.

61. Zhou M, Chen Y, Liu S, Ding Z, Pang Z, and Wan J. (1998) Oxidative and malondialdehyde modification of low-density lipoprotein; a comparative study of binding and degradation by macrophages and endothelial cells. British Journal of Biochemical Science, 55: 192-198.

62. Liu SX, Chen Y, Zhou M, Wan J (1998). Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages. Atherosclerosis, 136(1): 43-49.

63. Pang ZJ, Zhou M, Chen Y, Wan J. (1998) L929 cell-conditioned medium reduces the impairment in plasma membrane fluidity of U937 and J774 cell lines treated with tert-butyl hydroperoxide. Medical Science Research

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26(4): 241-243.

64. Zhou M, Chen Y, Wan J. (1997) The polysaccharide krestin prevents lipoperoxidative injury to experimentally atherosclerotic rabbits. Medical Science Research 25: 137-140.

65. Chen Y, Zhou M, Leu N, Liu SX, Pang Z, Wan J. (1997) The polysaccharide krestin prevents plaque formation in experimentally atherosclerotic rabbits. Medical Science Research 25(5): 297-300.

66. Shang X L, Zhou M, Wan J. (1997) Apoptosis in mouse peritoneal macrophages induced by oxidized low-density lipoprotein and prevention by the polysaccharide kreskin. Medical Science Research 25(6): 429-437.

67. Zhou M, Chen Y, Pang Z, Wan J. (1997) Preparation and characterization of two monoclonal antibodies against oxidatively modified low-density lipoprotein (O-LDL) and detection of O-LDL in serum in patients with coronary heart disease. Medical Science Research 25(7): 445-449.

68. Shang XL, Chen Y, Zhou M and Wan J. (1997) Protective effect of the polysaccaride krestin on inhibition of lipopolysaccharides-induced nitric oxide production in macrophages caused by oxidized low-density lipoprotein. Medical Science Research 25(8): 507-509.

69. Chen Y, Zhou M, Wan J. (1997) Oxidative and malondialdehde modification of low-density liporotein: a comparative study. British Journal of Biomedical Science 54: 159-165.

70. Wan JMF , Yang M and Sit WH. (1997) Mechanisms of Yun Zhi control of tumor cell proliferation. Chinese J. Integrated and Western Medicine. 3: 73-77.

71. Liu SX, Zhou M, Chen Y, Wen WY, and Wan J. (1996) Injury to mitochondria of mouse peritoneal macrophages caused by oxidised low-density lipoprotein, and protection afforded by polysaccharide krestin. Medical Science Research 24(10): 715-717.

72. Lim BL, Law MS, Yeung WS, Sim LD, Wan JMF, Leung FCC (1996). Field strains of infectious bursal disease virus (IBDV) discovered in Hong Kong. FASEB Journal, 10(6): A1345.

73. Istfan NW, Wan J, Chen ZY. (1995) Fish Oil and cell proliferation kinetics in a mammary carcinoma tumor model. Advances in Experimental Medicine & Biology 375: 149-56.

74. Wan, J . M., Istfan N.W., Ye, S-L and Bistrian B.R. (1995) Insulin-like growth factor- 1 is not mitogenic for the Walker-256 Carcinosarcoma. Life Sciences 56(10): 747-756.

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75. Wan JM, Ye SH, Bistrian BR, and Isftan NW. (1994) The Effect of Interleukin-2 on Walker-256 tumor cell-cycle kinetics: -measured by flow cytometry. Journal of Leukocyte Biology 55(2): 241-247.

76. Selleck, K, Wan J.M., Gollaher C. Babayan V, Bistrian B. (1994) Energy expenditure in gastrostomy-fed burned rats receiving variable amounts of dietary fat. American Journal of Clinical Nutrition 60: 216-222.

77. Istfan N.W. Wan J.M. Bistrian B.R. and Chen, Z.Y. (1994) DNA replication time account for tumor growth variation induced by dietary fat in a breast carcinoma model. Cancer Letters 86(2): 177-86.

78. Wan JM , Fogt F, Bistrian BR and Istfan NW. (1993) Evaluation of the tumoricidal effect of tumor necrosis factor in relationship to tumor protein dynamics and cell kinetics in Walker-256 carcinosarcoma bearing rat. American Journal of Physiology-Cell Physiology 265: 365-374.

79. Istfan NW. Wan JM, Bistrian BR. (1993) Nutrition and tumor promotion: In vivo methods for measurement of cellular proliferation and protein metabolism. Journal of Parenter Enteral Nutrition 16(6 Suppl): S76-S82.

80. Pscheide EM, Wan JM, Blackburn GL, Bistrian BR, Istfan NW. (1992) Influence of w-3 fatty acids on splanchic blood flow and lactate metabolism in an endotoxemic rat model. Metabolism 41: 698-705.

81. Wan JMF , Istfan NW, Chu, CC, Blackburn GL, Bistrian BR. (1991) Comparative effects of w-3 and w-6 polyunsaturated fatty acids on protein metabolism in rats bearing the mammary adenocarcinoma. Metabolism 40(6): 577-584.

82. Bagley JS, Wan J, Georgieff M, Forse RA, Blackburn GL. (1991) Cellular nutrition in support of early multiple organ failure. Chest 100:182S-188S.

83. Teo TC, Selleck KM, Wan JM, Pomposelli JJ, Babayan VK, Blackburn GL, Bistrian BR. (1991) Long term feeding with structured lipid composed of MCT and fish oil ameliorates endotoxic shock in guinea pigs. Metabolism 40(11): 1152-1159.

84. Fogt F, Wan JM, O’Hara C, Bistrain BR, Blackburn GL, Istfan NW. (1991) Flow Cytometric measurement of cell kinetics in rat walker-256 carcinoma following in vivo and in vitro pulse labelling with bromodeoxyuridine. Cytometry 12:33-41.

85. Wan JMF , Haw MP, Blackburn GL. (1989) Overview: Nutrition, immune function and inflammation: an overview. Proceedings of the Nutrition Society 48:315-335.

86. Wan JMF , Teo TC, Babayan VK, Blackburn GL. (1988) Invited

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Comment: Lipids and the development of immune dysfunction. Journal of Parenter Enteral Nutrition 12(6 Suppl): 43S-52S.

87. Wan JM, Grimble RF. (1987) Effect of dietary linoleate content on the metabolic response of rats to Escherichia coli endotoxin. Clinical Science 72:383-385.

Book Chapters

1. Wan Jennifer Man Fan and Kwan Hiu Yee. DObesity and Cancer Preventiosity Drug Discovery and Development, 2017. Vol 4, 1-24.

2. JMF. Polysaccharide Kretin (PSK) and Polysaccaropeptide PSP. Handbook of Biologically Active Peptides (Second Edition). Chapter 27, 2013, pp180-184. Edited by Abba Kastin, Academic Press. ISBN: 978-0-12-385095-9.

3. Wan Jennifer. The progress of using Chinese Herbal Medicines in Cancer Research. P131-153. The way Forward for Chinese Medicine. Editors: Chan K. and Lee H. Publisher: Tayor & Francis Inc, NY, 2001.

4. Wan J , Blackburn GL. Metabolic Responses to injury: physiologic or pathologic? Chapter 21. In New Horizons III, Bihari DJ and Cerra FB (eds), 1992.

5. Wan J, Kanders BS, Kowalchuk M, Knapp H, Bagley J, Blackburn GL. Omega-3 fatty acids and cancer metastasis. World Rev Nutr Diet 66:477-487, 1991.

6. Blackburn GL, Wan J, Teo TC, Georgieff M, Bistrian BR. Multiple Organ Failure: Metabolic Support in Organ Failure. In New Horizons III, Bihari DJ and Cerra FB (eds)., Chapter 18, p337-370, 1989.

Book Review

1. Wan J. Book review on: Current Topics in Nutrition and Disease: Mineral Homeostasis in the ldery. Current Topics in Nutrition and Disease. Bales CB (ed)., Vol 21, A.R. Liss. New York. J Ent Parent Nutri 13:668-668, 1989.

Conference papers

1. Wan JMF. Nutrigenomics: Exploiting system biology in Chinese nutrition and medicine.Nutrigenomics and Health. From Vision to Food. LMC international Food Congress 2006. Denmark March 15-16. Scandinavian Journal of Food and Nutrition Supplement 1, volume 50, p16-17, 2006.

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2. Wan JMF, Hui PY, Sit WH. Induction of S phase cell arrest and caspase activation by polysaccharide peptide (PSP) isolated from Coriolus versicolor enhanced the cell cycle dependent activity and apoptotic cell death of doxorubicin and etoposide, but not cytarabine in HL-60 cells. 10th World Congress on Advances in Oncology and 8th International Symposium on Molecular Medicine. 2005 Greece.

3. Wan JMF , Fu Kelvin HM, Chan DK and Sit WH. Protection of lethal toxicity of endotoxin by Salvia miltiorrhiza Bunge is via reduction in TNF-alpha release and liver injury. International Symposium on Bioinformatics and Chinese Medicine, Organized by Chengdu University of Traditional Chinese Medicine, Chengdu 2004.

4. Wan JMF . The immunomodulatory and anticancer properties of PSP: studied by Flow Cytometry. 10th Annual General and Scientific Meeting of the Hong Kong Society of Flow cytometry. Hong Kong, 2005.

5. Wan, JMF , and WH. Sit. Mechanisms of Yun Zhi Control of Tumor Cell Proliferation. p244-246. Advanced Research in PSP. International Symposium on Chinese Medicine. Organized by the University of Hong Kong. The Hong Kong Association for Health Care Ltd. Publisher, 1999.

6. Lee J. Wan JMF. Immunostimulatory Efficiency of YunZhi and Quercetin, p151-152. Advanced Research in PSP. International Symposium on Chinese Medicine. Organized by the University of Hong Kong. Organized by the University of Hong Kong. The Hong Kong Association for Health Care Ltd. Publisher, 1999.

7. Wan JMF , Haw MP, Blackburn GL. (1989) Overview: Nutrition, immune function and inflammation: an overview. Proceedings of the Nutrition Society 48:315-335.

(Impact Factor: 3.287. Ranking: 6 out of 53. SCI Impact 2003) (Cited by 42)

Abstracts Presented in International and local Conferences

1. Wan JMF, Wang H, Sit WH. MF. Extra Virgin olive oils protect CCl4-induced oxidative stress in liver injury: comparative proteome analysis reveals differential regulation of antioxidant enzymes (2014). ISANH Antioxidant World Congress 20114, Paris, France.

2. Wan JMF. Dietary lipids and Human Health. Vitafoods Asia Expose, Hong Kong September 2014.

3. Pingping Jiang, HH-Y Ngai, KC-L Lee, WH Sit, KL Chan, JMF Wan. (2007) Proteome Profile in Preterm Intestine Following Necrotizing Enterocolitis (NEC). 8th World Congress on Inflammation, Denmark.

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P06.08.

4. Pingping Jiang, PT Sangild, T Thymann, HH-Y Ngai, WH Sit, JMF Wan. (2007) Cellular Proteome Change over Time Induced by Lipopolysaccharide (LPS) in Murine Macrophage Raw 264.7 Cells. 8th

World Congress on Inflammation, Denmark. P07.25

5. Yisha Ye, H Ngai, WH Sit, PP Jiang, J Wan. (2007) Effect of Dietary Omega-3 Fatty Acids on Heymann Membranous Nephritis: A Proteomic Assessment. 8th World Congress on Inflammation, Denmark. P09.05.

6. Lee YK, Wan JMF, Sit WH, Man K, Tan-Un KC, Fan ST. The significance of COX-2 inhibitionby omega-3 fatty acids on human hepatocellular carcinoma proliferation. 13th Hong Kong International Cancer Congress, Novemeber, 2006, Hong Kong (abstract 2.2).

7. Irene WY Jor, Carol YK Lee, WH Sit, Leo Wong, ST Fan, M. Kwan, Wan JMF. Effects of Docosahexanoic acid and eixosapentaenoic acid on the differential protein expression in human haptocellular carcinoma cells. The 2nd International conference of the Hellenic Proteomics Society. 23-25 May 2007, Greece. Cancer Genomics and Protoemics vol 4 (4): 2007. abstract 43. p 279.

8. Lee YK, Fan ST. Sit WH, Jor Irene WY, Wong, Leo LY, Man K, KC Tan-Un, Wan JMF, Olive oil enriched diet suppresses hepatocellular carcinoma (HCC) tumor growth via focal adhesion pathway. American Assoication for Cancer Annual Meeting 2007, Los Angeles, CA, abstract LB-60, p.14.

9. So WY, Li TS, Jiang H, Ngai HY, Sit WH and Wan JMF. Proteomic characterization of white adipose tissue in a diet-induced obesity study. HUPO 5th Annual World Congress, October 28, 2006 USA (abstract 453, UPO 5th Annual World Congress, October 28, 2006 USA (abstract 111, p S106).

10. Jiang P, Sangild PT, Siggers H, Ngai HY, Sit WH and Wan JMF. Proteomic Profile of intestine from preterm pigs during development of necrotizing enterocolitis (NEC). HUPO 5th Annual World Congress, October 28, 2006 USA (abstract 111, Molecular & Cellular Proteomics p S23).

11. Ngai HY, Sit WH, Jiang P, Thongboonkerd and Wan JMF. Proteomic Comparative proteomics analysis reveals haptoglobin as a possible novel marker in human membranous nephropathy. HUPO 5th Annual World Congress, October 28, 2006 USA (abstract 496, Molecular & Cellular Proteomics p S 120).

12. Wan JMF , Ngai HY, Sit WH, Jiang P, Thongboonkerd. Establishment

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of a 2-DE glomerular proteome profile in Membranous nephropathy. HUPO 5th Annual World Congress, October 28, 2006 USA (abstract 497, Molecular & Cellular Proteomics p S120).

13. Lee CL, Sit WH and Wan JMF. Cyclosporine A-like immunomodulatory benefits of polysaccharopeptide (PSP) derived from Coriolus versicolor in activated human T-cells. 7th World Congress on Inflammation, Australia. S130, 2005 (Publication No: 104574).

14. Wan JMF , Hui PY, and Sit WH. Induction of S phase cell arrest and caspase activation by polysaccharide peptide (PSP) isolated from Coriolus versicolor enhanced the cell cycle dependent activity and apoptotic cell death of doxorubicin and etoposide, but not cytarabine in HL-60 cells, 10th World Congress on Advances in Oncology and 8th

International Symposium on Molecular Medicine, Crete, Greece. October, 2005.

15. Liu, KSY, Tsang JSH, Chow BKC, Leung PC. Wan JMF. Proteomics of macrophage-an approach to understand lipopolysaccharide challenged inflammation, 4th Annual World Congress. Human Proteome Organization. Munich, Germany, August 28-September 1, 2005, Munich (Publication No: 104576).

16. Chan LL, Sit WH, Hodgkiss IJ, Hsieh DP, Wan JMF. (2004) The use of species-specific and strain-specific peptides for the identification of PST-producing strains of Alexandrium minutum and A. tamarense. Congress Proteomics for Health, Switzerland. P.79.

17. Wan JMF and Sit WH. (2004) Activation of caspase is independent to cyclin E expression in camptothecin-induced apoptosis in HL-60 cells. XXII ISAC congress, p.117. France.

18. Yang, XT, Sit, WH and Wan, JMF. (2004) Bivariate flow cytometric analysis of HL-60 cell cycle progression affected by polysaccharopeptide (PSP) from coriolus versicolor mycelia. XXII ISAC congress, France.

19. Wan JMF , Fu Kelvin HM, Chan DK and Sit WH. Protection of lethal toxicity of endotoxin by Salvia miltiorrhiza Bunge is via reduction in TNF-aplha relase and liver injury. International Symposium on Bioinformatics and Chinese Medicine p.242, 2004.

20. K.W.Wong, W.H.Sit and M.F.Wan. (2003) The immunodulating effect of a Chinese medicinal herb extract, polysaccharide (PSP), in humans. British Journal of Haematology 121(Supp. 1): 41-86.

21. P.Y.Hui, W.H.Sit and M.F.Wan. (2003) Enhanced cytotoxicity of doxorubicin and etoposide by polysaccharide peptide (PSP) in HL-60 cells. British Journal of Haematology 121(Supp. 1): 1-40.

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22. Yang, XT, Sit, WH and Wan, JMF. (2002) The polysaccharopeptide (PSP) from Trametes versicolor mycelia induces apoptosis of HL-60 is related to cell cycle arrest at G1-S and cyclin E expression. Cytometry (Supp.1): 72

23. Hui KPY, Sit WH and Wan JMF. (2002) Induction of S phase cell arrest and caspase activation by polysaccharide peptide isolated from Coriolus versicolor enhanced the cell cycle dependent activity and apoptotic cell death of doxorubicin and etoposide but not cytarabine in HL-60 cells. 93th Annual Meeting of American Association for Cancer Research

24. Yang, XT, Sit, WH and Wan, JMF. (2001) The potential use of the polysaccharide peptide, an active ingredient of the Chinese medicinal mushroom, Yunzhi, for adjunctive chemotherapy. Abstracts of the Singapore Traditional Chinese Medicine (TCM) Research Symposium 2001. 12-14 November, Singapore.

25. J.M.F. Wan Lee, C.Y.J. and Woo SM. The Chinese traditional food “Pig knuckles and ginger” is a superior functional food for calcium. 11th World Congress of Food Science and Technology, Seoul Korea (April 22-27, 2001), P.241

26. Lee, C.Y.J. and J.M.F. Wan (2001). The regulation of vitamin E and selenium on oxidative stress and immunity in human lymphocyte cell culture. 11th World Congress of Food Science and Technology, Seoul Korea (April 22-27, 2001), P.209.

27. Lee, C.Y.J., C.H. Lee and J.M.F. Wan (1999). The competence of vitamin E on cell-mediated immunity and oxidative stress of healthy individuals. 한국식품과학회, 제 63 차 학술발표회, P24.

28. Chow, A, Sit, WH and Wan, JMF. (1999) Danshen, the Chinese Mushroom posses Apoptotic Effect on cancer cell. The American Association for Cancer Research 2000, Abstract, November.

29. Wan, JMF, Yang M and Sit WH. Mechanisms of Yun Zhi control of tumor cell proliferation. Advanced Research in PSP, 1999. The Hong Kong Association for Health Care Ltd, HK publisher, p.244, 1999.

30. Fu, K, Sit, WH and Wan, JMF. (1999) Radix Salviae Mitrirrhizae, Denshen, a Chinese Hebral Medicine, stimulates Human Natural Killer Cell, CD3+CD56+. The American Assoication for Cancer Research 2000, Abstract, November.

31. Wan, JMF, Chu, STC, Chiu, LCM, Lee, JCY, Ng, JYF. and Sit, WH. (1998) The application of flow cytometry in cancer research. Abstracts of the Fourth Annual Symposium of Hong Kong Society of Flow Cytometry. 3 December, Hong Kong SAR, China.

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32. Wan JMF , Sit WH. (1998) Anticancerous Mechanism and Clinical Significance of Polysaccaride-peptide of Corioulus Versicolor: studied by flow cytometry. International Symposium on “The worldwide herbal industry: present and future”, The Chinese University of Hong Kong, Hong Kong. Abstract: p19

33. Wan, JMF and Sit, WH. (1998) Yun Zhi extract inhibits human promyelocytic leukemic cancer cells growth by delaying cells transit through the cell cycle. APBN, 2, 2:30-33.

34. Chung-Yung J. Lee and Jennifer M.F. Wan (1998) The Immunostimulatory effect of Chinese functional foods – Mushroom extract and Tea Component. APBN, 2, 5&6:90-91.

35. Chu SCS, Wan JMF. (1998) Interleukin 1 (beta)-concerting enzyme (ICE) inhibitor and serine proteases inhibitor prevented up-regulation of cyclin E and B1 during campotothecin (CAM) induced apoptosis in the HL-60 cells. Cytometry (Supp. 9): 119.

36. Wan, JMF and Sit, WH. (1998) Flow cytometry as a powerful tool to evaluate herbal products for adjunctive chemotherapy. Cytometry (Supp. 9): 119.

37. Ng YF, Wan JMF. (1998) Dietary fatty acids induced necrosis and apoptosis in mammary tumors: Measured by flow cytometry. American Association for Cancer Research 39:126

38. Lee, C.Y.J. and J.M.F. Wan. (1998). The effect of vitamin E on oxidative stress and cell-mediated immunity on supplementation to healthy Hong Kong individuals. Society for the Study of Endocrinology Metabolism and Reproduction (Hong Kong). XIIth Annual Scientific Meeting. Publication No.12, P18.

39. Wan, JMF., Yang, M. and Sit, WH. (1997) Mechanisms of Yun Zhi control of tumor cell proliferation. International Symposium on Chinese Medicine and Public Health, University of Hong Kong, 35.

40. Ng YF and Wan JM. (1997) Fatty acids control of cell cycle distribution and expression of p53 tumor suppressor gene in mammary 13762 MAT tumors. Abstract 760, 88th Annual Meeting of American Association for Cancer Research,

41. Chu S and Wan JM. (1997) Cyclin E, cyclin B and tumor suppressor proteins are involved in camptothecin-induced apoptosis in the human promyelocytic leukemic cells (HL-60). 11th European Cell Cycle Conference, Italy, abstract 91.

42. Chiu, LCM, Sit, WH. and Wan, JMF. (1997) Polyunsaturated fatty acids induce apoptosis in the human promyolocytic leukamia HL-60 cells

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involves Bcl2. 11th European Cell Cycle Conference, Italy, 20.

43. Lee CYJ and Wan JMF. (1997) Alpha-tocopherol stimulates T-lymphocytes proliferation: measured by flow cytometry. Hong Kong Society for the Study of endocrinology, Metabolism and Reproduction

44. Lee CYJ and Wan JMF. (1997) The immunocompetence of polysaccaride-peptide and quercetin. 16th International Congress of Nutrition, Montrol, Canada, Abstrate 100

45. Chiu, LCM, Wan, JMF and Sit, WH. (1996) Effects of arachidonic acid on proliferation and apoptosis of human promyelocytic leukemia HL-60 cells. Abstracts of the First Scientific Meeting of the Centre for Cellular Biology. 11-12 October, Hong Kong. B04.

46. Wan, JMF, Sit, WH and M.Young. (1996) The anticancer potential of Yun Zhi is related to its direct cell-cell specific inhibition activity. Abstracts of Second International Symposium & Workshops of Asia Pacific Society of Bioscientists. 8-11 July, Hong Kong. PT1.13.

47. Chiu, LCM, Wan, JMF and Sit, WH. (1996) Effects of polyunsaturated fatty acids on proliferation of human promyelocytic leukemia HL-60 Cells. Abstracts of Second International Symposium & Workshops of Asia Pacific Society of Bioscientists. 8-11 July, Hong Kong. PT2.2.

48. Wan, JMF, Sit, WH and Young M. (1996) Flow cytometric analysis of cyclin B1 and cytokinetics of HL-60 cells during treatment with polysaccharide peptide of coriolus versicolor. Cytometry (Supp 8): 47.

49. Chiu, LCM, Wan, JMF and Sit, WH. (1996) Bromodeoxyuridine/DNA analysis by flow cytometry for proliferation inhibition and cell cycle regulation by polyunsaturated fatty acids in human leukemia HL-60. Cytometry (Supp 8): 46.

50. Chu SC, Wan JM. (1996) Induction of cyclin E expression in Human Promyelocytic leukemia (HL-60) after apoptotic stimulation. Cytometry (Supp 8): 50.

51. Lee, C.Y.J., W.W.M. Lee and J.M.F. Wan (1996). Immunostimulatory efficiency of Yun Zhi and Quercetin. Symposium of Chinese Medicine & Public Health, The University of Hong Kong. P35.

52. Selleck K, Gollaher C, Wan J, Babayan V, Bistrian B. (1990) Energy expenditure in gastrostomy-fed burned rats receiving variable amounts of dietary fat. J Fed Am Soc Exp Biol.

53. Wan JM, Fogt F, Bistrian BR, O’Hara C, Blackburn GL, Istfan NW. (1990) Evaluation of the tumoricidal effect of tumor necrosis factor in relationship to tumor protein dynamics and cell kinetics. Clin Research

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38:455A.

54. Assy W, Wan JM, Coyle S, Blackburn GL, Bistrian BR, Istfan NW. (1990) Fasting increases the sensitivity of blood pressure response to insulin in obese rats. Clin Research 38:477A.

55. Wan J , Grimble RF. (1989) The effect of fasting and weight cycling on blood pressure and glucose metabolism in the rat. J Fed Am Soc Exp Biol 757:A356.

56. Brown G, Hunt V, Wan J, Grimble RF. (1987) The differing responses of Zinc and Protein-metabolism to Escherichia-coli endotoxin in rats fed on diets containing maize, coconut and fish oils. Proc Nutri Soc (U.K) 46 (1): A36. (Cited by 6)

57. Wan J, Grimble RF. (1986) Diurnal influences on metabolic effects of 2 types of 2 types of Escherichia-coli endotoxin in rats. Proc Nutri Soc. (U.K) 45(3) A83 (Cited by 6).

58. Wan J , Grimble RF. (1986) Inhibitory effects of indomethacin on some features of the metabolic response to E.coli endotoxin in rats. Proc Nutri Soc (U.K) 45(2):A51.(Cited by 3).

59. Wan J, Grimble RF. (1986) Effect of a lipooxygenase inhibitor AA861 on the metabolic response to E.coli endotoxin. Proc Nutri Soc (U.K.) 45(1):A38. (Cited by 5).

60. Wan J , Grimble RF, Gore M (1986) Effects of dietary-fat concentration and saturation on the catabolic response of protein-metabolism to Escherichia-coli endotoxin. Proc Nutri Soc (U.K.) 45 (1): A27. (Cited by 4)

61. Wan J , Grimble RF, Gore M (1985) Decreased protein-synthesis in skin, muscle, and bone after interleukin-1 production by Escherichia-coli endotoxin in rats. Proc Nutri Soc (U.K)44 (2): A71. (Cited by 9)

Local Presented papers:

1. 39th Joint School Science Exhibition Invited speaker April 2006. Topic” Science unlimited

2. HKU TCM Workshop 2006, Faculty of Medicine, The University of Hong Kong

“Theraeutic Potential of Yun Zhi – a Chinese Medicinal mushroom

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