abraxane brochure

A Patient’s Guide to ABRAXANE®

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*Please see Indication, BoxedWarning & Important Safety Information on page 2.

When fightingmetastatic breast cancer*

little things count

Please see page 24 for full PrescribingInformation, includingWarnings,Precautions, and Contraindications.

Indication, Boxed Warning & Important Safety Information

One of the more important side effectsassociated with chemotherapy isneutropenia, which is a decrease in thenumber of infection-fighting white bloodcells (neutrophils). Normal levels rangefrom approximately 1,500 cells/mm3 to1,800 cells/mm3 (but vary according toseveral factors, such as age and race). Iflevels fall below 500 cells/mm3, your riskof developing an infection increases andtreatment may be interrupted. To avoidthe risk of serious infection and fever,your doctor will monitor your absoluteneutrophil count (ANC) during therapy.

Women should avoid becoming pregnantwhile being treated with ABRAXANE.Tell your doctor if you are pregnant, if youbecome pregnant, or you plan to becomepregnant while taking ABRAXANE. Discusswith your doctor how ABRAXANEmayaffect fertility. Nursing a baby while takingABRAXANE is not recommended becausethe drug may be present in breast milk.

The most important adverse events includedlower white and red blood cell counts,infections, tingling and numbness, nausea,vomiting, diarrhea, muscle and joint aches,and mouth sores. Other adverse reactionsincluded weakness, visual disturbances, fluidretention, hair loss, and liver and kidneydysfunction. Low platelet counts, allergicreactions (which in rare cases were severe),cardiovascular reactions, and injection sitereactions were uncommon.

Sensory neuropathy (numbness, tingling,or burning in the hands and feet) canoccur with ABRAXANE and other paclitaxelmedications. Severe sensory neuropathy canimprove with proper management, asprescribed by your doctor. You should tellyour nurse or doctor if you experiencenumbness, tingling, or burning in yourhands or feet while taking ABRAXANE.

Please talk to your doctor or nurse if youhave questions regarding the potential sideeffects of ABRAXANE therapy. You maywant to review the Product Information,including Warnings, Precautions, andContraindications.

You should receiveABRAXANE for Injectable Suspension (paclitaxelprotein-bound particles for injectable suspension) under the care of adoctorwho is trained to use cancer drugs. Because youmay have sideeffects fromyour treatment, you should get thismedicine in a clinic orhospital with doctors, nurses, and pharmacistswho are trained to givecancer drugs.

ABRAXANE therapy should not be given to patientswithmetastaticbreast cancerwho have lowwhite blood cell counts, whichmaymakeyoumore likely to get an infection. Your doctorwill schedule frequentblood tests for you in order to check for lowblood counts.

Note: ABRAXANE is paclitaxelmadewith the human blood proteinalbumin. Thismakes it behave differently in the body than regularpaclitaxel. DONOTSUBSTITUTE FORORWITHOTHERPACLITAXELDRUGS.

ABRAXANE® is indicated for the treatment of breast cancer after failure ofcombination chemotherapy formetastatic disease or relapsewithin 6months ofadjuvant chemotherapy. Prior therapy should have included an anthracyclineunless clinically contraindicated.

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Introduction Table of contentsIndication, BoxedWarning & Important Safety Information.......................2

What is metastatic breast cancer?.............................................................................6

What is ABRAXANE? ........................................................................................................8

Why ABRAXANE? ...........................................................................................................10

ABRAXANE side effects.................................................................................................12

Resources .............................................................................................................................16

Insurance and payment support...............................................................................19

Questions to ask your doctor....................................................................................20

Coping tips ..........................................................................................................................22

Contact information ......................................................................................................24

Notes......................................................................................................................................26

Prescribing Information................................................................Inside back cover

Please see Indication, BoxedWarning & Important SafetyInformation on page 2.

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Receiving a diagnosis of metastatic breast

cancer can be overwhelming, to say the

least. You’ve already been through a lot,

and emotionally it can be difficult to accept.

But despite all of the feelings youmay be

experiencing right now, know that it is still

important to stop and enjoy the little things

in life.

Perhaps you have heard of ABRAXANE®

and want to learn more. Maybe you’re

currently receiving solvent-based paclitaxel

(Taxol® (paclitaxel) Injection) and want to

know how ABRAXANE differs. Or maybe

your doctor has already prescribed

ABRAXANE to help you fight your disease.

Whatever the case, this guide will help you

better understand your condition, address

questions youmay have, and discuss how

ABRAXANE can help you in your battle

against metastatic breast cancer.

Please note that this material is not

intended to replace conversations

with your health care team. If you have

questions, comments, or concerns, please

speak with your doctor or nurse.

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Before you can understand andmake

informed decisions about possible

treatment options for metastatic breast

cancer, you need to knowwhat is

happening inside your body and why.

How a tumor forms

Unlike normal body cells that divide,multiply, and die in an orderly way,cancer cells multiply uncontrollably andaccumulate into a mass of extra tissuecalled a tumor. The reasons for thisabnormal growth are not well understood.

What is metastatic breast cancer?

How breast cancer cells spread toother parts of the body

When a tumor invades surrounding healthybody tissue, it is known as a malignanttumor. A malignant tumor can spread(metastasize) from its original site to otherparts of the body. Because of their spreadand growth in other organs, malignantbreast tumors can interfere with normalbody function and become life-threatening.

If breast cancer metastasizes, it is stillconsidered breast cancer in that new site.For example, if breast cancer spreads to alung, the tumor in the lung is not lungcancer but breast cancer that hasmetastasized.

Stage IV breast cancer

Doctors use the term “stage” to referto the extent of cancer within the body.Breast cancer staging takes into accountthe size and location of the primarybreast tumor, any regional lymphnode involvement near the breast andunderarm, and any metastatic disease.

In stage IV, also known as metastaticcancer, the disease has spread fromthe breast to other parts of the body,such as the bone, liver, lungs, or brain.

Normal Cells

Cancerous Cells

Primary tumor hasdeveloped in the breast.

Metastatic breast cancer hasspread to other parts of the body.

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What is ABRAXANE®?ABRAXANE has also been shown tobemore effective than solvent-basedpaclitaxel (Taxol® Injection). In aclinical trial, the tumor response ratewas nearly double for patients whoreceived ABRAXANE compared to thosewho received solvent-based paclitaxel.

How is ABRAXANE administered?

ABRAXANE is administered into a vein asan intravenous infusion. Each infusion isgiven in an outpatient clinic and takes only30minutes (unlike solvent-based paclitaxel(Taxol® Injection), which can take up to 3hours), giving youmore free time to spenddoing the little things that matter. Yourdoctor or nurse will determine the correctdose and treatment schedule for you.

The information found in this brochureis not intended to replace conversationswith your health care team. If you havequestions, comments, or concerns, pleasespeak with your doctor or nurse.

ABRAXANE is a treatment option that

uses a unique technology to deliver

the drug paclitaxel. Paclitaxel is a

potent chemotherapy treatment that

stops cancer cells from growing and

dividing by interfering with certain

cell structures and killing the cancer

cells. Paclitaxel can slow tumor growth

or temporarily stop tumor growth

altogether.

ABRAXANE is indicated for thetreatment of breast cancer afterfailure of combination chemotherapyformetastatic disease or relapsewithin6months of adjuvant chemotherapy.Prior therapy should have includedan anthracycline unless clinicallycontraindicated.


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ABRAXANE is the first and only albumin-bound taxane that utilizes nab™ technology

Paclitaxel

Bloodstream

Solvent*

* Solvents (chemical detergents) may causesevere, solvent-related hypersensitivityreactions requiring premedication.

Tumor Site

Bloodstream

Tumor Site

Paclitaxel

Albumin

ABRAXANE®

Albumin-bound paclitaxelTaxol® InjectionSolvent-based paclitaxel

How is ABRAXANE different?

Traditionally, paclitaxel must first bedissolved in a chemical solvent in orderfor the drug to be administered. This typeof paclitaxel is referred to as solvent-based(Taxol® Injection).

These solvents can cause side effects suchas difficulty breathing, hives, swollen eyesand lips, a flushed face, and severe allergicreactions (hypersensitivity reactions). Toreduce the risk of developing these solvent-related side effects, patients need to takeadditional medications such as steroidsand antihistamines before they receivesolvent-based paclitaxel (Taxol® Injection).This is called premedication.

ABRAXANE offers a different approachfor treating metastatic breast cancercompared to solvent-based paclitaxel(Taxol® Injection). It uses a process callednab™ technology to deliver paclitaxel.This technology uses albumin to create aformulation that eliminates the need forsolvents. Albumin is a human protein,normally present in the bloodstream,that carries nutrients throughout thebody. Because ABRAXANE does notcontain solvents, there is no risk ofsolvent-related hypersensitivity reactions,so premedication with steroids andantihistamines is not necessary.

The lack of solvents in ABRAXANE allowspatients to receive a higher dose of tumor-fighting paclitaxel. One study showedthat patients who received ABRAXANEcompared to solvent-based paclitaxel(Taxol® Injection) had a 49% higher doseof chemotherapy.

nab™ technology eliminates the need forsolvents and allows for a higher dose oftumor-fighting paclitaxel to be given.

Highlight 1:Nearly double the tumor response rate

In a clinical trial, the number of women who had tumorsthat reduced in size when given ABRAXANE was nearlydouble that of those who were given solvent-based paclitaxel(Taxol® Injection). Because ABRAXANE is solvent-free, womenparticipating in the study were not subject to solvent-relatedtoxicities and therefore could be given a higher dose of tumor-fighting paclitaxel.

What thismeans to you:

Each dose of solvent-free ABRAXANE provides you with moretumor-fighting paclitaxel than would a dose of solvent-basedpaclitaxel (Taxol® Injection).

Highlight 2:No premedication

Asmentioned, one of the most important differences betweenABRAXANE and solvent-based paclitaxel (Taxol® Injection) is thelack of solvents. Solvents can cause side effects such as difficultybreathing, hives, swollen eyes and lips, a flushed face, and severeallergic reactions (hypersensitivity reactions), which is why patientsneed to be premedicated with steroids and antihistamines. BecauseABRAXANE is solvent-free, patients treated with ABRAXANEdo not need premedication.


Without the need for premedication, ABRAXANE offers youa more convenient treatment option compared to solvent-based paclitaxel (Taxol® Injection).

Severe allergic reactions to ABRAXANE, although rare, canoccur. Contact your doctor if you experience any signs of anallergic reaction.

Highlight 3:Shorter infusion time

ABRAXANE is administered in only 30minutes, while solvent-based paclitaxel (Taxol® Injection) can take up to 3 hours.


ABRAXANE takes only about a half-hour to administer.This gives youmore free time away from the clinic—upto 2 1⁄2 hours more—to spend doing the things you enjoy.

Because ABRAXANE helps you fight the cancer, not thetreatment, you can focus on the little things that mattermost—and enjoy all life has to offer.


Why ABRAXANE®? Benefit highlights

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ABRAXANE® side effects

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Hair loss

Loss of eyebrows, eyelashes, pubic hair, andscalp hair may occur 14 to 21 days after youbegin treatment. Your hair will grow backonce the ABRAXANE treatment has ended.

What can I do?

Be gentle to your hair and scalp

Use low heat when using a hair dryer

Consider cutting your hair short

Protect your scalp from the sun

Infections due to lowwhite bloodcell count (neutropenia)

White blood cells are among the body’sdefenses against bacterial infections.ABRAXANE usually causes a brief drop inwhite blood cells, which may cause you tobemore susceptible to infection and fever.Between your treatment cycles, you willhave blood tests to check your white bloodcell counts.

What can I do?

Call your doctor if you experiencea fever over 100.4°F

Wash your hands often

Try to avoid crowds andpeople with colds

Immediately clean and protect cuts

Check with your doctor before gettingimmunization shots

Take a bath or shower dailyusing mild soap

Use lotion to prevent your skinfrom cracking

These side effects, known as sensoryneuropathy, occur often and usually getbetter or go away without medicationwithin 3 weeks of interrupting treatment.(It is sometimes necessary to interrupttreatment with ABRAXANE until thesesymptoms improve, after which timetreatment can be restarted at a lower dose.)

What can I do?

Immediately tell your doctor about theseside effects—your doctor mayfind it necessary to adjust the dose

Massage your hands and feet tostimulate nerves

Apply moisturizing cream/lotion toyour hands and feet

Avoid activities in extreme weather

Avoid wearing tight footwear

Avoid standing for long periods of timeand walk only short distances

Take extra precaution near fires, hotwater, or other sources of heat

Avoid using an ice pack on any partof your body

The following side effects were reported in ABRAXANE clinical trials.

Provided here is a description of these side effects and some helpful

information.


Numbness, tingling, or burning of hands and feet (neuropathy)

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ABRAXANE® side effects, continuedFatigue andweakness (asthenia)

Tiredness and weakness after treatmentis known as asthenia. It often disappearswithout interruption or modification oftreatment.

What can I do?

Get proper rest

Take part in activities that relax you

Eat a well-balanced diet

Drink plenty of fluids

Perform light exercise daily

Joint andmuscle pain

Soreness of the joints andmuscles mayoccur shortly after treatment begins, butusually disappears within a few days.

What can I do?

Tell your doctor if you are experiencingany severe joint or muscle pain

Perform light exercise

Low red blood cell count (anemia)

Anemia occurs when there are not enoughred blood cells in your blood. It may makeyou feel tired, appear pale, and experienceshortness of breath. Contact your doctorif you experience any of these symptoms.

What can I do?

Talk to your doctor about medicationsthat increase your red blood cell count

Conserve energy by doing only thethings that are most important to you

Take short naps throughout the dayinstead of one long nap

Perform light exercise

Get up slowly from lying or sittingpositions to reduce dizziness

Eat small meals frequentlythroughout the day

Drink plenty of fluids

Mouth or lip sores (mucositis)

Mouth or lip sores may occur a few daysafter starting treatment. This side effectusually disappears within 1 week.

What can I do?

Use lip balm or another lip moisturizer

Use a soft toothbrush and brush yourteeth after eating

Usemouthwash that does not containalcohol

Frequently rinse your mouth with warmsalt water

Avoid foods that might irritate yourmouth, such as spicy foods, orange juice,and pretzels

Upset stomach and diarrhea

Nausea, vomiting, and/or diarrheamay occur following treatment. If youexperience nausea or stomach upset,tell your doctor, because medicines canbe given to reduce or eliminate thesesymptoms. Diarrhea will usually disappearwithout treatment; however, tell yourdoctor right away if you experiencesevere abdominal or stomach areapain and/or severe diarrhea.

What can I do?

Drink plenty of fluids slowlyand frequently

Avoid drinking coffee, tea, and alcohol

Avoid sweets as well as fried, greasy,or spicy foods

Eat low-fiber foods such as eggs,potatoes, white bread, or creamedcereals

Avoid dairy products such asmilk, cheese, or ice cream

Irritation at the injection site

Youmay experience discomfort, redness,swelling, inflammation, or a deep sore orbreak in the skin at the site of the injection.

What can I do?

Inform your doctor if you experienceany irritation at the injection site

Low heart rate (bradycardia)

It is possible to experience a drop in yourheart rate, but patients do not usuallynotice these changes and they usuallydo not require treatment.

What can I do?

Tell your doctor if you have a history ofheart disease

Lowblood pressure (hypotension)

If you experience dizziness, fainting, orshortness of breath, talk to your doctor.

What can I do?

Have your doctor check yourblood pressure

Drink plenty of water

Exercise moderately to increaseblood flow

Avoid heavy lifting

Elevate the head of your bedto improve blood circulation

Eat small meals frequently

Rest after meals to minimize dizziness

Avoid hot showers and baths

Rise slowly from sitting or lying positions


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ResourcesBooks and publications

Advanced Breast Cancer: A Guide toLiving withMetastatic Disease

ByMusaMayer. 2nd edition. O’Reilly &Associates, Inc., 1998.

Practical advice and emotional supportfor women and families dealing with therealities of metastatic breast cancer.

Art.Rage.Us.: Art andWriting byWomenwith Breast Cancer

By Jill Eikenberry and Terry Tempest.Chronicle Books, 1998.

Inspiring artwork and writing bybreast cancer survivors, an outgrowthof an exhibit at the San FranciscoMainLibrary Gallery.

Betty Crocker’s Living with CancerCookbook: Easy Recipes and TipsThrough Treatment and Beyond

Betty Crocker, 2001.

Advice from cancer patients, from tips forcoping with emotions to making recipesmore appealing. Recipes are tagged toshowwhich are helpful for common sideeffects of cancer treatment.

The Breast Cancer Book of Strength &Courage: Inspiring Stories to See YouThrough Your Journey

By Ernie Bodai, M.D., and Judie FertigPanneton. 1st edition. Prima Lifestyles, 2002.

Uplifting stories of women who facedmastectomies, radiation, andchemotherapy with courage, humor, andgrace.

The CancerMonologue Project

By Tanya Taylor and Pamela Thompson.MacAdam/Cage Publishing, 2002.

In a series of workshops, people affectedby cancer were invited to write andperform their stories about living,resulting in these 30 engagingmonologues.

Holding Tight, Letting Go: Living withMetastatic Breast Cancer

ByMusaMayer. 1st edition. Patient CenterGuides, 1997.

A personalized and highly informedguide to life with metastatic breastcancer.

Here for Now: LivingWell with CancerThroughMindfulness

By Elana Rosenbaum. Satya HousePublications, 2005.

Mindfulness-based stress reductiontechniques.

Live Longer, Live Larger: AHolisticApproach for Cancer Patients andTheir Families

By SusanW. Buchholz, Ph.D., andWilliamM.Buchholz, M.D. 1st edition. Patient CenterGuides, 2001.

Stories and exercises to help conquerfear, find the right treatment, andincrease the quality andmeaning of life.

Online support and community

www.ABRAXANE.comYour primary source of information aboutABRAXANE®.

www.abraxisoncology.comProvides information about the proprietarynab™ technology of ABRAXANE.

www.astrazeneca-us.comA corporate site containing additionalinformation on breast cancer treatmentoptions.

www.breastcancer.orgA clearinghouse of breast cancer educationinformation on a spectrum of topics.Support resources include chat rooms,discussion boards, and online conferences.


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When going through treatment for

metastatic breast cancer, it is important

to have access to as many helpful

resources as possible. The following

provide information and support to help

you stay focused on your treatment plan

and overall health.

In addition to the information provided

here, be sure to talk to your doctor

about other sources of support.

This list of resources is providedmerelyas a convenience. Abraxis and AstraZenecatake no responsibility for the content of, orservices provided by, the resources andmakeno representations as to the accuracy orcompleteness of any information providedand shall have no liability for any damagesor injuries of any kind arising from theinformation contained within these resources.

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www.bcmets.orgThe largest online community of peopleliving with advanced breast cancer, theirfamilies, and their friends. Enter searchcriteria for information and patient mailinglist submissions.

www.breastcancerstories.comBreast cancer patients can uploaddiary entries and photos in this onlinecommunity. Friends and family memberscan follow their loved ones’ stories.

www.cancer.orgThe site of the American Cancer Society(ACS).

www.komen.orgThe Susan G. Komen Breast CancerFoundation provides useful information,research news, and information on howto get involved with the Komen Race forthe Cure®.

www.cancerhopenetwork.orgOffers free, confidential, one-on-onesupport for people with cancer andtheir families.

www.clinicaltrials.govInformation about federally andprivately supported clinical research.

www.lbbc.orgProvides news andmessage boardsfor women with breast cancer.

www.nci.nih.govProvides information from the NationalCancer Institute (NCI) on cancer and itstreatment.

www.canceradvocacy.orgThe National Coalition for CancerSurvivorship (NCCS)—the oldest canceradvocacy organization in the country.

nano.cancer.govNCI Alliance for Nanotechnology inCancer provides up-to-date informationon nanotech oncology.

www.nihroadmap.nih.govThe NIH Roadmap offers a guide tofinding information onmedical research.

www.y-me.orgOffers general cancer and lifestyleinformation from the Y-MENationalBreast Cancer Organization.

Resources, continued Insurance and payment support

The ARC of Support is a comprehensive

program that provides a broad range of

services for physicians and their patients

who are being treated with ABRAXANE®.

You or your doctor can call 800-564-0216,

option 3, to find out if you are eligible.

This program is available through yourdoctor and can help you with insuranceclaims, reimbursement, and payment issues.Our specially trained professionals can alsoassist your doctor with researchingcoverage options and verifying benefits onyour behalf. This program offers assistanceto both uninsured and insured patientsbased upon financial need. In addition,eligible patients may qualify for the AbraxisOncology Patient Access Program (APAP).Please talk to your doctor or nurse if youneed assistance with insurance or paymentissues related to ABRAXANE.

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Is ABRAXANE® right forme?

My doctor said:

HowcanABRAXANE treatmydisease?

My doctor said:

Howwill I know if ABRAXANE isworking?

My doctor said:

Howcan I prepare for treatment and reduce thechances of side effects?

My doctor said:

What are the side effects of ABRAXANE?

My doctor said:

Howwill I receiveABRAXANE?Howoften?And for how long?

My doctor said:

Wherewill I receivemy treatment?

My doctor said:

Willmy diet be restricted in anyway?My activities?Work? Exercise? Sexuality?

My doctor said:

Write any additional questions youmay have for your doctor:

Questions to ask your doctor

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Coping tipsTake care of your body

Become familiar with your body andbe aware of what is “normal” for you

Report any noticeable changes toyour doctor

Establish andmaintain a healthylifestyle that includes good nutrition.Try experimenting with new recipesto find those that agree with yourchanging taste buds—especially if treat-ment side effects are causing loss ofappetite, nausea, or changes in taste andsmell. Also talk to your doctor aboutmedications that may help prevent orreduce these side effects

Stay active. Aerobic exercise andresistance training have been shown tohelp alleviate some side effectsassociated with breast cancer and itstreatment, such as fatigue, depression,and anxiety. Before beginning anyexercise program, be sure to talk to yourdoctor

Don’t overdo it. Whenever possible, tryto plan your daily activities around timeswhen you feel your best. Get plenty ofsleep at night, and rest during the day ifyou feel tired

Pay attention to youremotional needs

Be positive. A positive attitude andhopeful outlook will help you feel better

Take time to do the things you enjoy.Nurture yourself with the little things lifehas to offer

Reach out to family and friends whenyou’re feeling sick, lonely, or scared—they’ll be eager to help however they can

Consider joining a support group—studies show that women withmetastatic disease who participatein support group therapy experienceless pain and emotional distress thanwomen who do not

Life is different with metastatic breast

cancer. Despite the challenges each day

may bring, there are things you can do

to take control and help ensure you’re

getting the most benefit from your

chemotherapy treatment.

Follow your treatment plan

Follow the treatment plan establishedby your doctor. Alert your doctorimmediately if you need to miss anappointment

Drink plenty of fluids, especially in thefirst few days after your treatment

Do not take aspirin during chemotherapy,and tell your doctor about any medicines,herbal remedies, or home remedies youare taking during your treatment cycles.Somemedications may interfere with theeffects of chemotherapy

Keep a journal of treatment datesand schedules. Write down detailedinformation about any symptoms or sideeffects you notice, including the severity,number of occurrences, and time ofoccurrence. Bring this journal withyou to each doctor visit

Become an active partnerin your care

Be persistent when communicatingyour concerns to your doctor

Know that you have a say in all aspectsof your care

Stay informed about your disease andtreatment options. If you have anyquestions, ask your doctor

Get organized

Keep emergency contact informationhandy. Make a list of the names andphone numbers of your doctors,pharmacists, family members, friends,and health insurance provider. Keepingall of your records in one place can helpgive you a sense of control and help youstay on top of your diagnosis


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Contact information Appointment scheduleMy doctors and other health care providers

Primary care physician

Telephone number

Oncologist

Telephone number

Oncology nurse

Telephone number

Nutritionist

Telephone number

Pharmacy

Telephone number

Emergency hospital

Address

Telephone number

Family or friends to contact in case of emergency

Name

Telephone number

Name

Telephone number

Name

Telephone number

My health insurance provider

Provider/plan

Telephone number

Group ID number

Date Time Location

Results

Date Time Location

Results

Date Time Location

Results

Date Time Location

Results

Date Time Location

Results

Date Time Location

Results

Date Time Location

Results

Date Time Location

Results

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Notes

Visit ABRAXANE.com or talk with yourdoctor to learn if ABRAXANE® is right for you.

ReferenceABRAXANE [prescribing information]. Los Angeles, Calif: Abraxis Oncology, a Division of AbraxisBioScience, Inc; May 2007.

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ABRAXANE ismarketedunder a co-promotion agreementbetweenAbraxis BioScience, Inc. andAstraZeneca.

AbraxisOncology is a division ofAbraxis BioScience, Inc. AllAbraxis BioScience, Inc. corporate names, names of services,andnames of products referred to herein are trade names,servicemarks and/or trademarks that are ownedbyor licensedtoAbraxis BioScience, its divisions or its affiliates, unlessotherwise noted. All other trademarks are the property of theirrespective owners.

AO461/249652 6/07

Visit ABRAXANE.com or talk with your doctor to learn if ABRAXANE® is right for you.

Please see Indication, Boxed Warning & Important SafetyInformation on page 2.

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abraxane brochure

Documents

patient center

boxed warning

full prescribing

important

health care

white blood

metastatic

severe allergic