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ABO INCOMPATIBLE TRANSPLANTATION Dr WS McKane MDSC175: Transplantation Science for Transplant Clinicians (Online) POSTGRADUATE SCHOOL OF MEDICINE A MEMBER OF THE RUSSELL GROUP CONTINUING PROFESSIONAL DEVELOPMENT Slide 2 2 ABO Incompatible Transplantation Measuring isohaemagglutininsRemoving/modulating/inhibiting synthesis of antibodyClinical ABOi transplantation Slide 3 3 ABO Incompatible Transplantation Nature of ABO antigens Glycolipids and glycoproteins Genetics encoded by the assembly enzymes Glycosyl transferases Highly complex system Subtypes E.g. A1 and A2 Core chains I-VI Differentially expressed Branching/non-branching chains A in AB individuals not identical to A in A individuals Slide 4 4 ABO Incompatible Transplantation Slide 5 5 A1 vs A2 A1 and A2 Subtle differences is structure Differences in antigen density A2